生物活性染色剂在白色白内障撕囊术中的应用

目的 评价生物活性染色剂在白色白内障超声乳化手术中显现晶状体前囊的可行性和安全性等。方法 55例白色白内障随机编人台盼蓝和吲哚青绿前囊染色组。采用气泡下染色技术完成连续环形撕囊。结果 台盼蓝和吲哚青绿均可充分着染前囊。染色辅助撕囊的总成功率为98．2％。吲哚青绿组和台盼蓝组分别为96．7％、100％。尚未观察到术后染色剂残存于眼组织或人工晶状体异色。术后矫正视力0．5～1．2。结论 生物活性染色剂可显著提高白色白内障超声乳化手术的安全性。     

台盼蓝染色在白色白内障超声乳化术中应用的改进

目的观察低浓度的蓝域Vision Blue(0．03％台盼蓝)染色在白色白内障超声乳化术中对于连续环行撕囊术的帮助及整个手术是否安全顺利进行。方法43例43眼白色白内障在术中用0．1ml蓝域稀释为．0．2ml直接注入前房，观察晶状体前囊膜染色情况及术中、术后情况。结果43例43眼晶状体前囊膜均一次性均匀着色，连续环行撕囊术均顺利完成，术中、术后无不良反应。结论低浓度的蓝域染色是一种有效的晶状体前囊膜染色技术，能有效提高前囊膜能见度，有利于白色白内障超声乳化术的顺利进行。     

改良亚甲蓝和台盼蓝前囊染色在白色白内障撕囊术中的临床应用对比

目的 探讨晶状体超声乳化术中改良亚甲蓝染色和台盼蓝染色对连续环形撕囊成功牢及对角膜内皮的影响.方法 67例(67眼)白色白内障(术中无红光反射者)随机分为3组进行前瞻性研究.改良亚甲蓝染色组25例,台盼蓝染色组24例,对照组(前囊不染色)18例.连续环形撕囊后行超声乳化及人工晶状体植入术.比较环形撕囊成功率、术中并发症、术后前房反应情况、视力、眼压、角膜内皮损失率及变异系数.结果 两种方法染色后撕囊成功率及人工晶状体囊袋内植入牢均为100.00%,无后囊破裂,与对照组相比差异有统计学意义;染色组术后视力高于对照组,但差异无统计学意义;3组术后眼压及角膜内皮损失率和变异系数筹异均无统计学意义.结论 改良亚甲监染色和台盼蓝染色均可明显提高连续环形撕囊成功率,降低超声乳化手术并发症,且无明显副作用,前者廉价易得,使用效果与台盼监相同.     

台盼蓝囊膜染色剂在白内障连续环形撕囊手术中的应用

目的研究台盼蓝囊膜染色剂在治疗白色白内障中,是否有助于连续环形撕囊的顺利完成及白内障手术的顺利进行。方法79例(80眼),随机分为2组,染色组40例(41眼),对照组39例(39眼),染色组使用台盼蓝囊膜染色剂,术中观察及对比前囊膜染色情况、连续环性撕囊成功率、晶状体后囊破裂及人工晶状体囊袋内植入情况,术后视力、前房炎症反应、角膜、人工晶状体有无蓝染及后囊混浊情况。并与对照组进行统计学分析。结果染色组的术中染色均匀,连续环形撕囊及人工晶状体囊袋内植入率为97.7%,晶状体后囊破裂率为2.44%,与对照组进行统计学分析有显著差异。术后追踪观察3个月,染色组术后视力好于对照组,前房炎症反应、晶状体后囊混浊2组无统计学差异。染色组术后角膜、人工晶状体未见蓝染,未见术中及术后并发症。结论台盼蓝囊膜染色剂目前是一种安全可靠的技术,手术中可以看清前囊,使连续环形撕囊顺利进行,人工晶状体稳定的位于囊袋内,增加了白色白内障手术的成功率。     

白内障手术连续环形撕囊的染色技术

目的:观察VisionBlue（0.06％台盼蓝）染色在白色白内障超声乳化手术中是否有助于连续环形撕囊（CCC）及整个手术安全顺利进行。方法:30例30只眼,术中前房注入0.1ml VisionBlue,观察前囊膜着色效果、撕囊成功率、在超声乳化手术中囊膜保护的完整率以及角膜内皮、眼压和房水炎症反应等。结果:28眼前囊膜周边及中央一次性均匀着色,2只眼经过两次染色后着色均匀;撕囊全部成功顺利,在后续的超乳手术中保留的囊膜边界清晰,完整率30/30;术中无并发症,术后视力提高,炎症反应轻,眼压及角膜内皮与术前无统计学差异;追踪3个月未见明显副作用。结论:VisionBlue染色是一种简单安全的技术,提高了前囊膜的可见度,有助于白色白内障超声乳化手术CCC和整个手术的安全顺利进行。     

台盼蓝染色技术在白内障超声乳化术中的应用

目的 观察在缺乏眼底红光反射的白内障超声乳化术中晶状体前囊膜台盼蓝染色技术的安全性及有效性。方法 对30例（30只眼）成熟期及过熟期白内障患者行超声乳化白内障吸除联合人工晶状体植入术,术中以0．1％的台盼蓝进行前囊膜染色,然后行连续环形撕囊术,观察术中情况,术后随访3个月,观察视力、眼压、角膜及房水情况。结果 30例白内障术中29例撕囊口边缘清晰可见．连续环形撕囊获得成功,手术顺利完成。1例术中囊膜染色不充分,囊口出现放射状撕裂,经补救撕囊．手术得以顺利进行。术后随访未发现与染色有关的眼部并发症。结论 在缺乏眼底红光反射的白内障超声乳化术中,以台盼蓝进行晶状体前囊膜染色后再行连续环形撕囊术是安全有效的方法。     

台盼蓝囊膜染色剂在复明工程成熟期白内障手术撕囊中的应用

目的 探讨台盼蓝囊膜染色剂在白内障复明工程白内障手术撕囊中的应用价值。设计 回顾性比较性病例系列。研究对象 2012-2013年期间河北省兴隆县人民医院“百万贫困白内障患者复明工程” 成熟期或过熟期白内障手术患者84例（84眼）。方法 随机分为观察组和对照组,每组42例（42眼）。观察组超声乳化白内障手术过程中接受0.1 ml 0.1%台盼蓝磷酸盐缓冲溶液前囊膜染色后行连续环形撕囊,对照组超声乳化白内障术中撕囊前未予染色。主要指标  术中囊膜染色情况,撕囊成功率,术后视力、眼压、前房炎症反应、角膜水肿及后囊混浊情况。结果 观察组台盼蓝染色后,晶状体前囊膜100%被染成淡蓝色。撕囊成功率观察组97.6%,对照组78.6%（P=0.003）;术后1个月视力、眼压、前房炎症反应、角膜水肿情况两组比较差异无统计学意义（均为P>0.05）;术后3个月后囊膜明显混浊观察组1/42例、对照组6/42例（P=0.027）。结论 白内障复明工程成熟期或过熟期白内障手术中采取台盼蓝囊膜染色剂行前囊膜染色,使连续环形撕囊相对容易,保证手术更顺利进行。（眼科,2014,23：271-273）     

台盼蓝在成熟期白内障超声乳化术中的应用

目的探讨台盼蓝着色前囊膜在成熟白内障超声乳化手术中的应用。方法本组32例老年性白内障成熟期、过熟期患者接受台盼蓝前囊膜染色,采用前房气泡下染色法,前房注入0.1mL染色液,数秒钟后用BSS液冲洗置换染液及气泡,注入粘弹剂后,连续环行撕囊。对照组取同期白内障超声乳化患者30例,比较环行撕囊成功率、术后视力、眼压及角膜水肿程度。结果经染色后32例前囊膜均呈淡蓝色,清晰可辨,撕囊成功率达97%,而对照组为80%,有显著差异。术后视力、眼压及角膜内皮水肿无显著差异。结论台盼蓝着色前囊膜后,连续环行撕囊更安全易行。     

白色白内障撕囊丢失囊膜台盼蓝染色的有效性探讨

目的 探讨成熟期和过熟期白色白内障连续环形撕囊(CCC)囊膜丢失后,在不吸除黏弹剂情况下使用台盼蓝染色找回丢失囊膜的有效性.方法 对52例(52只眼)术中连续环形撕囊发生囊膜丢失的连续性白色白内障病例进行前瞻性研究.随机分为两组,染色组27例(27只眼),对照组25例(25只眼).染色组不吸除前房玻璃酸钠,使用台盼蓝囊膜染色.对照组吸除前房玻璃酸钠后进行撕囊或截囊.对两组连续环性撕囊成功率、人工晶状体囊袋内植入率进行统计学分析.结果 染色组连续环形撕囊及人工晶状体囊袋内植入率高于对照组,差异具有统计学意义(P<0.01),无毒性及并发症发生.对照组有9只眼人工晶状体植入睫状沟,6只眼发生后囊膜破裂及玻璃体脱出.结论 在连续环形撕囊发生囊膜丢失后,采取不吸除前房黏弹剂,应用台盼蓝对晶状体前囊膜染色,对找回丢失囊膜和CCC继续完成是有效和安全的.     

吲哚菁绿运用于白色白内障超声乳化术中的临床研究

目的：探讨5g/L吲哚菁绿溶液前囊膜染色在白色白内障超声乳化术中连续环形撕囊的临床应用效果。

方法：白色白内障患者98例98眼,随机分为两组,观察组50例50眼,对照组48例48眼。对照组不做前囊膜染色。观察组采用黏弹剂下5g/L吲哚菁绿溶液前囊膜染色,前囊膜染色针抽取5g/L吲哚菁绿溶液0.1mL,自辅助切口注入到前囊膜中央表面,留置30s,平衡盐液置换出多余染料。两组均应用撕囊镊连续环形撕囊。

结果：观察组前囊膜呈现均匀的淡绿色,能见度显著提高,有48眼撕囊成功,成功率96%; 对照组有29眼撕囊成功,成功率60%,两组差异有统计学意义(P<0.05)。观察组术后裂隙灯显微镜下检查前房未见染料颗粒残存及虹膜炎及眼压升高等并发症。前房炎症反应、角膜透明度与对照组比较,差异无统计学意义。

结论：吲哚菁绿前囊膜染色使前囊清晰可辨,可提高对白色白内障患者术中撕囊的成功率,从而减少术中并发症的发生,使超声乳化白内障手术初学者较快掌握连续环形撕囊术,改善初学者的学习曲线。     

Staining the Anterior Capsule with Indocyanine Green or Trypan Blue for Capsulorhexis in Eyes with White Cataract

Aim: To assess the efficacy and safety of indocyanine green (ICG) 0.5% and trypan blue 0.1% for anterior capsule staining in cases of white cataract. Methods: This prospective study comprised 55 eyes of 55 patients with white cataract that had phacoemulsification with foldable intraocular lens implantation. ICG in 30 eyes and trypan blue in 25 eyes were used under air to stain the anterior lens capsule. The staining patterns and the ease of creating a continuous curvilinear capsulorhexis (CCC) were assessed; the intraoperative and postoperative complications were noted. The mean follow-up was 17.68±1.65 months. Result: Either ICG or trypan blue stained the anterior capsule uniformly. However, the staining provided by trypan blue was slightly superior. A CCC was successfully achieved in 25 eyes (100%) with trypan blue, and 29 eyes (96.7%) with ICG, respectively. There was no significant postoperative reaction in any eye. Conclusion: The use of vital dyes such as ICG and trypan blue guarantees a complete CCC and makes it possible to deliver the benefits of phacoemulsification in the patients with white cataract.     

Trypan blue as an adjunct for safe phacoemulsification in eyes with white cataract

PURPOSE: To assess the feasibility, risks, and postoperative outcomes of phacoemulsification with posterior chamber intraocular lens (PC IOL) implantation in cases of white cataract with the use of trypan blue as an adjunct for performing continuous curvilinear capsulorhexis (CCC) in the absence of a red reflex. SETTING: Dr. Agarwal's Eye Hospital, Chennai, India. METHODS: This prospective study comprised 52 eyes of 52 patients with white cataract that had phacoemulsification through a clear corneal temporal incision with PC IOL implantation. In all the cases, trypan blue was used under air to stain the anterior lens capsule and the karate-chop technique was used to emulsify the nucleus. The mean follow-up was 192.2 days. RESULTS: Trypan blue adequately stained the anterior lens capsule in all cases. The CCC was completed uneventfully in 96.15% eyes; 3.85% of cases had to be converted to a conventional extraction technique because of the loss of the CCC. The mean phacoemulsification time was 2.2 minutes. Intraocular complications included incomplete capsulorhexis (3.85%) and pupillary miosis (3.80%). Postoperatively, 3 eyes (5.77%) had corneal edema (striate keratopathy) and 1 eye (1.9%) had fibrin in the anterior chamber. Five eyes (9.61%) had more than 2+ cells and flare at 2 weeks. All responded well to intensive topical and subconjunctival steroids. There were no cases of endophthalmitis. The mean central endothelial cell loss, measured in 37 eyes, was 8.5%. Of the 4 eyes (7.69%) that had increased intraocular pressure (IOP) postoperatively, all responded well to medications and the IOP was normal by the second postoperative week. Fifty eyes (96.16%) had a final best corrected visual acuity of 20/30 or better. In 2 cases, the final visual acuity was worse than 20/200 because of preexisting posterior segment pathology. CONCLUSION: Phacoemulsification using trypan blue was safe and effective in managing white cataract and had a high success rate.     

台盼蓝与吲哚青绿在成熟期和过熟期白内障手术中的应用

目的：：观察台盼蓝与吲哚青绿在成熟期、过熟期白内障超声乳化手术中进行连续环形撕囊( continuous curvilineal capsulorrhexis, CCC)的作用及效果。方法：选取成熟期、过熟期白内障122例122眼,随机分为3组,台盼蓝染色组( A组)46例46眼,吲哚青绿染色组(B组)40例40眼,对照组(C组)36例36眼。染色组在手术中分别使用台盼蓝或吲哚青绿0.2mL注入前房,进行CCC。术中观察及对比连续环形撕囊成功率、晶状体后囊破裂及人工晶状体囊袋内植入情况。观察术后前房炎症反应,并与对照组进行观察分析。结果：台盼蓝染色组(A组)连续环形撕囊成功率、人工晶状体囊袋内植入率与对照组(C组)进行统计学分析有显著性差异(P<0.05)。吲哚青绿染色组(B组)人工晶状体囊袋内植入率与对照组(C组)进行统计学分析有显著性差异(P<0.05)。晶状体后囊破裂率三组间无显著性差异(P>0.05)。术后观察前房炎症反应三组间无明显差异。结论：应用台盼蓝或吲哚青绿对缺乏红色反光的成熟期、过熟期白内障进行晶状体囊膜染色后再行CCC,目前是一种安全可靠的技术,两者效果相当。手术中可以使连续环形撕囊顺利进行,提高了手术成功率。     

Trypan-blue- and endoillumination-assisted phacoemulsification in eyes with vitreous hemorrhage during combined cataract and vitreous surgery

PURPOSE: To study the safety and usefulness of trypan blue application and conventional endoillumination for enhancing visualization during phacoemulsification and foldable intraocular lens implantation in cases of cataract with vitreous hemorrhage. METHODS: Ten eyes of 10 patients with cataract and coexisting vitreous hemorrhage underwent combined trypan-blue- and endoillumination-assisted phacoemulsification and foldable intraocular lens implantation with vitrectomy. In a two-step surgery, after staining the anterior capsule with trypan blue, continuous circular capsulorhexis was performed; then, phacoemulsification was performed using conventional endoillumination. Specular microscopy was performed before and 3 months after surgery on eyes that underwent trypan-blue- and endoillumination-assisted phacoemulsification and on control eyes that underwent standard phacoemulsification to evaluate the toxic effect of trypan blue on corneal endothelial cells. RESULTS: Trypan blue application improved visualization of the anterior capsule, and a complete capsulorhexis could be performed in all eyes. In all 10 eyes, endoillumination was required to visualize the lens structure, and phacoemulsification could be accomplished. Specular microscopy revealed that there was no significant difference in the level of corneal endothelial cell loss between the trypan-blue- and endoillumination-assisted phacoemulsification group and the control group. CONCLUSION: The described double visualization technique may assist phacoemulsification in selected cases of cataract with vitreous hemorrhage.     

白内障手术中苔盼蓝晶状体囊染色的作用及安全性

目的观察苔盼蓝作晶状体囊染色在超声乳化术中应用的有效性和安全性。方法回顾分析使用晶状体苔盼蓝染色剂Vision Bule前后两个时期的晶状体全浑浊的白内障手术186例（212眼）。其中96例（118眼）使用了染色剂。对术中操作和术后效果进行了对比。结果晶状体囊苔盼蓝染色剂Vision Blue对晶状体前囊有较好的染色效果,可使手术操作变得安全易行,术中术后无不良反应。结论晶状体囊染色剂Vision Blue在超声乳化术中对晶状体前囊染色的应用是有效的和安全的。     

低浓度台盼蓝囊膜染色技术在白内障手术中的应用

目的：探讨台盼蓝染色晶状体前囊膜的最低有效浓度,评价白内障手术中应用囊膜染色技术的临床意义。

方法：收集2014-03/2016-12成熟期年龄相关性白内障患者60例60眼,晶状体皮质混浊程度为C4～C5、核混浊程度为N3(以晶状体混浊分类系统Ⅱ为标准),随机分为三组。三组患者术中分别使用0.03%、0.015%和0.0075%三种不同浓度台盼蓝。所有患者均由同一经验丰富手术医生完成手法小切口白内障手术。术中观察前囊膜染色情况以及撕囊难易程度。记录连续环形撕囊术(continuous circular capsulorhexis,CCC)成功、后囊袋破裂以及人工晶状体囊袋内植入情况。观察术后1d,1wk,3mo术眼角膜内皮细胞计数、眼压、前房炎症反应、角膜水肿和眼内结构染色情况。

结果：浓度低至0.015%的台盼蓝仍可对晶状体前囊膜有效染色,顺利完成CCC。0.03%与0.015%两组患者CCC成功率和IOL囊袋内植入率均高于0.0075%组,差异均有统计学意义(P<0.0083)。三组患者后囊破裂发生率和角膜内皮细胞平均损失率两两比较,差异均无统计学意义(P>0.0083)。术后晶状体前囊撕囊口边缘及侧切口的着染均于1wk内消失,未见其他眼内结构蓝染,前房炎症反应轻,未发现超过1wk的角膜水肿和眼压升高。

结论：白内障手术中应用台盼蓝晶状体前囊膜染色技术安全有效,可提高手术成功率,建议使用台盼蓝最低有效浓度为0.015%。     

晶状体前囊膜苔盼蓝染色在白内障超声乳化术中的临床应用观察

目的 探讨晶状体前囊膜染色技术在白内障超声乳化术中应用的有效性和安全性。方法 88例（90只眼）行白内障超声乳化术患者,分成染色剂辅助撕囊组A组40例（40只眼）,和常规手法撕囊组B组40例（40只眼）,观察撕囊成功率、在超声乳化手术中囊膜保护完整率以及眼压和房水炎症反应等。结果 连续环形撕囊成功者,A组为95％（38／40）,B组为62．50％（25／40）;A、B两组中,分别有2只眼及10只眼出现前囊膜向赤道部撕裂,并行前段玻璃体切割术。结论 染色剂辅助撕囊技术,对于一些缺乏眼底红光反射的白内障患者,可以明显提高连续环形撕囊的成功率,使这类患者的超声乳化术更加安全。