Nerve fiber analyzer measuring retinal nerve fiber layer thickness in normal and glaucomatous eyes

目的客观测量和比较青光眼病人与正常人视网膜神经纤维层（ＲＮＦＬ）厚度。方法用神经纤维分析仪（ＮＦＡ）对１５例（２５眼）开角青光眼病人及２５例（４２眼）正常人视盘区神经纤维层厚度进行测量,然后经计算机自动分析求出上、下、颞、鼻４个区ＲＮＦＬ厚度及平均厚度,所得数据经统计学分析。结果青光眼患者上、下区域ＲＮＦＬ平均厚度分别为（８４．４７±１２．０９）μｍ和（７７．４９±１６．６３）μｍ,总平均厚度（７２．５１±１２．０９）μｍ,均低于正常人［分别为（１０４．９２±２０．５６）μｍ,（９５．４８±１５．６２）μｍ和（８６．１５±１４．７５）μｍ）］,统计学差异有显著意义（Ｐ＜０．０１）;颞、鼻侧厚度与正常人差异不明显。结论ＲＮＦＬ厚度分析可望作为青光眼早期诊断依据之一。     

Evaluation of Retinal Nerve Fiber Layer in Patients with Idiopathic Optic Perineuritis using Optical Coherence Tomography

Abstract

The aim of this study was to assess the effect of idiopathic Optic perineuritis on the retinal nerve fiber layer, and determine the ability of optical coherence tomography to evaluate retinal nerve fiber loss after idiopathic Optic perineuritis. Four patients were assessed in this study. In all cases, average retinal nerve fiber layer was significantly thinner in the affected eye in comparison with the normal reference value and with the value for the contralateral normal eye at 12 months after the onset of optic perineuritis. Our study revealed that retinal nerve fiber layer loss occurs in idiopathic optic nerve sheath inflammation.     

Evaluation of Retinal Nerve Fiber Layer in Patients with Idiopathic Optic Perineuritis using Optical Coherence Tomography

The aim of this study was to assess the effect of idiopathic Optic perineuritis on the retinal nerve fiber layer, and determine the ability of optical coherence tomography to evaluate retinal nerve fiber loss after idiopathic Optic perineuritis. Four patients were assessed in this study. In all cases, average retinal nerve fiber layer was significantly thinner in the affected eye in comparison with the normal reference value and with the value for the contralateral normal eye at 12 months after the onset of optic perineuritis. Our study revealed that retinal nerve fiber layer loss occurs in idiopathic optic nerve sheath inflammation.     

光学相干断层扫描仪不同扫描程序测量视网膜神经纤维层厚度的比较

目的 探讨光学相干断层扫描仪(STRATUS OCT,OCT3)不同扫描程序对视网膜神经纤维层(RNFL)厚度测量 的影响。设计 前瞻性、病例对照研究。 研究对象 正常人38例72眼,原发性开角型青光眼(POAG)患者19例34眼。方法 所有被检查者分别用OCT3常规扫描程序(RNFL Thickness 3_4)和个性化扫描程序(RNFL Thickness 2．27×disc)进行检 查,比较两种程序测量RNFL厚度的结果。对两种扫描方式各象限RNFL厚度及其全周平均值进行对比;分别计算两种扫描程 序测量RNFL厚度值的ROC曲线下面积,以了解其诊断青光眼的准确性;并分别对两种扫描程序测量RNFL厚度值与 Humphery视野的平均偏差(MD)进行线性回归分析。主要指标 视网膜各象限及全周平均RNFL厚度;Humphery视野平均偏 差。 结果 正常人常规扫描的颞侧、上方、鼻侧、下方、平均的RNFL厚度分别为(75．36±13．22)μm、(122．11±16．78)μm、 (70．76±13．25)μm、(125．06±14．43)μm、(98．40±9．62)μm,而个性化扫描相应的RNFL厚度分别是(77．04±12．44)μm、 (121．99±13．86)μm、(70．76±13．50)μm、(124．26±16．05)μm、(99．42±9．08)μm,两种方式进行比较,差异无显著性(P值为 O．053-1．000)。POAG患者常规扫描的颞侧、上方、鼻侧、下方、平均的RNFL厚度分别为(65．12±13．10)μm、(92．59±21．93)μm、 (59．97±12．36)μm、(73．59±22．48)μm、(72．79±9．51)μm,而个性化扫描相应的RNFL厚度分别是(63．64±13．16)μm、 (90．52±19．44)μm、(59．91±13．52)μm、(73．86±23．34)μm、(73．32±9．54)μm,两种扫描程序比较,除颞侧有显著性差异(P= O．031)外,其余各方位及全周平均值差异无显著性(P值为0．107-0．954)。两种扫描程序测量RNFL厚度的ROC曲线下面积在 全周平均及下方最大,为0．959-0．973。颞侧、上方、下方及全周平均RNFL厚度与视野MD显著相关(P<0．05)。 结论 应用 OCT3测量RNFL厚度,常规扫描和个性化扫描均可准确地测量RNFL厚度,对青光眼有较高的诊断价值。     

视网膜神经纤维层检测在诊断青光眼及近视合并青光眼中的价值

视网膜神经纤维层(retinal nerve fiber layer,RNFL)厚度的现代检测手段主要有海德堡视网膜断层扫描仪、光学相干断层成像术和偏振激光扫描仪等。检测RNFL厚度可以对青光眼的早期诊断提供依据。与青光眼一样,近视眼的RNFL也会变薄。所以近视合并青光眼时经常容易被误诊而延误青光眼的治疗时机。因此我们必须将单纯近视眼与近视合并青光眼区别开来。对RNFL的检测能否将单纯近视眼及近视合并青光眼区别开,国内外学者存在不同观点,现综述如下。     

视网膜神经纤维层定量测定在青光眼方面的应用

青光眼的主要病理过程是视网膜节细胞轴突（即视神经纤维）的丢失，故测量视网膜神经纤维层（ｒｅｔｉｎａｌｎｅｒｖｅｆｉｂｅｒｌａｙｅｒ，ＲＮＦＬ）来确定轴突丢失的程度在青光眼的早期诊断和治疗上具有非常重要的意义。近年来，计算机图像分析技术应用于眼科，它能对ＲＮＦＬ作出客观的量化检测。该文综述有关文献，就ＲＮＦＬ定量测定方法的原理，以及它们在青光眼ＲＮＦＬ损害检测方面的应用情况作一介绍。     

近视眼视网膜神经纤维层厚度分析

目的:分析近视眼患者与正常人视网膜神经纤维层厚度的差异,探讨近视程度对视网膜神经纤维层厚度的影响。方法:采用视神经分析仪-GDxVCC(美国激光技术诊断公司生产)测量正常人23例42眼和近视眼患者85例166眼视网膜神经纤维层厚度,近视眼患者按等效球镜屈光度分为低、中、高、超高度近视四组,将所得结果用SPSS11.5统计软件包进行统计分析。结果:视乳头周围2.4～3.2mm的环形区域视网膜神经纤维层平均厚度正常人与低、中、高度及超高度近视组比较无显著性差异,不同程度近视眼组两两之间进行比较无显著性差异;上方120°区域视网膜神经纤维层厚度高度、超高度近视眼组与其他各组进行比较有非常显著性差异(P<0.01),高度与超高度近视组之间进行比较有显著性差异(P<0.01),其他各组两两之间进行比较无显著性差异;下方120°区域视网膜神经纤维层厚度各组之间进行比较无显著性差异;环形区域RNFL厚度平均值的标准差超高度近视组与其余各组之间的差异具有显著性(P<0.05);神经纤维指数高度近视组、超高度近视组与其他各组差异有显著性,且与屈光度呈线性关系(P<0.05)。结论:随着近视程度的增加,近视眼患者上方120!范围内视网膜神经纤维层厚度逐渐变薄,神经纤维指数逐渐增加。     

糖尿病视网膜病变前期患者视网膜神经纤维层厚度变化分析

目的：对比OCT测量正常人与糖尿病患者的视网膜神经纤维层厚度(RNFLT)。

方法：收集48例2型糖尿病患者与100名正常人纳入本研究。所有患者以及对照组接受OCT检查测量RNFLT,同时测量糖尿病患者的血糖以及糖化血红蛋白。

结果：糖尿病患者与正常人平均RNFLT存在显著统计学差异,视盘上方以及5：00,11：00,12：00位RNFLT存在显著统计学差异。随访6mo,记录糖化血红蛋白(HbA1C)与视盘上方,视盘颞侧,视盘下方RNFLT变化的关系。

结论：本研究证实控制血糖可以影响RNFLT,无视网膜病变的糖尿病患者与正常人比较,平均RNFLT以及视盘上方RNFLT有轻微减少。     

不同近视程度儿童视神经纤维层厚度的改变

目的:探讨4 ～ 10岁不同近视程度儿童视神经纤维层(retinal nerve fiber layer,RNFL)厚度改变.方法:收集2012-01/2014-05于我院就诊的高度近视儿童12例(屈光度≥-6.00D),中度近视儿童14例(-3.00D≤屈光度＜-6.00D),轻度近视儿童14例(0D≤屈光度＜-3.00D),对所有患儿完善RNFL厚度测量,并进行组间对比.结果:高度近视组平均RNFL厚度为102.36±10.33μm,中度近视组平均RNFL厚度为106.52±9.46μm,轻度近视组平均RNFL厚度为112.66±9.79μm.高度近视组较轻度近视组儿童平均RNFL厚度变薄,差异具有统计学意义(P＜0.05);高度近视组与中度近视组、中度近视组与轻度近视组相比,RNFL差异无统计学意义(P＞0.05);在下方象限,高度近视组与轻度近视组,中度近视组与轻度近视组RNFL对比差异具有统计学意义(P＜0.05),其余三组各象限对比差异均无统计学意义.结论:在高度近视患者平均R较轻度近视组明显变薄,且在下方象限高度近视与中度近视组较轻度近视组均明显变薄.在对近视儿童的诊疗过程中,我们应当完善近视RNFL厚度检查辅助诊断,可为近视儿童的观察及随访提供客观指标.     

人视网膜神经纤维层厚度与眼轴长度相关性的研究

目的　研究人视网膜神经纤维层厚度 (RNFLT)与眼轴长度的关系。方法　应用视网膜厚度分析仪 (RTA)检测 116例 ( 116眼 )正常志愿者RNFLT、屈光状态和眼轴长度并进行统计分析。结果　男女两组志愿者的平均RNFLT没有统计学差异 ;RNFLT与近视眼屈光度呈负相关关系 (r =-0 .64 69,P <0 .0 1) ;RNFLT与眼轴长度也呈负相关关系 (r =-0 .6971,P <0 .0 1)。结论　人视网膜神经纤维层厚度随眼轴长度增加而减少。在借助视网膜神经纤维层厚度诊断疾病时要考虑眼轴长度对结果的影响。     

眼底指标改变与脑卒中患病的相关性

【摘要】 目的  探讨眼底指标改变与脑卒中患病风险的相关性。设计  病例对照研究。研究对象  北京同仁医院、北京天坛医院年龄（63.6±10.2）岁的脑卒中患者450例,对照组为年龄（62.5±8.7）岁“北京眼病研究”非脑卒中受检者566例。方法  所有受试者单张45度眼底数码照相。两位眼科医师盲法评价眼底指标改变。应用Logistic 回归分析眼底指标与脑卒中患病的相关性及脑卒中发病风险性,应用Orange 2 软件统计图对分析结果进行可视化。主要指标  视网膜神经纤维层缺损（RNFLD）、视网膜动脉缩窄、动静脉交叉压迫征、视网膜静脉迂曲扩张、视盘改变、黄斑病变的构成比及与脑卒中患病的OR值。结果 非脑卒中组、脑卒中组视网膜动脉管径缩窄出现率分别为46.3%、65.1%（P<0.05）,视网膜静脉扩张出现率分别为12.5%、38.0%（P<0.05）,RNFLD出现率分别为12.7%、38.0%（P<0.05）,视网膜棉絮斑出现率分别为1.6%、4.4%（P<0.05）,视网膜出血出现率分别为4.6%、11.3%（P<0.05）,视盘病变出现率分别为7.1%、16.9%（P<0.05）,黄斑病变出现率分别为6.4%、13.1%（P<0.05）。Logistic 回归分析显示,RNFLD（OR=4.163, 95%CI 2.792-6.208）和视网膜静脉扩张（OR=3.443, 95%CI 2.333-5.082）与脑卒中患病高度相关。除性别对于脑卒中患病有负向影响（男性更易罹患脑卒中）外,RNLFD、视网膜静脉扩张、黄斑病变对脑卒中患病有正向影响。在眼底组合指标中,视网膜动脉缩窄、静脉扩张、RNFLD同时存在与脑卒中患病相关性最大。结论  眼底RNLFD、视网膜动脉缩窄、静脉扩张三项指标联合对脑卒中发病预警有重要提示作用,眼底血管变化与RNFLD改变可为脑血管病变的筛查提供简易方法。（眼科, 2015, 24： 13-18）     

视网膜光凝对糖尿病视网膜病变患者神经纤维层厚度的影响

目的：探讨分析糖尿病视网膜病变(diabetic retinopathy,DR)患者全视网膜激光光凝术(panretinal photocoagulation,PRP)治疗后1a视网膜神经纤维层(retinal nerve fiber layer,RNFL)厚度的变化。

方法：选取2014-05/2017-06在我院行PRP治疗的92例92眼DR患者,采用OCT的DISC CIRCLE程序,测量分析以视盘为中心、直径3.45mm范围DR患者PRP术前和术后1a(采用Follow-Up程序自动追踪模式)视盘周围RNFL厚度,按视盘上方(S)、下方(I)、鼻侧(N)、颞侧(T)4个象限分区所得的数值进行统计分析。

结果：DR患者PRP术后1a较术前视盘周围上方、下方、鼻侧、颞侧和全周平均RNFL厚度明显变薄,且差异有统计学意义(均P<0.05)。

结论：PRP治疗可导致视网膜RNFL变薄,临床上应充分重视和考虑RNFL的损伤,更好地保护视网膜神经细胞的机能对DR治疗具有重要意义。     

Retinal vessel diameters and their correlation with retinal nerve fiber layer thickness in patients with pseudoexfoliation syndrome

AIM: To compare retinal artery-vein diameters (RAVDs) of patients with pseudoexfoliation (PSX) syndrome with healthy controls and investigate the correlations between retinal nerve fiber layer (RNFL) thickness parameters and RAVDs. METHODS: Seventeen eyes with PSX and 17 eyes of age-matched controls were included in the study. All participants underwent routine ophthalmological examination, Humphrey visual field and RNFL examination by using Stratus OCT. Retinal images were obtained by using a retinal camera (Topcon 501X). RAVDs were measured from inferior nasal, inferior temporal, superior nasal and superior temporal arcuates by using IMAGEnet software. Superior, inferior, nasal, temporal and average RNFL thicknesses were recorded. RAVDs and RNFL parameters in groups and correlations were analyzed by Mann-Whitney U and Spearmann correlation tests. RESULTS: Only inferior quadrant and average RNFL thickness were detected thinner in the PSX group compared with control group (P=0.009, P=0.038, respectively). No statistically significant difference regarding RAVDs was found between two groups. CONCLUSION: RAVDs seems to be comparable in the PSX and control group. RNFL is thinner in the inferior quadrant in the PSX group. RNFL thickness and RAVDs show significant correlations in both groups. This correlation doesn’t seem to be specific to PSX.     

Assessment of retinal manifestations of Parkinson’s disease using spectral domain optical coherence tomography: A study in Indian eyes

Purpose:To assess the retinal manifestations of Parkinson’s disease using optical coherence tomography.Methods:A prospective case-control study comparing 30 eyes from 15 patients with Parkinson’s disease and 22 eyes from 11 healthy age-matched controls. Total macular subfield thickness and the thickness of the ganglion cell layer, nerve fiber layer, and peripapillary retinal nerve fiber layer were measured with spectral-domain optical coherence tomography (SD-OCT).Results:The mean age of PD patients was 68.4 years ± 10.64 (range: 46–82) and in the control group was 66.36 ± 5.22 (range: 64–68). The average disease duration in patients with PD was 6.7 ± 2.8 years (range: 2–10 years). The mean best-corrected visual acuity in PD was 20/26 and 20/20 in controls, with P = 0.0059, which was significant. Significant difference was also found in the contrast sensitivity between both groups. Structural differences in the central macular thickness (P = 0.0001), subfield thicknesses in the superior (P = 0.003), inferior (P = 0.001), nasal (P = 0.004), and temporal subfields (P = 0.017) was seen. Severe thinning of the ganglion cell layer was seen in PD patients (P = 0.000) as well as of the nerve fiber layer (P = 0.004). Peripapillary retinal nerve fiber thickness measured showed significant thinning in superotemporal (P = 0.000), superonasal (P = 0.04), inferonasal (P = 0.000), inferotemporal (P = 0.000), nasal (P = 0.000), and temporal quadrants (P = 0.000).Conclusion:Visual dysfunction was observed in patients with PD along with structural alterations on OCT, which included macular volumes, ganglion cell layer, and peripapillary retinal nerve fiber layer.     

Analysis of Refractive Status and Thickness of Retinal Nerve Fiber Layer in Children with or without Retinopathy of Prematurity

Objective: To compare the refractive status and retinal nerve fiber layer thickness (RNFLT) in pre-term children with or without retinopathy of prematurity (ROP) at 8 years old, and to investigate the effects ofpre-term birth and ROP on refractive status and RNFLT. Methods: This was a prospective study. From January 2009 to February 2011, premature babies (average gestational age: 33.6±4.1 weeks, average birth weight: 2 099±779 g) who underwent fundus screening in the Department of Ophthalmology, Children's Hospital of Chongqing Medical University, were divided into an ROP group and pre-term ROP group (pre-term group), and full-term babies of the same age were used as controls. A total of 112 children (222 eyes) were enrolled, including 24 in the ROP group (47 eyes), 55 in the pre-term group (110 eyes), and 33 in the full-term group (65 eyes). The RNFLT, axial length (AL), and retinoscopy were examined in the three groups at the age of 8. The incidence of refractive error and the difference in RNFLT were compared. Data were analyzed using Chi-squsure test and ANOVA. Results: The incidence of myopia (χ2 =8.062, P=0.018; χ2 =3.671, P=0.036) and astigmatism (χ2 =7.758, P=0.023; χ2 =3.710, P=0.034) in the ROP group and pre-term group were higher than those in the full-term group. There was no significant difference in the incidence of hyperopia (χ2 =4.910, P=0.250). The AL of the ROP group and pre-term group was shorter than that of the full-term group (both P<0.001). The average RNFLT of the pre-term group was thinner than that of the full-term group (F=2.593, P=0.030). The temporal quadrant RNFLT of the pre-term group was thinner than that of both the full-term group (P<0.001) and ROP group (P<0.001). Conclusions: The pre-term children and children with ROP have a shorter AL at 8 years of age, and are more prone to myopia and astigmatism. ROP and prematurity affect their refractive status, but prematurity plays a major role. Prematurity and ROP have different effects on RNFLT, especially in the temporal quadrant. The abnormalities of RNFLT caused by other diseases need to be identified during the follow-up period.     

早产儿及早产儿视网膜病变患儿的屈光状态及视神经纤维层厚度分析

目的：评估8岁段早产儿及早产儿视网膜病变（ROP）患儿的屈光状态和视网膜神经纤维层（RNFL） 厚度，探讨早产及ROP对屈光状态和RNFL厚度的影响。方法：前瞻性研究。收集2009 年1月至 2011年2月在重庆医科大学附属儿童医院眼科行眼底筛查的早产儿，孕周（33.6±4.1）周，出生体质 量（2 099±779）g，按有无ROP分为ROP组和早产无ROP组（简称早产组），并将同龄足月儿作为对照， 共纳入112例（222眼），其中ROP组24例（47眼）、早产组55例（110眼）、足月组33例（65眼）。纳入研 究第8年行RNFL厚度、眼轴长度及睫状肌麻痹视网膜检影检查，比较屈光不正发生率及RNFL厚度 差异。采用卡方检验、单因素方差分析进行数据处理。结果：ROP组及早产组的近视发生率较足月 组高（χ2 =8.062，P=0.018；χ2 =3.671，P=0.036）；ROP组、早产组及足月组的远视发生率差异无统计学 意义（χ2 =4.910，P=0.250）；ROP组及早产组的散光发生率较足月组高（χ2 =7.758，P=0.023；χ2 =3.710， P=0.034）。ROP组及早产组眼轴均较足月组短（均P<0.001）。早产组视盘周围平均RNFL厚度较足月 组薄（P=0.030），早产组颞侧RNFL厚度较足月组（P<0.001）、ROP组（P<0.001）薄。结论：8岁段早 产儿及ROP患儿眼轴较足月儿短，更易发生近视和散光，ROP和早产共同影响其屈光状态，其中早 产起主要作用。早产与ROP对RNFL厚度影响不同，尤其是颞侧象限，在随访中需与其他疾病所致 的RNFL厚度异常鉴别。     

飞秒激光LASIK手术负压吸引对视网膜厚度的影响

目的 探讨飞秒激光LASIK手术中负压吸引对近视眼黄斑区视网膜厚度和视网膜神经纤维层（RNFL）厚度的影响。设计 前瞻性对照研究。研究对象 接受飞秒激光手术的近视眼患者143例（279眼）。方法 采用相干光断层扫描（OCT）仪对中低度近视组（≥-6.00 D）和高度近视组（<-6.00 D）患者飞秒激光LASIK手术前、手术后1周~1年进行检查,测量以黄斑中心凹为中心3 mm半径内的视网膜平均厚度,以及以视盘为中心直径为3.4 mm的视网膜神经纤维层厚度,并以地形图分4个区域显示。主要指标 黄斑中心凹厚度及视盘周围RNFL厚度。结果 术前两组间各参数比较差异均无统计学意义（P均>0.05）。术后1年中低度近视组黄斑中心凹视网膜平均厚度为（147.2±18.3）μm;视盘鼻侧、颞侧、上方、下方的RNFL厚度分别是（62.4±15.7）μm、（94.3±20.2）μm、（136.4±17.6）μm、（131.3±21.7）μm,与术前比较差异均无统计学意义（P均>0.05）;术后1年高度近视组黄斑中心凹视网膜平均厚度为（149.3±18.7）μm;视盘鼻侧、颞侧、上方、下方的RNFL厚度分别是（59.3±19.0）μm、（90.7±17.2）μm、（129.2±25.1）μm、（123.3±21.8）μm,与术前比较差异均无统计学意义（P均>0.05）。结论 飞秒激光LASIK术中吸力环负压吸引未对视网膜神经纤维层厚度造成明显影响。（眼科, 2012, 21: 340-343）     

Stratus相干光断层扫描仪测量正常人视网膜神经纤维层的厚度

目的建立Stratus OCT测量我国正常人视网膜神经纤维层(RNFL)厚度的正常值,探讨正常人RNFL厚度的变异程度和与年龄及性别的关系。设计前瞻性横断面研究。研究对象10～69岁的正常人。方法用Stratus OCT的扫描程序(Fast RNFL Thickness 3.4)对210例(210眼)正常人进行视乳头环形扫描,测量各象限和平均RNFL厚度值,应用SPSS 11.5软件统计学处理。主要指标RNFL厚度值。结果210例正常人上方象限、颞侧象限、下方象限、鼻侧象限及全周平均的RNFL厚度分别为(145.5±16.8)、(84.2±12.8)、(147.6±15.2)、(84.7±14.2)μm。平均RNFL厚度变异最小,鼻侧RNFL厚度变异最大。除鼻侧象限外,其它各象限及平均RNFL厚度与年龄均呈负相关性。对正常人RNFL厚度无性别差异。结论用Stratus OCT测量的正常人RNFL厚度数值中,平均RNFL厚度变异最小,鼻侧RNFL厚度变异最大;RNFL厚度随年龄增长而变薄。     

应用GDx VCC检测原发性开角型青光眼视网膜神经纤维层

目的 采用GDx VCC检测青光眼和正常人视网膜神经纤维层厚度(retinal nerve fiber layer,RNFL),并进行对比分析.方法 选择正常人44人44眼,原发性开角型青光眼患者45例45眼行GDx VCC检查.将获取的参数(椭圆平均值、上方平均值、下方平均值、TSNIT标准差、眼间对称性、视神经纤维指征)进行分析.结果 所有参数在正常人组与青光眼组比较中均有统计学意义(P＜0.01).GDxVCC不同参数检测青光眼RNFL缺损敏感性为68.9%～82.2%,特异性84.1%～100.0%.其中下方平均值、视神经纤维指征ROC曲线下面积为0.959、0.964.结论 GDx VCC在RNFL检查中有较高的敏感性和特异性,可客观反应受检者的RNFL情况,对于青光眼的早期诊断有一定的临床价值.     

屈光参差性弱视儿童视网膜神经纤维层和黄斑区视网膜厚度的相关性分析

目的:探究屈光参差性弱视儿童视网膜神经纤维层(RNFL)和黄斑区视网膜厚度的变化情况及其相关性。方法:选取2020-10/2021-06在我院眼科治疗的屈光参差性弱视儿童159例159眼作为研究组,选取同期、同年龄段于我院眼科检查视力正常的儿童159例159眼作为对照组。研究组在给予屈光矫正、遮盖健眼的基础上对弱视眼进行传统综合训练结合4D视觉训练。比较研究组治疗前后与对照组RNFL和黄斑区视网膜厚度,分析研究组治疗前RNFL与黄斑区视网膜厚度的相关性。结果:研究组治疗前和治疗3mo后平均、上方、下方、鼻侧、颞侧RNFL厚度均高于对照组,且研究组治疗前平均、上方、下方、鼻侧、颞侧RNFL厚度均高于治疗3mo后(P<0.05)。研究组治疗前黄斑区外环平均、下方、鼻侧、颞侧、内环鼻侧及中心区视网膜厚度均高于治疗3mo后和对照组(P<0.05)。治疗前,研究组上方RNFL厚度与黄斑中心区视网膜厚度呈负相关(r=-0.330,P<0.05),下方、鼻侧RNFL厚度与黄斑区外环和内环颞侧视网膜厚度呈正相关(均P<0.05),颞侧RNFL厚度与黄斑区外环鼻侧和颞侧视网膜厚度...