Peroxynitrite in the tumor microenvironment changes the profile of antigens allowing escape from cancer immunotherapy

1. Download : Download high-res image (334KB)
2. Download : Download full-size image

     

Immune checkpoint HLA-E:CD94-NKG2A mediates evasion of circulating tumor cells from NK cell surveillance

1. Download : Download high-res image (245KB)
2. Download : Download full-size image

     

Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer

1. Download : Download high-res image (227KB)
2. Download : Download full-size image

     

A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity

1. Download : Download high-res image (328KB)
2. Download : Download full-size image

     

IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment

1. Download : Download high-res image (211KB)
2. Download : Download full-size image

     

Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma

1. Download : Download high-res image (181KB)
2. Download : Download full-size image

     

Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer

1. Download : Download high-res image (175KB)
2. Download : Download full-size image

     

Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer

1. Download : Download high-res image (257KB)
2. Download : Download full-size image

     

Visualizing Synaptic Transfer of Tumor Antigens among Dendritic Cells

1. Download : Download high-res image (269KB)
2. Download : Download full-size image

     

Immune phenotypic linkage between colorectal cancer and liver metastasis

1. Download : Download high-res image (187KB)
2. Download : Download full-size image

     

NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer

1. Download : Download high-res image (178KB)
2. Download : Download full-size image

     

Systematic elucidation and pharmacological targeting of tumor-infiltrating regulatory T cell master regulators

1. Download : Download high-res image (265KB)
2. Download : Download full-size image

     

Early immune pressure initiated by tissue-resident memory T cells sculpts tumor evolution in non-small cell lung cancer

1. Download : Download high-res image (127KB)
2. Download : Download full-size image

     

Commensal bacteria and fungi differentially regulate tumor responses to radiation therapy

1. Download : Download high-res image (226KB)
2. Download : Download full-size image

     

Simultaneous targeting of PD-1 and IL-2Rβγ with radiation therapy inhibits pancreatic cancer growth and metastasis

1. Download : Download high-res image (216KB)
2. Download : Download full-size image

     

Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma

1. Download : Download high-res image (135KB)
2. Download : Download full-size image

     

Tumor-induced erythroid precursor-differentiated myeloid cells mediate immunosuppression and curtail anti-PD-1/PD-L1 treatment efficacy

1. Download : Download high-res image (235KB)
2. Download : Download full-size image

     

Determinants of resistance to engineered T cell therapies targeting CD19 in large B cell lymphomas

1. Download : Download high-res image (279KB)
2. Download : Download full-size image

     

Remodeling of the immune and stromal cell compartment by PD-1 blockade in mismatch repair-deficient colorectal cancer

1. Download : Download high-res image (219KB)
2. Download : Download full-size image

     

Lineage tracing reveals clonal progenitors and long-term persistence of tumor-specific T cells during immune checkpoint blockade

1. Download : Download high-res image (257KB)
2. Download : Download full-size image