Family history of problem drinking among young male social drinkers: behavioral effects of alcohol

Two experiments examined the behavioral effect of alcohol on male social drinkers aged 19-25, who differed in their family histories of problem drinking--21 reported a problem drinker in their immediate family (FH+) and 22 had no such family history (FH-). These groups did not differ in age, weight or absolute alcohol per kg of body weight typically consumed on social occasions. After drinking absolute alcohol (0.83 ml/kg), subjects performed bead stringing and hand steadiness tasks when their blood alcohol levels (BALs) averaged 63 mg/dl on the rising and the declining limb of the BAL curve. The experiments consistently demonstrated that FH+ individuals displayed a greater degree of impairment on the tasks. One of the experiments also explored subjective ratings of the effects of alcohol at matching BALs and found no significant group differences. The greater behavioral sensitivity to alcohol of FH+ subjects and their apparent absence of a concomitant enhanced perception of its effects were discussed as a potential component of their higher risk of developing problem drinking.     

Alcohol-induced changes in body sway in women at risk for alcoholism: a pilot study

Family history of alcoholism appears to influence acute alcohol responses in young men. We report pilot data from a study designed to expand these observations by measuring blood alcohol levels (BALs), subjective intoxication effects, body sway and cognitive-motor task performance in women. Six young women with (FHP) and six without (FHN) alcoholic first degree relatives provided informed consent and were given 0.56 g/kg ethanol under double-blind conditions. Groups were matched for age, drinking history and height-weight ratio. Subjects performed tasks in random order at 90, 60 and 30 min before drinking alcohol, and 15, 30, 45, 60, 90, 120, 150 and 180 min after drinking alcohol. BALs peaked at 80 mg/dl 30 to 60 min after drinking alcohol. BALs were comparable and disappearance rates were similar for both groups. BALs and intoxication ratings for both FHP and FHN women had highly significant correlations. Alcohol decreased accuracy on an automated version of the Digit Symbol Substitution Test (DSST) for both groups, but FHN women made significantly more errors 30 min after alcohol. Significantly greater alcohol effects on body sway were apparent in FHN women 15, 30, 60, 90 and 120 min after alcohol. Compared with previous findings for men, both FHP and FHN women reported less intoxication at similar BALs, but body sway in FHN women was more affected by alcohol. Small sample size limits generalization of these findings but suggests that some effects of familial alcoholism in women are similar to those observed in men.     

Gender differences in acute psychomotor, cognitive, and pharmacokinetic response to alcohol

This study investigated gender differences in acute response to alcohol. After practicing several cognitive and psychomotor tasks while sober, male (n = 11) and female (n = 13) social drinkers were administered a 0.65 g/kg dose of ethanol. Subjects were tested on both the ascending and descending limbs of the blood alcohol curve on measures of divided attention, short-term memory, body sway, pursuit tracking ability, and subjective level of intoxication. Blood alcohol level (BAL) was sampled frequently throughout the procedure. Females achieved consistently higher BALs than did males throughout, due mainly to higher BALs among women in the middle stage of the menstrual cycle. Women not using birth control medications also attained higher BALs than did males. When gender differences in BALs were controlled statistically, only memory functioning distinguished the groups: males recorded memory functioning more quickly on the descending limb of the blood alcohol curve than did females. Stage of menstrual cycle or use of birth control medications did not influence psychomotor or cognitive performance while women were intoxicated.     

Prepartying promotes heightened risk in the college environment: an event-level report

Due to the emergence of research literature examining the prepartying behavior of college students, the present study examines students' varying drinking rates, blood alcohol levels (BALs), and alcohol-related consequences during two drinking events - one involving prepartying and one devoid of prepartying. Two-hundred and thirty-eight student drinkers completed an online drinking assessment detailing their two most recent drinking occasions involving and not involving prepartying. Participants responded to a series of questions regarding quantities consumed on the drinking day and occurrence of alcohol-related consequences. While men did not differ in drinking or estimated BALs, between the two drinking days, female participants drank significantly more drinks and reached higher BALs on the prepartying drinking day. Both males and females reported increased experience of alcohol-related consequences on the prepartying drinking day. In analyzing the prepartying drinking day specifically, we found that while men drink more alcohol during prepartying, but both men and women reached similar BALs during the event. Also, amount consumed during prepartying related to further drinking throughout the evening. It appears that prepartying may influence women to reach comparable levels of intoxication and alcohol-related consequences as their male peers. Quick drinking during prepartying may raise BALs and lead to alcohol-related consequences particularly for female students.     

Alcohol use and psychosocial well-being among older adults.

OBJECTIVE: The objective of this study was to examine the relationships of three dimensions of alcohol consumption (frequency of drinking, usual total weekly consumption and quantity per occasion) with social and leisure status, stress and psychological well-being among people ages 65 and older. METHOD: Nurse interviewers completed in-house surveys with 826 older persons (65% women) in one community (67% response rate of the census sample). RESULTS: Overall, relationships tended to be modest or nil. Those relationships between negative functioning and heavier alcohol use that did emerge tended to be associated with higher quantity drinking (i.e., drinks per drinking day) and to some extent volume, but not with frequency of drinking. Of the psychosocial variables, poorer psychological well-being, especially depression, was most highly correlated with heavier drinking. These results were the same controlling for sex, age, education, health and use of depressant medications. CONCLUSIONS: Higher quantity and volume of alcohol use among older people show a modest positive association with poorer psychological well-being, independent of other potentially confounding variables such as sex, age, health or use of depressant medications. Frequency of drinking, however, was not related to psychosocial status.     

Blood alcohol levels in rats: non-uniform yields from intraperitoneal doses based on body weight.

1 Sprague-Dawley rats (n = 72) weighing from 125 to 450 g were injected intraperitoneally (i.p.) with 16% (w/v) ethanol to provide 1, 2 or 3 g/kg doses. 2 Resulting blood alcohol levels (BALs) demonstrated a general inadequacy of dose/body weight (g/kg) formulations of ethanol to provide uniform BALs in animals of different weights. 3 BAL differences between heavier and lighter rats were not well accounted for by developmental changes in liver weight or alcohol dehydrogenase activity. 4 From the data, a table was derived of more appropriate ethanol injection volumes to produce 0-300 mg% BALs (20 mg% increments) in rats from 100-500 g (10 g increments).     

Age-related differences in the blood alcohol levels of Wistar rats

Knowledge of blood alcohol levels (BALs) that are achieved following ethanol administration is critical for contemporary efforts to develop animal models of alcoholism. Adolescent and adult male Wistar rats were administered varying doses of ethanol (0.75, 1.5 and 3.0 g/kg) via gavage or intraperitoneal injection and BALs were measured over a two hour period. The results showed that adolescent animals had lower BALs across all time points in comparison to adults following administration of 0.75 g/kg ethanol and that 1 h after administration of 1.5 g/kg ethanol, adolescent animals showed an enhanced rate of elimination. The highest dose of ethanol (3.0 g/kg) produced comparable BALs for both adolescents and adults during the two-hour sampling period; however, the BALs for both ages were lower following administration of ethanol by gavage at this dose. Furthermore, an order effects analysis highlights that depending on the route of administration, initial dose size can influence the BALs produced by lower doses of ethanol. The current data identify the importance of measuring the level of alcohol in the blood to confirm that target BALs are achieved for adolescents and equivalent BALs are being reached for both adolescent and adult animals when such comparisons are made.     

Alcohol and retrograde memory effects: role of individual differences

OBJECTIVE: When alcohol is consumed following learning, the effect on delayed, sober memory can vary from person to person. We examined a range of individual differences to look for predictors of this variability. METHOD: Male social drinkers (N = 65; average age 23.3 years) were exposed to emotionally charged verbal stimulus materials while sober. Participants consumed 1.0 ml/kg alcohol immediately afterward and remained in an environment designed to minimize retrograde interference. Stimulus recall and recognition were tested 24 hours later, when participants had breath-alcohol concentrations of zero. Relationship between memory scores and individual differences (in age, education, alcohol consumption, vocabulary, verbal learning, emotionality, mood state 24 hours after learning, response to alcohol, personality and alcohol expectancies) were determined. RESULTS: Only age and vocabulary were significantly associated with memory score following drinking, probably because they constrained initial understanding of the statements and mediated the effects of alcohol on memory consolidation. CONCLUSIONS: The effects of a given dose of alcohol on emotionally charged verbal memory are similar for men of equal age and verbal skill, but independent of other individual differences. It is most likely that alcohol affects incidental memory by nonspecific enhancement or interference processes.     

Event-specific risk and ecological factors associated with prepartying among heavier drinking college students

Using event-specific data, the present study sought to identify relevant risk factors and risky drinking patterns associated with prepartying. Analyses focused on drinking outcomes as a function of drinking game playing and the social context on occasions where prepartying did and did not occur. This research utilized a representative two-site sample of prepartiers who also reported a heavy episodic drinking event in the past month (n = 988). Results revealed that during a preparty event, participants drank significantly more, reached higher blood alcohol levels (BALs), and experienced significantly more negative consequences compared to the last occasion that they drank but did not preparty. Students who played drinking games when they prepartied had higher BALs and experienced more negative consequences than those who did not play drinking games. Whether females prepartied in a single-sex or coed setting had little effect on their BALs. For males, however, their BALs were greater when they prepartied in a coed setting compared to a single sex setting. Moreover, participants reported more negative consequences when they prepartied in a coed setting than in a single-sex setting. Finally, regression analyses demonstrated that participants' BAL, frequency of prepartying, and the interaction between BAL and frequency of prepartying all uniquely contributed to the prediction of event-specific alcohol-related negative consequences. As BAL increased, the number of negative consequences increased more sharply for those who prepartied infrequently, compared to those who prepartied frequently. Analyses were examined as a function of gender which revealed important gender effects and interactions. Interventions can be designed to intervene with high-risk prepartiers by using BAL education emphasizing the impact of time-limited prepartying drinking.     

Concordance of use of alcohol and other substances among older adult couples

This study used data from a community survey of 826 older adults to examine the level of concordance of substance use among married couples and the extent to which demographic, social and health factors were associated with concordant drinking patterns. Results showed significant concordance for use of alcohol, caffeine, tobacco and depressant medications, with very high concordance on frequency of drinking and overall volume of consumption of alcohol. Drinking spouses were also very accurate in reporting each other's usual frequency and quantity of alcohol consumption. Education and religiosity were associated with concordance on drinking status (drinker/abstainer), but few other variables were significantly associated with drinking status or drinking level. In particular, marital happiness did not appear to be affected by discordant drinking. The results also indicated that having a drinking spouse (versus an abstinent spouse) was associated with higher levels of drinking. These findings suggest that spousal influence on drinking is an important aspect of drinking among older persons and may have implications for understanding the effects of gender and widowhood on the development of late-onset problem drinking.     

A study of an alcohol advertisement for low alcohol beer

A study was undertaken to measure the blood alcohol levels (BALs) of five men and five women after they had consumed seven middies of Emu 2.2 (2.2% alcohol by volume) beer in 1 hour. This study was conducted in response to a newspaper advertisement which depicted a well-known football player drinking seven middies of Emu 2.2 beer over 1 hour and registering a BAL of 0.012%. As predicted, the BALs of the ten adults varied considerably, but all greatly exceeded the very low result obtained by the football player. More importantly, from the point of view of road safety, all ten BALs exceeded the 0.02% probationary driver limit in Western Australia, and two of the BALs were above the 0.05% legal limit for driving in several other Australian states.     

Older adult controlled drinkers and abstainers

Little is known about the lifetime course of alcohol problems, especially during late adulthood. Many individuals with a history of alcohol problems achieve remission of their symptoms through abstinence or controlled drinking. This study examined 135 older adults with a prior history of alcohol diagnoses who were symptom free for at least the past year. Two groups were identified based on their alcohol consumption within the past year: abstinent individuals (n = 92) and controlled drinkers (n = 43). The groups did not differ in age, racial composition, education, income, or years since their last alcohol-related symptom, but they did differ in gender composition, indices of alcoholism severity, history of formal and informal treatment, as well as lifetime alcohol consumption patterns. Abstinent individuals had more severe alcohol problems, consumed higher amounts of alcohol on drinking days, had more years of heavy alcohol consumption, and were more likely to have attended alcohol treatment and Alcoholics Anonymous (AA). The controlled drinkers had a longer history of moderate social drinking, and their current consumption habits appeared to be similar to symptom-free older adult drinkers. The results suggest that gender, alcoholism severity, history of formal and informal treatment, and past consumption patterns are associated with whether older adults with histories of alcoholism attain successful outcomes through abstinence or controlled drinking.     

The development of alcohol tolerance: acute recovery as a predictor

Two experiments examined individual differences in the rate of alcohol tolerance development as a function of acute recovery. Male social drinkers (n=18) were trained on a complex psychomotor task and subsequently returned for four drinking sessions in which they received the same dose (0.84 ml absolute alcohol/kg) and performed the task at intervals while blood alcohol concentrations (BAC) rose and fell (peak BAC=77.2 mg/dl). A subject's acute recovery from the impairing effect of alcohol during session 1 was measured by the difference in his performance at the same BAC on the rising and the falling limb of the curve. Rate-of-tolerance development was measured by the rate of change in the subject's average impairment under the alcohol during sessions 1–4. Acute recovery scores in both experiments significantly predicted the rate at which tolerance developed, accounting for 64% of the variance in these scores (P<0.0001). Subjects who displayed more acute recovery developed tolerance more quickly. The evidence was considered to imply that the same process may give rise to both acute recovery and tolerance.     

Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats

A 'binge' is defined by National Institute on Alcohol Abuse and Alcoholism as an excessive pattern of alcohol drinking that produces blood-alcohol levels (BALs) greater than 0.08 g% within a 2-h period and may or may not be associated with dependence. The purpose of this investigation was to explore the effects of several neuropharmacological agents in an animal model in which outbred rats voluntarily and orally self-administer pharmacologically meaningful alcohol doses that produce BALs >or=0.08 g% in daily limited access two-bottle choice and operant drinking sessions. Rats were trained to self-administer either 10% (w/v) alcohol solution sweetened with 'supersac' (3% glucose+0.125% saccharin) or supersac alone versus water in a two-bottle choice or operant situation during 30-min daily sessions. Rats were then injected systemically with multiple doses of duloxetine, naltrexone, and the corticotropin-releasing factor antagonist, MPZP, in Latin-square designs. Alcohol binge drinkers reliably consumed amounts of alcohol sufficient to produce BALs >or=0.08 g%. Duloxetine dose-dependently suppressed two-bottle choice alcohol binge drinking and operant alcohol responding as well as operant supersac responding, but did not affect two-bottle choice supersac drinking. Naltrexone-suppressed alcohol binge drinking at very low doses and suppressed supersac drinking at moderate-to-high doses. MPZP did not affect alcohol or supersac consumption. Different profiles for drugs that suppress binge-like alcohol drinking compared with dependence-induced drinking provide a heuristic foundation for future medications development.     

Time relations of the effects of alcohol compared to placebo

Summary 31 healthy male students were given a placebo and two different doses of alcohol (on different occasions and in random order). Choice-reaction-time, tapping-speed, bimanual hand-coordination, critical fusion frequency, standing steadiness, Bourdon's test, blood and urine alcohol content were measured before and 30, 60 and 90 min after drinking. Self-ratings of mood were made. 7 of the subjects were also examined after 2, 3 and 13 hours and altogether 4 doses of alcohol were used for this group. 24 subjects were given an additional dose of alcohol 2 hours after the first one and the tests were repeated 30, 60 and 90 min after the additional dose. The agreement between blood and urine alcohol levels was good and the alcohol curves showed an approximately linear fall-off. For the highest alcohol dose used there was a good agreement between blood alcohol level and test performance. The impairment of performance was most marked after 30–60 min. After 2 hours the impairment was very slight. The performance on Choice reaction time and Coordination was related to blood alcohol level also after a smaller dose. Statistically significant changes were obtained in most tests after the highest dose (0.8 g per kg body weight) and in Choice reaction time and Coordination after the smaller dose (0.4 g per kg body weight). No significant effects were obtained after administration of placebo.     

Pharmacokinetics and bioavailability of ciramadol,a new analgesic

Healthy male volunteers participated in two studies of the pharmacokinetics of ciramadol, an investigational analgesic. For the dose-proportionality study, subjects received single i.v. doses of 15, 30, or 60 mg of ciramadol on three separate occasions. Serum samples and urine were collected 48 hr after each dose. Overall mean kinetic values for ciramadol were: volume of distribution, 1.5 liters/kg; elimination half-life, 3.7 hr; total clearance, 4.9 ml/min/kg. Clearance did not change systematically with dose. Mean 48-hr urinary excretion was 40% of the dose as the intact drug, with another 24% excreted as ciramadol conjugates; these were dose-independent. For the bioavailability study, subjects received a 30-mg dose of ciramadol i.v., i.m., or orally on three separate occasions. The mean absolute systemic availability of the i.m. dose was 98%; the absolute availability of the oral dose was 82%. Peak serum concentration of 235 and 155 ng/ml were attained at 0.27 and 1.5 hr after the i.m. and oral doses, respectively.     

Effect of naltrexone on subjective alcohol response in subjects at high and low risk for future alcohol dependence

We investigated specific subjective effects of naltrexone pretreatment or placebo during various intervals on the breath alcohol level (BAL) curve in nonalcoholic volunteers. Fifteen high-risk (social drinkers with an alcoholic father) and 14 low-risk (no alcoholic relatives in at least two generations) subjects were tested in a double-blind, placebo-controlled study of the effects of 50 mg oral naltrexone on response to a moderate dose of alcohol. Dependent measures included subjective stimulation and sedation subscales from the Biphasic Alcohol Effects Scale (BAES) and mood subscales from the Profile of Mood States (POMS). At rising BALs, high-risk subjects showed a naltrexone-related attenuation of BAES stimulation. This effect was not evident in low-risk subjects, who directionally showed the opposite effect, although nonsignificant. For both groups, there were no significant naltrexone-related effects for BAES sedation; however, naltrexone did affect several POMS scales on alcohol response, such as decreased vigor, and increased fatigue, tension, and confusion. Confusion was significantly elevated for the high-risk group during rising BALs of the naltrexone session. The results suggest a differential response to naltrexone, based on paternal history of alcoholism and level of stimulation experienced during alcohol drinking. Received: 22 August 1995 / Final version: 25 July 1996     

Selective reduction by the 5-HT antagonist amperozide of alcohol preference induced in rats by systemic cyanamide.

This investigation was undertaken to determine the effect of a unique psychotropic agent on the volitional drinking of alcohol induced pharmacologically in the rat by an inhibitor of aldehyde dehydrogenase. Following administration of cyanamide in a dose of 10 mg/kg twice daily for 3 days, the pattern of drinking of ethyl alcohol was determined in each of 12 Sprague-Dawley rats by means of a standard preference test for 3-30% alcohol vs. water. Then, each rat was offered water and its maximally preferred concentration of alcohol, which ranged from 7-15%. After a 4-day predrug test, either the saline control vehicle or the diphenylbutylpiperazinecarboxamide derivative, amperozide, was administered subcutaneously. The injections of amperozide were given b.i.d. at 1600 and 2200 h over 3 days in a dose of 0.5, 1.0, or 2.5 mg/kg. The intake of alcohol during the sequence of amperozide injections was significantly reduced in a dose-dependent manner in terms of both absolute g/kg and proportion of alcohol to water intake, whereas the saline control vehicle was without any effect on alcohol consumption. Although the highest dose of amperozide reduced the total intake of fluid due to the sharp decline in alcohol drinking, neither the consumption of food nor level of body weight was affected by any dose of the drug either during or after its administration. Because amperozide acts centrally on the synaptic activity of dopaminergic and serotonergic neurons in limbic system structures, it is envisaged that the drug ameliorates the aberrant drinking of alcohol by virtue of a direct effect on either one or both of these classes of neurons.(ABSTRACT TRUNCATED AT 250 WORDS)     

The acute effects of alcohol on the blood pressure of young, normotensive men

Alcohol's acute effects on arterial blood pressure (BP) were examined. To separate the effects of alcohol on BP from those of fluid volume and expectancy, normotensive men were divided into three groups. The alcohol group received 1.0 ml of absolute alcohol/kg of body weight. The expectancy group expected alcohol but received only tonic. The control group expected and received only tonic. With age as a covariate, significant changes in systolic BP were found only in the alcohol group, indicating that the changes in systolic BP were not attributable to subject expectancy or volume of fluid consumed. The expectancy control groups did not differ from each other. A significant quadratic trend was found for systolic BP in the alcohol group, suggesting that alcohol may have an acute biphasic effect on systolic BP, with an initial decrease as the alcohol is ingested followed by an increase toward the basal level during detoxication. No significant effects were found for diastolic BP.     

The effects of alcohol and anxiousness on physiological and subjective responses to a social stressor in women

Several studies have examined the validity of the tension reduction hypothesis as an explanatory model for the development of alcohol problems, but support has been inconsistent. In recent years, researchers have begun to examine how various individual differences variables moderate the relationship between alcohol consumption and reduction of anxiety. The present study examined how 40 women, either moderate or low in anxiety sensitivity (AS), responded to a social stressor (giving a body image speech) after consuming either a low dose of alcohol (0.4 ml/kg of body weight) or a placebo. Results indicated that of the participants reporting moderate AS, participants consuming alcohol reported more stress dampening as measured by heart rate in anticipation to the stressor than participants not consuming alcohol. Furthermore, of the participants consuming alcohol, those reporting high social anxiety reported more of an increase in heart rate than participants not consuming alcohol. Findings are discussed in terms of considering individual differences factors when examining predictions made from the tension reduction hypothesis.