急性发热性嗜中性皮病1例

患者女,52岁。因面部、颈部及四肢出现红色丘疹及斑块,不痛不痒1个月,于2007年8月8日至我院皮肤科就诊。患者于1个月前双上臂出现散在红色丘疹及斑块,无自觉症状,表面无鳞屑,未予治疗。嗣后皮损逐渐增多,面部、颈部及双下肢出现同样皮损,无疼痛、瘙痒及烧灼感,不伴发热,无关节疼痛。曾在外院就诊,疑诊为肉芽肿予以药物（具体用药不洋）治疗,皮损未见好转。     

急性发热性嗜中性皮病1例

急性发热性嗜中性皮病亦称斯威特(Sweeet)综合征。是一种原因不明的慢性易复发性红斑与结节性皮肤病，临床常见但泛发伴有水疱，表皮坏死者少见。我们发现1例报道如下。临床资料患者男，43岁，农民。因感冒发热，伴发扁桃体炎，在当地医院静脉滴注青霉素5天好转。3周后在颈部、面部及四肢相继出现淡红色至暗红色斑块和结节，自觉灼热疼痛，触痛明显以致病人有时不能忍受，下肢膝关节痛，上肢肘、腕关节痛。在当地医院按病毒感染性疱疹治疗(药物不详)，效果不佳，于2003年12月来我站就诊，     

急性发热性嗜中性皮病1例

患者女,34岁,反复颜面、上肢红色斑块、水疱4月,再发4天.皮肤科检查:前额、面部、左前臂、左腕部、右肘部、手背、指背关节处可见多发散在鲜红色、水肿性斑块,表面可见多发小脓疱、水疱.皮损以右面部为重,边缘稍隆起,表面结黄色浆液痂或脓痂.触之有浸润感,压痛.皮损组织病理检查:真皮乳头水肿,真皮浅、深层弥漫性中性粒细胞浸润...     

以急性发热性嗜中性皮病皮疹为表现的白塞病1例

分析报告 1例以急性发热性嗜中性皮病皮疹为表现的白塞病。患者表现为急性发热性嗜中性皮病皮疹 ,伴口腔溃疡、关节疼痛 ,组织病理符合皮肤急性发热性嗜中性粒细胞增多性皮病 ,皮肤针刺反应阳性 ,诊断白塞病。     

慢性粒细胞性白血病急粒变并发急性发热性嗜中性皮病1例

1 临床资料 患者女,58岁,因双侧颧部红色斑块伴疼痛2d来我科就诊.患者于两日前双侧额部突然发生红色斑块,伴有疼痛,起病前无明显前驱症状,否认患处外伤或刺激性物品接触史.未经诊疗即来我科.近1个月以来脾脏进行性肿大,间断鼻衄.患者3年前曾确诊为慢性粒细胞性白血病.     

以急性发热性嗜中性皮病样皮疹为表现的白塞病1例

白塞病是一种多系统自身免疫性疾病,以急性发热性嗜中性皮病(Sweet综合征)样皮疹为表现的白塞病临床比较少见[1],现临床报道1例.     

20例急性发热性嗜中性皮病临床病理分析

对２０例ＡＦＮＤ进行临床病理分析，该病临床皮损主要表现为疼痛性水肿性红色斑块，皮损好发于面、颈部及四肢，多数伴有发热和中性多核粒细胞增多，病理特点主要在真皮内可见以中性多核粒细胞为主的弥漫性浸润。     

急性发热性嗜中性皮病1例

患者男,50岁。因面、颈部、四肢反复长结节、斑块伴疼痛、发热1yr,于2006年2月就诊。患者1yr前因感冒后,面、颈部出现暗红色斑块,感痒痛,触之较硬、有触痛,起皮疹时发热,继之四肢也出现类似皮损。曾于院外反复使用抗生素、激素治疗,皮疹可消退,局部不留疤痕,但留有暂时性褐色色素沉着,反复发作。病程中伴有发热,偶感关节疼痛。患者自患病以来,体重无明显变化,精神欠佳,睡眠、饮食可。既往无肝炎、结核等特殊病史,无药物过敏史,家族无同类病史。     

急性发热性嗜中性皮病合作樱桃血管瘤1例

1 临床资料 患才男，38岁。因面部反复红斑块8年，复发2周，头皮丘疹4年就诊，8年前无明显诱因出现面部红斑块，无痒痛感，闹事刺激性饮食后更明显，曾在当地医院诊治（过程不详），     

甘露消毒丹治愈急性发热性嗜中性皮病1例

<正>1临床资料患者男,37岁,因"面部、双上肢起疹伴发热半月"于2007年12月22日入住我科。入院时体格检查:心肺腹体征阴性。皮肤科检查:前额、眼睑、双手背见多处鲜红色大小不一浸润性斑块,斑块边缘见假水疱样改变,部分皮损中央可见结痂面,口腔黏膜多处黄豆至花生大溃疡。入院后实验室     

皮下型急性发热性嗜中性皮肤病1例

报告1例皮下型急性发热性嗜中性皮肤病。患者男,47岁。颈部、躯干、四肢起疼痛性红斑、结节伴发热1周。组织病理检查示真皮、皮下脂肪中有中性粒细胞、淋巴细胞浸润,可见核碎裂像。     

具有水疱及脓疱的急性发热性嗜中性皮肤病

报告1例具有水疱及脓疱的急性发热性嗜中性皮肤病。患者女，41岁。全身出现红色丘疹、斑块、水疱及脓疱伴疼痛1d。皮损组织病理检查示表皮下水疱形成，真皮全层有以中性粒细胞为主的弥漫性炎性细胞浸润。诊断：急性发热性嗜中性皮肤病。     

A case of extramedullary hematopoiesis presenting as hemorrhagic panniculitis and evolving in acute myeloid leukemia

Extramedullary hematopoiesis (EMH) in adults is a rare event, usually associated with myeloid disorders, and can be the first sign of chronic myelomonocytic leukemia. We report a case of EMH presenting as a hemorrhagic panniculitis in a patient who did not apparently present any myeloid disorders. The patient received previous chemotherapy for mantle cell lymphoma localized to the large bowel and had been in complete remission for 3 years. The diagnosis of EMH was achieved after a deep incisional biopsy of a nodule from the thigh, and with pathological examination that included immunohistochemical studies. After a follow‐up of 14 months, the patient developed an acute myeloid leukemia, classified as therapy‐related myeloid neoplasm, according to the 2016 World Health Organization (WHO) classification of hematological malignancies. As shown by the rare cases described in literature, the presence of cutaneous EMH should always be a trigger for investigating the patient's hematological system; also, in our experience, a long follow‐up is mandatory.     

Acute febrile neutrophilic dermatosis (Sweet's syndrome) in a patient with hairy-cell leukemia

A case of hairy-cell leukemia that started with cutaneous lesions similar to those of acute febrile neutrophilic dermatosis (Sweet's syndrome) is reported. The patient had leukopenia and a recurrent eruption for a year prior to the diagnosis of the hematologic disorder. Bone marrow examination eventually demonstrated characteristic "hairy" cells with tartrate-resistant, acid-phosphatase activity. Biopsy of a cutaneous lesion suggested an abscess showing a dense neutrophilic dermal infiltrate with perivascular predilection. The findings of IgA, IgM, C3, and fibrinogen in vessel walls by immunofluorescence and vascular disruption by electron microscopy contribute additional evidence for an immunologic determinant in this instance of Sweet's syndrome. It is known that neutrophilic infiltrates of Sweet's syndrome may have a variety of clinical presentations. This is the second case of hairy-cell leukemia with which Sweet's syndrome was associated.     

Myeloid sarcoma in a newborn: A rare manifestation of congenital acute myeloid leukemia

Cutaneous myeloid sarcoma is rarely present prior to the diagnosis of congenital acute myeloid leukemia (AML); the former is typically diagnosed with or after the leukemia. We report a 2-day-old male born with multiple cutaneous red to violaceous nodules. Histopathologic and immunohistochemistry findings from a skin nodule were suspicious for myeloid sarcoma. Bone marrow biopsy was initially negative for aberrant blasts; however, at age 4 months, AML with a KMT2A gene rearrangement was identified via bone marrow biopsy.     

Acute febrile neutrophilic dermatosis and abnormal bone marrow chromosomes as a marker for preleukemia

Acute febrile neutrophilic dermatosis or Sweet's syndrome is a rare disease, which occasionally is seen in patients with myeloid leukemia. We present a case of Sweet's syndrome in a patient with an abnormal chromosome pattern in bone marrow aspirate. Initially the patient had flu-like symptoms with high fever. Two weeks later raised, erythematous and painful plaques appeared on the skin. Various antibiotics were ineffective, but the symptoms vanished after administration of prednisone. Six months later a fulminant acute myeloid leukemia developed, the course of which was complicated by a fatal subdural bleeding. It is concluded that Sweet's syndrome may be a cutaneous sign of a neoplastic myeloid proliferation and that a complete hematological examination including chromosome analysis is mandatory in these patients.     

Cutaneous presentation preceding acute myeloid leukemia with CD4+/CD56+ expression misdiagnosed as a blastic plasmocytoid dendritic cell neoplasm: A case report

Acute myeloid leukemia (AML) may initially present as cutaneous lesions corresponding to blasts involving the skin as the first clinical manifestation prior to blood and bone marrow (BM) infiltration. Such presentation is known as myeloid leukemia cutis (LC). Blastic plasmocytoid dendritic cell neoplasm (BPDCN) is an aggressive tumor derived from the precursors of plasmocytoid dendritic cells with cutaneous and BM involvement and leukemic dissemination. Myeloid LC and BPDCN may be difficult to distinguish as they share similar clinical and histopathological features, in particular AML with monocytic differentiation. Nevertheless, the correct diagnosis has to be made to determine adequate and effective therapy. Here, we report the case of a 61‐year‐old woman who presented with an AML with MLL rearrangement and CD4+/CD56+ expression presenting as LC and that was misdiagnosed as BPDCN. We emphasize that careful and exhaustive analyses should be performed to make the correct diagnosis.     

Azathioprine hypersensitivity presenting as a neutrophilic dermatosis in a man with ulcerative colitis

We report a case of a 46-year-old man with ulcerative colitis being treated with oral prednisolone and azathioprine. Two weeks after the initiation of azathioprine he presented with fever, fatigue, myalgias and arthralgias and a painful cutaneous eruption that was most marked in a sun-exposed distribution. This was accompanied by loose, non-bloody diarrhoea. Histopathological assessment of a skin biopsy supported a diagnosis of a neutrophilic dermatosis. The azathioprine was temporarily withheld and oral prednisolone was increased as it was thought that the neutrophilic dermatosis was associated with the underlying ulcerative colitis. The patient's symptoms and cutaneous eruption resolved quickly and azathioprine was re-introduced. Within 24 h, systemic symptoms returned along with a florid recrudescence of his cutaneous eruption. This rapidly improved upon withdrawal of azathioprine.     

Sweet's syndrome following surgery: Cutaneous trauma as a possible aetiological co‐factor in neutrophilic dermatoses

A 47‐year‐old man presented with an acute, cutaneous eruption of exquisitely painful papules at the operative site 4 weeks after a right tibial osteotomy. Initially this was managed as a postoperative wound infection; however the exacerbation and spread of the cutaneous eruption prompted further investigation. Histopathology and clinical findings were consistent with the development of Sweet's syndrome and resolution was obtained after the initiation of dapsone. We propose that surgery may produce an acute inflammatory response in a similar manner to pathergy reactions, which play an aetiological role in other neutrophilic dermatoses, such as pyoderma gangrenosum. We conclude that there may be greater overlap between these neutrophilic dermatoses than previously appreciated.