联合高压氧综合治疗 Fournier坏疽（附14例报告）

目的：探讨Fournier坏疽（Fournier＇s gangrene, FG）的发病因素、诊断、联合高压氧的治疗方法及预后。方法对收治的14例FG患者的临床资料进行回顾性分析,并探讨我们的诊治经验。全部患者均早期采用外科清创引流、足量抗生素抗感染、高压氧等联合治疗措施,清创同时行阴茎切除术＋膀胱造瘘及肠造瘘各1例。 II期行阴囊缝合成型术4例,阴囊植皮术8例,阴茎切除术后行尿道外口成型＋阴囊植皮1例。结果痊愈出院13例,仅1例患者因脓毒败血症所致多器官功能衰竭而死亡。结论 FG应早期诊断,尽早行广泛清创引流、广谱抗生素及高压氧治疗。待创面无明显炎症反应并长出新鲜肉芽组织后,行II期缝合或植皮术重塑阴囊、会阴部及阴茎皮肤。     

Fournier坏疽的诊治(附16例报告)

目的　探讨Fournier坏疽的诊断及治疗。　方法　对 16例男性Fournier坏疽患者的临床资料进行分析。患者年龄 2 4～ 84岁 ,平均 5 1岁。其中阴囊坏疽 13例 ,阴茎皮肤坏疽 3例。细菌培养 14例 ,阳性 9例。 16例均行外科清创、引流、抗感染等治疗 ,4例行高压氧治疗。　结果　 13例经二期缝合痊愈出院 ,其中 2例 1个月后取皮瓣行阴茎、阴囊成形术。死亡 3例 ,其中 2例并发败血症 ,1例高龄患者早期出现肾功能受损而致多器官功能衰竭。　结论　治疗以早期广泛清创及应用广谱抗生素为主 ,加强局部引流 ,有条件者可行高压氧治疗。     

阴囊坏疽的治疗体会(附14例报告)

目的总结阴囊坏疽的治疗方法。方法2003年8月至2005年6月诊治阴囊坏疽14例，患者年龄27～74岁，平均48岁。阴囊坏疽并发肛周、阴茎坏疽者2例，并发肛周、阴茎、腹股沟区坏疽者10例，并发肛周、阴茎、腹股沟区、腹部皮下坏疽者2例。其中并发阴茎坏死3例，并发睾丸炎5例。14例细菌培养均为阳性。14例均采用Ⅰ期清创、阴囊成形、置管引流术，同时给予抗炎对症治疗。3例阴茎坏死者行阴茎全切、尿道造瘘术，2例腹部坏疽者行腹部皮下切开清创引流，5例睾丸炎者行单侧睾丸切除。结果12例阴囊成形术Ⅰ期愈合，2例尿道造瘘术患者痊愈出院。10例阴茎皮肤坏疽者1个月后阴茎植皮，痊愈出院。死亡2例。结论早期及时清创和抗炎对症治疗是治疗本病的关键，Ⅰ期清创、阴囊成形及置管引流是治疗阴囊坏疽的有效方法。     

阴囊Fournier坏疽的临床分析(附14例报告)

目的:探讨阴囊Fournier坏疽的临床特点、诊治方法及预后。方法:对我院2012年1月~2016年6月收治的14例阴囊Fournier坏疽患者的临床资料进行回顾性分析。结果:本组患者年龄为26~70岁,平均年龄48岁;6例合并2型糖尿病,3例合并肝硬化;原发于阴囊2例,继发于肛周脓肿12例。所有患者均行清创手术,积极的抗感染、支持治疗和换药处理;5例死亡,9例痊愈;1例直接缝合创缘,1例经长期换药后创面愈合,7例行重建手术。结论:早期清创手术和积极的抗感染治疗仍是处理阴囊Fournier坏疽的关键,创面的综合处理可以减少甚至避免重建手术,白蛋白可能成为预测Fournier坏疽预后的有效指标。     

多孔负压引流在阴囊Fournier坏疽治疗中的应用

目的:探讨多孔负压引流在Fournier坏疽治疗中的临床价值并总结该病诊治方法。方法:回顾2005年1月~2015年4月我院收治的3例阴囊Fournier坏疽患者,总结诊疗经验并复习相关文献。结果:2例患者给予阴囊坏疽清创术,术后给予多孔负压引流术。术后患者双侧阴囊恢复正常大小,阴囊可见肉芽组织,渗液及坏死物逐渐消退。1个月后随访,阴囊创面基本愈合,至今未复发。另1例患者因自动出院失去随访。结论:广泛阴囊坏死组织清创+多孔负压引流对治疗Fournier坏疽的效果安全有效,值得推广。     

Fournier坏疽1例报告并文献复习

目的:探讨Fournier坏疽(fournier’s gangrene,FG)的病因、诊断要点和治疗方法,提高对该疾病的认识。方法:回顾性分析我院收治的1例FG患者的资料,并复习相关文献。结果:患者阴囊、会阴部、阴茎皮肤完全坏疽,经过积极的手术清创引流,使用足量广谱抗生素,全身支持治疗,在创面无明显炎症反应并长出新鲜肉芽组织后,行植皮术重塑阴囊、会阴部、阴茎皮肤,患者治愈出院。结论:FG病情凶险,病死率高,应早期诊断,一旦确诊应积极采取手术清创(切开)引流和广谱(敏感)抗生素治疗,如有皮肤缺损,应在创面无炎性渗出并长出新鲜肉芽组织后,及时行植皮或皮瓣转移术闭合皮肤缺损。     

阴囊坏疽的阴囊重建

目的探讨阴囊坏疽的诊断、治疗及阴囊重建方法.方法 1992年1月～2004年9月,对15例阴囊坏疽进行临床资料分析,年龄23～80岁.创面细菌培养阳性14例,无菌生长1例,其中血培养阳性1例.均行抗感染、外科清创及引流等治疗.2例行高压氧治疗.清创术后根据情况采用皮瓣转移、植皮、直接缝合等方法行阴茎阴囊修复重建,其中2例高龄患者行睾丸去势术.结果住院时间21～34 d,平均26 d.所有患者术后创面均Ⅰ期愈合.获随访1～3年,平均1.5年.13例保留睾丸者阴囊外观满意,性功能正常,无睾丸萎缩发生.下肢、阴囊及腹股沟区无不适.结论阴囊坏疽确诊后应早期广泛清创并联合应用抗生素治疗,加强局部引流,有条件者可行高压氧治疗,根据具体情况重建阴囊.     

切断尿道口保留并加长尿道板尿道成形术治疗尿道下裂的初步研究

目的:探讨用切断尿道口保留并加长尿道板尿道成形术治疗尿道下裂的可行性。方法:选择尿道下裂患者48例,其中冠状沟下型18例,阴茎体型21例,阴囊阴茎交界型8例,阴囊型1例,采用切断尿道口保留并加长尿道板尿道成形术治疗,并观察其术后效果。结果:术后随访6～27个月,一期手术成功44例,2例出现尿瘘,2例出现尿道狭窄,尿瘘以及尿道狭窄均再次治疗而治愈。阴囊阴茎外观满意,阴茎伸展自如。结论:切断尿道口保留并加长尿道板尿道成形术是操作简单,安全有效的术式,可广泛应用于治疗尿道下裂。     

阴囊部位Fournier坏疽的外科诊疗分析

目的通过分析阴囊部位Fournier坏疽的临床特点、外科诊疗过程及疗效,探讨处理此类疾病的有效方法。方法收集自2015年8月至2017年8月治疗阴囊部位Fournier坏疽的8例患者的临床资料,并对临床诊断、创面清创及后期创面重建过程及治疗结果进行回顾性分析。结果 8例患者阴囊部位细菌培养均呈阳性。UFGSI和LRINEC中位评分为4(2～8)分和2(1～5)分,分数高低与住院天数及病情严重程度相符。其中3例经1次清创、5例经2次清创,之后采用负压辅助系统治疗;待创面新鲜后,采取直接缝合1例,局部皮瓣修复1例,自体中厚皮片植皮6例,均痊愈出院。中位随访16.5(11～23)个月,创面愈合良好,无复发。结论患者的临床表现、细菌培养和UFGSI、LRINEC评分,对于阴囊部位Fournier坏疽的诊断和预后判断具有重要意义。在控制基础疾病的同时,采取早期多次清创,并应用负压辅助系统,以及后期根据创面情况来选择合适的重建方式,均可获得较好的预后效果。     

阴囊纵隔折叠皮瓣尿道成形术治疗尿道下裂15例报告

2001年至2005年,我们对阴囊纵隔皮瓣尿道成形术进行改良,治疗尿道下裂15例,疗效较好,现报告如下。对象与方法本组15例。年龄3～20岁,平均8.6岁。临床分型:阴茎近端型5例、阴茎阴囊型10例。患者阴囊皮肤发育均较好。手术方法:术前清洁灌肠。耻骨上膀胱穿刺造瘘。阴茎头部缝牵引线,置     

Fournier's gangrene.

Twenty-five cases of gangrene of the scrotum and penis have been analysed. The anterior scrotum or the whole scrotum were the areas most frequently involved. The results of seminal analyses showed marked oligozoospermia during the infective period. Haemolytic streptococcus was the most common organism. The aetiology of the disease is reviewed and "infective gangrene of the scrotum and penis" is considered to be a more suitable diagnostic label than Fournier's gangrene.     

Fournier's gangrene of the penis: a report of two cases

Fournier's gangrene is a rare disease involving the scrotum and penis with occasional extension up the abdominal wall. Both of our cases were unusual in that only the penis was involved. In addition, the occurrence of squamous cell carcinoma in an area previously affected by Fournier's gangrene has never been reported. The usual organism is an anaerobic streptococcus synergistic with some second organism. Early therapy is key, including debridement of the entire shaft of the penis distal to the devastated area, intravenous broad-spectrum antibiotics, and skin grafting.     

A case of Fournier's gangrene reconstructed using a rectus abdominis muscle flap

We encountered a case of Fournier's gangrene complicated with vesicorectocutaneous fistula that was treated with a pedicled rectus abdominis muscle flap (pedicled RA m-c flap). A 75-year-old man was admitted with consciousness disorder and swelling of the scrotum. The patient had noticed swelling of the scrotum 4 days before admission, but he had ignored this condition. The scrotum and the penis appeared necrotic. On the basis of clinical and radiological findings, we diagnosed this condition as Fournier's gangrene. Surgical debridement was performed in conjunction with the use of broad-spectrum antibiotics. After the patient's general condition was improved, the broad defect in the perineal tissue was covered with a pedicled rectus abdominis muscle flap. The flap was successful. In Japan, this is the first case of Fournier's gangrene complicated with vesicorectocutaneous fistula that was treated with a pedicled RA m-c flap. In order to determine whether plastic surgery after debridement shortens the duration of hospitalization, we reviewed the cases of 120 patients with Fournier's gangrene in Japan. We conclude that plastic surgery after debridement does not shorten the duration of hospitalization, however, this procedures is very useful to deep and broad defects by Fournier's gangrene.     

Factors affecting mortality of Fournier's gangrene: review of 70 patients

BACKGROUND: Fournier's disease is a potentially fatal, acute, gangrenous infection of the scrotum, penis or perineum associated with a synergistic bacterial infection of the subcutaneous fat and superficial fascia. METHODS: The clinical records of 70 patients treated for Fournier's gangrene were evaluated retrospectively to determine prognostic indices and to stress Fournier's Severity Index (FSI), influencing outcome. RESULTS: The mortality rate in this study was 22.8%. Length of the hospitalization time and FSI were detected as effective factors on mortality of Fournier's gangrene (P < 0.05) by Binary Logistic Regression analysis and the area under the receiver operating characteristic curve of these variables was also found to be significant (P < 0.001). The average FSI was determined as 4.66 +/- 2.31 in survivors and 11.56 +/- 2.68 in non-survivors and 5.11 +/- 2.83 in patients with primary genito-urinary infection but 7.56 +/- 4.35 in primary anorectal infection. The FSI was also found predictive of hospitalization time and number of debridements among survivors. CONCLUSION: Fournier's Severity Index is a simplified way of comparing patients with this disease and may also have some significance in predicting outcome. The FSI is a more significant and predictive tool that should be popularized to predict the prognosis in Fournier's gangrene.     

Fournier坏疽五例报告

目的 探讨Ｆｏｕｒｎｉｅｒ坏疽的诊断和处理方法。方法 报告５例Ｆｏｕｒｎｉｅｒ坏疽的临床特点并进行文献复习。结果 ５例经清创引流,抗炎及对症治疗第,３例康复,随访１年无复发;死亡２例;结论Ｆｏｕｒｎｉｅｒ坏疽是一种累及阴囊、阴茎的感染性坏死性筋膜炎。及时正确的诊断,处理可减少其死亡率和并发症;超声显像,ＣＴ等技术有利于此病的早期发现;治疗原则为早期清创,引流,全身应用大剂量广谱抗生素等。     

Management of Fournier's Gangrene: Review of 45 Cases

Purpose Fournier's gangrene is a fatal synergistic infectious disease with necrotizing fasciitis of the perineum and abdominal wall along with the scrotum and penis in men and the vulva in women. Methods The clinical and operative records of 45 patients with Fournier's gangrene during a 14-year period were analyzed. Results The etiology of the infection was identified in 39 patients. The most common causes were colorectal diseases and urogenital diseases. Four patients died with an overall mortality of 8.8%. The mortality rate was higher in patients with diabetes mellitus, but it was not statistically different. The age, duration of the symptoms, and the presence of rectal abscess were not found to be significant factors regarding mortality rate. Conclusions Surgery with extensive debridement of all necrotic tissue is the main stay of treatment.     

Scrotal reconstruction after Fournier's gangrene

After primary treatment for Fournier's gangrene, patients are left with skin defects in the genital region. In extensive lesions the whole scrotum may be lost. In these cases various methods for scrotal reconstruction have been recommended. In 3 patients we succeeded in reconstructing the scrotum and covering the penis using split-thickness skin grafts only. We found it a safe and relatively easy method giving the best possible cosmetic results and only minor functional sequelae.     

暴发性阴囊坏疽的局部处理方法探讨

目的 探索暴发性阴囊坏疽的治疗方法。方法 回顾分析9例暴发性阴囊坏疽治疗方案。9例患者均行外科清创，冲洗引流，抗感染等治疗，其中4例感染广泛蔓延的患者清创术后，采用U形多孔双向引流管引流。3例外暴露的睾丸暂置于浅表腔隙中，二期重建阴囊回纳睾丸。结果 留置U形管引流者，重复清创手术的次数明显减少，体温及血象恢复正常的时间较普通引流显著缩短，术后恢复迅速。结论 暴发性阴囊坏疽的治疗仍以清创及应用抗生素为主，术中多毋须切除睾丸。U形多孔双向引流管在清创术后引流效果确切，在促进康复有明显优势。     

Pyoderma gangrenosum of the penis presenting as Fournier's gangrene: a case report

We report a case of pyoderma gangrenosum of the penis presenting as Fournier's gangrene. A 77-year-old man who had undergone radiotherapy for localized prostate cancer 16 month earlier, presented with penile pain and fever. Symptoms began with erythema and induration on the dorsal surface of the penile shaft followed by spontaneous purulent drainage with severe pain. Magnetic resonance imaging was unremarkable except for swelling of the penile skin. Biopsy of the ulcerative penile lesion demonstrated a nonspecific inflammation without vasculitis or malignancy. Despite broad-spectrum antibiotics and debridement, the penile lesion extended and new satellite lesions developed as pustules on the glans. Since cultures were negative for aerobic and anaerobic bacteria, a course of intravenous prednisolone was then initiated at 100 mg/day. Within 24 hours the temperature normalized, progression of the penile lesions stopped and became convalescent. The steroid was then tapered and discontinued. The penile lesions healed slowly during the subsequent 1-month period. Based on the clinical course and histopathological findings as well as exclusion of other ulcerative conditions, a diagnosis of pyoderma gangrenosum was made. Penile involvement of this non-infectious ulcerating skin disease has rarely been reported. Pyoderma gangrenosum affecting the penile skin, such as that in present case, may show a similar presentation as Fournier's gangrene. Prompt differential diagnosis is mandatory since effective management for each processes is markedly different.     

Fournier's gangrene. Report of three cases and review of the literature

Fournier's gangrene, or synergistic gangrene of the male external genitalia is a rapidly spreading necrotising infection of the penis and scrotum. Although not so frequent in our civilized world it is by no means rare. In early days it was characterised by a high mortality. Aggressive surgical debridement, broad spectrum antibiotics and plastic reconstructive technics have all contributed to a better survival of the patients.