代谢性心脑血管疾病综合征患病情况调查

按全国糖尿病防治协作中心调查方法，在蚌埠地区城乡普查２２８２人，确诊糖尿病６０例，患病为２．６３％；糖耐量降低（ＩＧＴ）３０例，糖尿病组中高胰岛素血症。高脂血症、高血压及心电图异常发生率分别为３５．００％、３８．３３％、３６．６６％３５．９００％，与对照组相比，差异有显著生。糖尿病组中体重指数（ＢＭＩ）显著高于对照组（Ｐ〈０．０５）。代谢性心血管疾病综合征患病率为３１．６７％，ＣＨＡＯＳ综合征患病     

常见心脑血管疾病患者代谢综合征患病情况调查

目的 :探讨常见心脑血管疾病患者代谢综合征的患病情况。方法 :根据 6 5 7例常见心脑血管疾病患者(男性 35 4例 ,女性 30 3例 ,年龄 33岁～ 89岁 )的各代谢因素指标 ,计算代谢综合征及各因素的标准化发病率。结果 :心脑血管病人超重、高空腹血糖 (FPG)、高血压、高胆固醇 (TC)、高甘油三酯 (TG)、低高密度脂蛋白胆固醇 (HDL - C)、代谢综合征的发病率分别为 36 .5 3%、37.4 4 %、80 .37%、2 4 .2 0 %、5 6 .6 2 %、10 .5 0 %、4 2 .0 1%。结论 :常见心脑血管疾病患者具有较高的代谢综合征及相关疾病的患病率     

常见心脑血管疾病患者代谢综合征患病情况调查

目的:探讨常见心脑血管疾病患者代谢综合征的患病情况.方法:根据657例常见心脑血管疾病患者(男性354例,女性303例,年龄33岁～89岁)的各代谢因素指标,计算代谢综合征及各因素的标准化发病率.结果:心脑血管病人超重、高空腹血糖(FPG)、高血压、高胆固醇(TC)、高甘油三酯(TG)、低高密度脂蛋白胆固醇(HDL-C)、代谢综合征的发病率分别为36.53 %、37.44 %、80.37 %、24.20 %、56.62 %、10.50 %、42.01 %.结论:常见心脑血管疾病患者具有较高的代谢综合征及相关疾病的患病率.     

2型糖尿病合并代谢性炎症综合征的危险因素研究

目的　探讨2型糖尿病（T2DM）合并代谢性炎症综合征（MIS）的危险因素。方法　选取于2016年3—10月在辽宁中医药大学附属医院内分泌科住院的T2DM患者1 014例为研究对象。根据MIS诊断标准,将患者分为非MIS组（n=162）和MIS组（n=852）。收集患者一般资料和实验室检查结果,采用Logistic回归分析探讨T2DM合并MIS的危险因素。结果　两组患者体质指数（BMI）、腰围（WC）、空腹C肽（FCP）、餐后2 h C肽（2 hCP）、三酰甘油（TG）、总胆固醇（TC）、C反应蛋白（CRP）、并发糖尿病周围神经病变的比例比较,差异有统计学意义（P<0.05）;两组患者性别、年龄、病程、糖化血红蛋白（HbA1c）、低密度脂蛋白胆固醇（LDL-C）、并发糖尿病肾病、糖尿病视网膜病变的比例比较,差异无统计学意义（P>0.05）。多因素Logistic回归分析结果显示,高水平CRP、高BMI是T2DM合并MIS的危险因素（P<0.05）。结论　高水平CRP、高BMI是T2DM合并MIS的危险因素,了解其危险因素有利于早期筛查和防治,改善T2DM患者预后。     

代谢综合征患病情况的调查

目的 :调查 4 0岁以上干部代谢综合征的患病情况。方法 :采用体检的方法 ,对受检人员询问病史 ,测定血糖、血脂、血压、心电图、身高、体重、腰围、臀围等。以 10岁为一个年龄段。结果 :2 6 19名干部中发现代谢综合征 2 6 3例 ,患病率为10 .0 4 %。 4 0～ 80岁各年龄段的患病率分别为 5 .4 5 %、6 .97%、9.4 0 %、14 .81%、19.2 8%。代谢综合征者腰 /臀围比明显大于无代谢综合征者。代谢综合征患者近 5 0 %同时患有冠心病。结论 :代谢综合征发病率较高 ,且随年龄增长逐渐增高。代谢综合征者多为中心性肥胖 ,伴有冠心病的高发病率 ,对身体的危害较大。     

老年人群代谢综合征及其相关疾病患病情况分析

目的: 分析2004年度我院老年人群代谢综合征及其相关疾病的患病情况。方法: 检测532名血糖、血脂、血压和体重指数,并对结果进行统计分析。结果: 老年体检人员中糖尿病、高血压、血脂紊乱、超重、肥胖、代谢综合征患病比例分别为18.98%、45.68%、50.38%、28.76%、7.52%和13.35%。结论: 老年人群中代谢综合征及其相关疾病的患病比例较高。     

北京市1822名男青年外生殖器疾病患病情况调查

对2004至2008年北京市征兵身体检查的1822名男青年的外生殖器疾病患病情况进行调查。常见男性外生殖器疾病患病率：包皮过长67.07％,包茎2.36％,中重度精索静脉曲张1.43％。因包茎、中重度精索静脉曲张未达征兵体检要求者68名,占3.73％。中重度精索静脉曲张在征兵体检中为不合格,故建议社区卫生站和专科医生联合在学校、单位对男性青少年进行外生殖器检查及健康宣传教育,使男性外生殖器疾病及早得到治疗,提高征兵体检合格率。     

煤矿职工代谢综合征的患病情况调查

目的探讨煤矿职工代谢综合征(MS)的患病情况,为积极地进行早期、有效、有针对性的干预提供依据。方法选择2005-2007年来院进行健康体检的煤矿职工1865人,按年龄分为6个组进行调查。结果MS的检出率为17.80%,男性为18.22%,女性为17.30%。本组人群MS相关病病的检出率:血糖升高为24.08%,高血压为43.75%,血脂紊乱为53.08%,超重或肥胖为43.59%。结论随着年龄的增长代谢综合征的患病率呈现增长趋势,应该对该人群进行全面的干预。     

妇女病普查慢性宫颈炎患病情况调查分析

目的:通过妇女病普查分析可能引起妇女慢性宫颈炎的相关因素,为预防提供依据。方法:对全镇2839名已婚妇女进行妇科普查及相关实验室检查,将所得结果进行统计分析。结果:慢性宫颈炎患病率为27.19%。分析表明慢性宫颈炎的患病率与妇女的年龄、避孕方法、人工流产有关。结论:慢性宫颈炎受多种因素影响,应多学科、多部门协作,重视妇女病普查普治,加大生殖健康宣传力度,加强保健意识,提高妇女生殖健康水平。     

急性重症肢体缺血致代谢性肌肾综合征的治疗体会

目的:探讨肢体急性重症缺血后继发肾功能不全又可称为代谢性肌肾综合征(myonephropathic-methbolic syndrome,MMS)的处理。方法:回顾性分析我院2008年8月～2010年8月收治的因肢体急性重症缺血致肾功能不全共12名患者的临床资料。结果:12例患者中1例来我院等待手术过程中突然死亡,1例于术中即死亡,1例于术后2 h死于高钾血症,共9名患者存活,保肢者7人,2例行高位截肢术,其中1例从髋关节截肢,另1例从大腿中下1/3处截肢。病死率25%,截肢率16.7%。结论:急性肢体缺血所致肾功能不全患者病死率高,致残率高,患者在行手术取栓治疗后,要注意急性肾功能不全的发生,及早地应用甘露醇脱水,碳酸氢钠碱化尿液,清除自由基,促进肌红蛋白及其他代谢产物的排除。     

Metabolic syndrome and coronary artery calcification: a community-based natural population study

Background Little is known about the influence of metabolic syndrome （MetS） on coronary artery calcification （CAC） in China. In this article, we aimed to explore the distribution of CAC in populations with and without MetS, and estimate the influence of MetS and its components on CAC in a community-based population of Beijing. Methods A total of 1647 local residents of Beijing, age 40-77 years, were recruited for a cardiovascular risk factors survey and were determined fasting plasma glucose （FPG）, blood lipids, and 64 multi-detector computed tomography （64-MDCT） coronary artery calcium score （CACS） measurement （Agatston scoring）. The distribution of CAC was described, and the influence of MetS components on CAC was evaluated. Results In this population, the prevalence and extent of CAC increased with increasing age and both were higher in MetS subjects compared to nonMetS subjects （all P 〈0.05）, with the exception of those older than 65 years old. The risk of CAC increased with increasing numbers of MetS components, and the odds ratios for predicting positive CAC in subjects with 1, 2, 3, and 〉4 MetS components were 1.60, 1.84, 2.12, and 3.12, respectively （all P 〈0.05）. Elevated blood pressure, elevated FPG, elevated triglycerides, and overweight increased the risk of CAC, yielding odds ratios of 2.64, 1.67, 1.32, and 1.37, respectively （all P 〈0.05）. Conclusions In the Beijing community-based population, MetS increases the risk of CAC. The risk of CAC increases with increasing numbers of MetS components. Not only the number, but also the variety of risk factors for MetS is correlated with the risk of CAC. Elevated blood pressure, hyperglycemia, hypertriglyceridemia and overweight increase the risk of CAC.     

Prevalence of Metabolic Syndrome and Its Associations with Other Metabolic Disorders and Cardiovascular Changes in Health Examination Population in Beijing

Objective To investigate the prevalence of metabolic syndrome （MS） and its associations with other metabolic disorders and cardiovascular changes in health examination population in Beijing. Methods Totally, 10 916 individuals who received health examination in Health Examination Center of Peking Union Medical College Hospital were enrolled. The height, weight, blood pressure, serum levels of triglyceride, high-density lipoprotein cholesterol （HDL-C）, and fasting blood glucose were recorded. MS was diagnosed based on the working criteria of Chinese Diabetes Society 2004 （CDS2004）. Meanwhile, other metabolic disorders, including fatty liver and hyperuricemia, were recorded. The cardiovascular changes were reflected by the reports of electrocardiogram （ECG） ST-T changes and atherosclerosis of reti- nal arteries. Results The overall prevalence rate of MS was 6.1% （666/10 916） in the population. The preva- lence rate of MS in male was much higher than that in female （9.0% vs. 2.7%, P=0.000）. For individuals with MS, the prevalence rates of fatty liver and hyperuricemia were significantly higher than those without MS, respectively （70.4% vs. 35.4%, P=0.000; 29.9% vs. 17.7%, P=0.000）. As for cardiovascular changes, the prevalence rates of ECG ST-T changes and atherosclerosis of retinal arteries were significantly higher in individuals with MS than those without MS, respectively （13.8% vs. 11.7%, P=0.012; 12.0% vs. 6.8%, P=0.000）. Conclusions The prevalence of MS in Beijing population is high. The individuals with MS have a higher risk for other metabolic disorders and cardiovascular changes.     

代谢综合征和女性膀胱过度活动症的相关性

目的:观察代谢综合征和女性患者膀胱过度活动症(overactive bladder,OAB)的关系。方法:2009年3月²012年12月间在我院泌尿外科门诊及住院患有OAB或者其他泌尿系统疾病的女性病人,共459例。代谢综合征及OAB诊断参考中华医学会标准。分为OAB组及对照组,调查OAB危险因素和生活习惯,抽血检测血糖、高密度脂蛋白、甘油三酯等代谢指标。采用logistic回归分析探索OAB患病的影响因素。结果:186例OAB患者中,53例(28.49%)患有代谢综合征;而273例未患OBA的患者中,有41例(15.02%)患有代谢综合征,两者差异具有统计学意义(P<0.001)。多因素logistic回归显示,代谢综合征的OR=3.375,P=0.016。结论:在女性患者中,代谢综合征可能是OAB患病的原因之一。     

A follow-up study of women with a history of severe preeclampsia: relationship between metabolic syndrome and preeclampsia

Background  Women with a history of preeclampsia have twice the risk of cardiovascular diseases, and there is a graded relationship between the severity of preeclampsia and the risk of cardiac disease. Moreover, metabolic scores are associated with developing preeclampsia. However, since there are no diagnostic criteria for metabolic syndrome during pregnancy and pregnant women undergo metabolic changes, it is difficult to elucidate the relationship between preeclampsia and metabolic syndrome. We carried out a cross-sectional study to investigate the relationship between metabolic syndrome and preeclampsia among women with a history of severe preeclampsia shortly after an indexed pregnancy.

Methods  We recruited 62 women with a history of severe preeclampsia 1 to 3 years after an indexed pregnancy. Blood pressure and body compositional indices were recorded. Fasting blood samples were tested for glucose, total cholesterol, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, triglycerides, and insulin. A questionnaire was used to collect demographic data including pre-pregnancy weight and family history of diseases associated with cardiovascular diseases. Criteria for metabolic syndrome were defined by the National Cholesterol Education Program, Adult Treatment Panel III 2001 (NCEP III) and International Diabetes Federation 2005 (IDF). Data were analyzed by the α² test and multivariate Logistic regression.

Results  According to NCEP III and IDF standards, 17 (27%) and 24 (39%) women, respectively, were identified as having metabolic syndrome. Being overweight pre-pregnancy and currently overweight were risk factors, and currently overweight was an independent risk factor. A combination of blood pressure and waist circumference was predictive of metabolic syndrome with a sensitivity of 91.67% and specificity of 94.74%.

Conclusions  An unfavorable metabolic constitution in women may lead to metabolic syndrome, preeclampsia, and long-term cardiovascular disease. In women with severe preeclampsia, therapeutic interventions should include weight-control shortly after pregnancy, especially among women who were previously overweight.

     

慢性阻塞性肺病和代谢综合征

目的评估慢性阻塞性肺病(COPD)人群中代谢综合征的发生率,并探索两者间潜在的关联。方法老年病科的呼吸门诊中征募70例男性COPD患者及68例男性吸烟非COPD患者分别作为COPD组和对照组。每例患者进行腰围、胆固醇、甘油三脂、高密度脂蛋白、低密度脂蛋白、空腹血糖、血压及肺功能测定,采用国际糖尿病联盟的定义诊断代谢综合征。结果COPD组有30名(42.9%)患代谢综合征,明显高于对照组(22.1%)(P<0.05)。代谢综合征的5个组分中只有腹型肥胖、血压升高和血糖升高在COPD组的发生率高于对照组,而COPD组的低HDL-C和高TG发生率低于对照组。重度、极重度COPD患者的代谢综合征发病率较轻中度患者升高。结论本老年病科的呼吸门诊中,代谢综合征在男性COPD患者中相当普遍,可能是COPD患者增加患心血管疾病风险的一个原因,在此人群中进行代谢综合征的检查是必要的。     

2型糖尿病患者LP(a)水平与代谢综合征的关系

目的研究2型糖尿病患者LP(a)水平与伴发的代谢综合征组分相关性。方法采用横断面研究对上海地区1040例2型糖尿病患者进行了LP(a)水平的调查，同时采用Spearman单因素相关、Partial偏相关分析LP(a)与代谢综合征各组分的相关性，同时根据患者伴发代谢综合征组分数目分组，并对组间LP(a)水平进行统计分析。结果2型糖尿病患者LP(a)水平与尿微量白蛋白排泄率、血尿酸、空腹血糖及低密度脂蛋白胆固醇呈显著正相关性，而与胰岛素敏感指数呈显著负相关，但与肥胖、血压等无明显关联。同时LP(a)水平随着伴发代谢综合征组分数目的增加而明显升高。结论LP(a)水平与代谢综合征关系密切；监测2型糖尿病患者LP(a)水平有助于了解2型糖尿病患者伴发代谢综合征的情况；降低LP(a)水平有利于预防2型糖尿病患者慢性并发症的发生。     

代谢综合征与心血管疾病的研究进展

代谢综合征是近年来研究的热点问题.高血压、血脂异常、糖耐量减低和肥胖常同时发生,与心血管关系密切.本文就其意义、发病机制和防治方法做一综述.     

4092例成人中代谢综合征患病率分析

目的评价柳州市人群中代谢综合征（MS）的惠病情况。方法整群抽取柳州市常住成年居民4092人。进行身高、体质量、腰围、血压、血脂及血糖等指标检测，按中华医学会糖尿病分会提出的标准诊断MS并进行统计分析。结果MS的总惠病率为10．42％，男性患病率高于女性（12．56％对6．69％，P〈0．001）。患病率有随年龄增大而增高的趋势。MS组中高甘油三酯、超重的检出率分别为83．33％和82．61％。结论本组中MS的患病率已达较高水平，高甘油三酯及超重对MS诊断的贡献率最高。     

代谢综合征与结肠癌关系的 Meta 分析

目的：通过 Meta 分析探讨代谢综合征与结肠癌的关系。方法计算机检索中国知网、万方数据库、PubMed、Ovid-sp 数据库,时限为1990年1月至2014年5月。按纳入和排除标准,进行文献筛选及资料提取。采用 STATA12.0软件进行 Meta分析。结果共纳入8篇文献(6项队列研究、2项病例对照研究)。Meta 分析结果显示,代谢综合征结肠癌发病风险明显高于对照组(OR=1.43,95%CI ：1.23~1.66,P <0.05);分层分析发现,男性人群中,代谢综合征结肠癌发病风险高于对照组(OR =1.50,95%CI ：1.22~1.84,P <0.05),然而,女性人群中,其合并效应量 OR 为1.39(95%CI ：0.98~1.96,P =0.07),差异却无统计学意义。另外,与对照组相比,代谢综合征结肠癌死亡风险并未发生变化(OR=1.22,95%CI ：0.92~1.63,P =0.17)。结论代谢综合征与结肠癌发病有一定联系,但存在性别差异。代谢综合征结肠癌死亡风险并未增加,有待更多前瞻性队列研究进一步证实。