单纯髌内侧滑膜皱襞综合征诊断及关节镜治疗

[目的]探讨膝关节单纯髌内侧滑膜皱襞综合征临床诊断、关节镜治疗及其疗效.[方法]2008年1月～2010年6月根据shelf征、MPP试验及MRI检查诊断并收治单纯髌内侧滑膜皱襞综合征患者32例,全部在关节镜下行内侧滑膜皱襞完全切除术.[结果]随访12 ～40个月.根据改良Lysholm评分标准,其中优27例,良4例,可1例,优良率96.9％.[结论]单纯髌内侧滑膜皱襞综合征可以根据shelf征、MPP试验及MRI检查共同确定临床诊断,应用关节镜技术可取得良好的治疗效果.     

关节镜下治疗膝关节内侧滑膜皱襞综合征

目的探讨膝关节内侧滑膜皱襞综合征的临床诊断、治疗方法及结果。方法自2006年10月至2010年11月期间,我院共诊治膝关节内侧滑膜皱襞综合征患者87例,其中46例采取保守治疗后症状无缓解而接受关节镜下手术切除滑膜皱襞。男24例,女22例;年龄23～72岁,平均年龄为41岁。按Sakakibara法对滑膜皱襞进行分类,在关节镜下行皱襞切除术,并随访记录其疗效。结果 46例经关节镜下皱襞切除的患者,其中A型27例,B型15例,C型3例,D型1例;同时合并9例半月板损伤,5例髌股关节内侧面骨关节炎形成。增生的滑膜皱襞均采用篮钳或刨削器将其切除。43例获得随访,平均随访时间为25个月,无复发病例。膝关节功能根据Lysholm评分进行评定,术后功能较术前明显改善,治疗结果优良率为90.7%。结论膝关节内侧滑膜皱襞综合征根据临床症状和MRI表现即可诊断,关节镜下可以确诊,同时镜下行滑膜皱襞切除可获得满意的效果。     

髌内侧滑膜皱襞撕裂的诊断及治疗

目的 :讨论髌内侧滑膜皱襞撕裂的诊断及治疗方法。方法 :698例关节镜检查中髌内侧滑膜皱襞撕裂者 34例 ,占 4 % ,均在局麻关节镜下行撕裂的滑膜皱襞切除术 ,术后在髌内侧滑膜皱襞的对应处用绷带加压包扎 2～ 3d。结果 :术后随访 2～ 1 0年 ,由髌内侧滑膜皱襞撕裂引起的疼痛均消失 ,膝关节功能恢复正常。结论 :关节镜下切除撕裂的髌内侧滑膜皱襞创伤小 ,恢复快 ,效果好     

误诊为半月板损伤的膝关节紊乱的关节镜诊断和治疗

[目的]探讨临床半月板损伤的鉴别,提高膝关节紊乱的临床诊断水平.[方法]2004年以来对62例经临床检查和MR检查诊断为半月板损伤的患者经关节镜检查确诊为非半月板损伤的膝关节紊乱.男35例,女27例,年龄16～59岁.髌内侧滑膜皱襞综合征15例,Hoff's病8例,滑膜软骨瘤病11例,滑膜瘤6例,髌骨半脱位7例,剥脱性骨软骨炎6例,色素沉着绒毛结节性滑膜炎7例,滑膜血管病2例.全部病例均在关节镜下确诊后,一期行镜下手术治疗.[结果]62例术前诊断为半月板损伤的患者经关节镜检查确诊为非半月板损伤的膝关节紊乱,随诊11～27个月,术后较术前临床症状明显改善.疗效评定:优30例(49%),良23例(37%),可9例(14%).[结论]膝关节内很多疾患尽管病因不同,但在临床症状、体征方面有许多相似之处,只有通过临床仔细的鉴别诊断,才能提高诊断的准确率,不能单纯依据MR进行诊断,关节镜检查是确诊的重要手段.     

髌内侧滑膜皱襞综合征的关节镜治疗

目的:探讨关节镜下微创治疗髌内侧滑膜皱襞综合征的临床效果.方法:2000年5月～2003年4月对37例髌内侧滑膜皱襞综合征患者进行治疗,男25例,女12例,平均年龄32.8岁.8例病史较短采用皱襞部分切除,29例采用皱襞完全切除.结果:术后32例获随访,随访4～35个月,平均20.5个月,其中优25例(78.1%),良5例(15.6%),可2例(6.3%),优良率93.7%.结论:关节镜下诊断治疗髌内侧滑膜皱襞综合征创伤小、恢复快、疗效确实.     

髌内侧滑膜皱襞综合征的关节镜治疗

目的:探讨关节镜下微创治疗髌内侧滑膜皱襞综合征的临床效果.方法:2000年5月～2003年4月对37例髌内侧滑膜皱襞综合征患者进行治疗,男25例,女12例,平均年龄32.8岁.8例病史较短采用皱襞部分切除,29例采用皱襞完全切除.结果:术后32例获随访,随访4～35个月,平均20.5个月,其中优25例(78.1%),良5例(15.6%),可2例(6.3%),优良率93.7%.结论:关节镜下诊断治疗髌内侧滑膜皱襞综合征创伤小、恢复快、疗效确实.     

膝关节镜诊治滑膜皱襞综合征

内侧滑膜皱襞是最常引起临床症状的皱襞，滑膜皱襞综合征常指内侧滑膜皱襞综合征，滑膜皱襞综合征症状不典型，单纯依靠物理检查医生难以确切诊断，致使患者延误治疗。我院自2001年3月-2003年4月对87例膝关节内侧疼痛患者进行膝关节镜检查，其中被诊断为滑膜皱襞综合征19例，经关节镜治疗，取得了满意疗效。     

膝关节内侧滑膜皱襞综合征的关节镜诊治

目的探讨膝关节内侧滑膜皱襞综合征的临床诊断、关节镜诊断及疗效。方法回顾分析1996年1月～2007年12月收治的420例诊断为膝关节痛或半月板损伤或滑膜皱襞综合征的患者,其中有70例内侧滑膜皱襞综合征患者。按Sakakibara法分析其关节镜下形态,在镜视下行皱襞切除术、挛缩内侧支持带松解术,随访分析其疗效。结果70例内侧滑膜皱襞综合征中,镜下A型8例,B型13例,C型24例,D型25例。经镜下行皱襞切除,获得随访43例,随访时间为6个月～5年,平均32个月,按Lysholm法进行疗效评定,优良率90.7%。结论关节镜仍是该病确诊的"金标准",镜下彻底切除滑膜皱襞、松解挛缩内侧支持带是治疗该病有效的方法。     

关节镜下治疗内侧滑膜皱襞综合征

目的探讨关节镜下治疗内侧滑膜皱襞综合征方法及疗效。方法对47例(54膝)内侧滑膜皱襞综合征,术前确诊31膝,术中确诊23膝,行关节镜下内侧滑膜皱襞切除术。结果本组术前症状完全消失,术后疗效评价,优41例,良6例。本组无一例症状复发。治愈率100%。结论关节镜下内侧滑膜皱襞切除术是治疗内侧滑膜皱襞综合征较好的方法。其具有损伤小、恢复快、疗效佳等优点。     

诊断不明膝关节交锁症的病因探讨和疗效观察

目的　探讨诊断不明膝关节交锁症的病因、症状特点 ,经关节镜治疗后的临床疗效。　方法　对 4 7例膝关节不明原因交锁的病例均施行关节镜检查。镜下发现的病变 :34例滑膜疾病、4例Hof fa病、9例髌股关节排列异常 ,滑膜疾病镜下刨削切除滑膜皱襞、增生肥厚的滑膜团块及滑膜瘤样病变 ,Hoffa病镜下部分切除髌下脂肪垫 ,髌骨半脱位行髌骨外侧支持带松解、胫骨结节前内侧移位。　结果　平均随访 1年 ,全部病例术后交锁症状消失 ,4 6例膝关节疼痛完全消失或明显缓解 ,术前存在膝关节功能障碍的大多数病例术后恢复或接近正常。　结论　诊断不明膝关节交锁症的原因较多 ,其主要病因是滑膜疾病、Haffa病、髌股关节排列异常。关节镜术是一个重要的诊断和治疗手段 ,并可获得满意的临床效果。     

Vasopressor hormone response following mesenteric traction during major abdominal surgery

Background : We investigated the vasopressor hormone response following mesenteric traction (MT) with hypotension due to prostacyclin (PGI₂) release in patients undergoing abdominal surgery with a combined general and epidural anesthesia. Methods : In a prospective, randomized, placebo-controlled study we administered 400 mg ibuprofen (i.v.) in 42 patients scheduled for abdominal surgery. General anesthesia was combined with epidural anesthesia (T4-L1). Before as well as 5, 15, 30, 45, and 90 min after MT we recorded plasma osmolality, hemodynamics and measured 6-keto-PGFlα (stabile metabolite of PGI₂), TXB₂ (stabile metabolite of thromboxane A₂) active renin, and arginine vasopressin (AVP) plasma concentrations by radioimmunoassay. Catecholamine levels were assessed by high-pressure liquid chromatography (HPLC) with electrochemical detection. Results : Following MT, arterial hypotension occurred along with a substantial PGI₂ release. This was completely abolished by ibuprofen administration. Although plasma levels of 6-keto-PGF_1α (1133 (708) vs. 60 (3) ng/L, median (median absolute deviation), P=0.0001, placebo vs. ibuprofen) remained significantly elevated, blood pressure was restored within 30 min after MT in the placebo group. At the same point in time plasma concentrations of TXB² (164 (87) vs. 58 (1) ng/L, P=0.0001), epinephrine (46 (33) vs. 14 (6) ng/L, P=0.001), AVP (41 ± (18) vs. 12 (7) ng/L, P=0.0004), and active renin (27 (12) vs. 12 (4) ng/L, P = 0.001) were significantly higher in placebo-treated patients. Conclusion : Under combined general and epidural anesthesia arterial hypotension following MT due to endogenous PGI₂ release is associated with enhanced release of AVP, active renin, epinephrine and thromboxane A₂, presumably contributing to hemodynamic stability within 30 min after MT.     

A Teaspoon Pump for Pumping Blood with High Hydraulic Efficiency and Low Hemolysis Potential

Abstract: Virtually all blood pumps contain some kind of rubbing, sliding, closely moving machinery surfaces that are exposed to the blood being pumped. These valves, internal bearings, magnetic bearing position sensors, and shaft seals cause most of the problems with blood pumps. The original teaspoon pump design prevented the rubbing, sliding machinery surfaces from contacting the blood. However, the hydraulic efficiency was low because the blood was able to "slip around" the rotating impeller so that the blood itself never rotated fast enough to develop adequate pressure. An improved teaspoon blood pump has been designed and tested and has shown acceptable hydraulic performance and low hemolysis potential. The new pump uses a nonrotating "swinging" hose as the pump impeller. The fluid enters the pump through the center of the swinging hose; therefore, there can be no fluid slip between the revolving blood and the revolving impeller. The new pump uses an impeller that is comparable to a flexible garden hose. If the free end of the hose were swung around in a circle like half of a jump rope, the fluid inside the hose would rotate and develop pressure even though the hose impeller itself did not "rotate"; therefore, no rotating shaft seal or internal bearings are required.     

Microspheres Based Detoxification System: A New Method in Convective Blood Purification

Abstract: A variety of protein-bound or hydrophobic substances, accumulating as a result of pathologic conditions such as exogenous or endogenous intoxications, are removed poorly by conventional detoxification methods because of low accessibility (hemodialysis), insufficient adsorption capabilities (hemosorption), low efficiency (peritoneal dialysis), or economic limitations (high-volume plasmapheresis). Combining advantages of existing methods with microspheric technology, a module-based system was designed. Major operating parameters of the latter can be modified to allow for adjustment to individual clinical situations. An extracorporeal blood circuit including a plasmafilter is combined with a secondary high-velocity plasma circuit driven by a centrifugal pump. Different microspheric adsorbers can be combined in one circuit or applied in sequence. Thus, a prolonged treatment can be tailored using specially designed selective adsorber materials. Comparing this system with existing methods (high-flux hemodialysis, molecular adsorbent recycling system), results from our in vitro studies and animal experiments demonstrate the superior efficiency of substance removal.     

Tissue perfusion in relation to cardiac output during continuous positive-pressure ventilation and administration of propranolol or verapamil

Background : Our objective was to determine whether administration of propranolol or verapamil modifies the hemodynamic adaptation to continuous positive-pressure ventilation (CPPV), in particular the regional distribution of cardiac output (CO).
Methods : General hemodynamics and regional blood flows assessed by microsphere technique (15 (μm) were recorded in 16 anesthetized pigs during spontaneous breathing (SB) and CPPV with 8 cm H₂O end-expiratory pressure (CPPV8) before and after intravenous administration of propranolol (0.3 mg · kg⁻¹ followed by 0.15 mg · kg⁻¹ · h⁻¹, n=8) or verapamil (0.1 mg · kg⁻¹ followed by 0.3 mg · kg⁻¹ · h⁻¹, n=8).
Results : CPPV8 depressed CO by 25% without shifts in its relative distribution with the exception of a noteworthy increase in adrenal perfusion. Propranolol increased arterial blood pressure, and due to a fall in heart rate, CO dropped by 25%. The kidneys and, to a lesser extent, the splanchic region and central nervous system received increased fractions of the remaining CO at the expense of skeletal muscle flow. Similar patterns were seen during SB and CPPV8 such that the combination of propranolol and CPPV8 depressed CO by 50%. The circulatory effects of verapamil were less evident but myocardial perfusion tended to increase.
Conclusions : The combination of propranolol or verapamil with CPPV does not result in any specific hemodynamic interaction in anesthetized pigs, except that the combined effect of propranolol and CPPV may severely reduce CO.     

Volatile anaesthetics reduce adhesion of blood platelets under low-flow conditions in the coronary system of isolated guinea pig hearts

Background : Inhibitory effects of volatile anaesthetics on platelet aggregation have been demonstrated in several studies. However, the influence of volatile anaesthetics on intracoronary platelet adhesion has not been elucidated so far.
Methods : Isolated hearts of guinea pigs were perfused with buffer in the absence or presence of volatile anaesthetics (0.5 and 1 MAC) at constant coronary flow rates of 5 ml/min for 25 min, then 1 ml/min for 30 min and again 5 ml/min for 10 min. Before, during and after low-flow perfusion, a bolus of human platelets was applied into the coronary system. To simulate thrombogenic conditions, 0.3 U/ml human thrombin was infused during low-flow perfusion and reperfusion. The number of platelets sequestered to the endothelium was calculated from the difference between coronary in- and output of platelets. The myocardial production of lactate and consumption of pyruvate and coronary perfusion pressure were also determined.
Results : At a flow rate of 5 ml/min only about 3% of the applied platelets did not emerge from the coronary system, in any group. In contrast, 13.1±1.2% (mean±SEM) of infused platelets became adherent in low-flow perfusion in the control group without anaesthetic. The adherence was reduced with each 1 MAC isoflurane (to 6.2±1.2%), sevoflurane (to 4.4±0.9%) or halothane (to 3.2±1.5%) (each P <0.05 vs. control). Volatile anaesthetic, 0.5 MAC, did not inhibit platelet adhesion to a statistically significant extent in any case. Perfusion pressure and metabolic parameters were not statistically different between the control and the hearts exposed to anaesthetics.
Conclusion : Volatile anaesthetics in a concentration of 1 MAC can reduce the adhesion of platelets in the coronary system under reduced flow conditions. This action does not arise from vasodilation or inhibition of ischaemic stress.     

Bariatric Surgery in Some "Central and East-European (former Eastern bloc)"Countries - Current Status and Prediction for the Next Millennium

Background: Obesity is increasing globallly, including in the formerly "Eastern Bloc" countries. Methods: A survey was made of obesity and bariatric surgery. Results: In the 8 East and Central European countries studied, with total population 300 million, roughly 43% of the population was overweight (BMI 25-30), 23% obese (BMI > 30), with about 15 million people morbidly obese (BMI > 40). From 0-10 morbidly obese individuals/100,000/year undergo bariatric surgery. Conclusion: Most countries were found to provide inadequate treatment for obesity.The majority of the morbidly obese are not treated effectively. However, health-care awareness of obesity and bariatric surgeons are slowly increasing.     

Is the recovery profile of mivacurium independent of the rate of decay of its plasma concentration in patients with normal plasma cholinesterase activity?

Background: The duration of action of muscle relaxants is poorly correlated to the rate of decay of their plasma concentration. The plasma concentration of mivacurium may rapidly decrease below its active concentration because of the extensive hydrolysis of mivacurium. By inflating a tourniquet on one upper limb for 3 min after the administration of atracurium, mivacurium or vecuronium, we studied the influence of the initial decline of their plasma concentration on their effect. Methods: In 50 patients anaesthetised with thiopental, isoflurane and fentanyl, the effect of bolus doses of 0.15 or 0.25 mg . kg^?1 mivacurium (MIV 15, MIV 25), 0.3 or 0.5 mg . kg^?1 atracurium (ATR 30, ATR 50) and 0.06 or 0.1 mg . kg^?1 vecuronium (VEC 06, VEC 10) were measured on both arms (evoked response of the adductor pollicis to train-of-four stimulation every 12 s), a tourniquet being applied on one arm just before and during 3 min after the muscle relaxant bolus. Results: Tourniquet inflation of 3 min almost abolished the neuromuscular effect of mivacurium. In the vecuronium groups and in the ATR 50 group, tourniquet inflation did not modify the maximum degree of depression of the twitch response. Also, the duration of action of vecuronium was unaffected by the tourniquet. In the ATR 30 group, times to return of the twitch response to 25% (duration 25%) and 75% (duration 75%) of control response were significantly shorter in the cuffed arm, 23 min vs 27 min, and 41 min vs 45 min, respectively. In the ATR 50 group, only duration 25% was significantly shorter in the cuffed arm (41 min vs 45 min). Conclusion: The results suggest that the rate of decline of the plasma concentration of mivacurium is so rapid, that a very low and almost clinically ineffective concentration is present as soon as 3 min after its administration. The results also indicate that the recovery from a mivacurium-induced neuromuscular blockade is not influenced by the rate of decay of its plasma concentration in patients with genotypically normal plasma cholinesterase.     

Membranes in Artificial Organs

Abstract: Membrane processes play a pivotal and enabling role in modern replacement therapy for acute and chronic organ failure and in the management of immunologic diseases. In fact, virtually all contemporary extracorporeal blood purification methods employ membrane devices, and the next generation of artificial organs and tissue engineering therapies are almost certain to be similarly grounded in membrane technology. In this short essay, we comment on the similarities and differences among synthetic membranes and their natural counterparts and also provide a critical overview of the demographics and technology of hemodialysis, hemofiltration, apheresis, oxygenation, and emerging membrane technologies and applications.     

Synergistic interaction between the effects of propofol and midazolam with fentanyl on phrenic nerve activity in rabbits

Background: It has been shown that the depressive effects of both propofol and midazolam on consciousness are synergistic with opioids, but the nature of their interactions on other physiological systems, e. g. respiration, has not been fully investigated. The present study examined the effect of propofol and midazolam alone and in combination with fentanyl on phrenic nerve activity (PNA) and whether such interactions are additive or synergistic. Methods: PNA was recorded in 27 anaesthetised and artificially ventilated rabbits. In three groups, propofol, fentanyl and midazolam were administered intravenously in incremental doses to construct dose-response curves for the depressant effects of each one on PNA. In another two groups, the effect of pretreatment with either fentanyl 1 μg · kg^?1 i. v. or midazolam 0.05 mg · kg^?1 i. v. on the effects of propofol and fentanyl respectively on PNA were studied. Results: Propofol and fentanyl caused a dose-dependent depression of PNA with complete abolition at the highest total doses of 16 mg · kg^?1 i. v. and 32 μg · kg^?1 i. v., respectively. In contrast, midazolam in incremental doses to a total of 0.8 mg · kg^?1 reduced mean PNA by 63%, but approximately 12% of PNA remained at a total dose as high as 6.4 mg · kg^?1. The mean ED₅₀s, calculated from dose-response curves, were 5.4 mg · kg^?1, 3.9 μg · kg^?1 and 0.4 mg · kg^?1 for propofol, fentanyl and midazolam, respectively. Initial doses of either fentanyl 1 μg · kg^?1 i. v. or midazolam 0.05 mg · kg^?1 i. v. acted synergistically with subsequent doses of either propofol or fentanyl to abolish PNA at total doses of 8 mg · kg^?1 and 8 μg · kg^?1, respectively. Conclusion: Fentanyl has a synergistic interaction with both propofol and midazolam on PNA and hence potentially on respiration.     

Influence of dopexamine hydrochloride on haemodynamics and regulators of circulation in patients undergoing major abdominal surgery

Background: Catecholaminergic support is often used to improve haemodynamics in patients undergoing major abdominal surgery. Dopexamine is a synthetic vasoactive catecholamine with beneficial microcirculatory properties. Methods: The influence of perioperative administration of dopexamine on cardiorespiratory data and important regulators of macro- and microcirculation were studied in 30 patients undergoing Whipple pancreaticduodenectomy. The patients received randomized and blinded either 2 μg · kg^?1 · min^?1 of dopexamine (n=15) or placebo (n=15, control group). The infusion was started after induction of anaesthesia and continued until the morning of the first postoperative day. Endothelin-1 (ET-1), vasopressin, atrial natriuretic peptide (ANP), and catecholamine plasma levels were measured from arterial blood samples. Measurements were carried out after induction of anaesthesia, 2 h after onset of surgery, at the end of surgery, 2 h after surgery, and on the morning of the first postoperative day. Results: Cardiac index (CI) increased significantly in the dopexamine group (from 2.61±0.41 to 4.57±0.78 1 · min^?1 · m^?2) and remained elevated until the morning of the first postoperative day. Oxygen delivery index (DO₂I) and oxygen consumption index (VO₂I) were also significantly increased in the dopexamine group (DO₂I: from 416±91 to 717±110 ml/m² · m²; VO₂I: from 98±25 to 157±22 ml/m² · m²), being significantly higher than in the control group. pHi remained stable only in the dopexamine patients, indicating adequate splanchnic perfusion. Vasopressive regulators of circulation increased significantly only in the untreated control patients (vasopressin: from 4.37±1.1 to 35.9±12.1 pg/ml; ET-1: from 2.88±0.91 to 6.91±1.20 pg/ml). Conclusion: Patients undergoing major abdominal surgery may profit from prophylactic perioperative administration of dopexamine hydrochloride in the form of improved haemodynamics and oxygenation as well as beneficial influence on important regulators of organ blood flow.