Student’s Academic Engagement: the Relation between Teacher’s Academic Optimism and Female Student’s Perception of School Climate

The goal of the present research is to identify the correlation between students’ perception of their school climate, their teachers’ academic optimism, and how these two factors affect overall academic engagement among students. The research sample comprised of 1200 female students and 48 teachers. Findings indicated that the perception of teacher’s support and perception of student’s autonomy have significant impact on the student’s academic engagement. Further, the relationship between a teacher’s efficacy and positive role in student engagement was found to be significant.     

The Regulating Role of Negative Emotions in Children’s Coping with Peer Rejection

This study examined the role of emotions as predictors of children’s coping responses to peer rejection experiences. Children ages 7–12 (N = 79) completed questionnaires to assess emotional and coping responses to peer rejection scenarios. This study examined three coping factors specific to peer rejection (positive reappraisal, ruminative coping, and aggressive coping) and examined results separately for two negative peer experiences (teasing and exclusion). Children’s emotions predicted coping responses after controlling for peer experiences. Specifically, anger was associated with aggressive coping, whereas sadness was associated with ruminative coping, supporting theory that emotions have distinct motivational-behavioral properties. Peer experiences were also important, as victimization was associated with aggressive coping, and receipt of prosocial peer behaviors was associated with positive reappraisal. These findings provide an empirical foundation for future research and the development of interventions to facilitate adaptive reactions to peer rejection.     

Supportive and Controlling Parental Involvement as Predictors of Children’s Academic Achievement: Relations to Children’s ADHD Symptoms and Parenting Stress

This study investigated the role of parenting stress, the parental involvement style, and attention-deficit/hyperactivity disorder (ADHD) symptoms in predicting academic achievement in 8- to 12-year-old children. Guided by the Family–School Relationships Model path analysis was used to compare the effects of a controlling versus supportive style of parental involvement in relation to children's learning. Results revealed that high levels of parenting stress were associated with the use of more controlling strategies regarding children’s academics, whereas lower stress was associated with a more supportive style of involvement. Controlling parental involvement was associated with more parent-rated symptoms of ADHD and lower academic achievement in children, while supportive involvement was associated with fewer parent-rated ADHD symptoms and higher achievement. The relation between both styles of parental involvement and academic achievement was accounted for by children’s inattention, but not hyperactivity/impulsivity, in the home. These findings demonstrate the combined risk of parenting stress, controlling parental involvement, and children’s inattentive behaviors for poor achievement in children.     

Deficits in Free Recall Persist in Asperger’s Syndrome Despite Training in the Use of List-appropriate Learning Strategies

Free recall in adults with Asperger’s Syndrome (AS) was compared with that in matched controls in an experiment including semantically similar, phonologically similar and unrelated word lists. Without supportive instructions, adults with AS were significantly impaired in their recall of phonologically and semantically related lists, but not unrelated lists. Even when trained to make use at study of the relations among the words, the adults with AS recalled fewer words than the control group. Participants rehearsed the study lists out loud and the rehearsal data was analysed. Despite a very slight trend for adults with AS to engage in less elaborative rehearsal and more rote rehearsal, their rehearsal did not differ significantly from that of controls.     

Effectiveness of a children’s home and community-based services waiver program

Objective Limited alternatives exist to residential treatment or hospitalization for children with the most serious emotional disturbances. Community-based interventions are intended to offer less restrictive and expensive options than traditional treatment. One such program is New York State’s Home and Community-Based Services (HCBS) Waiver Program. Methods From 1996 to 2002, 169 children were enrolled in the Manhattan HCBS. All spent at least one month on the wait list prior to admission to the waiver program. We used our wait list as a control group (WLC), allowing for comparison of the HCBS intervention. Results Sample consisted of 169 children between the ages of five and eighteen. The ethnic composition was 46.8% Hispanic (N = 79), 47.9% African-American (N = 81), and 5.3% Caucasian (N = 9). Average stay was 12 months in the HCBS program and 3.5 months for the WLC. Only 30% of children in the WLC were maintained in the community, while 81% of children in the HCBS were similarly maintained (P < 0.001). Also, the rate of hospitalization for the HCBS group was significantly lower (3 versus 41%; P < 0.001). There was also a trend for the WLC group to have had substantially higher rates of removal by the Administration for Children’s Services (New York City’s protective service agency) (8.3 versus 1.8%) and to more frequently require residential treatment (13.0 versus 8.9%). Conclusions It would seem that the HCBS program appears to be a clinically and cost-effective method of maintaining children in their community. Presented in part at the 50th annual meeting of the American Academy of Child and Adolescent Psychiatry, Miami, FL Oct. 14-19, 2003.     

Rutin Protects Dopaminergic Neurons from Oxidative Stress in an Animal Model of Parkinson’s Disease

This study was undertaken to investigate the neuroprotective effects of rutin (vitamin P) on 6-hydroxydopamine (6-OHDA)-induced Parkinson's disease (PD) in rats. Oxidative stress and inflammation is an important event, play a crucial role in neurodegenerative diseases. Rutin has been shown to have antioxidant and anti-inflammatory actions, and thus was tested for its beneficial effects using 6-OHDA-induced PD rat model. Male Wistar rats were pre-treated with rutin (25?mg/kg bwt, orally) for 3?weeks and subjected to unilateral intrastriatal injection of 6-OHDA (10?μg in 0.1% ascorbic acid in normal saline). Three weeks after 6-OHDA infusion, rats were tested for neurobehavioral activity, and were killed after 4?weeks of 6-OHDA infusion for the estimation of thiobarbituric acid reactive substances, glutathione, and its dependent enzymes (glutathione peroxidase and glutathione reductase), dopamine (DA) and its metabolite 3,4-dihydroxyphenyl acetic acid. The increase in 6-OHDA-induced rotations and deficits in locomotor activity and motor coordination and decrease in antioxidant level, DA content and its metabolite and increase in the number of dopaminergic D2 receptors in striatum were protected significantly with lesioned group pre-treated with rutin. These findings were further supported by the histopathological and immunohistochemical findings in the substantia nigra that showed that rutin protected neurons from deleterious effects of 6-OHDA. These results suggest that the consumption of rutin, which is novel vitamin, may have the possibility of protective effect against the neurological disorder such as PD.     

Effectiveness of a dance-physiotherapy combined intervention in Parkinson’s disease: a randomized controlled pilot trial

Neurological Sciences - Physical therapies have been recommended as crucial components in Parkinson’s disease (PD) rehabilitation. The study aims to examine the effectiveness of a new...     

Effectiveness of Relatives’ Psychoeducation on Family Outcomes in Bipolar Disorder

Abstract:

The chronicity and recurrent nature of manic and depressive episodes in bipolar disorder render it a major public health concern. Not surprisingly, the development of effective treatment interventions is a priority. The impact of family psychoeducation, as an adjunct to pharmacotherapy, has also received heightened attention. The present study endeavors to assess the effectiveness of relatives-group psychoeducation on caregivers’ knowledge, family burden, and psychological distress. Eighty relatives were recruited from the Families’ Association for Mental Health and randomly allocated either to the control condition (treatment as usual) or the intervention group (seven psychoeducation sessions). Participants were interviewed at baseline, completion of intervention, and six-month follow-up by researchers blind to treatment allocation. The structured interview included the Knowledge About Bipolar Disorder Questionnaire, the Family Burden Scale, and the General Health Questionnaire–12. Findings indicated that relatives psychoeducation had a positive effect on participants’ outcomes upon completion of the intervention as well as at the six-month follow-up. Family psychoeducation is a promising intervention for effectively managing and treating bipolar disorder.     

Postpartum Stress as A Predictor of Women’s Minor Psychiatric Morbidity

The purpose of this study was to predict women’s minor psychiatric morbidity after they had childbirth as measured repeatedly at the first, the third, and the fifth weeks of the postpartum period. The Chinese Health Questionnaire, the Postpartum Stress Scale, the Zung’s Self-rating Depression Scale and Anxiety Scale, and the Social Support Scale were used at the three points of time. A total of 526 women in Taiwan participated in the study. The results indicated that postpartum stress and anxiety are important predictors for postpartum women’s minor psychiatric morbidity at three points in time. Chich-Hsiu Hung is affiliated with the College of Nursing and Department of Nursing at Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung City, Taiwan.     

The Relationship Between Parents’ and Children’s Automatic Thoughts in a College Student Sample

Research demonstrates the importance of early social interactions in the development of schemas and automatic thoughts. It does not appear, however, that the existing research examines intergenerational correlations in automatic thoughts. As a result, this study explores the relationship between the automatic thoughts of parents and those of their college-age children in a sample of 252 college students and their mothers and fathers. Results of this study suggest that there are significant relationships between parents’ and college students’ positive automatic thoughts. Different trends by gender also are noted in the relationships among variables for male and female college students with their mothers and fathers. Further, mothers’ positive ATs predicted the positive ATs of their college students, with mothers’ ratings of their own communication with their college students mediating partially this relationship. Finally, college students’ anxiety and self-esteem is predicted significantly by their mothers’ anxiety and self-esteem (respectively) as well as their own positive and negative ATs. These findings suggest the possibility that ATs play a role in the intergenerational transmission of certain domains of psychological functioning.     

Neurobiology of Delusions in Alzheimer’s Disease

Alzheimer’s disease (AD) is associated with cognitive and functional impairment as well as neuropsychiatric sequelae, including psychotic symptoms such as delusions and hallucinations. Strong evidence supports the need to study delusions separate from hallucinations. Integrating the epidemiology, clinical correlates, and neuropathological and genetic literature for delusions in AD allows us to speculate on etiology and mechanisms. Plaque and tangle deposition in individuals with susceptible alleles of serotonergic, muscarinic, nicotinic, or Apoε4 genes appears to result in disruption of cortical circuitry, culminating in delusions. While delusions in AD correspond to a phenotype distinct from AD without delusions, subtypes of delusions may also define further distinct clinical entities. Persecutory delusions may occur earlier in the illness and have a more significant genetic component than misidentification delusions, which are associated with increased cognitive impairment and advanced dementia. Clearly distinguishing between these two syndromes is essential to making progress in the area of delusions in AD.     

Impact of drooling in Parkinson’s disease

Drooling is a well known problem in patients with Parkinson's disease (PD). The aim of this study was to investigate the severity and consequences of drooling in PD. A comprehensive drooling questionnaire was sent to 105 PD outpatients, who had volunteered drooling during a previous questionnaire (n = 216). Among 63 patients who responded and confirmed drooling, 27% experienced severe saliva loss. Social and emotional consequences were reported by 17% to 77% of patients, and significantly more often by those with severe drooling. We conclude that drooling is a frequent, disabling and apparently undertreated symptom of PD. History taking ought to be detailed and specific to understand the full impact of drooling for an individual patient. Therapeutic options should be evaluated more intensively.     

Pharmacotherapy of Parkinson’s disease in Germany

Treatment standards or guidelines have been developed for most features of Parkinson’s disease (PD). However, data on the actual treatment that is put into practice are scarce. In 2000, a nationwide survey on the topic of sudden onset of sleep (SOS) in PD was initiated among the members of the German patient support group (deutsche Parkinson–Vereinigung, dPV). A part of this mailed questionnaire survey covering the antiparkinsonian and concomitant medication of the participants is presented here. This study analyses data sets from more than 6,500 PD patients. The mean dopaminergic dose was equivalent to 599 ± 387 mg levodopa/die. The most frequently administered drugs were levodopa (94.2 %), dopamine agonists (DA) (71.7 %), amantadine (40.1 %), selegiline (27.6 %), entacapone (20.4 %), budipine (12.3 %), and anticholinergics (11.8 %). Costs of pharmacotherapy were estimated to be approximately € 399 million/year in Germany. PD drug therapy in general strongly depended on age, disease duration, and the level of care. The treatment guidelines were apparently not consistently followed underlining the need for their continuous propagation throughout the medical community. In addition our data suggest that non–motor symptoms in PD are not adequately treated and that concomitant sedative medication contributes to the occurrence of SOS.     

Role of Synucleins in Alzheimer’s Disease

Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common causes of dementia and movement disorders in the elderly. While progressive accumulation of oligomeric amyloid-β protein (Aβ) has been identified as one of the central toxic events in AD leading to synaptic dysfunction, accumulation of α-synuclein (α-syn) resulting in the formation of oligomers has been linked to PD. Most of the studies in AD have been focused on investigating the role of Aβ and Tau; however, recent studies suggest that α-syn might also play a role in the pathogenesis of AD. For example, fragments of α-syn can associate with amyloid plaques and Aβ promotes the aggregation of α-syn in vivo and worsens the deficits in α-syn tg mice. Moreover, α-syn has also been shown to accumulate in limbic regions in AD, Down’s syndrome, and familial AD cases. Aβ and α-syn might directly interact under pathological conditions leading to the formation of toxic oligomers and nanopores that increase intracellular calcium. The interactions between Aβ and α-syn might also result in oxidative stress, lysosomal leakage, and mitochondrial dysfunction. Thus, better understanding the steps involved in the process of Aβ and α-syn aggregation is important in order to develop intervention strategies that might prevent or reverse the accumulation of toxic proteins in AD.     

Peripheral expression of MAPK pathways in Alzheimer’s and Parkinson’s diseases

Alteration of mitogen-activated protein kinase pathways may cause aberrant protein phosphorylation and enhanced apoptosis in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Increased susceptibility of lymphocytes to apoptosis has been reported in AD. To our knowledge this is the first study to investigate the expression and phosphorylation status of p38 mitogen-activated protein kinase (p38MAPK) and c-Jun N-terminal kinase (JNK) in peripheral blood lymphocytes of 20 AD and 20 PD patients and 20 healthy controls using western blot analysis. Compared with controls, no significant difference of total p38MAPK or JNK levels were observed in AD and PD patients, whereas phosphorylated p38MAPK and phosphorylated JNK levels were significantly increased in the AD and PD groups (p < 0.001). However, the increased levels of the two phosphorylated kinases in AD versus PD patients presented no significant difference. Interestingly, phosphorylated p38MAPK and phosphorylated JNK levels were positively correlated with disease duration (r = 0.602, p = 0.005 and r = 0.561, p = 0.010, respectively) and negatively correlated with the Mini Mental State Examination score (r = −0.664, p = 0.001 and r = −0.578, p = 0.008, respectively) in AD patients. No correlations between protein levels and clinical variables were found in PD patients. Investigation of peripheral changes in the expression of p38MAPK and JNK may lead to the development of innovative biomarkers of neurodegenerative diseases, particularly for AD.     

Role of exosomes in the pathogenesis of inflammation in Parkinson’s disease

Inflammatory responses,including glial cell activation and peripheral immune cell infiltration,are involved in the pathogenesis of Parkinson’s disease(PD).These inflammatory responses appear to be closely related to the release of extracellular vesicles,such as exosomes.However,the relationships among different forms of glial cell activation,synuclein dysregulation,mitochondrial dysfunction,and exosomes are complicated.This review discusses the multiple roles played by exosomes in PD-associated inflammation and concludes that exosomes can transport toxicα-synuclein oligomers to immature neurons and into the extracellular environment,inducing the oligomerization ofα-synuclein in normal neurons.Misfoldedα-synuclein causes microglia and astrocytes to activate and secrete exosomes.Glial cell-derived exosomes participate in communications between glial cells and neurons,triggering anti-stress and anti-inflammatory responses,in addition to axon growth.The production and release of mitochondrial vesicles and exosomes establish a new mechanism for linking mitochondrial dysfunction to systemic inflammation associated with PD.Given the relevance of exosomes as mediators of neuron-glia communication in neuroinflammation and neuropathogenesis,new targeted treatment strategies are currently being developed that use these types of extracellular vesicles as drug carriers.Exosome-mediated inflammation may be a promising target for intervention in PD patients.