The role of cost effectiveness analysis in health care evaluation.

This paper provides an overview of the key elements of cost effectiveness analysis (CEA). CEA is a method for evaluating the relative costs and benefits of treatments and procedures. Typically, CEA compares a proposed intervention with (at least) one alternative intervention, yielding an incremental cost effectiveness ratio. This ratio reflects both the longevity and health status of the differing interventions and permits the researcher to more completely compare and evaluate the "payoff" of the interventions. This paper discusses different perspectives CEA studies might adopt, and reviews the major methods for measuring both outcomes and costs.     

Outpatient metrizamide myelography: prospective evaluation of safety and cost effectiveness

A group of 228 consecutive patients undergoing metrizamide myelography was prospectively evaluated for postprocedure symptoms. The observed prevalence of these symptoms concurs with previously reported inpatient studies, with the most common sequelae being exacerbation or onset of spine or extremity pain, headache, nausea, and paresthesia. Limitation of administered dose of metrizamide in lumbar myelography may slightly reduce the occurrence of common symptoms, but withdrawal of contrast medium at the completion of examination had no impact on their occurrence. There was a higher occurrence of paresthesia in cervical myelography, but otherwise there was no significant difference in symptoms between cervical and lumbar studies. Outpatient metrizamide myelography can be performed with relative safety with the potential for significant cost savings.     

Clinical effectiveness in radiologic technology students: an empirical perspective

This article describes two studies that examine the nature of effective clinical performance among radiologic technology students. The first study includes the perspective of staff technologists on student performance, while the second study includes the perspective of clinical instructors, important dimensions of performance that are identified include organization, relationship with peers and staff, relationships with patients, flexibility, and initiative. These dimensions are linked to specific student behaviors in clinical practice.     

The cost effectiveness of CT-assisted radiotherapy planning

The cross-sections displayed by computed tomography are an ideal basis for radiotherapy planning because the bodycontour, tumour target and adjacent normal tissues are accurately visualized. Using this format, dose distribution plans can be computed using an integrated radiotherapy planning system and these techniques make an important contribution to the management of many tumours. With an estimated improvement in cure rate of 4.5% and cost-effective factors of 5.0 (Netherlands) and 3.3 (United Kingdom), CT-assisted radiotherapy planning appears to be a worthwhile procedure.     

The cost effectiveness of Air Force optometry

A study was performed which attempted to assess the relative value of a military optometric practice and to provide epidemiological information on ocular pathologies typical in that practice setting. A mock billing system was employed which assessed fees against patient examinations and procedures using Current Procedural Terminology codes. The fees were determined from a survey of the fee structures of local optometrists. The study showed that the military optometric practice was cost effective in relation to the cost that would be incurred through civilian referral. It also demonstrated that military optometric practice is full in scope and encounters a wide variety of pathological entities above and beyond standard refractive modalities.     

Decision analysis for the cost effectiveness of sestamibi scintimammography in minimizing unnecessary biopsies.

BACKGROUND: The purpose of this study was to assess if breast cancer screening using sestamibi scintimammography (SSMM) in conjunction with mammography (MM) is cost effective in avoiding biopsies in healthy patients. METHODS: Quantitative decision tree sensitivity analysis was used to compare the conventional MM alone strategy (strategy A) with two decision strategies for screening with SSMM; SSMM after an indeterminate mammogram (strategy B) or SSMM after both a positive and an indeterminate mammogram (strategy C). Cost effectiveness was measured by calculating the expected cost per patient and the average life expectancy per patient for baseline values as well as over a range of values for all of the variables of each strategy. RESULTS: Based on Medicare reimbursement values, strategies B and C showed a cost savings of $9 and $20 per patient respectively as compared to strategy A. This translates into respective savings of $189 and $420 million per year assuming 21 million females undergo screening each year. Strategies B and C did however have a loss of mean life expectancy of 0.000178 and 0.000222 years respectively as compared to strategy A due to interval progression of breast cancer in a small number of women. Strategies B and C significantly lowered the number of biopsies performed on healthy patients in the screening population by 750,063 and 1,557,915 biopsies respectively as compared to strategy A. CONCLUSIONS: These results quantitatively verify the potential utility of using SSMM in avoiding unnecessary biopsies.     

Improving performance by multiple interpretations of chest radiographs: effectiveness and cost.

The accuracy and cost of four methods of duplicate reading were evaluated. Eight radiologists interpreted 100 random chest radiographs. Using a third independent interpretation to resolve disagreements between pairs of readers ("Pseudoarbitration") was the most effective method overall, reducing errors 37%, increasing correct interpretations 18%, and adding 19% to the cost of an error-free interpretation. Resolving disagreements in facor of positive diagnoses was the best method for reducing omissions, but it almost doubled false-positive diagnoses. The choice between single and multiple interpretations must be evaluated in each clinical setting and should consider expected improvements in accuracy, implications for patient care, and additional costs.     

International dosimetry: an evaluation of treatment planning in clinical trials.

A tissue-equivalent phantom containing thermoluminescent dosimeters was mailed in succession to Mount Vernon Hospital, Northwood, Middlesex, England, to Groote Schuur Hospital, Capetown, South Africa, and to Winnipeg General Hospital, Winnipeg, Canada, to determine the accuracy and consistency in treatment for carcinoma of the cervix under hyperbaric oxygen conditions. (Protocol of the Medical Research Council's Working Party on Radiotherapy and Hyperbaric Oxygen.) The data were analysed by the Radiological Physics Center, Houston, Texas, and substantiate uniformity at and between the participating institutions.     

Outpatient arteriography: its safety and cost effectiveness

An 11-year experience with 2,029 outpatient arteriograms in a 500-bed community hospital with active vascular and cardiovascular services is reported. During this period 3,864 inpatient arteriograms were also obtained. The major complication rate has been lower for the outpatient procedures than for the inpatient procedures, and no malpractice claims have been made as a result of outpatient arteriography. There were considerable cost savings with the outpatient arteriography. Since conventional arteriography can be done safely and economically on an outpatient basis, and provides images of superior quality, it is considered highly competitive with digital subtraction angiography.     

Radiology 1984. A conflict of high technology and high cost

Radiology is confronted now by exciting but challenging times. The excitement derives from dramatic technological advance; the challenge from the economic constraints on health care delivery. The large and growing expense of providing health care is readily apparent and high technology medicine can too easily be blamed for the growth. The pressures for improved service at no extra cost will demand much of the negotiating skills of our specialty and our ability to survive administrative confusion and fragmentation. Equally, manpower planning is a feature of modern medicine. Often this is done from inadequate data and as a specialty we must continue to think constructively about our own future in this context, not least in recognizing the contribution of women to our specialty. Forces also to be recognized are decentralization, electronic information transfer, concerns about radiation exposure and litigation. Not least we need to be better able to define our specialty as its scope is now changing rapidly. For the future I hope that we can be part of the development of the controls which we must inevitably face; we should lead in instituting cost-accounting in our departments; we must be at the leading edge of technological change in both imaging and data transfer, and we must be both more business-like as well as act effectively as the patient's advocate. Radiology has an important and growing responsibility in patient care and most of the technological advances both improve that care and can be justified economically. I am proud to be a radiologist in 1984.     

Clinical evaluation of twin screen-film chest radiography: cost effective lung and mediastinal imaging

Objective: A new twin screen-film cassette system optimised for conventional chest radiography was evaluated by four thoracic radiologists. Materials and Methods: The twin screen-film cassette system produces two film images, the front film optimised for the mediastinal region of the chest, the rear for the lung region. Image degradation on either screen-film system due to internal photon scatter has been virtually eliminated due to the use of a dividing filter. Fifty patients were included in a trial that resulted in a set of chest images for each patient, taken on the same inspiration, by both the twin screen-film cassette and the conventional system. The resultant fifty sets of images were evaluated by four chest radiologists who scored 12 radiographic features of the chest and patient pathologies present, using a paired difference technique. Results: The image quality of the twin screen-film cassette system was judged to be significantly superior to the conventional screen-film system in nine of the 12 radiographic features scored (P<0.003). In the three other regions and for the patient pathologies, no significant conclusions were drawn. Conclusion: The new twin screen-film system showed improved visualisation of radiographic features, particularly in the mediastinal and retrocardiac lung regions. This new system shows promise in both standard and portable clinical applications.     

Pathologic conditions in pregnancy. Preliminary evaluation of the effectiveness of magnetic resonance

Some authors suggested that MR imaging could represent an effective diagnostic alternative in the study of pathologic conditions of mother and fetus during pregnancy. To verify the actual role of MR imaging, we examined 20 patients in the 2nd and 3rd trimester of gestation, after a preliminary US examination. Fifteen patients presented fetal or placental pathologies; in 4 patients the onset of the pathologic condition occurred during pregnancy; in 1 case of US diagnosis of fetal ascites, MR findings were normal and the newborn was healthy. As for placental pathologies, our series included a case of placental cyst, two hematomas between placenta and uterine wall, and two cases of partial placenta previa. As for fetal malformations, we evaluated a case of omphalocele, one of Prune-Belly syndrome, a case of femoral asymmetry, one of thanatophoric dwarfism, a case of thoracopagus twins with cardiovascular abnormalities, two fetal hydrocephali, and three cases of pyelo-ureteral stenosis. As for maternal pathologies during pregnancy, we observed a case of subserous uterine fibromyoma, one of right hydronephrosis, one of protrusion of lumbar intervertebral disk, and a large ovarian cyst. In our experience, MR imaging exhibited high sensitivity and a large field of view, which were both useful in the investigation of the different conditions occurring during pregnancy. In the evaluation of fetal and placental abnormalities, especially during the 3rd trimester, the diagnostic yield of MR imaging suggested it as a complementary technique to US for the evaluation of fetal malformations and of intrauterine growth retardation.     

Usefulness and cost effectiveness of cardiovascular screening of young adolescents

OBJECTIVES: This study was conducted to assess the usefulness of a screening system for cardiovascular disease in Kagoshima, Japan, and to compare its cost-effectiveness with that of a similar system reported in the United States. BACKGROUND: Preparticipation screening of young athletes has been implemented in many countries to prevent sudden death, but sudden death in young nonathletes remains a problem. In Japan, both athletes and nonathletes have been screened for the presence or absence of cardiovascular diseases for more than 20 yr. METHODS: From 1989 to 1997, all seventh graders in schools in Kagoshima, Japan, were screened for cardiovascular disease using a questionnaire and electrocardiogram before physical examination. They were screened again in the same way 3 yr later. One subject newly diagnosed with cardiovascular disease and recommended to limit athletic participation was defined as "high-risk." Situations leading to cases of sudden death were verified with a report from the school in question. RESULTS: Of the initial study population, 99% participated in the program every year. A total of 37,807 subjects, including nine high-risk subjects, were evaluated consecutively for 6 yr. Of these nine subjects, six, including three patients with hypertrophic cardiomyopathy, were nonathletes. Three sudden deaths occurred during the study period; one student was from the high-risk group. The cost of this screening system was lower than that reported in the United States. CONCLUSIONS: Population-based screening for heart disease in this age range is limited by various factors. To analyze the mechanisms of sudden death in adolescents, we, therefore, are in need of a nationwide registry that includes autopsies for all deadly events.