Metabolic syndrome in patients with gastrointestinal diseases

AIM: To study gastrointestinal pathology in patients with metabolic syndrome (MS). MATERIAL AND METHODS: The examination of 536 patients with MS and gastrointestinal diseases included clinical tests, biochemical hepatic tests, determination of blood lipid spectrum, x-ray of the esophagus, stomach, duodenum, colon, esophagogastroduodenoscopy, ultrasonic investigation of the liver, gall bladder and pancreas. 56 patients have undergone puncture biopsy of the liver. RESULTS: Esophageal, hepatic and biliary, pancreatic, colon diseases were detected in 72, 64, 18 and 74%, respectively. Clinical manifestations of these associated diseases had no definite symptoms and were characterized by cross-over syndromes. CONCLUSION: MS patients with gastrointestinal diseases showed polymorbidity. Treatment of the above diseases should be supplemented with drug correction of MS.     

Actual diet of patients with gastrointestinal diseases

The study of actual nutrition of patients with erosive-ulcerative lesions in the gastroduodenal zone and of patients with operated ulcer has revealed defects in intake of essential nutrients by these patients: overeating of animal fat and refined carbohydrates, deficiency of oil, vitamins A, B2, C, D and food fibers.     

Whole body elemental composition in patients with essential hypertension

Abstract. The whole body content of sodium, chlorine and potassium has been measured in 30 patients with essential hypertension, using the techniques of in vivo neutron activation analysis and whole body counting. Total exchangeable sodium and potassium were also measured, and found to be well correlated with the total body amounts of these elements. Comparable measurements on normotensive subjects could not be obtained, but results for both elements were similar to those expected on the basis of published values for healthy normal body composition. Similarly, no abnormality was found in the average body content of the other major elements (chlorine, calcium, phosphorus and nitrogen). We therefore have no evidence that essential hypertension is associated with any abnormality in the mean body content of these elements. However, there was some evidence of a relationship between body sodium and blood pressure in this study group.     

Clinical features of gastrointestinal diseases in patients with primary mitral prolapse

Whether patients with mitral prolapse (MP) have specific features in the course of their gastrointestinal diseases (GD) was studied in 420 MP patients with various GD. Echocardiography and examination of the vegetative status were conducted in all the patients. On demand, esophagogastroduodenoscopy, ultrasonic investigation of the abdominal organs, multistage fraction duodenal intubation were made. The findings evidence of more severe course of GD in MP patients. This manifests in early onset, severe pain and dispeptic syndromes, marked mucosal inflammation and is explained by dysfunction of the vegetative nervous system and generalized dysplasia of the connective tissue.     

改善重症神经系统疾病患者胃肠动力不全的临床研究

目的 探讨改善重症神经系统疾病患者胃肠动力不全的有效方法.方法 选择需经鼻胃管途径予肠内营养的胃肠动力不全患者,将患者随机分为营养液输注减速组与药物组[甲氧氯普胺（胃复安）肌注].比较两组72 h内改善胃肠动力不全的疗效、血生化指标、并发症和预后情况.两组治疗无效的患者,床边放置螺旋形鼻肠管,记录放置的成功率.结果 共80例患者入组,减速组与药物组各40例,药物组治疗期间平均每日摄入营养液总量、总热量和平均每日摄入总热量达到目标值的例数均明显高于减速组（P＜O.05）.药物组治疗有效率（36/40,90.0％）高于减速组（33/40,82.5％）,平均治疗起效时间亦短于减速组,但两组间比较无统计学差异.两组治疗无效的11例患者,9例（81.8％）成功放置螺旋形鼻肠管.减速组腹胀的发生率高于药物组（P＜0.05）.两组患者人组1个月后血红蛋白、白蛋白、胆固醇、甘油三酯和体重变化以及患者住监护室时间和入组后1个月时预后均无统计学差异.结论 营养液输注减速与胃复安药物均能改善患者胃肠动力不全的症状,后者疗效优于前者,如果上述两种方法无效可采用放置鼻肠管予肠内营养.     

Homeostasis and its correction in burn patients with gastrointestinal erosive-ulcerative diseases

Acute erosive ulcerative hemorrhage (EUH) is one of the most grave complications of burn disease, caused by impaired blood rheology, clotting, and protein status. Twenty-three patients with burns of 12-70% body surface were examined, 17-25% of burns being deep. The most pronounced changes in blood rheology and clotting with formation of erythrocyte aggregations, fibrin precipitation and imbalance of visceral proteins were observed during the shock stage (days 1-3), particularly pronounced in patients with acute EUH. Development of septicotoxemia favored secondary increase in blood clotting and rheological parameters, which led to thrombotic complications. The data helped improve the complex of infusion-transfusion therapy for preventing and treating ulcerative and erosive lesions.