Evaluación del tratamiento del vértigo posicional paroxístico benigno mediante el cuestionario DHI-S

Benign paroxysmal positional vertigo (BPPV) is a recurrent chronic disease and its handicap is usually understimated. The aim of this study is to determine the impact of the treatment by Epley maneuver on short-term BPPV- related quality of life. Forty-two individuals with BPPV were included: 39 with posterior canal afected, 2 with the lateral canal and one with the anterior canal. Diagnosis was established if a consistent clinical history was found and Dix-Hallpike test (DHT) in cases with canal posterior involvement. Subjects with positive DHT were treated by a single Epley maneuver and were recommended to avoid supine for the next 48 hours. The BPPV relapses were investigated at 7th and 30th day post-treatment. BPPV-associated quality of life was evaluated by the Dizzness Handicap Inventory Short-form (DHI-S) at days 1st and 30th post-treatment. Total and partial scores for emotional, physical and functional subscales were compared by Wilcoxon test for paired samples. Dix-Hallpike test was found positive in el 59% individuals (23/39), and 41% cases did not required any treatment. Among 23 patients treated with Epley maneuver, DHT was found negative in 90% at 30th day follow-up. Mean and standard deviation of the total scores obtained in the DHI-S at the first day were 19.22 ± 9.66 in the DHT positive- patients and 19.79 ± 10.14 in the whole group (DHT positive or negative). These scores significantly decreased to 10.84 ± 10.99 at 30 days post-treatment (p= 0.002 and p=0.001, respectively). In conclusion, the DHI-S is a specific health questionnaire able to assess BPPV –related health and the effectiveness of treatment.     

后半规管良性阵发性位置性眩晕患者复位中眼震分析

目的 分析后半规管良性阵发性位置性眩晕(posterior semicircular canal benign paroxysmal positional vertigo,PC-BPPV)患者复位中的眼震,探讨BPPV可能的发病机制.方法 2007年12月至2008年4月眩晕门诊就诊的66例PC-BPPV患者,详细记录病史、体位试验及复位中不同位置眼震的情况,对PC-BPPV患者可能发病机制进行探讨.结果 变位试验完伞符合贵阳会议诊断标准的66例PC-BPPV患者,采用改良Epley复位,视频眼震记录技术记录复位中四个位置的眼震方向及强度,24例患者复位中出现的眼震均为垂直扭转向上眼震;21例除第一个位置出现上向扭转眼震,其余三个位置眼震阴性;7例变位试验初诊PC-BPPV的患者在第二次复位中出现强烈水平眼震;14例患者复位的第二或第三个位置出现下向垂直眼震.由复位中不同位置出现的眼震分析,66例确诊为PC-BPPV的患者,52例复位中的表现符合管石及嵴顶耳石症理论,占78.8%.结论 除了目前公认的管石症及嵴顶耳石症理论外,推测部分PC-BPPV可能与耳石器官及球囊椭圆囊神经病变有关.     

阻塞性睡眠呼吸暂停低通气综合征患者健康相关生命质量与多导睡眠监测结果相关性

目的 评估阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者健康相关生命质量（HRQoL）,并研究其与多导睡眠监测（PSG）结果、过度白天嗜睡的相关性,寻找影响OSAHS患者HRQoL的因素。方法 对64例OSAHS患者和50例正常对照使用健康结局问卷（SF-36）和Epworth嗜睡问卷（ESS）评估并比较其HRQoL。研究OSAHS患者SF-36评分与PSG监测结果、ESS评分和生理指标之间的相关性,分析造成其HRQoL变化的因素。结果 OSAHS患者与正常对照相比, SF-36中4个维度及总分显著下降,整体处于白天过度嗜睡状态;OSAHS患者ESS评分与 SF-36中6个维度及总分呈显著负相关;SF-36总分、ESS评分与觉醒指数呈显著负相关;SF-36总分与血氧低于90％占睡眠比例（SaO2　90％）呈显著负相关;ESS是OSAHS患者HRQoL的独立预测因素,能解释SF-36总分变异的26.9％。结论 OSAHS患者健康相关生命质量有明显的损害。过度白天嗜睡、夜间严重持续的低氧血症和睡眠结构的破坏可能是引起HRQoL损害的主要原因。     

不同变位试验在良性阵发性位置性眩晕的诊断价值

目的：探讨不同变位试验在诊断良性阵发性位置性眩晕（BPPV）中的价值。方法：对我科2000年2月～2004年4月诊断的后半规管（PC）源性良性眩晕72例,采用交叉设计,随机将其中36例先行Dix-Hallpike试验,再行侧卧试验;男36例试验排序与其相反。此后再行仰卧侧头位试验。结果：Dix-Hallpike试验和侧卧试验在诊断PC—BPPV中所得结果具有关联性（P〈0．01）,诊断阳性率差异无统计学意义（P〉0．05）;两者裸眼观察到眼震的典型阳性反应分别为77．9％及77．1％,差异亦无统计学意义（P〉0．05）。2种试验诱发眩晕和（或）眼震具有的潜伏期、持续期及性质、方向等特征无差异。1例患者同时仰卧侧头位试验阳性,诊断同时存在PC—BPPV。结论：在诊断PC—BPPV中,侧卧试验与Dix-Hallpike具有相同的客观诊断价值。在活动受限的情形下,侧卧试验更易于操作及更具安全性,可完全取代Dix-Hallpike试验。在前2种试验出现水平眼震时应同时行仰卧头位试验,以确定是否同时伴有或为水平半规管源性病变。     

Position in bed is associated with left or right location in benign paroxysmal positional vertigo of the posterior semicircular canal

PURPOSE: To determine if position during bedrest is related to the canal affected in posterior canal benign paroxysmal positional vertigo (BPPV). MATERIALS AND METHODS: Fifty-five individuals with posterior canal BPPV were investigated. Diagnosis was established if a consistent clinical history was found with vertigo and induced positional nystagmus elicited on the Dix-Hallpike test (DHT). Preference for left or right position during bed rest was determined before performing the DHT. All patients were treated by a single particle repositioning procedure, and relapses were investigated at the seventh and 30 days posttreatment. RESULTS: Forty-five individuals always slept on the same side (29 on the right, 16 on the left side), and 10 patients preferred to change sides during bed rest. Among those patients able to maintain a constant position during bed rest, 27 and 18 presented a positive DHT on the right and left sides, respectively. The canal affected was found to be significantly associated with side during bed rest (relative risk = 2.75; P = 0.01, Fisher exact test). DHT was negative in 86% of patients at 30 days. No differences were found between individuals who presented a constant position in bed and those who changed positions. CONCLUSIONS: Lateral supine position during bed rest is associated with the canal affected in BPPV. We speculate that gravity might facilitate the deposition of particulate material on the posterior semicircular near the ampulla canal during bed rest.     

良性阵发性位置性眩晕治疗前后生活质量研究

目的:探讨管石复位法(CRP)治疗前后良性阵发性位置性眩晕(BPPV)患者健康相关生活质量(QOL)的变化。方法:采用中文版SF-36健康调查量表(SF-36)和汉化英文版眩晕障碍量表(DHI),分别对86例施行CRP的BPPV患者(治疗组)和120名健康体检者(对照组)进行QOL的调查与评估,并将2组的结果进行对比。结果:通过SF-36和DHI评估显示,BPPV患者治疗前SF-36的维度计分均低于对照组,DHI各条目计分均高于对照组,差异均有统计学意义(均P<0.05)。BPPV患者治疗后3个月SF-36和DHI量表得分与对照组差异均无统计学意义(均P>0.05)。结论:CRP可明显改善BPPV患者的QOL;SF-36和汉化DHI量表能有效评估BPPV患者的QOL。     

Effectiveness of the particle repositioning maneuver in subtypes of benign paroxysmal positional vertigo

OBJECTIVES: To assess the efficacy of the particle repositioning maneuver (PRM) in patients presenting with idiopathic benign paroxysmal positional vertigo (BPPV) compared with those with evidence of additional peripheral vestibulopathies. METHODS: Retrospective administration of the Dizziness Handicap Inventory (DHI) to 41 patients with primary BPPV and 31 patients with secondary BPPV to subjectively evaluate their symptoms before and after the PRM. RESULTS: Both groups indicated a marked improvement in symptoms after the PRM. Only two patients reported an increase in their symptoms after the PRM and both had secondary BPPV. CONCLUSIONS: The PRM was found to be highly effective in all forms of BPPV, but careful history and judicious testing may identify patients requiring additional intervention to relieve their symptoms.     

Efficacy of particle repositioning maneuver in BPPV: a prospective study

PURPOSE: A single blinded prospective randomized controlled trial was conducted in 40 patients with benign paroxysmal positional vertigo (BPPV) to determine the efficacy of particle repositioning maneuver (PRM). MATERIALS AND METHODS: Out of 40 patients, 20 underwent PRM with the rest receiving a placebo treatment. Postprocedural instructions were given to all the patients who underwent PRM. Follow-up was for 1 year at regular intervals. Analysis was based on the symptomatic status and the Hallpike maneuver at each visit. RESULTS: After the initial week, 95% showed complete resolution of symptoms with none reporting a recurrence after PRM. On the contrary, only 15% of the controls had complete resolution with 14 out of 20 reporting a recurrence of BPPV. Results remained more or less the same at the end of 4 weeks. Six months after PRM, 19 of 20 patients had no vertigo with a meager 5% showing recurrence versus 75% of controls reporting a recurrence with only 3 of 20 reporting a favorable symptom status. At the end of 1 year, 18 of 20 patients had complete relief from symptoms with only 10% showing Hallpike maneuver positive in the study group compared with 3 of 20 reporting a relief from symptoms with 90% turning out to be Hallpike maneuver positive in the control group. CONCLUSIONS: This study establishes the efficacy of PRM in short- and long-term management of BPPV; the procedure is easy and simple.     

Treatment outcomes of benign paroxysmal positional vertigo.

OBJECTIVE: The purpose of this study was to examine the efficacy of the particle repositioning manoeuvre (PRM) in the treatment of benign paroxysmal positional vertigo (BPPV). DESIGN: A randomized prospective study of patients with BPPV. METHODS: Seventy-one patients were randomized to one of three groups at their first clinic visit. These groups included the PRM, a sham PRM, and a control group. Patients were followed up in clinic at 2 weeks and 3 months. The mean long-term follow-up was 12 months. A telephone questionnaire was also conducted. RESULTS: At 2-week follow-up, 81.8% of patients in the PRM group had a resolution of symptoms and a negative Dix-Hallpike test compared with 15.3% in the sham PRM group and 60% in the control group. This difference was statistically significant between the treatment (PRM) and sham PRM groups and between the sham and control groups. It nearly reached significance between the treatment and control groups (p = .06). The sham treatment group had by far the worst outcome at the 2-week interval. There was no statistically significant difference between the groups after 2 weeks. CONCLUSION: The PRM is side specific. It may help induce remission of the vertiginous symptoms of BPPV in the short term. This cannot be attributable to a placebo effect. The PRM does not seem to affect the natural history of the disorder in the long term. The sham treatment causes a delay in spontaneous recovery, possibly by preventing the particles from falling into the utricle. This study has not compared the frequency or severity of symptoms.     

Quality of life in elderly patients with dizziness: analysis of the Short-Form Health Survey in 197 patients

CONCLUSION: Elderly patients with chronic dizziness had a poor HRQoL, which could be successfully assessed using the SF-36, a generic health-status instrument. The frequency of dizziness and comorbid psychological distress were predictive of impairment in QoL. OBJECTIVES: To evaluate health-related quality of life (HRQoL) and its relationship to characteristics of dizziness in elderly persons with chronic dizziness. MATERIAL AND METHODS: A standardized dizziness questionnaire was used to evaluate characteristics of dizziness as well as medical, functional and demographic data in 197 consecutive patients with chronic dizziness aged > or =60 years. HRQoL was evaluated using the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) and the Hospital Anxiety and Depression Scale (HADS). RESULTS: Compared with normative data, results from patients with dizziness indicated a pervasive multidimensional decline in SF-36 scores. This decline was most notable in terms of role limitations in the physical and emotional dimensions. The frequency of attacks of dizziness correlated with perceived disability. Patients with chronic dizziness also had great psychological distress, as measured by the HADS score, which had a detrimental influence on their QoL.     

颗粒复位法治疗后半规管良性阵发位置性眩晕

目的 评价颗粒复位法治疗良性阵发性位置性眩晕的效果。方法 对１９９６年７月－１９９８年６月间治疗的３１一半规管性良性性位置性眩晕患者进行回顾分析。地规管耳右症假说,患者接受１次颗粒复位法治疗。治疗结束２周后复查并评价疗效。结果 ２１例患者的眩晕和眼一立刻或在１－２周内逐渐消失。６例改善,４例无效。总有效率８７．１％。结论 颗粒复位法对大多数良性阵发性位置性眩晕患者有效,推荐作为治疗该的首选方法。     

鼻咽癌放疗致位置性眩晕(附3例报告)

目的：探讨电离辐射对内耳前庭的影响。方法：报道鼻咽癌（ＮＰＣ）放疗致发作性位置性眩晕（ＢＰＰＶ）伴听力减退患者３例。采用耳石微粒复位法（ＰＲＭ）治疗ＢＰＰＶ,针对听力减退给予丹参治疗。结果：３例ＢＰＰＶ,２例痊愈,１例显效,听力下降的４耳语音频率平均提高１０ｄＢ。结论：ＢＰＰＶ可能与辐射所致的前庭损害有关,ＰＲＭ是治疗ＢＰＰＶ是一种有效方法。     

Monitoring of caloric response and outcome in patients with benign paroxysmal positional vertigo.

OBJECTIVE: To analyze the time course of caloric response in patients with Benign Paroxysmal Positional Vertigo (BPPV). PATIENTS: Seventy-four individuals with diagnosis of BPPV during Dix-Hallpike (DH) test. STUDY DESIGN: A prospective, longitudinal study. SETTING: A tertiary referral center. INTERVENTION: Patients were treated by particle repositioning maneuvers according to the affected canal, and the effectiveness was evaluated at 180 and 360 days. Bithermal caloric response was obtained by using 44 and 30 degrees C water irrigations at diagnosis, 6 months, and 1 year after. MAIN OUTCOME MEASURE: Canal paresis (CP) and response to DH after treatment. RESULTS: The effectiveness of the treatment for BPPV (absence of vertigo and positional nystagmus during DH) was 65.2% (45 of 69) after 1 year of follow-up. Twenty-five percent of (16 of 64) individuals with BPPV presented CP at diagnosis, 27% (12 of 44) at 6 months, and 16% (9 of 56) 1 year after. One year after, seven individuals with CP showed a normal caloric response, another seven demonstrated persistent CP, and one case developed a bilateral CP. The effectiveness of particle repositioning maneuvers was not significantly different between subjects with or without CP after 1 year of follow-up (odds ratio, 1.31 [95% confidence intervals, 0.35-4.89], p = 0.88). CONCLUSION: Canal paresis is not associated with a lower outcome to repositioning.     

Anterior semicircular canal benign paroxysmal positional vertigo and positional downbeating nystagmus

PURPOSE: The aim of this study was to describe the clinical features and video-oculographic findings in patients with anterior semicircular canal benign paroxysmal positional vertigo (BPPV). MATERIALS AND METHODS: STUDY DESIGN: This is a prospective case series. SETTING: The study was set at an outpatient clinic in a general hospital. PATIENTS: Fourteen individuals with symptoms of BPPV and positional downbeating nystagmus (pDBN) were included in the study. The diagnosis was based on a history of brief episodes of vertigo and the presence of pDBN confirmed in the video-oculographic examination during Dix-Hallpike test (DH) or head-hanging maneuver. INTERVENTION: Patients were treated by particle repositioning maneuver and the effectiveness was evaluated at 7, 30, and 180 days posttreatment. The treatment was repeated up to 4 times if pDBN was persistent. MAIN OUTCOME MEASURES: The main outcome measure is the number of patients without pDBN at 30 and 180 days. RESULTS: Video-oculography showed a predominant pDBN in response to DH. Of the 14 patients, 7 had arterial hypertension, and 5 of 14 cases presented abnormalities on the caloric test. Horizontal spontaneous nystagmus was found in 3 of 14 individuals. Positional nystagmus at different positional test was observed in 5 of 14 individuals, suggesting the involvement of several canals. Of the 14 patients, 10 (71%) did not present vertigo, and the positional tests were negative at 30 days. However, 3 cases presented a positive DH with persistence of BPPV episodes and pDBN at 30 days, and another developed a contralateral posterior canal affectation. One of the patients maintained a persistent pDBN at 180 days despite the repeated maneuvers. CONCLUSIONS: Video-oculography demonstrates that anterior canal BPPV is characterized by a predominant downbeating nystagmus in response to DH. These individuals may show alterations in the vestibular caloric, and they can have multicanal affectation.     

Particle repositioning manoeuvre in benign paroxysmal positional vertigo: is it really safe?

OBJECTIVE: A prospective study to determine the safety of the particle repositioning manoeuvre (PRM) by analyzing the various complications of the procedure. SETTINGS: Outpatient Department of Otorhinolaryngology, Nehru Hospital, Chandigarh, India. METHODS: Thirty patients with the classic findings of benign paroxysmal positional vertigo (BPPV) were included in the study. Clinical symptoms prior to the procedure were noted. Twenty-nine of them were subjected to PRM, and postprocedural instructions were given to all patients. Various side effects during and following the procedure were recorded. They were classified into early and late based on the period and into major and minor based on severity. All patients were reviewed after 3 days, 7 days, and 1 month. RESULTS: Of the 29 patients, 19 patients (65.52%) had heaviness in the head, with 11 each (37.93%) reporting nausea and imbalance and 9 (31.03%) reporting instability during the procedure. A major complication, asystole, was noted in one patient. The percentage of side effects remained more or less the same in the early phase following the procedure. Only 5 of 29 patients were entirely asymptomatic. Ninety percent were relieved of symptoms by the end of 7 days, with no major complication recorded. CONCLUSIONS: PRM is an easy, effective, and relatively safe procedure. The risk of major complications with PRM, such as arrhythmias and asystole, highlights the need to consider other management modalities for BPPV in certain medically unfit patients.     

Quality of life in elderly patients with dizziness: analysis of the short-form health survey in 197 patients

Conclusion Elderly patients with chronic dizziness had a poor HRQoL, which could be successfully assessed using the SF-36, a generic health-status instrument. The frequency of dizziness and comorbid psychological distress were predictive of impairment in QoL.

Objectives To evaluate health-related quality of life (HRQoL) and its relationship to characteristics of dizziness in elderly persons with chronic dizziness.

Material and methods A standardized dizziness questionnaire was used to evaluate characteristics of dizziness as well as medical, functional and demographic data in 197 consecutive patients with chronic dizziness aged≥60 years. HRQoL was evaluated using the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) and the Hospital Anxiety and Depression Scale (HADS).

Results Compared with normative data, results from patients with dizziness indicated a pervasive multidimensional decline in SF-36 scores. This decline was most notable in terms of role limitations in the physical and emotional dimensions. The frequency of attacks of dizziness correlated with perceived disability. Patients with chronic dizziness also had great psychological distress, as measured by the HADS score, which had a detrimental influence on their QoL.     

前庭性眩晕疾病患者焦虑和抑郁状况研究

目的 研究临床上常见的四种前庭性眩晕患者的焦虑/抑郁状况及其眩晕残障程度等相关因素并进行分析,为临床诊治四种前庭性眩晕提供依据。 方法 搜集确诊为前庭性眩晕的患者,分别为良性阵发性位置性眩晕(BPPV)、前庭性偏头痛(VM)、梅尼埃病(MD)及前庭神经炎(VN)四种疾病,记录患者的病程、持续时间等一般资料,完善耳科学检查并进行医院焦虑抑郁量表(HAD)、眩晕残障量表(DHI)测定。 结果 纳入前庭性眩晕患者121例,其中BPPV47例,VM31例,MD29例,VN14例,四组患者焦虑/抑郁阳性率分别为BPPV 31.9%、VM 71.0%、MD 75.9%、VN 42.9%;轻度、中度及重度眩晕残障程度分别为BPPV 58.9%、19.8%、21.3%,VM 19.4%、25.8%、54.8%,MD 6.9%、24.1%、69.0%,VN 38.6%、21.4%、40.0%。焦虑与抑郁评分之间线性相关(r=0.570,P<0.05);DHI与HAD评分之间线性相关(r=0.804;P<0.05)。 结论 前庭性眩晕患者存在不同程度的焦虑/抑郁,且焦虑和抑郁有一定的相关性;VM和MD患者焦虑/抑郁的发生率较高;VM、MD及VN患者眩晕残障程度高于BPPV患者。因此在临床上诊治前庭性眩晕疾病的时候要重视患者的焦虑/抑郁状态,特别是VM、MD患者,以便更好的治疗前庭性眩晕。     

Health-related quality of life outcomes following adult cochlear implantation: A prospective cohort study

Introduction: The benefits of cochlear implantation extend beyond improved speech recognition and into overall health-related quality of life (HRQoL). Several measures of HRQoL, categorized as generic or disease specific, have been used in the cochlear implant literature. The clinical utility of generic HRQoL measures have been reported to be variable by previous investigators. The degree to which HRQoL correlates to speech perception is largely unknown.

Methods: A prospective single-subject design at a large tertiary care center. Self-reported HRQoL was measured at the preoperative and 12-month post-activation test intervals. The measures of HRQoL included a generic form, (Medical Outcome Study Short Form; SF-36), and disease specific form (Nijmegen Cochlear Implant Questionnaire; NCIQ). Speech recognition was measured at the preoperative, 6- and 12-months post-activation test intervals using the Consonant-Nucleus-Consonant (CNC) monosyllabic word test.

Results: A total of 61 patients (mean 67 years; range 30–87 years) were included in the final analysis. Average speech recognition on the CNC word test was 10% pre-operatively, and 66.7% at 12-months post-activation. The HRQoL scores improved significantly for seven of the eight subdomains of the NCIQ, and one of the nine domains of the SF-36.

Conclusion: Cochlear implantation significantly improves HRQoL, regardless of age. Disease specific measures, such as the NCIQ, are better able to demonstrate differences in HRQoL compared to general health surveys.     

神经内科良性阵发性位置性眩晕临床特点分析

目的 分析良性阵发性位置性眩晕(BPPV)患者发病的季节特点及人群分布特点、受累半规管特点、起病时间特点等,为其防治提供更多依据和策略.方法 回顾性分析2018年1-12月湘潭市中心医院神经内科确诊BPPV患者671例,其中住院202例,门诊469例,总结患者的发病的季节、人群分布特点、受累半规管特点及起病时间特点.结...     

Vestibular evoked myogenic potentials in benign paroxysmal positional vertigo and Meniere’s disease

The objective was to investigate vestibular evoked myogenic potentials (VEMP) in benign paroxysmal positional vertigo (BPPV) and Meniere’s disease, and to determine if this type of testing is valuable for assessing the vestibular system. A prospective controlled clinical study was designed in a tertiary referral center setting. The 62 participants included 17 healthy controls and 45 other subjects selected from patients who presented with the complaint of vertigo (25 diagnosed with BPPV and 20 diagnosed with Meniere’s disease). The main outcome measures of VEMP were recorded in all subjects and findings in each patient group were compared with control findings. The VEMP for the 30 affected ears in the 25 BPPV patients revealed prolonged latencies in eight ears and decreased amplitude in one ear (nine abnormal ears; 30% of total). The recordings for the 20 affected ears in the Meniere’s disease patients revealed four ears with no response, six ears with prolonged latencies (ten abnormal ears; 50% of total). Only two (5.9%) of the 34 control ears had abnormal VEMP. The rate of VEMP abnormalities in the control ears was significantly lower than the corresponding rates in the affected BPPV ears and the affected Meniere’s ears that were studied (P=0.012 and P<0.001, respectively). The results suggest that testing of VEMP is a promising method for diagnosing and following patients with BPPV paroxysmal positional vertigo and Meniere’s disease. Further investigations with this method in other neurotologic pathologies might also be informative.