男性海洛因依赖者性功能研究

对５６名男性海洛因依赖者进行体检、吸毒史与性生活史调查，其中３０名检测了血清Ｔ、ＦＴ、ＰＲＬ、ＦＳＨ、ＬＨ及血ＳＨＢＧ等浓度水平。以３０名健康男性对照组。结果表明，吸毒前性功能基本正常，吸毒后８３．９％出现性欲低下，性交频率明显低于吸毒前（Ｐ＜０．０１），９４．６％存在阴茎勃起障碍，２１．４％有射精延迟；血清Ｔ、ＦＴ、ＦＴ／Ｔ及ＬＨ浓度明显低于对照组，血清ＰＲＬ浓度则高于对照组。本结果证实了海洛因     

男性海洛因依赖者性功能研究

对５６名男性海洛因依赖者进行体检、吸毒史与性生活史调查，其中３０名检测了血清Ｔ、ＦＴ、ＰＲＬ、ＦＳＨ、ＬＨ及血ＳＨＢＧ等浓度水平。以３０名健康男性为对照组。结果表明，吸毒前性功能基本正常，吸毒后８３．９％出现性欲低下，性交频率明显低于吸毒前（Ｐ＜０．０１），９４．６％存在阴茎勃起障碍，２１．４％有射精延迟；血清Ｔ、ＦＴ、ＦＴ／Ｔ及ＬＨ浓度明显低于对照组；血清ＰＲＬ浓度则高于对照组。本结果证实了海洛因依赖可导致男性下丘脑－垂体－睾丸轴功能紊乱及男性性功能异常，并阐明了两者之间的内在联系。     

海洛因依赖者的心电图及心功能改变

海洛因滥用对各器官系统均有没程度的损害。本文观察了１５５例海洛因依赖者的心电图改变，其中３１例进行了无创性心功能检查，发现心电图异常率高达７６．１３％，其中ＳＴ段改变１０７例，窦性心律不齐５２２列，窦性心动过缓并不齐２０例，心电轴右偏１７例，其它还有窦性心动过速或过缓，不完全性右束支传导阻滞等；     

全麻辅助脱毒快速治疗海洛因依赖者的临床研究

目的观察全麻辅助脱毒快速治疗海洛因依赖者的临床疗效、安全性及患者的依从性。方法40例ASAⅠ~Ⅱ级海洛因依赖者随机分成两组,两组在麻醉前均口服纳曲酮50mg,R组为快速脱毒组,采用东莨菪碱、咪唑安定静脉全麻方法进行快速脱毒;U组为超快速脱毒组,采用静吸复合全麻方法进行超快速脱毒。C组为对照组,取同期常规美沙酮递减法20例进行疗效对照。结果R、U组的脱毒成功率均为100%;在6~8h内控制戒断症状。但U组尿吗啡定性转阴快于R组(P<0.05);R、U、C三组的复吸率相当;R、U两组均未出现较严重的麻醉并发症;患者的依从性(可接受性):R组优于U组(P<0.05)。结论快速脱毒和超快速脱毒均是一种快速、有效和安全的阿片类药物依赖者的脱毒方法。     

精液生精细胞检查的临床意义

本文报告了精液生精细胞检查与疾病的关系。化疗、放疗可引起生精细胞形态异常，精液中以多核精子细胞为主；长期服用雷公藤药物生精停滞于初级精母细胞阶段；长期接触高温、肾功能不全而行血透者生精细胞停滞于初级精母细胞及精子细胞阶段；双侧隐睾及克氏综合征患者精液中无精子及生精细胞；阴囊鞘膜积液患者约20％生精停滞于精子细胞阶段；精索静脉曲张（Ⅱ～Ⅲ°）精液中以精子细胞为主；睾丸及附睾炎症患者精液中除出现次级精母细胞、精子细胞外，以中性粒细胞、淋巴细胞、巨噬单核细胞多见。本研究为精液常规检查增加了新内容，为诊断与治疗不育症及环境遗传因素引起的生精障碍提供了客观指标。     

精液生精细胞检查与男科疾病

目的：探讨精液生精细胞检查与疾病的关系。方法：采用端－姬染色法观察精液生精细胞形态、数量及存在比例。结果：化疗、放疗病人出现生精细胞形态异常；长期服用雷公藤药物生精停滞皇初级精毒细胞阶段，长期接触高温、肾功能不全而行血透者生精细胞停滞于初级精母细胞及精子细胞阶段；双侧隐睾及Ｋｌｉｎｅｆｅｌｔｅｒ综合征病人精液中无精子及生精细胞；阴囊鞘膜积液约２０％的病人生精停清点于精子细胞阶段，精索静脉曲张精液中     

精液中生精细胞染色体的直接制备与初步应用

对３８例正常男性进行精液生精细胞染色体的直接低渗制备和Ｇ显带核型分析，成功率为６８．４％，正常组中总畸变率为３．７１％，不育男性中总畸变率分别为无精症组１５．３％，少精症组６．５％，精索静脉曲张组６．２５％，均较正常人组增加，在流产组中，染色体以数目畸变主。     

海洛因依赖多药滥用患者心理状况调查分析

目的了解海洛因依赖多药滥用患者的心理状况,为正确制定护理措施提供依据。方法采用SCL 90症状自 评量表及自编药物滥用筛查表对61例海洛因依赖多药滥用患者进行调查,评估其心理健康状况,调查多药滥用的 原因及药物获取途径。结果海洛因依赖患者SCL 90总分及各因子分显著高于国内成人常模(P<0.05,P< 0.01),其中海洛因依赖多药滥用患者的分值均显著高于单纯海洛因依赖患者(均P<0.01);多药滥用的原因主要 为替代海洛因使用,促进睡眠或增加欣快感;药物获取途径主要为自行购买(药店或黑市)。结论海洛因依赖多药 滥用患者的心理健康状况较差,应针对性地进行心理支持及宣传教育。     

救治特重度烧伤并海洛因依赖戒断综合征四例

1990～ 2 0 0 0年 ,笔者单位收治特重度烧伤并海洛因戒断综合征患者 4例。其中男 3例 ,女 1例 ,年龄 19～ 30岁 ,平均(2 4 .5± 5 .5 )岁。烧伤面积 73%～ 92 %TBSA ,其中Ⅲ度面积为 10 %～ 5 0 %TBSA。吸毒方式 :3例为烫吸 ,1例为静脉注射。吸毒时间 :最长为 5年 ,最短为半年。 1例戒毒后复吸。临床特点 :患者除有烧伤休克症状外 ,出现哈欠、流泪、流涕、出汗等类似感冒的卡他症状。随后各种戒断症状陆续出现 ,包括打喷嚏、起鸡皮疙瘩、寒颤、厌食、恶心呕吐、腹绞痛、腹泻 ;全身骨和肌肉酸痛及肌肉抽动 ;软弱无力、失眠易醒、心慌、心…     

男性不育症病人的精液分析与性激素检测的探讨

本文测定了４０例正常生育男性和５０例不育男性的精液分析，以及血清ＦＳＨ、ＬＨ、ＰＲＬ的浓度，按照精子密度分为正常组、少精症组和无精症组。我们观察到正常组、少精症组、无精症组之间的精液液化时间、ｐＨ、量的差异均无显著性（Ｐ＞０．０５）．而精子的活动率与正常形态精子却有明显的不同，精子的活动率差，其畸形精子的百分率就高，且呈非常显著的关系。少精症组与无精症组中的ＦＳＨ、ＬＨ、ＰＲＬ的浓度明显高于正常组（Ｐ＜０．０５），而无精症组的ＦＳＨ、ＬＨ、ＰＲＬ值又明显高于少精症组（Ｐ＜０．０５）。当ＦＳＨ、ＬＨ明显升高时，精子的活动率、密度的百分率明显下降（Ｐ＜０．０１）。本文结果是无精症组血清ＰＲＬ与正常组有显著性差异（Ｐ＜０．０５），而少精症组则无明显差异（Ｐ＞０．０５）。     

Gonadal function in male heroin and methadone addicts

Gonadal function was elevated in 80 male heroin and/or methadone addicts by measuring basal plasma levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL) and testosterone. In 41 subjects semen analyses were also undertaken. Three groups were distinguished consisting of 15 heroin addicts, 42 undergoing methadone treatment but continuing to take heroin, and 23 taking only methadone. All patients had normal plasma levels of FSH, LH and testosterone. Prolactin levels were normal in all subjects except for the 15 heroin addicts, in whom they were significantly higher than in controls (P less than 0.025). Semen analyses from all of the heroin addicts and from the dual heroin-methadone users were abnormal, whereas only 10 out of 22 (45%) of the methadone takers were pathological. In all cases asthenospermia was one of the abnormalities (100%). Twenty-four per cent also showed teratospermia and hypospermia and 17% showed oligozoospermia. Such seminal pathology, especially of forward motility, even in combination with normal hormone levels, might be an early indication of heroin toxicity to the male reproductive tract.     

Gold in Human Semen

Gold im menschlichen Sperma
Die Bestimmung von Gold im Samen-Plasma mittels Neutronenaktivierung ergab bei 14 Normalproben 2 positive Befunde.
Die Bedeutung einiger Spurenelemente für die Motilität der Spermatozoen wird auch für das Gold diskutiert. Möglicherweise ist das Gold aus den Spermatozoen freigesetzt worden, wie es für Zink beschrieben wurde. In vier Fällen wurde die Bestimmung an Splitejakulaten durchgeführt; auch hier ergab sich kein Nachweis von Gold.     

Presence of Several Elements in Normal and Pathological Human Semen Samples and its Origin

Summary:  Spectroscopic analysis of seventeen normal and pathological semen samples was done to reveal the different elements present in it. The sensitivity of the instrument was 1 μg/g. The observed elements include sodium, potassium, magnesium, calcium, phosphorus, iron, manganese, zinc, copper, boron, silicon, thalium, vanadium, aluminium, mercury and gold. This is the richest source of gold reported in biological materials. An attempt was done to locate the origin of these elements. Thus gold is released from caput epididymis.
Zusammenfassung:  Das Vorhandensein verschiedener Spurenelemente im normalen und pathologischen Spermaplasma und ihre Herkunft
Spektroskopische Analysen von siebzehn normalen und pathologischen Spermaproben wurden vorgenommen, um die darin enthaltenen Spurenelemente nachzuweisen. Die Empfindlichkeit des instrumentes betrug 1 μg/g. Die beobachteten Spurenelemente umfaßten Natrium, Magnesium, Kalzium, Phosphor, Eisen, Mangan, Zink Kupfer, Bor, Silicium, Thallium, Vanadium, Aluminium, Quecksilber und Gold. Es handelt sich um den größten Goldanteil, der in biologischen Materialien nachgewiesen wurde. Es wurde der Versuch unternommen, die Herkunft dieser Spurenelemente zu lokalisieren. Dabei zeigte sich, daß Gold vom Nebenhodenkopf freigesetzt wird.     

Leukophages in Canine Semen

Spermiophages and leukophages were found in teratozoospermic canine semen. Spermiophagy was the role of neutrophilic granulocytes. Leukophages are believed to be oversize macrophages transformed by and released from a chronic inflammatory lesion in the pelvic urethra or the prostate. The term leukophages was adopted to indicate that the cells phagocytize leukocytes, specifically neutrophilic granulocytes. Direct observations on living cells revealed a surprising interaction between these two cell types. It is inferred that neither of the phagocytic cells are related to the disturbed spermiogenesis nor the teratozoospermia.     

Semen quality and sperm functional parameters in fertile Indian men

The reports of a decline in the reproductive health of men worldwide prompted the present study to be undertaken so that baseline semen parameters could be established in Indian men. Semen profile and sperm function parameters were evaluated in 368 Indian men of proven fertility, settled in Delhi. The results of the study were compared with available published information from Indian men. The mean sperm concentration and semen volumes were 68.22 +/- 15.14 x 10(6) ml(-1) and 3.20 +/- 0.94 ml, respectively. Rapid, linear progressive motility and sluggish linear motility were 40.95 +/- 9.15% and 24.95 +/- 7.01%, respectively. A comparison of the results of the present study with earlier published data did not support the contention of a decrease in the semen quality in Indian men.     

男性血液和精液中微量元素含量与精子活力的相关性研究

目的:探讨男性血液和精液中微量元素的分布及其与男性精液参数的相关性。方法:采用BH-5100五通道原子吸收仪、YY-1001血铅仪和伟力彩色精子自动分析仪,对113例男性血液和精液进行钙、镁、铜、锌、铁、铅的测定及精液常规分析,以了解微量元素和精液参数的相互关系。结果:①血液与精液中铅、铜、锌、铁含量显著相关,其中以铜的相关系数最大;钙、镁没有相关性。②血液和精液中铅、铜、锌、钙、镁、铁6种微量元素分布存在显著性差异。③精液中钙与精子活率、直线运动精子活率、曲线速度、平均移动角度、活跃精子密度、直线速度、平均路径速度、侧摆幅度等指标显著正相关;铅与精子活率、直线运动精子活率、活跃精子密度、活动精子密度、直线运动精子密度等指标呈显著负相关;镁元素与精子活率、直线运动精子活率、直线运动精子密度呈显著负相关;精液酸碱度与钙、镁、铁3种元素呈显著负相关。④血液中的锌与精子活率和直线运动精子活率呈显著负相关,镁与精子活率、直线运动精子活率、平均路径速度呈显著负相关,铅与侧摆幅度呈显著正相关。结论:不同体液中的微量元素分布和精子的运动功能存在不同的相关性。     

Semen quality in adult male survivors 5 years after the 2008 Wenchuan earthquake

The influence of the Wenchuan earthquake on semen quality of adult male survivors is unclear. We investigated the semen quality included 673 male survivors from the worse‐affected counties in the earthquake between Aug 2008 and July 2013. Semen parameters including pH, volume, concentration, motility and morphology were measured according to the World Health Organization (WHO) criteria. Kruskal–Wallis analysis of variance was used to examine the statistical differences between years, and a logistic regression was used to analyse the impacts caused by earthquake on the changes of semen quality. We found the medians (5th and 95th) were 2.5 ml (0.6–5.5) for semen volume, 59.0 × 10⁶ ml^?1 [(13.0–133.0)] × 10⁶ ml^?1 for semen concentration, 46% (13–64%) for sperm progressive motility and 3.0% (0–17.5%) for normal morphology for adult male survivors. Semen concentration, the percentage of sperm progressive motility, total motility and sperm normal morphology were all decreased in the first 3 years, and the differences among years 1, 2 and 3 were significant except the percentage of sperm progressive motility (P < 0.05). The casualties and heavy housing damage caused by earthquake had a negative effect on semen quality. The main findings will provide further diagnosis and therapy basis of male fertility by data, for affected populations in the earthquake.     

Semen inflammatory markers and Chlamydia trachomatis infection in male partners of infertile couples

Previous studies have given conflicting results about the effect of generally infection and Chlamydia trachomatis on seminal ILs and semen parameters. The aim of this study was to investigate the relationship between semen quality and the level of seminal interleukins (ILs) in infertile couples with C. trachomatis. Blood, first void urine (FVU) and semen were obtained from 250 infertile men who had failed to conceive after 12 months of trying. Serological analysis for specific IgA, IgM and IgG antibodies to C. trachomatis in serum, the presence of C. trachomatis in FVU and semen sample and semen analysis were carried out. The main results are as follows: (i) elevated IL‐6 and IL‐8 are observed in C. trachomatis‐positive men, but this is not significant and it varies by diagnostic method; and (ii) IL‐6 and IL‐8 levels were correlated with each other and the concentration of leucocytes, but IL‐8 was correlated with semen volume and patient's age. This study showed that men with such an infection in FVU samples (PCR positive) had only lower semen volume compared with men without infection.     

Fructose and Proteins in Human Semen/Fruktose und Proteine des menschlichen Spermaplasmas

Summary: The aim of this study was to correlate human seminal fructose determinations by enzymatic UV method with protein content, using three different methods (Biuret, Lowry, Meulemans).
On one hand, the incidence on fructose levels of partial deproteinization after treatment by perchloric acid was tested: the fructose levels values increased after deproteinization 14.1 ± 3.7 versus 4.2 ± 1.7 mMol/l.
On the other hand, physiologically, semen proteolysis occurs for many hours after collection and concerns mainly low molecular weight proteins. No modifications were found in protid levels and fructose concentrations during the first four hours, at 20° C.
All these data seem to indicate a better linkage of fructose to the highest molecular weight proteins and might explain the absence of fructose rise during the first four hours.
Zusammenfassung: Ziel dieser Studie war, die enzymatisch über U.V. ermittelte Fruktose des menschlichen Spermaplasmas mit dem mittels drei verschiedener Methoden (Biuret, Lowry, Meulemans) bestimmten Proteinspiegel in Korrelation zu bringen. Einerseits wurde die Inzidenz der Deproteinisierung durch Perchlorsäure auf den Fruktose-Spiegel untersucht: dieser erhöht sich nach Deproteinisierung auf 14.1 ± 3.7 gegen 4.2 ±1.7 mMol/l und andererseits die physiologische Proteolyse, die mehrere Stunden nach Kollekte auftritt und die niedermolekularen Proteine betrifft: innerhalb der ersten vier Stunden wurde bei 20° C keinerlei Veränderung des Proteinspiegels oder der Fruktose angetroffen.
Das Ganze scheint letztlich auf eine bessere Bindung der Fruktose an die hochmolekularen Proteine hinzuweisen und könnte das Fehlen einer Fruktose-Erhöhung innerhalb dieser vier Stunden erklären.