不同入路减压内固定术治疗无骨折脱位型颈脊髓损伤患者的疗效及术后并发症情况

目的:探究不同入路减压内固定术治疗无骨折脱位型颈脊髓损伤患者疗效及术后并发症情况。方法:选取2015年1月～2019年5月期间某院接受医治的无骨折脱位型颈脊髓损伤40例,按照随机法分为A组和B组各20例,其中A组行前路减压内固定术,B组行后路减压内固定术治疗,比较两组临床疗效及术后并发症。结果:A组术后下床活动时间以及住院时间均低于B组对应数值(P0.05);两组手术时间、术中出血量比较差异无统计学价值(P0.05)。A组并发症发生率为15.00%,B组并发症发生率为10.00%,组间比较无显著性差异(P0.05)。结论:前路、后路减压内固定术治疗无骨折脱位型颈脊髓损伤疗效相当,但前路术后下床活动间较短,且术后住院天数较少,有利于患者术后康复。     

无骨折脱位型颈脊髓损伤的手术时机与术后近期疗效的关系

目的:分析无骨折脱位型颈脊髓损伤的手术时机与术后近期疗效的关系。方法:选取2016年的1月~2018年的1月在我院接受治疗的无骨折脱位型颈脊髓损伤病患,两组患者均接受手术治疗,但两组实施手术的时机不同,观察两组患者术后恢复情况。结果:治疗A组在接受手术后3周、3个月时的JOA评分均高于治疗B组,组间比较差异明显,P0.05。结论:手术是治疗无骨折颈脊髓损伤的有效手段,而实施手术的时机应当是越早越好,可促进患者术后脊髓功能及早恢复,获得更佳的近期疗效。     

手术时机选取在治疗老年CSCIWOFD患者的意义

目的:分析在不同时机进行手术的无骨折脱位型颈脊髓损伤的老年患者病例的恢复情况,为改善老年无骨折脱位型颈脊髓损伤患者预后提供理论支持。方法:选取2007年6月~2015年6月某院脊柱外科收治的无骨折脱位型颈脊髓患者126例,对患者进行随机分为两组,其中观察组52例,对照组患者74例。观察组进行必要的术前检查后尽早进行手术治疗;对照组患者首先进行康复锻炼治疗和术前检查,待脊髓损伤稳定后进行手术治疗,用NDI评分、JOA评分两种评分系统分析患者预后情况,SF-36量化患者术后生活治疗,观察两组患者预后情况和生活质量的差异。结果:观察组和对照组患者术前一般情况对比没有统计学差异(P0.05);两组患者术后脊髓功能恢复,生活质量水平改善情况对比,观察组明显优于对照组,两者3项指标比较,观察组显著优于对照组(P0.05)。结论:老年患者发生无骨折脱位型颈脊髓损伤时尽早实施手术,对患者的术后脊髓功能康复和生活质量的改善均有所帮助。     

手术治疗无骨折脱位型颈脊髓损伤的临床分析

目的分析探讨无骨折脱位型颈脊髓损伤手术治疗的临床疗效。方法选取2003年4月至2013年4月收治的58例无骨折脱位型颈脊髓损伤患者为研究对象,其中36例为对照组进行保守治疗,22例为观察组进行手术治疗,对两组患者治愈情况、治疗前后及随诊JOA评分、远期并发症情况进行比较。结果两组患者经治疗后,观察组治愈率86.36%(19/22),对照组治愈率47.22%(17/36),观察组远期的JOA评分为(16.89±1.75),显著高于对照组的(9.24±1.22),两组比较差异均具有显著性(P<0.05),具有统计学意义。观察组的并发症发生率显著低于对照组,差异也有统计学意义(P<0.05)。结论手术治疗无骨折脱位型颈脊髓损伤的临床疗效明显优于保守治疗,且尽早进行手术治疗的远期疗效更为显著。     

单开门颈椎管扩大成形术治疗无骨折脱位型颈脊髓损伤疗效观察

目的探讨单开门颈椎管扩大成形术治疗无骨折脱位型颈脊髓损伤的临床疗效。方法回顾性分析34例无骨折脱位型颈脊髓损伤患者的临床资料,其中10例行非手术治疗,24例行单开门颈椎管扩大成形术,比较2组患者在治疗前后ASIA评分及改善率。结果2组在治疗后感觉及运动功能较治疗前有明显提高(P<0.05)。但手术组疗效明显优于非手术组(P<0.01)。手术组病例减压充分,无再“关门”现象。结论手术治疗效果明显优于非手术治疗,单开门颈椎管扩大成形术操作简单、安全、并发症少,维持“开门”效果好。     

无骨折脱位型颈脊髓损伤的手术治疗

目的 探讨无骨折脱位型颈脊髓损伤的手术治疗及效果.方法 对93例无骨折脱位型颈脊髓损伤患者手术治疗(手法方法为后路单开门椎管扩大成形术,前路间盘切除、植骨、肽板内固定或前后路联合手术).结果 手术随访3月～8年,所有病例脊髓功能均有不同程度恢复.JOA评分术前平均4.30分,术后2周平均达8.08分,术后3个月平均10.03分,远期随访(2～8年)达12.3分.结论 无骨折脱位型颈脊髓损伤应早期手术.     

一期前后路联合手术治疗无骨折脱位型颈脊髓损伤疗效分析

目的 探讨一期前后路联合手术治疗无骨折脱位型颈脊髓损伤的临床疗效.方法 选择2008年1月至2011年1月采用一期前后路联合手术治疗的15例无骨折脱位型颈脊髓损伤患者,通过随访比较手术前后的美国脊髓损伤协会(ASIA)残损分级及JOA评分进行疗效评价.结果 随访12～36个月,平均18个月.所有患者脊髓功能均得到不同程度改善,ASIA残损分级提高1～3级,JOA评分由术前平均(5.3±2.5)分上升至末次随访时平均(12.2±3.7)分.结论 一期前后路联合手术治疗无骨折脱位型颈脊髓损伤具有减压充分、固定可靠、脊髓功能恢复好等优点.     

无骨折脱位型颈脊髓损伤25例临床治疗分析

目的：探讨治疗无骨折脱位型颈脊髓损伤的手术方法及临床效果。方法分析25例无骨折脱位型颈脊髓损伤患者的临床资料,根据脊髓损伤情况及MRI表现,采取颈前路或后路手术,并比较手术前后的Frankel分级变化。结果本组患者术中无副损伤,术后恢复良好,无并发症。随访时间3~20个月,按Frankel分级：术前A级2例,1例未恢复,1例恢复到B级;术前 B级6例,恢复到C级4例,2例未恢复;术前C级13例,恢复到D级4例,其余及术前分级为D级的4例患者全部恢复到E级。结论根据脊髓损伤情况及MRI表现,采取颈前路或后路手术治疗无骨折脱位型颈脊髓损伤,可获得满意的临床效果。     

颈椎椎弓根钉固定治疗颈椎管狭窄伴无骨折脱位型颈脊髓损伤的临床观察

目的探讨颈椎椎弓根钉固定治疗颈椎管狭窄伴无骨折脱位型颈脊髓损伤的临床效果。方法回顾性分析96例颈椎管狭窄伴无骨折脱位型颈脊髓损伤患者的临床资料,观察颈椎椎弓根钉固定(观察组)与非手术治疗(对照组)的临床效果。结果观察组患者治疗后JOA评分显著高于对照组(P<0.05);观察组患者治疗优良率显著高于对照组(P<0.05)。结论颈椎椎弓根钉固定治疗颈椎管狭窄伴无骨折脱位型颈脊髓损伤疗效肯定,具有较好的应用前景。     

两种方法治疗无骨折脱位型颈脊髓损伤的疗效对比分析

目的探讨与比较无骨折脱位型颈脊髓损伤中非手术与手术疗法的临床疗效。方法回顾性分析2009—2012年我院收治的56例无骨折脱位型颈脊髓损伤患者的临床资料。按照患者接受的治疗手段分为非手术组27例,手术组29例,对比分析,患者入院时及治疗6、12个月后的JOA(日本骨科学会的颈脊髓功能评定标准)评分结果;治疗7d及28d后,应用美国ASIA脊髓损伤神经学标准评价在运动、感觉方面的得分情况。结果两组患者治疗6、12个月后JOA评分均较前有明显改善(P<0.05),手术组的评分均高于非手术组(P<0.05);治疗28d后患者的运动、感觉评分较前明显提高(P<0.05),但两组间的评分无显著改变(P>0.05)。结论无骨折脱位型颈脊髓损伤手术治疗效果在一定程度上优于非手术治疗。     

Degraded and undegraded carrageenans and experimental gastric and duodenal ulceration

The prevention of histamine-induced gastric and duodenal ulceration in the guinea-pig has been examined using a series of undegraded and degraded carrageenans. Undegraded carrageenans were active at lower doses than degraded carrageenans. The high viscosity of the undegraded carrageenans in solution prevented their use in larger doses. Degradation of carrageenan without serious loss of sulphate, gives a product which allows the dose to be increased to an extent that its effect more than offsets the slight loss in activity caused by the degradation. No single feature of carrageenan structure can be related to anti-ulcer activity although degradation, and hence reduction of molecular size, generally reduces activity. Sulphate contents over 30% have little apparent effect on activity; κ-carrageenans were not consistently different in anti-ulcer activity from Λ-carrageenans. This contrasts with the antipeptic activity of carrageenans where κ-carrageenans are less active than their Λ-counter-parts. As with antipeptic activity, the degree of anti-ulcer activity is probably determined by a combination of structural features which includes molecular size and polyanionic properties.     

Affective and Anxiety Disorders and Alcohol and Drug Dependence:

Depression and anxiety frequently coexist in patients with substance use disorders. This clinically-oriented article examiens the relationship between these conditions and emphasizes data showing that substances of abuse can cause signs and symptoms of both depression and anxiety. These substance-related syndromes appear to have a different course and prognosis than uncomplicated, independent anxiety and major depressive disorders, and clinicians should consider the role of alcohol and other drugs in all patients presenting with these complaints. The authors will also outline an approach for diagnosing and managing patients with the combination of a substance use and depressive or anxiety disorder.     

Alcohol and Substance Use and Abuse in Women and Children

No abstract available for this article.     

Glucosidase and fucosidase inhibitors and Advances in nucleosides and nucleotides.

The American Chemical Society Symposium "Glucosidase and fucosidase inhibitors" took place on 1 April 1998 and was organized by Professors Zbigniew J Witczak (UConn, School of Pharmacy, CT, USA), Kuniaki Tatsuta (Waseda University, Tokyo, Japan) and Waldemar Priebe, MD (Anderson Cancer Center, University of Texas, USA). Professor Witczak provided introductory remarks including the status of existing glucosidase inhibitors, and chaired the morning session, which consisted of six lectures. The symposium was well received, and was particularly attractive for those interested in networking, as attendance was about sixty. In addition, some participants and attendees presented posters on the subject during the regular poster session organized by the Division of Carbohydrate Chemistry.