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Tyrone G. Harrison Shannon M. Ruzycki Matthew T. James Paul E. Ronksley Kelly B. Zarnke Marcello Tonelli Braden J. Manns Deirdre McCaughey Prism Schneider Elijah Dixon Rebecca L. Hartley Victoria S. Owen Zhihai Ma Brenda R. Hemmelgarn 《American journal of kidney diseases》2021,77(3):365-375.e1
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Anna Porter Michael J. Fischer Xuelei Wang Deborah Brooks Marino Bruce Jeanne Charleston William H. Cleveland Donna Dowie Marquetta Faulkner Jennifer Gassman Leena Hiremath Cindy Kendrick John W. Kusek Keith C. Norris Denyse Thornley-Brown Tom Greene James P. Lash 《Journal of the American Society of Nephrology : JASN》2014,25(8):1849-1855
Low health-related quality of life (HRQOL) has been associated with increased risk for hospitalization and death in ESRD. However, the relationship of HRQOL with outcomes in predialysis CKD is not well understood. We evaluated the association between HRQOL and renal and cardiovascular (CV) outcomes in 1091 African Americans with hypertensive CKD enrolled in the African American Study of Kidney Disease and Hypertension (AASK) trial and cohort studies. Outcomes included CKD progression (doubling of serum creatinine/ESRD), CV events/CV death, and a composite of CKD progression or death from any cause (CKD progression/death). We assessed HRQOL, including mental health composite (MHC) and physical health composite (PHC), using the Short Form-36 survey. Cox regression analyses were used to assess the relationship between outcomes and five-point decrements in MHC and PHC scores using measurements at baseline, at the most recent annual visit (time-varying), or averaged from baseline to the most recent visit (cumulative). During approximately 10 years of follow-up, lower mean PHC score was associated with increased risk of CV events/CV death and CKD progression/death across all analytic approaches, but only time-varying and cumulative decrements were associated with CKD progression. Similarly, lower mean MHC score was associated with increased risk of CV events/CV death regardless of analytic approach, while only time-varying and cumulative decrements in mean MHC score was associated with CKD progression and CKD progression or death. In conclusion, lower HRQOL is associated with a range of adverse outcomes in African Americans with hypertensive CKD. 相似文献
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Joshua D. Bundy Xuan Cai Julia J. Scialla Mirela A. Dobre Jing Chen Chi-yuan Hsu Mary B. Leonard Alan S. Go Panduranga S. Rao James P. Lash Raymond R. Townsend Harold I. Feldman Ian H. de Boer Geoffrey A. Block Myles Wolf Edward R. Smith Andreas Pasch Tamara Isakova 《American journal of kidney diseases》2019,73(6):806-814
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