膨胀期白内障继发青光眼围手术期的治疗

目的 :探讨膨胀期白内障继发青光眼围手术期的治疗方案。方法 :对膨胀期白内障继发青光眼 36例、36眼进行规范的围手术期检查及治疗。 2 9例采用白内障囊外摘除虹膜周边切除联合人工晶体植入术 ;7例采用白内障囊外摘除人工晶体植入联合小梁切除术。结果 :术后随访 2年。术后矫正视力 >0 .2者 34例(94 .4 % ) ,眼压 14 .5 7～ 18.86mmHg者 34例 (94 .4 % ) ;2例 (5 .6 % )视力为光感～ 0 .0 2 ,眼压 2 2 .38～ 2 8.0 1mmHg ,眼底可见视神经萎缩。结论 :根据膨胀期白内障继发青光眼的临床特点制定规范的围手术期治疗方案 ,提高了手术安全性及术后治愈率     

三联术治疗青光眼合并白内障18例体会

目的　探讨小梁切除联合白内障超声乳化及人工晶体植入术 (三联手术 )治疗青光眼合并白内障的效果。方法　应用三联术对 1 8例 (2 0眼 )青光眼合并白内障患者进行手术治疗。术后随访 3～ 36个月 ,平均 1 8个月。结果　术前平均眼压 2 2 38mmHg ,术后随访最终平均眼压降至 1 5 88mmHg(P <0 0 1 )。术后随访最终矫正视力范围 0 0 5～ 1 0 ,其中≥ 0 5者 1 6眼 (80 % )。术后早期 2眼使用降眼压药物 ,随访后期无需使用。术后早期角膜水肿 4眼 (2 0 % )、浅前房 1眼 (5 % )。结论　三联术治疗青光眼合并白内障患者 ,具有恢复有用视力快、滤过泡失败率低、眼压控制稳定、角膜散光小、减少术后用药及并发症少等理想效果     

超声乳化联合房角分离术治疗膨胀期白内障继发青光眼

目的 观察白内障超声乳化吸出联合房角分离术治疗膨胀期白内障继发青光眼的临床效果.方法 对35例(35眼)膨胀期白内障继发青光眼的患者行白内障超声乳化吸出、囊袋内人工晶状体植入联合房角分离术,并进行术后随访,随访时间6～24个月,平均18个月.观察比较手术前后术眼视力和眼压变化,同时应用UBM及前房角镜观察手术前后前房深度及房角粘连范围的变化.结果 随访期间32眼术后视力较术前提高,视力未提高的3眼经眼底检查诊断为视神经萎缩;术后29眼眼压恢复正常,4眼应用0.5%噻吗心胺滴眼液点眼后眼压正常,2眼应用降眼压药物后,眼压仍高于正常.术后前房深度较术前明显增加,26眼(74.3%)房角开放,9眼房角仍有部分粘连;并发症主要是角膜水肿及瞳孔区渗出膜.结论 膨胀期白内障继发青光眼患者行白内障超声乳化、囊袋内折叠人工晶状体植入联合房角分离术可使前房加深、房角开放,提高视力并有效降低眼压.     

青光眼合并白内障联合手术的疗效观察

目的:探讨青光眼合并白内障施行小梁切除联合白内障囊外摘除及人工晶体植入术(三联手术)的疗效.方法:对18例(20只眼)青光眼合并白内障患者施行三联手术治疗.术后随访4～36个月,平均18个月.结果:术前平均眼压22.36mmHg,术后随访最终眼压降至15.65mmHg.术后随访矫正视力范围0.05～1.0,其中≥0.5者16只眼(80%).术后早期3只眼使用降眼压药物,随访后期无需使用.术后早期角膜水肿4只眼占20%.浅前房1只眼占5%.结论:青光眼合并白内障联合手术治疗患者,疗效肯定,住院时间短,能迅速有效地控制眼压,而且恢复视力快,是目前两病并存的一种较好治疗方法.     

超声乳化白内障吸除术治疗晶体溶解性青光眼7例临床分析

目的：探讨白内障防盲筛查中晶体溶解性青光眼的临床特点及治疗方法,以提高对本病的认识。方法对7例最终确诊为晶体溶解性青光眼的临床资料进行分析。入院明确诊断后,给予超声乳化白内障手术摘除晶状体,术后随访3个月。结果均为老年患者,门诊初诊为晶体溶解型青光眼4例,葡萄膜炎继发青光眼2例,年龄相关性白内障过熟期1例,该患者行散瞳检查后遂出现晶体囊膜破裂皮质溶解,临床表现与另6例大致相同。6例术后第1天眼压降至正常,1例术后3d眼压为30～42mmHg,经多次前房放液及降眼压药物治疗,术后2周逐渐停用所有降眼压药物,眼压恢复至正常。视力因病程及眼底情况不同恢复不一致,但均较术前提高。结论①晶体溶解性青光眼在患者刚就诊时不易确诊;②前房冲洗后行白内障摘除为治疗晶体溶解性青光眼的有效方式;③落后地区仍然存在较多白内障过熟期患者,应加强宣传,使患者远离继发性青光眼损害。     

小切口白内障摘除治疗膨胀期白内障继发青光眼31例疗效观察

目的:观察小切口白内障摘除治疗膨胀期白内障继发青光眼的临床疗效。方法:对31例(31眼)老年性白内障膨胀期继发急性青光眼患者实施小切口白内障囊外摘除联合人工晶状体植入术,术后随访3~12个月。结果:矫正视力>0.5者17眼,0.05~0.5 12眼,<0.05 2眼。术后27眼眼压正常,4眼药物稳定眼压。结论:小切口白内障摘除对老年性白内障膨胀期继发青光眼患者临床疗效良好。     

超声乳化白内障吸除术治疗原发性闭角型青光眼

目的 :观察单纯行超声乳化白内障吸除联合人工晶体植入术治疗闭角型青光眼的疗效。方法 :对原发性急性或慢性闭角型青光眼患者行超声乳化白内障吸除联合人工晶体植入术。随访 3～ 1 8个月 ,平均 6 .78个月。结果 :所有病例术后眼压在 9～ 1 7.7mmHg范围之内 ,无 1例需局部或全身使用降眼压药物治疗。术后中央前房深度明显加深。最佳矫正视力均有不同程度的提高。结论 :单纯行超声乳化白内障吸除联合人工晶体植入术是治疗原发性闭角型青光眼的一种有效方法。     

三联手术治疗膨胀期白内障继发青光眼

目的:评价膨胀期白内障继发青光眼三联手术的临床疗效.方法:对14例(14眼)老年性白内障膨胀期引起的继发性急性闭角形青光眼患者行小切口白内障囊外摘除,后房型人工晶体植入联合小梁切除(三联手术)治疗.结果:术后平均随访14个月,视力达0.2～0.4者占42.85%,≥0.5者占50%;12眼术后眼压正常.结论:膨胀期白内...     

超声乳化白内障吸除术治疗白内障合并继发性闭角型青光眼

【目的】初步评价单纯超声乳化白内障吸除加后房型折叠式人工晶体植入术治疗合并有白内障的继发性闭角型青光眼的疗效。【方法】回顾分析 1997年 5月至 2 0 0 0年 3月收住本院青光眼病区资料完整的 2 7例 (2 7眼 )继发性闭角型青光眼病例 ,19例为继发性急性闭角型青光眼 ,8例为继发慢性闭角型青光眼 ,患者均有不同程度的晶状体混浊。患者入院后均行透明角膜切口超声乳化白内障吸除加后房型折叠式人工晶状体植入术。随访 3个月～ 4年 ,平均 (19± 11)个月。【结果】所有患者术中、术后没有出现严重的并发症。术后最佳矫正视力 0 35± 0 19,明显好于术前 0 11± 0 0 7(配对秩和检验 ,P<0 0 5 ) ;眼压 (2 0 3± 0 72 )kPa及联合使用不同类抗青光眼药物的种数 (0 87± 0 4 2 )种 ,较手术前的 (4 0 9± 1 6 1)kPa和(2 6 7± 0 2 4 )种药物减少 (配对秩和检验 ,P <0 0 5 ) ;前房深度也由术前的 (1 2 5± 0 5 6 )mm加深到术后的 (2 4 3± 0 6 7)mm(配对t检验 ,P <0 0 5 ) ,原来狭窄的房角增宽 ,关闭的房角部分开放。【结论】单纯白内障超声乳化摘除联合人工晶体植入术是治疗合并有白内障的继发性闭角型青光眼的一种新的有效的选择     

膨胀期白内障继发青光眼手术疗效分析

目的 :探讨膨胀期白内障继发青光眼不同术式的手术疗效。方法 :对 2 0例膨胀期白内障继发青光眼分别采用周边虹膜切除、白内障囊外摘除联合人工晶体植入或白内障囊外摘除联合小梁切除术以及白内障囊外摘除、人工晶体植入联合小梁切除三种不同术式进行手术治疗。结果 :术后随访 3～ 2 5个月 ,2 0例术后视力≥ 0 5者 14例 (70 % ) ;视力≥ 1 0者 2例。三种术式术后平均眼压分别为 2 11kPa、2 30kPa、2 30kPa。结论 :对膨胀期白内障继发青光眼根据不同病情 ,及时施行上述三种术式治疗 ,术后视力均提高良好 ,眼压得到控制 ,本病的预后同成熟期白内障术后一样良好     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.