52例缺血性脑血管病患者脑血管造影分析

目的：分析缺血性脑血管病患者的脑数字减影血管造影术（ DSA）结果,为进一步治疗缺血性脑血管病提供依据。方法：回顾性分析我院2010年1月～2012年12月行脑DSA检查的52例缺血性脑血管病患者,对其脑DSA结果进行分析,了解颅内、外血管病变情况。结果：52例缺血性脑血管病患者中脑供血动脉狭窄或闭塞40例（76．9％）,其中共发现病变66处,颅外动脉病变共38处（57．6％）,颅内动脉病变28处（42．4％）。结论：DSA在诊治缺血性脑血管病方面具有非常先进的优势,能够准确定位评估病变血管以及侧支代偿情况,是评价缺血性脑血管病是否行血管内介入治疗的依据。     

数字减影血管造影应用于缺血性脑血管病介入治疗的护理

目的：探讨数字减影血管造影在缺血性脑血管病中介入治疗的价值和护理方法。方法：150例疑有缺血性脑血管病的患者均经数字减影血管造影确定部位后,再通过导管注入尿激酶、右旋糖酐以观察注药后血管影像学变化,同时检查临床症状和体征是否改善。结果：150例疑有缺血性脑血管病的患者中,有116例（占77.4%）显示脑血管异常改变,96例脑动脉狭窄或闭塞病变者行介入灌注治疗后,即刻观察肌力变化有不同程度提高,无1例发生护理并发症。结论：数字减影血管造影能够提高缺血性脑血管病的检出率,是评价脑血管狭窄、闭塞和选择治疗方案的金标准,它对缺血性脑血管病的进一步治疗起着关键性的作用,良好的护理配合是数字减影血管造影成功的因素之一。     

数字减影血管造影在脑血管病诊断中的应用

目的：探讨数字减影血管造影（DSA）技术对脑血管病的诊断价值。方法：对36例脑血管病患者进行DSA检查,观察血管病变及侧支循环建立情况,分析疾病与血管病变的关系。结果：36例中,颅内外血管病变24例,阳性检出率66.7%。术中发现血管病变37处,其中狭窄29处,闭塞7处,动脉瘤1处。术中出现脑血管痉挛1例。结论：DSA是诊断脑血管疾病的重要检查方法;颈内动脉病变在脑梗死、短暂性脑缺血、椎基底动脉供血不足等疾病的发生中起重要作用。     

78例数字减影全脑血管造影分析

目的探讨数字减影全脑血管造影在缺血性脑血管病诊断中的应用。方法选取2017年4月至2019年5月本院收治的78例神经内科患者进行回顾性分析,比较常规CT检查与数字减影全脑血管造影检查结果、数字减影全脑血管造影检查并发症发生情况等。结果数字减影脑血管造影检出血管闭塞39例,检出率为100%;血管狭窄36例,检出率为92.31%;CT检出血管闭塞32例,检出率为82.05%;血管狭窄29例,检出率为74.36%;数字减影脑血管造影对血管闭塞、血管狭窄的检出率高于CT,差异有统计学意义(P<0.05);采用数字减影脑血管造影发生皮下淤1例,占比1.29%,周围神经损2例,占比2.56%;未发生脑血管痉挛情况,并发症总发生率为3.85%。结论神经内科开展缺血性脑血管病介入治疗可作为安全有效的脑血管病诊治手段,与CT比较,血管闭塞、血管狭窄的检出率较高,且并发症较少,值得临床推广应用。     

血管超声与数字减影血管造影检查对颈动脉粥样硬化病变的诊断价值比较

目的：比较分析血管超声与数字减影血管造影检查（digital subtraction angiography,DSA）对颈动脉粥样硬化病变的诊断价值。方法选取48例颈动脉粥样硬化病变患者作为研究对象,患者均接受血管超声及数字减影血管造影检查,对两种检测方法硬化斑块检出情况进行观察分析。结果超声与减影血管造影检查在颈动脉狭窄诊断中具有较高的一致性,尤其是闭塞动脉及重度狭窄的诊断;超声诊断硬化斑块检出率显著高于DSA（P<0.05）。结论血管超声与数字减影血管造影检查颈动脉粥样硬化病变均有显著价值,检出率较高,超声诊断在斑块检测中效果明显优于减影血管造影检查。     

数字减影脑血管造影在脑血管病诊断中的应用

目的探讨数字减影脑血管造影术(DSA)在脑血管病诊断中的应用价值。方法回顾性分析130例不同脑血管病的DSA阳性检出率、安全性及临床特点。结果所有受检者无一例发生永久性神经功能缺损。总的DSA阳性检出率高达75.4%,其中缺血性脑血管病阳性率最高为86.3%(69/80),主要血管病变为脑动脉粥样硬化性狭窄或闭塞,颅外段受累多见。其次为脑实质出血(75.0%)、蛛网膜下腔出血(61.5%)。单侧动眼神经麻痹(66.7%)等。症状性癫痫的DSA结果均为阴性。结论规范化操作可充分保障DSA检查的安全性。慎重筛查DSA纳入病例可提高DSA的阳性检出率及提高效率/费用比,有效指导二级预防治疗。     

全脑DSA对缺血性脑血管病诊断的临床运用研究

目的探讨全脑数字减影血管造影(DSA)对缺血性脑血管病诊断的临床运用价值。方法对182例缺血性脑血管病患者采用全脑数字减影血管造影检查,对颅内外动脉血管的狭窄程度以及狭窄部位进行分析。结果全脑数字减影血管造影检查7例脑血管正常,175例颅内外血管异常,110例颅内血管异常,65例颅外血管异常,50例血管狭窄程度<50%,85例血管狭窄程度达50%～70%,40例血管狭窄程度>70%;全脑数字减影血管造影可明确狭窄部位以及对狭窄程度进行诊断;颈内动脉颅内段狭窄的严重程度高于颈内动脉颅外段(P<0.05)。结论对缺血性脑血管病患者采用全脑数字减影血管造影检查,可对患者病变部位以及狭窄程度进行明确诊断,并对脑血管的血流动力学改变、侧支代偿以及动脉回流情况进行检查,为临床治疗方案的实施提供理论依据,具有重要的临床运用价值。     

数字减影脑血管造影术(DSA)对缺血性脑血管病诊断的影响分析

目的:探讨数字减影血管造影(DSA)在缺血性脑血管病检查的价值。方法:对100例反复发作的短暂脑缺血发作或脑梗死患者的脑血管造影检查的结果进行回顾性分析。结果:100例患者的DSA阳性检出率为75.5%,其中缺血性脑血管病的阳性率最高为80.6%,其次原发性脑室出血的为81%,脑叶出血的为68.70%,蛛网膜下腔出血的为62.5%。结论:全脑DSA检查是缺血性脑血管病诊断的"金标准",与MRA相比更能明确病变部位、形态、性质及侧枝循环情况。     

CTA、TCD与DSA用于缺血性脑血管病检查的对比分析

目的比较CT血管造影术（CT angiography,CTA）、经颅多普勒（transcranial Doppler,TCD）与数字减影血管造影（digital subtraction angiography,DSA）用于缺血性脑血管病检查的价值。方法选取2009-04/2013-04月在作者医院进行治疗并经头颅CT或头颅MRI检查确诊为缺血性脑血管病的患者43例,所有患者均行CTA、TCD与DSA检查,比较三种检查的血管狭窄或闭塞情况。结果以DSA检查为标准,CTA诊断血管狭窄或闭塞的敏感性为83.50%,特异性为93.51%,准确度为91.33%;TCD的敏感性为69.90%,特异性为87.30%,准确度为83.51%。结论对于缺血性脑血管病的诊断,CTA和TCD检查与DSA检查的符合率高,可作为临床诊断的重要参考依据。     

超声与数字减影血管造影对颈动脉粥样硬化病变诊断的应用比较

目的 比较血管超声与数字减影血管造影(DSA)检查对颈动脉粥样硬化病变的诊断价值.方法 对96例缺血性脑血管病患者进行颈部动脉超声及DSA检查,以及对诊断颈部血管狭窄的敏感性和特异性,以及对硬化斑块检出率的差异.结果 超声与DSA在诊断颈动脉狭窄上有较高程度的一致性,尤其是对重度狭窄及闭塞动脉的诊断(经Kappa检验,...     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.