左侧面部巨大基底细胞样鳞状细胞癌1例报告

基底细胞样鳞状细胞癌是鳞状细胞癌中的一种特殊亚型,临床较为少见,发生于口腔颌面部皮肤者更少。本文报告1例57岁男性患者,因左侧面部溃烂就诊,临床检查发现左侧面部较大面积皮肤破溃,活检病理报告为基底细胞样鳞状细胞癌。全麻下扩大切除肿瘤后,以前臂游离皮瓣修复缺损,术后配合放疗,目前已随访12个月,未见复发。本文结合相关文献,对基底细胞样鳞状细胞癌的临床特点及危险因素、组织来源、诊断及鉴别诊断、治疗及预后进行分析。     

原发性下颌骨鳞状细胞癌1例报告及文献复习

原发性下颌骨鳞状细胞癌由于早期缺少特征性的临床表现,诊断较为困难。本文报告1例原发性下颌骨鳞状细胞癌,并复习相关文献,就其组织来源、临床表现、诊断、治疗及预后进行讨论。     

舌癌肉瘤和鳞状细胞癌共存1例报告及文献复习

癌肉瘤是一种既有癌又有肉瘤成分的恶性肿瘤,也称为梭形细胞肉瘤。原发于舌的癌肉瘤极其罕见,约占头颈部肿瘤的1%。本文报告1例舌癌肉瘤和鳞状细胞癌共存的病例,并结合文献复习,对癌肉瘤和鳞状细胞癌的临床表现、病理特征、治疗及预后进行探讨。     

痣样基底细胞癌综合征1例报告

痣样基底细胞癌综合征（Naevoid basal cell carcinoma syn-drome,NBCCS）又称Gorlin-Goltz综合征。由White于1894首次描述,是由皮肤基底细胞癌、多发性颌骨角化囊肿及骨骼系统异常和各种其他病变组成的综合征,常伴有多器官发育障碍。我科最近收治1例,报告如下。     

痣样基底细胞癌综合征1例报告

痣样基底细胞癌综合征是一种罕见的常染色体显性遗传疾病，以颌骨多发性角化囊肿、皮肤痣样基底细胞癌及多种骨骼异常为主要临床表现。作者报告1例典型病例．并对其临床、病理和治疗进行了讨论．     

原发性颌骨内鳞状细胞癌1例报告及文献复习

原发性颌骨内癌是一种罕见的来源于牙源性上皮剩余的恶性肿瘤。本文报告1例发生于右侧下颌骨内的鳞状细胞癌病例。该患者表现为右侧下颌骨拔牙创口迁延不愈且伴肉芽组织形成,局部疼痛,但不影响进食及言语功能。采用手术切除、左侧血管化游离腓骨肌皮瓣修复,术后病理检查证实为鳞状细胞癌。     

口腔基底样鳞状细胞癌的临床病理及免疫组织化学特点

目的研究口腔基底样鳞状细胞癌的临床病理学特点。方法用ＨＥ染色、病理学观察及免疫组织化学染色法对１４例基底样鳞状细胞癌进行了分析。结果口腔基底样鳞状细胞癌占口腔鳞状细胞癌的１％，男性多于女性，可发生在口腔粘膜任何部位，临床表现主要为肿物和溃疡。肿瘤由基底样细胞和鳞状细胞构成，以基底样细胞为主，常形成粉刺样坏死，核分裂较多，邻近上皮常有异常增生。肿瘤细胞角蛋白ＡＥ１／３、ＣＫ１３阳性，Ｓ１００阴性，增殖细胞核抗原（ｐｒｏｌｉｆｅｒａｔｉｎｇｃｅｌｎｕｃｌｅａｒａｎｔｉｇｅｎ，ＰＣＮＡ）阳性细胞多，ｐ５３阳性率为５０％。３５．７％的病例初次手术时已有淋巴结转移。结论口腔基底样鳞状细胞癌较普通鳞状细胞癌恶性程度高，具有独特的组织学特点，临床及病理上应予重视。     

舌鳞状细胞癌放疗后骨肉瘤1例报告及文献复习

放疗诱发肉瘤（radiation induced sarcoma,RIS）是放射治疗后一种少见而严重的并发症,在全身多个部位的原发肿瘤放疗后均有报道,其恶性程度高,预后差,在临床诊断及治疗上均有极大难度。本文报告1例舌鳞状细胞癌放疗后诱发下颌骨骨肉瘤,同时伴发舌、口底第二原发癌的患者,并结合国内外文献,对头颈部放疗诱发肉瘤（radiation-induced sarcoma of head and neck,RISHN）的发病因素、诊断标准、临床特点、治疗及预后进行讨论。     

痣样基底细胞癌综合征伴先天性左眼缺失1例

痣样基底细胞癌综合征（NBCCS）又称基底细胞痣综合征或Goltz-Gorlin综合征,是一种复杂且罕见的常染色体显性遗传疾病,大量研究文献证实PTCH1基因与NBCCS有关。本文报道1例NBCCS伴先天性左眼缺失的病例,并结合相关文献探讨以进一步了解该综合征。     

Neck dissection with the harmonic scalpel in patients with squamous cell carcinoma of the oral cavity

Our purpose was to evaluate the use of the Harmonic scalpel in neck dissections.Material and methodsWe conducted a randomized prospective intervention study to compare the Harmonic scalpel (32 patients) with the conventional technique (31 patients).ResultsOperative time was lowered by 64 min (p < 0.001) and 7.5 min (p = 0.367); blood lost during surgery was lowered by 80.5 ml (p < 0.001) and 76.6 ml (p < 0.001); the length of time the drains were kept in place was lowered by 1.3 days (p < 0.001) and 1.5 days (p < 0.01); and the volume of drainage was lower by 228.7 ml (p < 0.001) and 187.6 ml (p < 0.01) in selective and comprehensive neck dissections respectively in patients treated with the Harmonic scalpel.ConclusionsThe Harmonic scalpel shortens operative time in selective dissections. It reduces blood loss during surgery; time drains are kept in place and the amount of drainage in comprehensive and selective neck dissections.     

Basaloid squamous cell carcinoma report of a case and review of literature.

Basaloid squamous cell carcinoma (BSCC) is an aggressive distinct variant of squamous cell carcinoma that mandates recognition as a separate entity owing to the difference in its clinical behaviour. Histologically this tumor can mimic other neoplasms like adenoid cystic carcinoma, neuroendocrine carcinoma and basal cell adenocarcinoma. BSCC occurs most commonly in older men and has a site predilection for the upper aero-digestive tract. We report a case of basaloid squamous cell carcinoma for its relative rarity, which was diagnosed in a 52 year old woman, with a brief review of literature.     

局部晚期口腔鳞癌新辅助免疫靶向治疗2例及文献复习

新辅助治疗是针对无远处转移恶性肿瘤患者在局部治疗前进行的全身性治疗,主要目的是减少肿瘤负荷、增加肿瘤根治机会、降低远处转移、缓解症状等。本文报道2例上海交通大学医学院附属第九人民医院进行前瞻性临床试验过程中,局部晚期口腔鳞癌患者接受卡瑞利珠单抗联合阿帕替尼的新辅助治疗方案的病例,并对新辅助治疗相关文献进行复习和讨论。     

Distinct expression of perforin and granzyme B in lip and oral cavity squamous cell carcinoma

J Oral Pathol Med (2011) 40 : 380–384 Background: Perforin and granzyme B (GB) are the main constituents of cytotoxic T‐lymphocyte granules, and they have important roles in preventing the initiation and progression of cancer. Methods: The aim of this study was to compare the expression of CD8⁺/perforin⁺ double‐staining and GB⁺ cells, by immunohistochemistry, in primary oral cavity squamous cell carcinoma (OCSCC), lip squamous cell carcinoma (LSCC), non‐dysplastic leukoplakia (LK), dysplastic LK, actinic cheilitis (AC), oral lichen planus (LP) and normal oral mucosa. Results: Our results showed a higher expression of CD8⁺/perforin⁺ and GB⁺ cells in LSCC when compared with the samples of OCSCC, non‐dysplastic and dysplastic LK, AC, oral LP and normal oral mucosa. In addition, increased CD8⁺/perforin⁺ and GB⁺ cell numbers were observed in all pre‐malignant lesions (non‐dysplastic LK, dysplastic LK, AC) when compared with the control. Conclusions: Perforin and GB proteins may contribute to antitumoural immunity, leading to the direct killing of tumour cells; however, it seems to occur more effectively in LSCC than OCSCC.     

口腔梭形细胞鳞癌2例报告

回顾分析2例口腔梭形细胞鳞癌病例资料,对其临床表现、组织病理学特征、治疗方法及预后等进行讨论。该肿瘤系鳞状细胞癌的变异型,由明确的鳞癌区和具有上皮分化特征的梭形细胞2部分组成,多发于60～70岁男性,好发于下唇、舌和牙龈,临床表现浸润性强,易经淋巴道转移。治疗方法以局部扩大切除加颈淋巴清扫术为主,浸润深度、局部复发和颈淋巴结转移是影响预后的重要指标,患者预后一般较差。     

Evaluation of glutathione in oral squamous cell carcinoma

Purpose  

To estimate the RBC level of glutathione among oral squamous cell carcinoma cases and normal healthy individual. The study compares the pre and postoperative blood levels of glutathione in patients with oral squamous cell carcinoma.     

透明质酸在口腔鳞状细胞癌组织中的表达

目的 本研究旨在探讨透明质酸在不同分化口腔鳞状细胞癌中的表达及意义.方法 应用免疫组织化学法检测37例不同分化程度口腔鳞状细胞癌组织中透明质酸的表达.结果 按阴性(-)、弱阳性( )、阳性( )、强阳性( )表示,并进行统计学分析.结果 透明质酸主要表达于肿瘤间质和细胞外基质,细胞膜和胞浆中染色相对较少.37例口腔鳞状细胞癌组织中,低分化鳞癌透明质酸的表达明显高于高分化鳞癌(P＜0.05),表达随肿瘤分化程度降低而增强.结论 透明质酸的表达与口腔鳞状细胞癌的分化程度有关,分化越低,其表达越强.透明质酸的高表达可能有利于病变的侵袭和转移.     

Basaloid squamous carcinoma of the oral cavity: Report of a case

A case of basaloid squamous carcinoma that involves the posterior buccal mucosa is described. The major histopathologic feature is a carcinoma with a basaloid pattern in association with squamous differentiation. The basaloid cells exhibit large and vesicular nuclei and eosinophilic clear or vacuolated cytoplasm. Cells are distributed in cords, trabeculae, or lobules that occasionally show glandular arrangement. The majority of the tumor cells are positive for keratin and a large group of cells distributed in glandular arrangement are positive also for vimentin.