共查询到20条相似文献，搜索用时 31 毫秒
1.
V. Bosch-Canto C. Cruz J.C. Ordaz-Favila 《Archivos de la Sociedad Espa?ola de Oftalmología》2018,93(1):3-6
Retinoblastoma is the most frequent intraocular tumour in childhood. The definitive treatment is enucleation. The management of the anophthalmic socket consists in the use of a plastic implant. The problem is that they are expensive and they usually extrude. The use of dermal-fat grafts minimises the hemi-facial hypoplasia. They usually grow with the face, and help to expand the orbital bones, thus avoiding the psychological and physical consequences.
Objective
To determine if there is hemi-facial hypoplasia, using MRI images after the use of a dermal-fat implant in patients enucleated for RB.Method
The study included patients enucleated for RB in which a dermal-fat implant was used and MRI images were taken in the period between June 2010 and December 2012. Facial growth and cosmesis was measured.Results
The study included 12 patients, aged between 6 to 41 months. After 24 months of follow up, none of them developed hemifacial hypoplasia. All had a good cosmesis with the prosthesis. There were no complications after the surgery.Conclusions
The use of dermal-fat implant is a good option for the anophthalmic socket in patients with RB after enucleation. 相似文献2.
Oded Sagiv Elkanah Rosenfeld Elinor Kalderon Tamar Brutman Barazani Ofira Zloto Uriel Martinowitz Guy J. Ben Simon Isaac Zilinsky 《Canadian journal of ophthalmology. Journal canadien d'ophtalmologie》2018,53(6):600-604
Objective
Postoperative ecchymoses or hematomas can prolong healing from surgery, and a search for locally administered agents that decrease bleeding is warranted. The objective of this study is to evaluate whether preoperative subcutaneous injection of tranexamic acid (TXA) reduces intra- and postoperative bleeding or ecchymoses in skin-only upper eyelid blepharoplasty surgery.Design
This is a prospective randomized, double-blind, controlled study.Participants
We included 34 consecutive patients who were referred to an upper eyelid blepharoplasty surgery in our institution.Methods
The patients were equally randomized to a preoperative local injection of lidocaine mixed with either TXA or normal saline. All patients stopped antiaggregates 1 week before surgery. All surgeries were performed by a single surgeon who was unaware of group assignment. Total surgical time, cumulative time of cautery use, blood loss, the surgeon’s assessment of bleeding extent, pain level reported by the patient, periocular ecchymoses during the first postoperative week, and time for patient’s return to normal daily activity were recorded.Results
There was a trend toward smaller ecchymoses in the TXA group compared with the placebo group on the seventh day (p = 0.072). There were no group differences in total surgery time, cumulative cautery time, net blood weight in surgical pads, patient-reported pain level, surgeon’s assessment of hemostasis, or periocular ecchymosis size on the first postoperative day.Conclusions
Subcutaneous TXA was associated with similar intra- and postoperative hemorrhage in upper eyelid blepharoplasty compared with placebo. The effect of TXA in patients who did not stop antiaggregate use before surgery warrants further study. 相似文献3.
Suresh Sagili Jerome Ha 《Canadian journal of ophthalmology. Journal canadien d'ophtalmologie》2019,54(1):98-101
Objective
To describe a modification of trans-conjunctival, lower eyelid retractor advancement to correct tarsal ectropion.Design
A retrospective case review.Participants
Consecutive patients with lower eyelid tarsal ectropion.Methods
Cases of lower eyelid tarsal ectropion, surgically corrected by advancement of inferior retractor to the lower border of tarsus via a transconjunctival approach, were identified. Lateral tarsal strip was also performed simultaneously in all cases.Results
Twenty patients (25 eyelids) were included in this study. There were 19 primary lower eyelid tarsal ectropion and 6 recurrent tarsal ectropion. Complete resolution of tarsal ectropion was achieved in all patients postoperatively. Mean follow-up was 8.4 months (range 1–36 months). There were no cases of overcorrection, recurrent ectropion, suture abscess, wound dehiscence, or inferior fornix shortening after surgery.Conclusions
Visualization of the lower eyelid retractor (white-line) and advancement to the inferior border of tarsus through a transconjunctival approach is effective in correcting both primary and recurrent cases of tarsal ectropion. This can be performed through a small conjunctival incision in the middle third of the lower eyelid, without the need for any excision of tissue or suture loop tie on the skin surface. 相似文献4.
Jacob A. Evans Thomas J.E. Clark Kai Wang Erin M. Shriver 《Canadian journal of ophthalmology. Journal canadien d'ophtalmologie》2018,53(5):462-465
Objective
To introduce “iris show,” the amount of visible iris tissue between the superior pupil border and the upper eyelid margin, to evaluate the effect of iris show on perceived upper eyelid height, and to discuss potential nonsurgical treatment options for mild blepharoptosis.Methods
Participants completed a survey containing 4 subject photographs. These photographs depicted images of varying iris colouration (blue, green, light brown, and dark brown) with identical upper eyelid marginal reflex distance (MRD1) values, but asymmetric pupil size/amount of visible iris show. Study participants were asked to select the eyelid that appeared “droopier,” or choose “same height.” Statistical analyses used 1-tailed and 2-tailed t tests.Results
390 participants completed the survey. In photographs of blue and green irides, both eyelids had equal MRD1s, but the eyelid with less iris show was perceived as more ptotic (p = 0.002 and 0.03, respectively). In patients with dark brown irides, eyelid heights were perceived as identical despite differences in iris show (p = 0.002).Conclusions
Decreased iris show corresponds to perceived lowering of the upper eyelid in light-coloured irides (e.g., blue and green), but may be less impactful in brown and/or dark brown irides where the iris tissue is less distinguishable from the pupil. Topical instillation of apraclonidine may represent a nonsurgical option for treatment of mild blepharoptosis in patients with light irides as it both elevates the upper eyelid margin and induces miosis, resulting in an increase in iris show and corresponding enhanced perception of upper eyelid elevation. 相似文献5.
Samuel M. Philbrick Darrell E. Baskin 《Canadian journal of ophthalmology. Journal canadien d'ophtalmologie》2018,53(3):222-228
Objective
To determine whether stereoscopic footage of cataract surgery could be captured with smartphones and to develop a procedure for editing and viewing the footage. The authors sought to measure whether subjectively convincing stereo footage could be captured with smartphones, whether it would be possible to sync this footage for stereoscopic viewing, and whether these tasks could easily be performed at lower cost than commercially available options.Design
Brief research report.Participants
The entities studied were phones and programs.Methods
Surgeries were recorded at Fort Belvoir Community Hospital. Two smartphones were attached to the eyepieces of a surgical microscope’s assistant scope. Surgical footage was recorded. Videos from the left and right eyepieces were edited and combined into videos that facilitated stereoscopic viewing.Results
Stereo footage was captured with 2 smartphones and edited to enable 3D viewing with both anaglyph glasses and head-mounted displays. Viewing experience was superior when using head-mounted displays compared to using anaglyph glasses.Conclusions
Stereoscopic footage of operations performed under the surgical microscope may be captured and viewed using inexpensive equipment and simple procedures requiring minimal prior expertise. The techniques described in this paper may enable more training programs to capture and distribute 3D footage of their operations, enhancing the educational value of ophthalmic surgical videos. 相似文献6.
Jianxin Ni Xi Chen Shengjie Zhou Jia Liu Ben Chen 《Canadian journal of ophthalmology. Journal canadien d'ophtalmologie》2019,54(1):102-105
Objectives
To investigate the outcomes for correction of involutional lower eyelid entropion by wedge resection of the tarsus combined with the modified Hotz procedure.Design
Retrospective study.Participants
Patients with lower eyelid involutional entropion that was surgically repaired by wedge resection of the tarsal plate combined with the modified Hotz procedure.Methods
In a consecutive series of 43 patients with involutional lower eyelid entropion, wedge resection combined with the modified Hotz procedure was performed with an average follow-up period of 29.6 months (range, 6–62 months).Results
Among the patients, 93% had an excellent outcome within the follow-up period. For one patient, the outcome of both eyes was poor. For another patient, incision dehiscence of the eyelid margin in one eye occurred after the stitches were removed. The incision was sutured again, and it healed well. One patient complained of foreign body sensation in one eye after removal of the skin stitches. The complaint was resolved after wearing a corneal contact lens. No other significant complications occurred.Conclusions
In our clinic, tarsal plate wedge resection combined with the modified Hotz procedure has been highly effective for correction of involutional lower eyelid entropion. Although this approach does not directly address lateral canthal tendon laxity, it does preserve the eyelid in case there is a future need for reconstruction due to ocular surface disease or trauma. Thus, wedge resection of the tarsal plate combined with modified Hotz procedure is a safe and effective method for involutional lower eyelid entropion. 相似文献7.
Jinhwan Park Joohyun Kim Hwa Lee Minsoo Park Sehyun Baek 《Canadian journal of ophthalmology. Journal canadien d'ophtalmologie》2018,53(4):373-379
Objective
The purpose of this study was to evaluate the structure and function of the meibomian gland and the incomplete blinking rate to understand the pathophysiology of dry eye in thyroid eye disease (TED) patients.Methods
Patients who were diagnosed with TED were enrolled between October 2015 and February 2016. Clinical measurements were performed in the following order: (i) external examination (Hertel exophthalmometer and palpebral fissure height), (ii) LipiView interferometer (lipid layer thickness [LLT], incomplete blinking rate, and meibography), (iii) slit-lamp biomicroscopy (corneal surface staining, tear breakup time, meibum expression, Marx line).Results
Thirty eyes of 30 TED patients (male = 8; female = 22) were included in this study. The TED patient population had a mean age of 42.9 ± 11.8 years and a mean clinical activity score (CAS) of 2.33 ± 1.60. The meiboscore was 1.17 ± 0.90 in the upper eyelid and 0.70 ± 0.65 in the lower eyelid; scores were significantly higher in the upper eyelid (p < 0.001). The mean LLT was 82.43 ± 24.52 nm, and the mean incomplete blinking rate was 51.04 ± 33.62% (0–100%). CAS was the only variable that correlated with the meiboscore. There was no significant correlation between incomplete blinking and a degree of palpebral fissure height or proptosis.Conclusions
Tear film instability due to increased incomplete blinking can cause dry eye in TED. In addition to the increase in CAS, meibomian gland dysfunction may also be a cause of dry eye in TED. However, further comparative studies are needed to confirm these results. 相似文献8.
Parveen Sen Vinay Kumar S. Pramod Bhende Pukhraj Rishi Ekta Rishi Chetan Rao Dhanashree Ratra Pradeep Susvar Sreelakshmi Kummamuri Sufiyan Shaikh Lingam Gopal 《Canadian journal of ophthalmology. Journal canadien d'ophtalmologie》2018,53(1):49-55
Objective
To study the outcome and complications of sutured scleral fixated intraocular lenses (SSFIOL) in children.Design
Retrospective study.Subjects
A total of 279 eyes of 230 children who underwent SSFIOL at ≤18 years of age in a tertiary eye care centre in India.Methods
Treatment-naive children having traumatic cataract or subluxated lens underwent a single-sitting lensectomy and pars plana vitrectomy (PPV), along with SSFIOL insertion. Children with aphakia underwent PPV with SSFIOL, and vitrectomized eyes underwent only SSFIOL implantation. Fixation of SSFIOL was done by the 4-point ab externo fixation technique using 10-0 prolene suture.Main outcome measures
Preoperative and postoperative visual acuity, as well as intraoperative and postoperative complications.Results
The mean age at which SSFIOL was performed was 10.8 ± 4.22 years. The most common indication of SSFIOL in our study was traumatic subluxation of lens (47.63%; n = 133 patients), followed by congenital subluxation in 38.7% (n = 108). Best-corrected visual acuity was maintained or improved from the preoperative visual acuity in 93.19% of eyes. The complications included choroidal detachment in 2.86% (n = 8), dispersed vitreous hemorrhage in 2.86% (n = 8), endophthalmitis in 0.72% (n = 2), raised intraocular pressure in 12.54% (n = 35), diplopia in 0.72% (n = 2), retinal detachment in 5.73% (n = 16), and dislocation of the SSFIOL in 4.6% (n = 13). The mean follow-up after SSFIOL implantation was 39.68 months.Conclusions
SSFIOLs are effective in correcting aphakia in children; long-term follow-up of these children is, however, necessary. 相似文献9.
Kyung Jun Choi Min Joung Lee 《Canadian journal of ophthalmology. Journal canadien d'ophtalmologie》2018,53(4):384-390
Objective
To compare the reliability of orbital parameters calculated using 2-dimensional computed tomography (CT) and Hertel exophthalmometry when measuring exophthalmos in normal subjects and in patients with thyroid-associated orbitopathy (TAO).Design
Retrospective, observational case series.Participants
CT images of 33 normal orbits and 69 orbits with TAO were included.Methods
In central axial CT scans, globe area (GA), orbital area (OA), and GA/OA ratio were calculated by 2 observers using ImageJ. Interobserver agreement was analyzed for Hertel exophthalmometer and CT parameters. In patients with TAO, the association with activity and severity of TAO were also evaluated.Results
GA and the GA/OA ratio measurements showed excellent interobserver agreement, whereas OA and the Hertel exophthalmometry measurements showed moderate agreement between the 2 observers. GA and the GA/OA ratio were significantly correlated with Hertel exophthalmometry measurements (r = ?0.740, r = ?0.706, respectively; all p < 0.001). GA and the GA/OA ratio were significantly correlated with the activity and severity of TAO (all p < 0.01).Conclusions
GA and the GA/OA ratio were reliable CT parameters with a high intraclass correlation coefficient compared with Hertel exophthalmometer. 相似文献10.
Ana Gabriela Palis Karl Clifford Golnik Eduardo Pedro Mayorga Helena Prior Filipe Prashant Garg 《Canadian journal of ophthalmology. Journal canadien d'ophtalmologie》2018,53(2):145-149
Background
The Accreditation Council for Graduate Medical Education and other organizations recommend 360-degree assessments for evaluation of interpersonal and communication skills, professional behaviours, and some aspects of patient care and system-based practice. No such tool has been developed for ophthalmology or received international content validation.Objective
To develop a valid, internationally applicable, ophthalmology-specific 360-degree assessment tool.Design
Exploratory study.Methods
A literature review was conducted. Individual 360-degree evaluation items from several publications were catalogued and classified according to different groups of assessors. A panel of international authors reviewed the list and voted on items that were most appropriate for international use. The list was trimmed to reduce redundancy and to make it as brief as possible while still capturing the essential components for each category. A second panel of international ophthalmic educators reviewed the international applicability and appropriateness of this collated list; relevant comments and suggestions were incorporated.Results
A tool for the evaluation of interpersonal and communication skills, professionalism, and system–based practice was developed. The tool has face and content validity.Conclusion
This assessment tool can be used internationally for giving formative feedback based on the opinions of the different groups of people who interact with residents. 相似文献11.
Bo Li Sapna Sharan 《Canadian journal of ophthalmology. Journal canadien d'ophtalmologie》2018,53(1):45-48
Objective
To describe the presentation, clinical evaluation, work-up, surgical management, and surgical outcomes in children older than 8 years with spontaneous, comitant, acquired nonaccommodative esotropia (ANAET).Design
Retrospective chart review.Participants
Children who underwent bilateral medial rectus recession surgery for ANAET with initial esotropia onset later than 8 years of age.Methods
The medical records of children older than 8 years presenting with ANAET from 2009 to 2015 were retrospectively reviewed. The clinical presentation, work-up, surgical intervention, preoperative and postoperative deviations, and surgical outcomes were recorded.Results
A total of 7 healthy patients were identified. The average age of onset was 11.9 years. All patients presented with symptoms of diplopia with large-angle esotropia. Most patients had no preceding illness and presented with minimal refractive error. All 7 patients had unremarkable neurological and general pediatric evaluations without findings of acute intracranial pathology on neuroimaging. Bilateral medial recession surgery was performed for all 7 patients with resolution of diplopia and excellent stereopsis postoperatively.Conclusions
Diplopia is the most common presenting symptom among older children presenting with ANAET. Bilateral medial recession surgery achieved excellent postoperative results with resolution of diplopia and excellent stereopsis. 相似文献12.
Erika Massicotte Salima Hassanaly Marie-Lyne Bélair Karin Oliver Eric Fortin 《Canadian journal of ophthalmology. Journal canadien d'ophtalmologie》2018,53(5):435-440
Objective
Idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome is a rare entity with a potentially poor visual prognosis. Our objective is to review the clinical presentation and long-term outcomes of patients with IRVAN syndrome.Design
This is a retrospective case series.Methods
We reviewed the charts of all the patients diagnosed with IRVAN syndrome at our tertiary care centre from 2002 to 2015.Results
We included the long-term clinical outcomes of 7 eyes (5 patients) diagnosed with IRVAN syndrome. After a mean follow-up of 84.9 months, best-corrected visual acuity was 20/40 or better in the majority of eyes (70%). Four (57.1%) patients had systemic conditions, namely, multiple sclerosis, ischemic stroke, and positive antiphospholipid titres. All eyes were treated with laser photocoagulation. Four (40%) eyes received adjunctive intravitreal bevacizumab injections.Conclusion
IRVAN is an important diagnosis for clinicians to recognize. When treated in a timely manner, long-term visual outcomes can be favourable. 相似文献13.
Edsel Ing Christian Pagnoux Felix Tyndel Arun Sundaram Seymour Hershenfeld Paul Ranalli Shirley Chow Tran Le Carla Lutchman Susan Rutherford Kay Lam Harleen Bedi Nurhan Torun 《Canadian journal of ophthalmology. Journal canadien d'ophtalmologie》2018,53(3):215-221
Objectives
To determine the role of the ocular pulse amplitude (OPA) from Pascal dynamic contour tonometry in predicting the temporal artery biopsy (TABx) result in patients with suspected giant cell arteritis (GCA).Design
Prospective validation study.Participants
Adults aged 50 years or older who underwent TABx from March 2015 to April 2017.Methods
Subjects on high-dose glucocorticoids more than 14 days or without serology before glucocorticoid initiation were excluded. The OPA from both eyes was obtained and averaged just before TABx of the predominantly symptomatic side. The variables chosen for the a priori prediction model were age, average OPA, and C-reactive protein (CRP). Erythrocyte sedimentation rate (ESR), platelets, jaw claudication, and eye findings were also recorded. In this study, subjects with a negative biopsy were considered not to have GCA, and contralateral biopsy was performed if the clinical suspicion for GCA remained high. An external validation set (XVAL) was obtained.Results
Of 109 TABx, 19 were positive and 90 were negative. On univariate logistic regression, the average OPA had 0.60 odds for positive TABx (p = 0.03), with no statistically significant difference in age, sex, CRP, ESR, or jaw claudication. In suspected GCA, an OPA of 1 mm Hg had positive likelihood ratio 4.74 and negative likelihood ratio 0.87 for positive TABx. Multivariate regression of the prediction model using optimal mathematical transforms (inverse OPA, log CRP, age >65 years) had area under the receiver operating characteristic curve (AUROC) = 0.85 and AUROCXVAL = 0.81.Conclusions
OPA is lower in subjects with biopsy-proven GCA and is a statistically significant predictor of GCA. 相似文献14.
Michelle M. Porter Andrew W. Cull 《Canadian journal of ophthalmology. Journal canadien d'ophtalmologie》2018,53(5):538-541
Objective
Cataract surgery can have many benefits for older adults, including enabling continued ability to drive. However, it is not known how objectively measured driving patterns change after cataract surgery. The purpose of this study was to examine how participants drove before and after cataract surgery.Design
Longitudinal study.Participants
Individuals from the Winnipeg site of Candrive (a longitudinal study of older drivers in Canada).Methods
An in-vehicle device monitored all trips taken in 1-second intervals, allowing for the analysis of distances driven, number of trips, time of trips, speeding, excessive braking/accelerating, and types of roadways.Results
Over the 4 years of data collection, there were 16 cases of participants having cataract surgery, whereby there was also suitable driving data for analyses. Participants drove 28% further after surgery (p = 0.022). They also drove further from home and more on primary roads (p < 0.05) and had fewer episodes of hard braking per distance travelled (p < 0.001). No other variables significantly changed.Conclusions
This study suggests that older drivers changed some of their driving patterns after cataract surgery. Future studies could explore the effects of increased driving exposure, in conjunction with potentially safer driving behaviors, on overall driving safety after cataract surgery. 相似文献15.
David S. Sands Stephanie C.Y. Chan Chloe C. Gottlieb 《Canadian journal of ophthalmology. Journal canadien d'ophtalmologie》2018,53(4):349-353
Objective
To assess corticosteroid-sparing and inflammation control in patients with noninfectious scleritis treated with methotrexate.Design
Retrospective review.Participants
Patients who received methotrexate treatment for noninfectious scleritis and who had 12 months of follow-up after treatment initiation were included in this review.Methods
The clinical records of noninfectious scleritis patients presenting at the University of Ottawa Eye Institute between September 1, 2010 and December 31, 2014 treated with methotrexate were retrospectively reviewed. Seventeen patients (21 eyes) were included in the study. Main outcome included inflammation control and corticosteroid-sparing success. Secondary outcomes were reduction of immunosuppression load and best-corrected visual acuity.Results
The proportion of eyes with corticosteroid-sparing success was 69.2% at 3 months and 92.3% at 12 months. The proportion of eyes that achieved inflammation control was 61.9% at 3 months and 90.5% at 12 months. The corticosteroid immunosuppression load at treatment start was 1.9 ± 2.07 and at 12 months was 0.48 ± 1.03 (p < 0.01). There was no statistically significant difference in best-corrected visual acuity.Conclusions
The treatment of noninfectious scleritis with methotrexate appears to be effective at both achieving steroid-sparing success and controlling inflammation during 12 months of therapy. Immunosuppression load decreased significantly over 12 months of therapy while best corrected visual acuity was stable. 相似文献16.
Oded Ohana Igor Kaiserman Yuval Domniz Eyal Cohen Oz Franco Tzahi Sela Gur Munzer David Varssano 《Canadian journal of ophthalmology. Journal canadien d'ophtalmologie》2018,53(5):523-528
Objective
To report the outcomes and complications of combined photorefractive keratectomy (PRK) and collagen crosslinking (CXL).Design
A retrospective cohort study of consecutive patients undergoing combined PRK-CXL between 2011 and 2013 at Care Laser, Inc, Tel Aviv, Israel.Participants
Ninety-eight eyes of 56 patients were included. Only patients without keratoconus were included.Methods
Data were collected from the patients’ files and imaging devices. Main outcome measures were corrected and uncorrected distance visual acuity (CDVA/UDVA); spherical equivalent (SE); refractive, keratometric, and pachymetric stability; and the occurrence of postoperative complications.Results
Mean age was 27.69 ± 6.6 years. UDVA improved from 1.38 ± 0.60 to 0.15 ± 0.24 logMAR (p < 0.001). SE improved from ?4.45 ± 2.87 diopter (D) to +0.20 ± 0.90 D (p < 0.001), and 69% of the patients were within ±0.50 D from emmetropia. Four eyes had significant corneal haze; of them 3 eyes lost more than 2 Snellen lines. No cases of corneal ectasia were recorded.Conclusions
In our cohort PRK-CXL achieved significantly improved UDVA and SE compared to baseline. Corneal haze was a significant complication. Refractive results were less accurate than published for patients undergoing PRK procedures. Although no cases of corneal ectasia were seen, given the rarity of such complication, the added benefit of CXL remains to be proven. 相似文献17.
Edsel B. Ing Harleen Bedi Ahsen Hussain Helena Zakrewski Royce Ing Navdeep Nijhawan Amal Al-Sayyed Bryan J. Winn 《Canadian journal of ophthalmology. Journal canadien d'ophtalmologie》2018,53(5):466-470
Objective
To determine the effect of bicanalicular silicone intubation (SI) on dacryocystorhinostomy (DCR) success rate in adult primary acquired nasolacrimal duct obstruction.Design
Meta-analysis of randomized controlled trials (RCTs).Methods
PubMed, Embase, Cochrane CENTRAL, Ovid Medline, Google Scholar, and grey literature search was performed from inception to June 2017. All prospective DCR trials with randomization of SI were considered. Cases with non-SI or adjunctive mitomycin were excluded. Where possible we analysed only 1 eye from each subject. Random effects meta-analysis was performed.Results
We retrieved 1142 articles and after filtering there were 14 RCTs with a total of 1311 DCR cases. There were 444 external DCRs and pooled estimate showed risk ratio (RR) was 1.08 (95% confidence interval [CI] 1.01–1.15). There were 867 predominantly endonasal DCR with RR 1.04 (95% CI 0.99–1.09). When all DCR modalities were combined the RR was 1.05 (95% CI 1.01–1.09).Conclusions
Overall, there was a 5% statistically significant improvement in DCR success rate with SI, but more endonasal DCR RCTs are required. 相似文献18.
Zaid Shalchi Mali Okada Alice Bruynseels David Palethorpe Ammar Yusuf Rohan Hussain Christina Herrspiegel Antonio Scazzarriello Abubakar Habib Razia Amin Ranjan Rajendram 《Canadian journal of ophthalmology. Journal canadien d'ophtalmologie》2018,53(4):415-419
Objective
To investigate the effect of serum glycosylated hemoglobin (HbA1c) on the outcomes of ranibizumab therapy for diabetic macular edema (DME).Design
Retrospective cohort study.Participants
Patients receiving ranibizumab injections for centre-involving DME in a National Health Service setting.Methods
The Moorfields OpenEyes database was used to study eyes with DME treated with ranibizumab from October 2013 to November 2015 at the Moorfields City Road, Ealing, Northwick Park, and St George’s Hospital sites. Only eyes receiving a minimum of 3 injections and completing 12 months of follow-up were included. If both eyes received treatment, the first eye treated was analyzed. When both eyes received initial treatment simultaneously, random number tables were used to select the eye for analysis. HbA1c was tested at the initiation of ranibizumab treatment. Multivariate regression analysis was used to identify relationships between HbA1c and the outcome measures.Outcomes
The primary outcome was change in visual acuity (VA) Early Treatment of Diabetic Retinopathy study (ETDRS) letters. The secondary outcomes were change in central subfield thickness (CSFT) and macular volume (MV), as well as number of injections in year 1.Results
Three hundred and twelve eyes of 312 patients were included in the analysis. HbA1c was not related to change in VA (p = 0.577), change in CSFT (p = 0.099), change in MV (p = 0.082), or number of injections in year 1 (p = 0.859).Conclusions
HbA1c is not related to functional or anatomical outcomes at 1 year in DME treated with ranibizumab. 相似文献19.
Dana Ahnood Ahmad Souriti Gwyn Samuel Williams 《Canadian journal of ophthalmology. Journal canadien d'ophtalmologie》2018,53(6):637-638
Objective
To canvass views about whether argon laser pretreatment to ischemic areas of retina would be acceptable if it resulted in a reduced burden of intravitreal injections.Method
A postal survey was mailed to all 813 patients under the care of the diabetic eye clinic at Singleton Hospital with 10 questions, explanatory information, and a stamp-addressed envelope available for returning completed questionnaires.Results
Patients were strongly supportive (9.14 out of 10) of the idea of undergoing laser pretreatment if it meant less injections were needed for diabetic macular edema.Conclusion
This is the first time any survey has analyzed patient attitude to laser pretreatment and showed that patients were strongly in favour if it was found to reduce the need for intravitreal injections. 相似文献20.
Dana Ahnood Ahmad Souriti Gwyn Samuel Williams 《Canadian journal of ophthalmology. Journal canadien d'ophtalmologie》2018,53(3):207-209