心脏MR初始T＿1值及组织追踪技术在心肌淀粉样变和肥厚型心肌病的初步应用价值

目的:探讨磁共振初始T₁值及组织追踪技术(CMR-TT)在鉴别心肌淀粉样变(CA)和肥厚型心肌病(HCM)中的价值。方法:对14名CA患者、16名HCM患者及16名健康受试者行3.0T心脏磁共振检查,测量基底部、乳头肌部及心尖部心肌初始T₁值,采用CMR-TT技术测量左心室三维(3D)整体纵向应变(GLS)、周向应变(GCS)及径向应变(GRS),描绘左心室心肌应变曲线。采用受试者操作特征曲线(ROC)评估初始T₁值及各应变指标对CA和HCM的鉴别诊断价值。结果:CA组总体、基底部、乳头肌部、心尖部心肌初始T₁值[分别为(1455.68±153.23)ms、(1446.97±170.53)ms、(1442.31±151.92)ms、(1468.31±141.83)ms]高于HCM组[分别为(1329.14±40.19)ms、(1329.45±46.14)ms、(1330.04±41.49)ms、(1327.41±46.55)ms],差异有统计学意义(P均<0.001)。CMR-TT应变分析结果...     

Duchenne muscular dystrophy carriers

Summary By means of magnetic resonance imaging (MRI), the proton spin-lattice relaxation times (T1 values) of the skeletal muscles were measured in Duchenne muscular dystrophy (DMD) carriers and normal controls. The bound water fraction (BWF) was calculated form the T1 values obtained, according to the fast proton diffusion model. In the DMD carriers, T1 values of the gluteus maximus and quadriceps femoris muscles were significantly higher, and BWFs of these muscles were significantly lower, than in normal control. Degenerative muscular changes accompanied by interstitial edema were presumed responsible for this abnormality. No correlation was observed between the muscle T1 and serum creatine kinase values. The present study showed that MRI could be a useful method for studying the dynamic state of water in both normal and pathological skeletal muscles. Its possible utility for DMD carrier detection was discussed briefly.     

Investigating the effect of exchange and multicomponent T(1) relaxation on the short repetition time spoiled steady-state signal and the DESPOT1 T(1) quantification method

PURPOSE: To examine the spoiled steady-state (spoiled gradient-recalled echo sequence [SPGR]) signal arising from two-compartment systems and the role of experimental parameters, in particular TR for resolving signal from each compartment. MATERIALS AND METHODS: Using Bloch-McConnell simulations, we examined the SPGR signal from two-component systems in which T(1) is much greater than the mean residence time (tau(m)) of proton spins in each component. Specifically, we examined the role of TR on the ability to resolve each components signal, as well as the influence of experimental parameters on derived DESPOT1 T(1) values. RESULTS: Results revealed that when TR < or = 0.01 tau(m), the measured SPGR signal may be modeled as a summation of signal from each species using a no-exchange approximation. Additionally, under this short TR condition, the driven equilibrium single pulse observation of T(1) (DESPOT1) mapping approach provides T(1) values preferentially biased toward the short or long T(1) species, depending on the choice of flip angles. CONCLUSION: The ability to model the SPGR signal using a no-exchange approximation may permit the quantification multicomponent T(1) relaxation in vivo. Additionally, the ability to preferentially weight the DESPOT1 T(1) value toward the short or long T(1) may provide a useful window into these components.     

Change in the proton T1 of fat and water in mixture

This work describes observed changes in the proton T₁ relaxation time of both water and lipid when they are in relatively homogeneous mixtures. Results obtained from vegetable oil–water emulsions, pork kidney and lard mixtures, and excised samples of white and brown adipose tissues are presented to demonstrate this change in T₁ as a function of mixture fat fraction. As an initial proof of concept, a simpler acetone‐water experiment was performed to take advantage of complete miscibility between acetone and water and both components' single chemical shift peaks. Single‐voxel MR spectroscopy was used to measure the T₁ of predominant methylene spins in fat and the T₁ of water spins in each setup. In the vegetable oil–water emulsions, the T₁ of fat varied by as much as 3‐fold when water was the dominant mixture component. The T₁ of pure lard increased by 170 msec (+37%) when it was blended with lean kidney tissue in a 16% fatty mixture. The fat T₁ of lipid‐rich white adipose tissue was 312 msec. In contrast, the fat T₁ of leaner brown adipose tissue (fat fraction 53%) was 460 msec. A change in the water T₁ from that of pure water was also observed in the experiments. Magn Reson Med, 2010. © 2009 Wiley‐Liss, Inc.     

First clinical application of a novel T1 mapping of the whole brain

BackgroundThe aim of this study was to evaluate the reproducibility and clinical value of the novel single-shot T1 mapping method for rapid and accurate multi-slice coverage of the whole brain, described by Wang et al. 2015.MethodsAt a field strength of 3 Tesla, T1 mappings of 139 patients (51 of them without pathologic findings) and two repeats of five volunteers were performed at 0.5 mm in-plane resolution. Mean T1 values were determined in 18 manually segmented regions-of-interest without pathologic findings. Reproducibility of the repeated scans was calculated using mean coefficient of variations. Pathologies were grouped and separately evaluated.ResultsThe mean age of the cohort was 49 (range 1–95 years). T1 relaxation times for ordinary brain and pathologies were in accordance with the literature values. Intra- and inter-subject reproducibility was excellent, and mean coefficient of variations were 2.4% and 3.8%, respectively.DiscussionThe novel rapid T1 mapping method is a reliable magnetic resonance imaging technique for identifying and quantifying normal brain structures and may thus serve as a basis for assessing pathologies. The fast and parallel online calculation enables a comfortable use in everyday clinical practice. We see a possible clinical value in a large spectrum of diseases, which should be investigated in further studies.     

Role of magnetic resonance imaging in pre-operative assessment of ano-rectal fistula

Aim of the work

To evaluate the role of magnetic resonance imaging (MRI) in preoperative assessment of ano-rectal fistula and tracing its full extent and relationship.

Materials and methods

Twenty-four patients with ano-rectal fistula were enrolled in this study. They were examined with different MRI sequences for evaluation of the fistulas and their extent. Fistulas were classified according to St. James’s University Hospital MRI based classification system (which correlates the Parks surgical classification to anatomic MRI findings) into 5 grades. Then, interrelation between surgical and MRI findings was statistically analyzed with evaluation of the accuracy of each MRI sequence used.

Results

Grade 1 was the most frequent (37.5%) type of ano-rectal fistula. The most common location of the internal opening of the fistula was at 6 o’clock position. Combination of oblique coronal and axial planes of contrast-enhanced fat suppressed T1-weighed fast spin-echo (CE FS T1WFSE) sequence images showed the highest accuracy (99.4%) in diagnosis of ano-rectal fistula.

Conclusion

MRI is a useful imaging tool in the preoperative assessment of ano-rectal fistula. A significant accordance between surgical and MRI findings was achieved by using combination of coronal and axial planes of CE FS T1WFSE sequence images.     

High magnetic field water and metabolite proton T1 and T2 relaxation in rat brain in vivo.

Comprehensive and quantitative measurements of T1 and T2 relaxation times of water, metabolites, and macromolecules in rat brain under similar experimental conditions at three high magnetic field strengths (4.0 T, 9.4 T, and 11.7 T) are presented. Water relaxation showed a highly significant increase (T1) and decrease (T2) with increasing field strength for all nine analyzed brain structures. Similar but less pronounced effects were observed for all metabolites. Macromolecules displayed field-independent T2 relaxation and a strong increase of T1 with field strength. Among other features, these data show that while spectral resolution continues to increase with field strength, the absolute signal-to-noise ratio (SNR) in T1/T2-based anatomical MRI quickly levels off beyond approximately 7 T and may actually decrease at higher magnetic fields.     

Suitability of T(1Gd) as the dGEMRIC index at 1.5T and 3.0T.

Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) is based on the theory that Gd-DTPA(2-) will distribute in inverse relation to cartilage glycosaminoglycan (GAG). T(1Gd) (T(1) after penetration of a 0.2 mmol/kg dose of Gd-DTPA(2-)) has been used as the dGEMRIC index, although (1/T(1Gd)-1/T(1o)) should be more representative of Gd-DTPA(2-) concentration (where T(1o) = T(1) before contrast). T(1o) and T(1Gd) were measured in 20 volunteers at both 1.5T and 3T and the correlation between the metrics of T(1Gd) and (1/T(1Gd)-1/T(1o)) was calculated. There was a high correlation coefficient between the two metrics at both field strengths, with R = 0.94, 0.93, and 0.90 for central medial femur, posterior medial femur, and medial tibia, respectively, at 1.5T and 0.87, 0.94, 0.96 at 3T. In all cases P < 0.0001. Therefore, these data suggest that, for native cartilage, the current practice of measuring T(1Gd) (but not also T(1o)) is adequate at both 1.5T and 3T.     

地震伤磁共振检查扫描方案的探讨

目的：探讨地震伤MRI检查的扫描时间、序列和成像平面在快速显示病变中的作用,提出地震伤MRI检查的合理扫描方案。方法：用1．5TMR根据临床要求和伤情,对20例汶川地震伤员分别行横轴位和冠状位的T1WI、T2WI及T2WI＋FS扫描,评价显示病变的效果和成像时间。结果：T2WI＋Fs序列对病变的显示范围优于T2WI,但显示解剖结构比T2WI差。轴位显示病变与周围组织清晰,但成像时间成倍增加;冠状位能在很短时间内完成较大范围扫描。结论：T1WI、T2WI及T2WI＋FS为必须扫描序列,轴位和冠状位为必须基本扫描平面;增加重BWI水成像和GRE快速序列,以显示继发脏器损伤。     

Synchronized inversion recovery-spin echo sequences for precise in vivo T1 measurement of human myocardium: A pilot study on 22 healthy subjects

An ECG-triggered, two-sequence MRI technique is proposed for the precise measurement of proton T₁ relaxation times of the human myocardium at a field strength of 0.5 T. The combination of an inversion recovery (IR) sequence and a spin echo (SE) sequence is not new. It is, however, rarely used in quantitative in vivo cardiac studies. Our approach employs a synchronization of the 90° read pulse to the systolic period. In a study of 22 healthy volunteers, the globally measured T₁ value was estimated to be 714 ± 23 ms. Four of the volunteers also underwent additional imaging scans for the purposes of reproducibility assessment. The T₁ precision was found to be 3.9 ± 1.1% for the IR/SE combination and 16.9 ± 5.3% for a combination of SE sequences. Total imaging time for the IR and SE sequences was 19.2 ± 3.0 mins. The relative rapidity of this classic technique and the T₁ precision obtained give this technique an obvious application in the discrimination of normal and diseased myocardium. In the same study, valuable supplementary tissue characterization is provided by T₂, calculated from the SE sequence. T₂ was evaluated to be 50 ± 3 ms.     

以低场磁共振为首诊急性基底节区脑出血13例影像分析

目的探讨低场强MRI对于基底节区脑出血T1、T2加权像(T1WI、T2WI)信号的影像特征,减少误诊。方法对13例以低场强磁共振为首诊的脑出血患者作常规横断位SE T1WI、FSE T2WI和T1FLAIR、T2 FLAIR序列扫描。结果与结论低场MRI对急性基底节区脑出血的诊断有特异性,充分认识,可以避免误诊。     

Characterization of proteoglycan depletion in articular cartilage using two-dimensional time domain nuclear magnetic resonance.

In vitro proteoglycan (PG) depletion in the 20-40% range (enzymatic PG depletion of normal cartilage in the early osteoarthritis (OA) PG depletion range) was investigated in articular cartilage using 2D time domain NMR relaxation techniques. Spin-lattice relaxation times were measured at low fields (T(1rho)) and at high fields (T(1)) using nonselective and selective excitation pulse sequences. The short relaxation time magnetization components in T(1rho) ( approximately 8% signal) and nonselective T(1) ( approximately 5% signal) experiments were significantly altered with PG degradation. In addition, a magnetization component ( approximately 5% signal) with a "fast " T(1) approximately 7 ms was observed in the T(1) experiment involving selective excitation. This fast T(1) was at least 10 times shorter than the short T(1) in the nonselective experiment and was associated with a strong magnetization exchange mechanism between collagen and PG. The results suggest that T(1rho) and T(1) (nonselective and selective) relaxation based MRI techniques, which focus on the short relaxation time magnetization components, have the potential of detecting molecular abnormalities associated with early OA earlier than single, long relaxation time component approaches.     

7 Tesla MR imaging of the human eye in vivo

Purpose:

To develop a protocol which optimizes contrast, resolution and scan time for three‐dimensional (3D) imaging of the human eye in vivo using a 7 Tesla (T) scanner and custom radio frequency (RF) coil.

Materials and Methods:

Initial testing was conducted to reduce motion and susceptibility artifacts. Three‐dimensional FFE and IR‐TFE images were obtained with variable flip angles and TI times. T₁ measurements were made and numerical simulations were performed to determine the ideal contrast of certain ocular structures. Studies were performed to optimize resolution and signal‐to‐noise ratio (SNR) with scan times from 20 s to 5 min.

Results:

Motion and susceptibility artifacts were reduced through careful subject preparation. T₁ values of the ocular structures are in line with previous work at 1.5T. A voxel size of 0.15 × 0.25 × 1.0 mm³ was obtained with a scan time of approximately 35 s for both 3D FFE and IR‐TFE sequences. Multiple images were registered in 3D to produce final SNRs over 40.

Conclusion:

Optimization of pulse sequences and avoidance of susceptibility and motion artifacts led to high quality images with spatial resolution and SNR exceeding prior work. Ocular imaging at 7T with a dedicated coil improves the ability to make measurements of the fine structures of the eye. J. Magn. Reson. Imaging 2009;30:924–932. © 2009 Wiley‐Liss, Inc.     

T1, T2 and proton density measurements in the grading of cerebral gliomas

The possibility that cerebral tumours may be graded by measuring T1 or T2 with magnetic resonance (MR) imaging was studied. A consecutive series of patients with subsequently verified gliomas was enrolled, and studied with MR. Patients who had prior surgical, chemotherapeutic or steroid treatment were excluded. Single slice multiple saturation recovery and multiple spin echo techniques were used to measure T1, T2 and proton density in the tumour. In 33 patients with cerebral gliomas there were 5 grade I, 12 grade II, 7 grade III and 9 grade IV. T1 and T2 values tended to be smaller in grade I gliomas than in grades II, III and IV gliomas. Relaxation parameters overlapped considerably in tumours with different grades. Proton density values did not show much change between different grades of gliomas. Relaxation parameters cannot be used to determine tumour grade reliably. Correspondence to: S. Newman