共查询到20条相似文献,搜索用时 31 毫秒
1.
Body position with respect to the head or body position in space is coded by lumbar interneurons 总被引:2,自引:0,他引:2
In decerebrate cats, we have studied the response of neurons in the L3-L6 segments of the spinal cord to stimulation of neck and vestibular receptors. Neck receptors were stimulated by head rotation in labyrinthectomized cats or by body rotation with the head fixed in labyrinth-intact cats. Vestibular receptors were stimulated by whole-body tilt in the latter preparation. Most neurons were located outside the motoneuron nuclei and were arbitrarily classified as interneurons. Combinations of roll and pitch stimuli at frequencies of 0.1 or 0.05 Hz were used to determine the horizontal component of the polarization vector, i.e., the best direction of tilt, for each neuron. Two types of stimuli were used; rotation of a fixed angle of tilt around the head or body ("wobble," Ref. 22) or sinusoidal stimuli in several planes. Polarization vectors of the responses to neck stimulation were widely distributed; different neurons responded best to roll, pitch, and angles in between. For every neuron, the amplitude of the response decreased as the cosine of the angle between the direction of maximal sensitivity and the plane of the stimulus. The direction of the vector remained stable as the frequency of stimulation was varied. Neurons with different vectors had similar dynamics that resembled those of cervical interneurons (27). Many neurons responded to both neck and vestibular stimulation, although the vestibular response usually had a much lower gain. Neck and vestibular vectors were approximately opposite in direction. We suggest that neck responses originate in receptors, probably spindles, in perivertebral muscles. Each of these muscles presumably is best stretched by a particular direction of pull. It seems likely that convergence from receptors in selected muscles determines the direction of a spinal neuron's vector. Vestibular responses probably are due mainly to activity in otolith afferents. 相似文献
2.
Laurence Ris Brigitte Capron Catherine de Waele Pierre-Paul Vidal E. Godaux 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1999,124(2):159-165
In the guinea pig, lateral deviation of the head is a cardinal symptom of the vestibular syndrome caused by unilateral labyrinthectomy. In the course of recovery from this syndrome (vestibular compensation), lateral deviation of the head disappears completely in 2–3 days. Because this symptom is known to be due to the lesion of the horizontal semicircular canal system, and since obliquus capitis inferior (OCI) muscle is activated predominantly by yaw rotation (horizontal vestibulocollic reflex), we hypothesized that changes in the activity of this muscle could be at least in part responsible for the lateral head deviation caused by unilateral labyrinthectomy. In order to test this hypothesis, electromyographic (EMG) activities of the right and left OCI muscles, as well as eye movements, were recorded in 12 head-fixed alert guinea pigs at various times after left surgical labyrinthectomy (performed with the animals under halothane anesthesia). After the operation, a decrease in tonic EMG activity was observed in the right (contralateral to the lesion) OCI muscle while an increase in tonic EMG activity was detected in the left (ipsilateral) OCI muscle. In addition, phasic changes in EMG activity associated with ocular nystagmic beats occurred in the OCI muscles. These phasic changes were in the opposite direction to those of the tonic changes. There were bursts of activity in the right OCI and pauses in the left OCI. From measurements of rectified averaged EMG activities which took into account both parts (tonic and phasic) of the phenomenon, it was concluded that the labyrinthectomy-induced asymmetry between the activities of the left and right OCI muscles was high enough and lasted long enough to be an important mechanism in the lateral deviation of the head caused by unilateral labyrinthectomy. 相似文献
3.
Robert E. McMasters Arthur H. Weiss Malcolm B. Carpenter 《Developmental dynamics》1966,118(1):163-193
In 35 monkeys attempts were made to produce localized unilateral lesions in individual vestibular nuclei in order to study vestibular projections to nuclei of the extraocular muscles. Portions of the medial, superior and inferior vestibular nuclei were destroyed selectively; lesions in Deiters' nucleus involved small portions of either the superior or inferior vestibular nuclei. Fiber degeneration was studied by the Nauta-Gygax technic. Exclusively ascending fibers from the superior vestibular nucleus project to ipsilateral extraocular nuclei. Ascending fibers from the inferior vestibular arise only from rostral portions of the nucleus, are not numerous and pass to all extraocular nuclei. The medial vestibular nucleus projects ascending fibers via the MLF bilaterally, asymmetrically and differentially to all extraocular nuclei. Prominent projections pass to: (a) the contralateral trochlear nucleus, and (b) the contralateral intermediate cell column and the ipsilateral ventral nucleus of the oculomotor complex. Ascending fibers from Deiters' nucleus, arising only from ventral portions of the nucleus, project primarily to: (a) the contralateral abducens and trochlear nuclei, and (b) specific asymmetrical portions of the oculomotor complex. Ascending vestibular fibers from the medial and lateral vestibular nuclei appear capable of mediating all patterned eye movements resulting from stimulation of ampullary nerves from individual semicircular canals. Vestibular projections to nuclei of the extraocular muscles are most abundant to those nuclei innervating muscles whose primary functions concern horizontal and rotatory eye movements. 相似文献
4.
Beloozerova IN Zelenin PV Popova LB Orlovsky GN Grillner S Deliagina TG 《Journal of neurophysiology》2003,90(6):3783-3793
A deviation from the dorsal-side-up body posture in quadrupeds activates the mechanisms for postural corrections. Operation of these mechanisms was studied in the rabbit maintaining balance on a platform periodically tilted in the frontal plane. First, we characterized the kinematics and electromyographic (EMG) patterns of postural responses to tilts. It was found that a reaction to tilt includes an extension of the limbs on the side moving down and flexion on the opposite side. These limb movements are primarily due to a modulation of the activity of extensor muscles. Second, it was found that rabbits can effectively maintain the dorsal-side-up body posture when complex postural stimuli are applied, i.e., asynchronous tilts of the platforms supporting the anterior and posterior parts of the body. These data suggest that the nervous mechanisms controlling positions of these parts of the body can operate independently of each other. Third, we found that normally the somatosensory input plays a predominant role for the generation of postural responses. However, when the postural response appears insufficient to maintain balance, the vestibular input contributes considerably to activation of postural mechanisms. We also found that an asymmetry in the tonic vestibular input, caused by galvanic stimulation of the labyrinths, can affect the stabilized body orientation while the magnitude of postural responses to tilts remains unchanged. Fourth, we found that the mechanisms for postural corrections respond only to tilts that exceed a certain (threshold) value. 相似文献
5.
Operational unit responsible for plane-specific control of eye movement by cerebellar flocculus in cat 总被引:1,自引:0,他引:1
1. Main findings in our previous studies are as follows: 1) there are three Purkinje cell zones running perpendicular to the long axis of the folia in the cat flocculus, 2) the caudal zone controls activity of the superior rectus (SR) and inferior oblique (IO) extraocular muscles via the y-group and oculomotor nucleus (OMN) neurons, and 3) the middle zone controls activity of the lateral (LR) and medial rectus (MR) muscles via the medial vestibular (MV) and abducens nucleus (ABN) neurons. In the present study, the neuronal pathways from the remaining rostral zone were investigated in the anesthetized cat. 2. Target neurons of rostral zone inhibition in the superior vestibular nucleus (SV) were identified by observing cessation of spontaneous discharges after rostral zone stimulation. Efferent projections were studied by the use of systematic microstimulation techniques. Unitary responses to stimulation of the eighth nerves were also investigated. 3. There are two types of the target neurons: 1) those, being located in the central and dorsal parts of the SV, project to the trochlear and oculomotor nuclei innervating superior oblique and inferior rectus muscles via the ipsilateral medial longitudinal fasciculus (MLF); and 2) those, being located along the dorsal border of the SV, project to the contralateral oculomotor nucleus innervating superior rectus and inferior oblique muscles via the extra-MLF route. 4. Both types receive monosynaptic anterior canal nerve input but not posterior canal nerve input. Some neurons receive polysynaptic excitatory input from the contralateral eighth nerve, although commissural inhibition was never observed. 5. From neuronal connections of the rostral and caudal zones and action of the extraocular muscles, it was expected that 1) activity changes of Purkinje cells in the rostral and/or caudal zones on one side resulted in conjugate eye movement in the plane of the anterior canal on the side of the activity changes, 2) cooperative increased activity on both sides resulted in conjugate downward eye movement, and 3) increased activity on one side and decreased activity on the other side resulted in conjugate rotatory eye movement. The rostral and caudal zones may be responsible for eye-movement control in the sagittal plane by cooperative activity changes on both sides and in the transverse plane by reciprocal activity changes on both sides. For eye-movement control in the anterior canal plane, Purkinje cell activity on one side would be sufficient to produce the required movement. In a functional sense, we call the rostral and caudal zones, the vertical-plane zones.(ABSTRACT TRUNCATED AT 400 WORDS) 相似文献
6.
Sacculo-ocular reflex connectivity in cats 总被引:3,自引:0,他引:3
Isu N Graf W Sato H Kushiro K Zakir M Imagawa M Uchino Y 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2000,131(3):262-268
The otolith system contributes to the vestibulo-ocular reflexes (VOR) when the head moves linearly in the horizontal plane or tilts relative to gravity. The saccules are thought to detect predominantly accelerations along the gravity vector. Otolith-induced vertical eye movements following vertical linear accelerations are attributed to the saccules. However, information on the neural circuits of the sacculo-ocular system is limited, and the effects of saccular inputs on extraocular motoneurons remain unclear. In the present study, synaptic responses to saccular-nerve stimulation were recorded intracellularly from identified motoneurons of all twelve extraocular muscles. Experiments were successfully performed in eleven cats. Individual motoneurons of the twelve extraocular muscles--the bilateral superior recti (SR), inferior recti (IR), superior obliques (SO), inferior obliques (IO), lateral recti (LR), and medial recti (MR) were identified antidromically following bipolar stimulation of their respective nerves. The saccular nerve was selectively stimulated by a pair of tungsten electrodes after removing the utricular nerve and the ampullary nerves of the semicircular canals. Stimulus intensities were determined from the stimulus-response curves of vestibular N1 field potentials in order to avoid current spread. Intracellular recordings were performed from 129 extraocular motoneurons. The majority of the neurons showed no response to saccular-nerve stimulation. In 17 (30%) of 56 extraocular motoneurons related to vertical eye movements (bilateral SR and IR), depolarizing and/or hyperpolarizing postsynaptic potentials (PSPs) were observed in response to saccular-nerve stimulation. The latencies of PSPs ranged from 2.3 to 8.9 ms, indicating that the extraocular motoneurons received neither monosynaptic nor disynaptic inputs from saccular afferents. The majority of the latencies of the depolarization, including depolarization-hyperpolarization, were in the range of 2.3-3.3 ms. Latencies of hyperpolarizations were typically longer than those of depolarizations. Only one contralateral SO motoneuron of 43 recorded oblique extraocular motoneurons (bilateral SO and IO) showed a depolarization-hyperpolarization in response to saccular-nerve stimulation at a latency of 2.5 ms. None of 30 recorded horizontal extraocular motoneurons (bilateral LR and MR) responded to stimulation of the saccular nerve. The neural linkage in the sacculo-ocular system is relatively weak in comparison to the utriculo-ocular and sacculo-collic systems, suggesting that the role of the sacculo-ocular system in stabilizing eye position may be reduced when compared with utriculo-ocular and semi-circular canal-ocular reflexes. 相似文献
7.
Mechanical characteristics and electrical activity were studied in the extraocular muscles of the catfish, Ictalurus punctatus. The contractile properties were determined by stimulation of the individual muscle nerve branches to lateral and medial rectii and the superior and inferior oblique muscles. The speed of contraction was higher than in most other fish muscle, with a twitch contraction time of about 12 ms and a tetanus fusion frequency of 150–170 Hz in all four eye muscles. The fatigue resistance was also high. These properties were the same in fully innervated and partially innervated muscle, largely irrespective of what part of the muscle that was activated. Although different fibre types are known to exist in fish extraocular muscle, it was not possible to obtain functional separation of the mechanical force profile even in the lateral rectus with two distinct motoneuronal innervations. We suggest that polyneuronal innervation of the muscle fibres produces the mechanical responses. Since EMG activity during spontaneous eye movements was similar in the global and the orbital parts of the muscle, all types of fibres in fish extraocular muscle are probably recruited for all types of eye movements. 相似文献
8.
Spatial organization of neck and vestibular reflexes acting on the forelimbs of the decerebrate cat 总被引:4,自引:0,他引:4
EMG recording was used to study the spatial organization of vestibular and tonic neck reflexes acting on forelimb and shoulder muscles of the decerebrate cat. Neck reflexes were studied in preparations with intact labyrinths as well as those with acute or chronic labyrinthectomies. Reflexes were described by response vectors whose orientation component is aligned with the optimal excitatory direction of tilt or head rotation. A muscle's vector orientation remained reasonably stable over a period of hours, although there was sometimes drift at the beginning or end of an experiment. Orientation of muscle response vectors did not change systematically with stimulus frequency of 0.05-2.0 Hz. For vestibular reflexes this is so, although their dynamics are consistent with convergent input from semicircular canals and otolith organs. Regardless of the preparation, a consistent reflex pattern emerged. Vestibular reflexes are characterized by response vector orientation near ear-down roll. Neck vector orientation lies in the opposite direction from the vestibular vector but typically lies further from the roll plane: Nose-up pitch is excitatory for the shoulder muscles supra- and infraspinatus, and for the medial and lateral heads of triceps, whereas nose-down pitch excites the long head of triceps. Our results generally agree with the pattern proposed by Roberts (28) for neck reflexes but disagree in part with his proposed pattern of vestibular reflexes; we did not see the expected consistent excitation by nose-down pitch. 相似文献
9.
N H Barmack 《Journal of neurophysiology》1976,39(5):1009-1019
1. The stiffness of the eye and the extraocular muscles of the conscious rabbit was measured and compared with similar measurements made on human subjects. 2. The extraocular muscles of the rabbit developed less than 0.5 g at optimal isometric length when the contralateral eye was in "primary position". Deviations of the eye of the rabbit from primary position were accomplished by an increase in force of the agonist muscle with only a nominal decrease in force in the antagonist. 3. With all muscles attached to the globe, the stiffness of the eye for displacements of up to 35 degrees from primary position was 0.11 +/- 0.03 g/deg. 4. The stiffness of the human eye to lateral rotations was 1.09 +/- 0.24 g/deg. Hence, identical disturbances in force would cause deviations in the position of the eye of the rabbit which are nearly an order of magnitude greater than those of man. 5. The stiffness of the extraocular muscles of the rabbit was sensitive to levels of muscle activation produced either by indirect electrical stimulation or by the vestibuloocular reflex. 6. The implications of these findings for the development of eye position control in animals with good binocular vision are discussed. 相似文献
10.
K Nakashima T Azumi M Ohta N Hamasaki K Takahashi 《Electromyography and clinical neurophysiology》1989,29(4):203-211
The electromyographic (EMG) responses in leg muscles after electrical stimulation of the peripheral nerves were examined in patients with myelopathy. The stimuli were delivered to the tibial nerve at the ankle joint. The EMG responses were recorded from the anterior tibial muscle at the latencies of 80-280 ms. In myelopathy patients with tonic seizures in the extremities, the EMG responses evoked both by single and repeated stimulation were frequently observed. Electrical stimulation also provoked the following tonic seizures in the legs. Stimulation of the back of the big toe or of the sural nerve, also produced the EMG responses in the anterior tibial muscle, and tonic seizure in the leg. There was no difference in the appearance of the EMG responses between patients with and without pain sensation during the seizure. A kind of flexor reflex might be related to tonic seizures in patients with myelopathy, at least in part. 相似文献
11.
Roger E. Hofer William L. Lanier Paul A. Iaizzo 《Pflügers Archiv : European journal of physiology》1995,430(5):779-786
The temporal relationship between intraocular pressure and extraocular muscle activation was studied in cats in response to the administration of the depolarizing muscle relaxant, succinylcholine (i.e. bolus doses of 0.1 and 1.0 mg/kg). Simultaneous changes in intraocular pressure, extraocular muscle force, extraocular electromyograms (EMGs), limb muscle EMGs and hindlimb muscle afferent activity were recorded. Increases in intraocular pressure were associated with extraocular muscle activation and had two components: (1) an initial abrupt increase (lasting seconds) which correlated with fasciculations within the extraocular and hindlimb muscles; and (2) a latter more sustained component (minutes) presumably due to tonic muscle activation which correlated with increases in hindlimb muscle afferent activity (e.g. due to sustained activation of bag 1 intrafusal fibers by succinylcholine). In a separate group of animals, in which the extraocular muscles were detached from the right eye bilateral intraocular pressures were measured: depolarization by succinylcholine caused a significant increase in intraocular pressure only for the eye with intact muscles. Thus, increases in intraocular pressure following the administration of succinylcholine are directly related to the changes in extraocular muscle tension which is dependent on both tonic and phasic muscle fiber responses. 相似文献
12.
P. Denise C. Darlot V. J. Wilson A. Berthoz 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1987,67(2):411-419
Summary Modulation of vestibulo-spinal reflexes by gaze is a model system for studying interactions between voluntary and reflex motor activity. In the alert cat, the EMG of Splenius and Obliquus capitis muscles increases with ipsilateral gaze eccentricity during spontaneous eye movements. Labyrinth stimulation by current pulses evokes EMGs with latencies consistent with a three neuron vestibulocollic pathway. The amplitude of evoked activity increases with eye position. The directions in which eye movements increase EMG was usually the same for both spontaneous and induced EMG activity, namely, horizontal and ipsilateral. However, sometimes the increase in spontaneous EMG occurred with horizontal eye position, whereas the induced EMG changed with vertical eye position. Spontaneous and evoked EMG are then modulated by different eye position signals. Command signals reflecting eye position probably reach two different types of neurons in the vestibulo-collic pathway, most likely secondary vestibular neurons and neck muscle motoneurons.V.J. Wilson's participation was made possible in part by NIH grant NS02619 and in part by a fellowship from I. N. S. E. R. M. 相似文献
13.
M. Fetter J. Heimberger R. Black W. Hermann F. Sievering J. Dichgans 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1996,108(3):463-472
The otolith-semicircular canal interaction during postrotatory nystagmus was studied in ten normal human subjects by applying fast, short-lasting, passive head and body tilts (15, 30, 45, or 90° in the roll or pitch plane) 2 s after sudden stop from a constant-velocity rotation (100°/s) about the earth-vertical axis in yaw. Eye movements were measured with three-dimensional magnetic search coils. Following the head tilt, activity in the semicircular canal primary afferents continues to reflect the postrotatory angular velocity vector in head-centered coordinates, whereas otolith primary afferents signal a different orientation of the head relative to gravity. Despite the change in head orientation relative to gravity, postrotatory eye velocity decayed closely along the axis of semicircular canal stimulation (horizontal in head coordinates) for large head tilts (90°) and also for small head tilts (15–45°) for reorientations in the pitch plane. Only for small head tilts (15–45°) in the roll plane was there a reorientation of the eye rotation axis toward the gravitational vector. This reorientation was approximately compensatory for 15° head tilts. For 30° and 45° head tilts the eye rotation axis tilted toward the gravitational vector by about the same amount as for 15° head tilts. These results suggest that, with the exception of small head tilts in the roll plane, there was no compelling data showing a relationship between the eye rotation axis and head tilt and that postrotatory nystagmus is largely organized in head-centered rather than gravity-centered coordinates in humans. This indicates a rudimentary, nonlinear, and direction-specific interaction of semicircular canal and otolith signals in the central vestibular system in humans. 相似文献
14.
The role of the primate superior colliculus (SC) in orienting head movements was studied by recording electromyographic (EMG) activity from multiple neck muscles following electrical stimulation of the SC. Combining SC stimulation with neck EMG recordings provides an objective and sensitive measure of the SC drive onto neck muscle motoneurons, particularly in relation to evoked gaze shifts. In this paper, we address how neck EMG responses to SC stimulation in head-restrained monkeys depend on the rostrocaudal, mediolateral, and dorsoventral location of the stimulating electrode within the SC and vary with manipulations of the eye position prior to stimulation onset and changes in stimulation current and duration. Stimulation predominantly evoked EMG responses on the muscles obliquus capitis inferior, rectus capitis posterior major, and splenius capitis. These responses became larger in magnitude and shorter in onset latency for progressively more caudal stimulation locations, consistent with turning the head. However, evoked responses persisted even for more rostral stimulation locations usually not associated with head movements. Manipulating initial eye position revealed that the magnitude of evoked responses became stronger as the eyes attained positions contralateral to the side of stimulation, consistent with a summation between a generic command evoked by SC stimulation and the influence of eye position on tonic neck EMG. Manipulating stimulation current and duration revealed that the relationship between gaze shifts and evoked EMG responses is not obligatory: short-duration (<20 ms) or low-current stimulation evoked neck EMG responses in the absence of gaze shifts. However, long-duration stimulation (>150 ms) occasionally revealed a transient neck EMG response aligned on the onset of sequential gaze shifts. We conclude that the SC drive to neck muscle motoneurons is far more widespread than traditionally supposed and is relayed through intervening elements which may or may not be activated in association with gaze shifts. 相似文献
15.
A lamprey maintains the dorsal-side-up orientation due to the activity of postural control system driven by vestibular input. Visual input can affect the body orientation: illumination of one eye evokes ipsilateral roll tilt. An important element of the postural network is the reticulospinal (RS) neurons transmitting commands from the brain stem to the spinal cord. Here we describe responses to vestibular and visual stimuli in RS neurons of the intact lamprey. We recorded activity from the axons of larger RS neurons with six extracellular electrodes chronically implanted on the surface of the spinal cord. From these multielectrode recordings of mass activity, discharges in individual axons were extracted by means of a spike-sorting program, and the axon position in the spinal cord and its conduction velocity were determined. Vestibular stimulation was performed by rotating the animal around its longitudinal axis in steps of 45 degrees through 360 degrees. Nonpatterned visual stimulation was performed by unilateral eye illumination. All RS neurons were classified into two groups depending on their pattern of response to vestibular and visual stimuli; the groups also differed in the axon position in the spinal cord and its conduction velocity. Each group consisted of two symmetrical, left and right, subgroups. In group 1 neurons, rotation of the animal evoked both dynamic and static responses; these responses were much larger when rotation was directed toward the contralateral labyrinth, and the dynamic responses to stepwise rotation occurred at any initial orientation of the animal, but they were more pronounced within the angular zone of 0-135 degrees. The zone of static responses approximately coincided with the zone of pronounced dynamic responses. The group 1 neurons received excitatory input from the ipsilateral eye and inhibitory input from the contralateral eye. When vestibular stimulation was combined with illumination of the ipsilateral eye, both dynamic and static vestibular responses were augmented. Contralateral eye illumination caused a decrease of both types of responses. Group 2 neurons responded dynamically to rotation in both directions throughout 360 degrees. They received excitatory inputs from both eyes. Axons of the group 2 neurons had higher conduction velocity and were located more medially in the spinal cord as compared with the group 1 neurons. We suggest that the reticulospinal neurons of group 1 constitute an essential part of the postural network in the lamprey. They transmit orientation-dependent command signals to the spinal cord causing postural corrections. The role of these neurons is discussed in relation to the model of the roll control system formulated in our previous studies. 相似文献
16.
Contractile properties and temperature sensitivity of the extraocular muscles, the levator and superior rectus, of the rabbit. 总被引:1,自引:1,他引:1
下载免费PDF全文
![点击此处可从《The Journal of physiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
1. Contractile and fatigue-resistance characteristics, temperature sensitivity (10-37 degrees C) of contraction, and histochemical fibre types were determined for two of the extraocular muscles, the superior rectus and levator palpebrae superioris (levator), of the rabbit. 2. The levator displayed similar contractile characteristics (time to peak, half-relaxation time of twitch response, and twitch-tetanus force ratio) to mammalian fast-twitch limb muscle at room temperature (20 degrees C). However, normalized twitch and tetanic force levels were significantly less than those found in limb muscle. The superior rectus displayed the characteristics of even faster contraction than the levator at 20 degrees C, but generated lower maximum force levels than the levator. 3. The twitch response of the superior rectus showed a biphasic relaxation phase. This response was not due to non-twitch (tonic) fibres present in the superior rectus as it was unaffected by propranolol application during muscle stimulation. 4. The superior rectus and levator displayed significantly less fatigue in the tetanic force response than fast-twitch limb muscles did in response to a fatiguing electrical stimulation protocol. The levator was significantly more fatigue resistant than the superior rectus. 5. The force responses of both extraocular muscles displayed a similar dependence on temperature (10-37 degrees C) to limb skeletal muscles. 6. The superior rectus and levator exhibited a high proportion of fast-twitch muscle fibres (type II) as shown by myosin ATPase staining. Succinate dehydrogenase activity indicated that these muscles showed a high oxidative capacity, with a staining intensity typical of type I or type II A fibres of limb muscles. 7. The results emphasize the morphological and functional complexity of mammalian extraocular muscles. The combination of very fast contractile properties with high oxidative capacity make these muscles well suited to their role in eye/eyelid movement. 相似文献
17.
Corticospinal input in human gait: modulation of magnetically evoked motor responses 总被引:12,自引:0,他引:12
M. Schubert A. Curt L. Jensen V. Dietz 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1997,115(2):234-246
Transcranial magnetic stimulation (TMS) of the motor cortex was applied during locomotion to investigate the significance
of corticospinal input upon the gait pattern. Evoked motor responses (EMR) were studied in the electromyogram (EMG) of tibialis
anterior (TA), gastrocnemius (GM) and, for reference, abductor digiti minimi (AD) muscles by applying below-threshold magnetic
stimuli during treadmill walking in healthy adults. Averages of 15 stimuli introduced randomly at each of 16 phases of the
stride cycle were analysed. Phase-dependent amplitude modulation of EMR was present in TA and GM which did not always parallel
the gait-associated modulation of the EMG activity. No variation of onset latency of the EMR was observed. The net modulatory
response was calculated by comparing EMR amplitudes during gait with EMR amplitudes obtained (at corresponding background
EMG activities) during tonic voluntary muscle contraction. Large net responses in both muscles occurred prior to or during
phasic changes of EMG activity in the locomotor pattern. This facilitation of EMR was significantly higher in leg flexor than
extensor muscles, with maxima in TA prior to and during late swing phase. A comparison of this facilitation of TA EMR prior
to swing phase and prior to a phasic voluntary foot dorsiflexion revealed a similar onset but an increased amount of early
facilitation in the gait condition. The modulated facilitation of EMR during locomotion could in part be explained by spinal
effects which are different under dynamic and static motor conditions. However, we suggest that changes in corticospinal excitability
during gait are also reflected in this facilitation. This suggestion is based on: (1) the similar onset yet dissimilar size
of facilitatory effects in TA EMR prior to the swing phase of the stride cycle and during a voluntary dynamic activation,
(2) the inverse variation of EMR and EMG amplitudes during this phase, and (3) the occurrence of this inversion at stimulation
strengths below motor threshold (motor threshold was determined during weak tonic contraction and EMR were facilitated during
gait). It is hypothesized that the facilitation is phase linked to ensure postural stability and is most effective during
the phases prior to and during rhythmical activation of the leg muscles resulting in anticipatory adjustment of the locomotor
pattern.
Received: 17 May 1996 / Accepted: 29 November 1996 相似文献
18.
S. Gustave Dit Duflo L. Borel F. Harlay J. Léonard M. Lacour 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1998,120(4):439-449
The purpose of this study was to investigate changes in neck muscle and eye movement responses during the early stages of
vestibular compensation (first 3 weeks after unilateral vestibular neurectomy, UVN). Electromyographic (EMG) activity from
antagonist neck extensor (splenius capitis) and flexor (longus capitis) muscles and eye movements were recorded during sinusoidal
visual and/or otolith vertical linear stimulations in the 0.05–1 Hz frequency range (corresponding acceleration range 0.003–1.16
g) in the head-fixed alert cat. Preoperative EMG activity from the splenius and longus capitis muscles showed a pattern of
alternate activation of the antagonist neck muscles in all the cats. After UVN, two motor strategies were observed. For three
of the seven cats, the temporal activation of the individual neck muscles was the same as that recorded before UVN. For the
other four cats, UVN resulted in a pattern of coactivation of the flexor and extensor neck muscles because of a phase change
of the splenius capitis. In both subgroups, the response patterns of the antagonist neck muscles were consistent for each
cat independently of the experimental conditions, throughout the 3 weeks of testing. Cats displaying alternate activation
of antagonist neck muscles showed an enhanced gain of the visually induced neck responses, particularly in the high range
of stimulus frequency, and a gain decrease in the otolith-induced neck responses at the lowest frequency (0.25 Hz) only. By
contrast, for cats with neck muscle coactivation, the gain of the visually induced neck responses was basically unaffected
relative to preoperative values, whereas otolith-induced neck responses were considerably decreased in the whole range of
stimulation. As concerns oculomotor responses, results in the two subgroups of cats were similar. The optokinetic responses
were not affected by the vestibular lesion. On the contrary, otolith-induced eye responses showed a gain reduction and a phase
lead. Deficits and short-term changes after UVN of otolith- and semicircular canal-evoked collic and ocular responses are
compared.
Received: 15 April 1997 / Accepted: 29 December 1997 相似文献
19.
Guzman-Lopez J Buisson Y Strutton PH Bronstein AM 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2011,214(1):37-45
We investigated the interaction between vestibular and corticospinal stimuli in 8 healthy volunteers. Vestibular stimulation
was induced with unilateral ear caloric irrigation (30°C) with subjects supine. Single transcranial magnetic stimulation (TMS)
pulses were delivered (double-cone coil, intensities 60–75% maximal output) every 10–20 s during vestibular activation and
during baseline. Bilateral surface electromyography (EMG) from splenius capitis, sternocleidomastoid (SCM), obliquus externus
abdominis, vastus lateralis, biceps femoris (BF), tibialis anterior and peroneus longus was obtained. During whole-body maximal
rotatory voluntary isometric contraction (MRVC), only SCM and BF displayed EMG activation/inhibition patterns indicating axial
rotatory action. TMS-induced motor evoked potentials (MEPs) after caloric irrigation revealed that only SCM showed consistent
vestibular-mediated excitation/inhibition responses, i.e. an increase in MEP area contralateral to the irrigation and a decrease
in MEP area ipsilaterally (+12.7 and −6.3% of the MRVC, respectively). A putative head turn induced by this SCM activity pattern
would be in the same direction of the slow-phase eye movement. EMG in the 100 ms preceding TMS showed muscle tone values of
approximately 10% of MRVC. After caloric irrigation, these values increased by ca. 2% for all muscles bilaterally and hence
cannot explain the direction-specific SCM MEP changes. Thus, SCM MEPs show caloric-induced amplitude modulation indicating
that SCM is under both horizontal semicircular canal and corticospinal control. This vestibular modulation of corticospinal
SCM control likely occurs at cortical levels. The direction of the MEP modulation indicates a directional coupling between
vestibularly induced head and eye movements. 相似文献
20.
1. The primary functions of the superior colliculus (SC) are thought to include both the spatial localization of sensory stimuli and the initiation of an orienting response. It has been hypothesized that, in cat, both of these SC functions may be influenced by feedback from the extraocular muscles. The present investigation was initiated to determine which SC cells receive this extraocular muscle feedback and how this feedback influences the discharge properties of SC cells and their ability to integrate input from other sensory modalities. These questions were addressed in cats prepared with various anesthetic agents. 2. During the course of these experiments it became apparent that responses of SC cells to extraocular muscle stimulation could be elicited only under very specific conditions, and these observations questioned the existence of functional extraocular inputs to SC cells. 3. Rotating the eye or stretching the extraocular muscles was never found to be effective in activating SC cells unless the drug chloralose was used in the experimental preparation. In these chloralose-anesthetized animals, responses to eye rotation or muscle stretch were long and variable in latency, the discharge did not reflect the metrics of the stimulus, and the velocity and amplitude thresholds of these cells usually exceeded the cat's oculomotor range. Responses usually consisted of one to three impulses and, in appropriate conditions, could be inhibited by responses to visual or auditory stimuli. 4. The origin of this SC response to eye rotation/extraocular-muscle stretch could not be localized to the extraocular muscles. Responses to passive stretch of extraocular muscles were not eliminated by anesthetizing the muscles with injections of lidocaine. Active contraction of the extraocular muscles induced by electrical stimulation of the oculomotor nerve was never observed to evoke SC responses. Furthermore, transection of the muscle nerves, which isolated the extraocular-muscle receptors from the CNS, did not affect the response initiated by stretching the extraocular muscles. However, in the absence of intact muscle nerves, pulling the periorbital tissue elicited responses very much like those produced by stretching the muscles in the intact preparation, suggesting the periorbita as the source of responses in intact preparations as well. 5. These data are not consistent with the hypothesis that feedback from extraocular-muscle receptors influences the activity of SC cells. 相似文献