Relationship among dream threat level , life events and childhood trauma in depressive patients

目的 探讨抑郁症患者梦的威胁模拟水平及其与童年创伤和生活事件的关系.方法 采用梦威胁事件问卷(DTQ)对55例抑郁症患者和51例正常对照者的梦威胁模拟水平进行调查,作童年创伤问卷(CTQ)和生活事件量表(LES)评估,分析童年创伤、生活事件与梦威胁模拟水平的关系.结果 患者组DTQ总分明显高于对照组,两组比较差异有统计学意义(P<0.01);相关分析显示,患者CTQ、LES和DTQ得分之间均呈正相关(P<0.05);童年创伤可直接预测梦威胁模拟水平(β=0.041,P<0.05),在负性生活事件与梦的威胁模拟水平的关系中起着完全中介作用.结论 抑郁症患者梦威胁模拟水平增高,童年创伤是影响梦威胁模拟水平的重要因素,生活事件通过童年创伤的完全中介效应对梦的威胁模拟水平产生影响.     

抑郁症患者梦威胁模拟水平与童年创伤和生活事件的关系

目的探讨抑郁症患者梦的威胁模拟水平及其与童年创伤和生活事件的关系。方法采用梦威胁事件问卷(DTQ)对55例抑郁症患者和51例正常对照者的梦威胁模拟水平进行调查,作童年创伤问卷(CTQ)和生活事件量表(LES)评估,分析童年创伤、生活事件与梦威胁模拟水平的关系。结果患者组DTQ总分明显高于对照组,两组比较差异有统计学意义(P<0.01);相关分析显示,患者CTQ、LES和DTQ得分之间均呈正相关(P<0.05);童年创伤可直接预测梦威胁模拟水平(β=0.041,P<0.05),在负性生活事件与梦的威胁模拟水平的关系中起着完全中介作用。结论抑郁症患者梦威胁模拟水平增高,童年创伤是影响梦威胁模拟水平的重要因素,生活事件通过童年创伤的完全中介效应对梦的威胁模拟水平产生影响。     

精神分裂症患者童年创伤与梦威胁模拟水平和功能失调性态度的相关性研究

目的探讨精神分裂症患者的童年创伤经历与梦的威胁模拟水平和功能失调性态度的关系。方法采用童年创伤问卷(CTQ)、梦威胁事件问卷(DTQ)和功能失调性态度问卷(DAS)对62例精神分裂症患者(患者组)进行评估,同时与72名正常人(对照组)作比较,分析童年创伤经历、梦威胁事件模拟水平和功能失调性态度的关系。结果患者组CTQ总分46.90±12.81、DTQ分3.68±2.70和DAS总分143.50±24.16明显高于对照组(分别为:34.41±7.05、1.83±2.35和125.63±26.09),(P<0.01)。相关分析显示,患者CTQ总分、DTQ分和DAS总分之间均两两显著相关(P<0.05);回归分析发现,梦威胁模拟水平可以直接预测功能失调性态度(β=0.263,P<0.05),在童年创伤和功能失调性态度的关系中起着完全中介作用。结论精神分裂症患者的童年创伤经历、梦的威胁模拟水平和功能失调性态度水平均增高,梦的威胁模拟水平是影响功能失调性态度的主要因素,童年创伤通过梦的威胁模拟水平的完全中介效应对功能性失调态度产生影响。     

精神分裂症患者童年创伤经历与眼区情绪识别的相关性

目的 探讨精神分裂症患者童年创伤经历及其与眼区情绪识别能力的关系.方法 采用童年创伤经历问卷(CTQ)对71例精神分裂症患者作评估,同时作眼区基本情绪识别任务(EBEDT)测试,与52例健康对照者进行比较.结果 患者组CTQ总分[(47.86±13.26)分]高于对照组[(34.27±7.27)分],情感虐待、躯体虐待、性虐待、情感忽视和躯体忽视分量表分均高于对照组,差异具有统计学意义(P＜0.01).患者组EBEDT总正确率[(73.42±11.86)％]低于对照组[(86.74±6.16)％],总平均反应时[ (4321.40±1956.83) ms]高于对照组[(2776.75±703.42) ms],喜、惊、恐、悲、厌和怒六种情绪的正确率和平均反应时两组间差异均具有统计学意义(P＜0.01).患者组CTQ总分与EBEDT总正确率及喜、惊、悲和怒眼区情绪识别的正确率呈负相关(分别为r=-0.390,r=-0.419,r=-0.451,r=-0.391,r=-0.344,P＜0.01);正常对照者CTQ总分与EBEDT总分呈负相关.结论 精神分裂症患者童年创伤水平与眼区情绪认知能力存在相关,提示早年的创伤经历可能会影响患者的社会认知功能.     

256名外来教师心理健康状况和生活事件应付方式的研究

目的 了解东莞市外来教师心理健康状况、生活事件及应付方式.方法 应用症状自评量表(SCL-90)、生活事件量表(LES)、应付方式问卷(CQ),对中学教师进行调查和分析.结果 外来教师组SCL-90总分[(150.74±44.57)分]、躯体化[(1.69±0.56)分]、强迫症状[(1.84±0.58)分]、抑郁[(1.77±0.60)分]、焦虑[(1.63±0.55)分]、敌对[(1.68±0.61)分]、精神病性因子分[(1.54±0.48)分]均高于本地组,两者差异有显著性(P＜0.01).相关分析显示,外来教师 SCL-90因子分与LES总分及因子分均呈显著正相关(P＜0.05,P＜0.01);SCL-90因子分与CQ评分中解决问题因子分呈明显负相关(P＜0.01),与CQ其他因子分呈显著正相关(P＜0.01).结论 东莞市外来教师心理健康状况较差,生活应激因素较多,应付方式欠妥.     

社会心理因素对多发性硬化患者心理健康状况的影响

目的 探讨社会、心理因素对多发性硬化(multiple sclerosis,MS)患者心理健康状况的影响及与疾病发生、发展的关系.方法 采用生活事件量表(LES)、艾森克人格问卷(EPQ)、社会支持量表(SSRS)和症状自评量表(SCL-90)对30例患者进行评估,对照组是性别、年龄、受教育年限相匹配的健康体检者.结果 1.MS组的抑郁[(2.09±0.80)分]、焦虑[(1.96±0.76)分]、恐惧[(1.73 ±0.84)分]、强迫[(1.98±0.70)分]、人际关系紧张[(1.94±0.66)分]、躯体化障碍[(1.93±0.49)分]等多种负性情绪和症状均较对照组差异具有显著性(P＜0.05);2.MS组负性生活事件总量[(38.17±41.16)分]、家庭有关问题[(33.67±35.27)分]、支持利用度[(6.97 ±1.83)分]较对照组具差异有显著性(P＜0.05);3.MS组的多种负性情绪与人格类型上的神经质得分呈正相关、与内外向得分呈负相关(P＜0.05);4.MS组的多种负性情绪与生活事件总数、负性生活事件和家庭有关问题呈正相关(P＜0.05);5.MS组的多种负性情绪与支持利用度呈负相关(P＜0.05).结论 社会心理因素与MS的发病有着十分密切的关联,作为一个主要的参与因素,它在MS的发病中起到了不可忽视的重要作用.     

精神分裂症患者梦威胁模拟水平与敌意归因偏向及精神症状的关系

目的 探讨精神分裂症患者梦威胁模拟水平与敌意归因偏向及精神症状的关系。方法 选取2017年6月至2019年5月在安徽医科大学附属心理医院精神科住院治疗的精神分裂症患者68例为患者组,另选取本院及周边社区的70例健康志愿者作为对照组。采用梦威胁事件问卷(DTQ)评估患者组和对照组的梦威胁模拟水平,采用中文版模棱两可、目的和敌意问卷(AIHQ-C)评估患者组和对照组的敌意归因偏向,采用阳性和阴性症状量表(PANSS)评估精神分裂症患者的精神症状。结果 患者组DTQ分、AIHQ-C的各项评分均高于对照组,差异有统计学意义(P＜0.05)。Spearman相关分析显示,精神分裂症患者DTQ得分与敌意偏向总分(r=0.529,P＜0.05)、责备偏向总分(r=0.398,P＜0.001)、攻击偏向总分(r=0.442,P＜0.05)及阳性症状分(r=0.395,P＜0.05)呈正相关。敌意偏向总分(r=0.507,P＜0.05)、责备偏向总分(r=0.426,P＜0.05)及攻击偏向总分(r=0.481,P＜0.05)与阳性症状分均呈正相关。精神分裂症患者DTQ总分(r=-0.272,P＜0.05)、敌意偏向总分(r=-0.299,P＜0.05)及责备偏向总分(r=-0.397,P＜0.05)与阴性症状分均呈负相关。回归分析显示,精神分裂症患者的敌意偏向与阳性症状均可以预测梦的威胁模拟水平。结论 精神分裂症患者梦的威胁模拟水平过度激活,敌意归因偏向明显,阳性症状及敌意归因偏向均对梦威胁模拟水平有一定影响。     

女性更年期综合征患者人格特征、生殖激素生活事件及生活质量的对比分析

目的 探讨人格特征、生殖激素、生活事件及生活质量在女性更年期综合征中的作用.方法 用Kupperman改良评分表、艾森克人格问卷(EPQ)、生活事件量表(LES)、世界卫生组织生存质量测定量表简表(WHOQOL-BRIEF)对84例年龄在45～55岁之间的妇女进行调查,并测定其生殖激素.将Kupperman改良量表评分大于或等于14分定为高分组(n=39),小于或等于13分定为低分组(n=45).结果 高分组EPQ-N评分[(12.31±5.07)分、LES总分(41.15±29.34)分、负性值(37.44±29.24)分]及正性值[(3.72±6.58)分]均高于低分组[(4.60±3.97)分,(3.69±10.67)分,(3.42±10.70)分,(0.27±1.10)分,P＜0.01],而WHOQOL-BRIEF中的生理分量表[(13.41±2.16)分vs(15.84±1.52)分]、心理分量表[(12.70±1.88)分vs(15.08±1.96)分]、社会关系分量表[(13.13±2.24)分vs(15.29±1.65)分]、环境分量表[(12.28±2.14)分vs(13.89±2.02)分]低于低分组(P＜0.01);高低分组6种生殖激素水平差异无显著性(P＞0.01).结论 不稳定的个性、生活事件及生活质量对更年期综合征的症状影响较大.     

躯体形式障碍患者心理社会危险因素的研究

目的 探讨躯体形式障碍患者的心理社会危险因素.方法 采用生活事件量表(LES)、防御方式问卷(DSQ)及社会支持评定量表(SSRS)对42例躯体形式障碍患者(研究组)以及45例正常志愿者(对照组)进行测查,分析躯体形式障碍患者的心理社会危险因素.结果 研究组生活事件和负性生活事件的频度及严重度、不成熟防御机制评分[分别为(2.21±0.717)分,(2.12±0.633)分,(29.62±4.254)分,(27.24±1.154)分,(4.57±0.668)分]高于对照组[分别为(1.78±0.599)分,(1.67±0.546)分,(27.24±4.453)分,(22.38±3.962)分,(3.91±0.773)分],而社会支持利用度[(6.74±3.269)分]低于对照组[(8.76±3.001)分],差异有显著性(P＜0.05).负性生活事件总值高、不成熟防御机制多和社会支持利用度低会增加躯体形式障碍发病的危险性(OR值分别为7.51,4.21,1.94,P＜0.01).结论 负性生活事件、不成熟防御机制和社会支持利用度与躯体形式障碍的发病密切相关.     

东莞市外来警察心理健康状况与生活事件应付方式的研究

目的 了解东莞市外来警察心理健康状况、生活事件及应付方式.方法 应用症状自评量表(SCL-90)、生活事件量表(LES)、应付方式问卷(CQ),对外来警察(n=136)和本地警察(n=238)进行调查和分析.结果 外来警察组SCL-90总分[(159.68±50.46)分]、抑郁[(1.79±0.62)分]、恐怖[(1.54±0.63)分]、附加因子分[(1.82±0.59)分]高于本地警察组,差异有显著性(P＜0.05).相关分析显示,外来警察SCL-90因子分与LES总分及因子分均呈显著正相关(P＜0.05),P＜0.01;SCL-90因子分与CQ评分中解决问题因子分呈明显负相关(P＜0.01),敌对、恐怖因子与CQ因子中自责无相关性,与CQ其他因子分呈显著正相关(P＜0.01).结论 东莞市外来警察心理健康状况较差,生活应激因素较多,应付方式欠妥,应引起重视.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.