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1.
目的 比较腹膜透析患者不同透析剂量的临床疗效.方法 横断面调查西安交通大学医学院第一附属医院腹膜透析中心透析超过3个月但处于稳定状态的腹膜透析患者,根据透析剂量不同分为3组,A组≤4000ml,B组≤6000ml,C组≥8000ml.比较3组患者的透析充分性、血浆白蛋白、校正的蛋白分解率、24 h腹透液蛋白定量、体表面积、用尿尿素氮清除率与尿肌酐清除率的均值计算肾小球滤过率.结果 3组患者总尿素氮清除指数和总肌酐清除率比较差异无统计学意义(P>0.05);A组患者腹膜Kt/V和腹膜总肌酐清除率与B、C组比较差异有统计学意义(P<0.01);c组患者残肾Kt/V和残肾总肌酐清除率及肾小球滤过率与A、B组比较差异有统计学意义(P<0.01);A组患者白蛋白与C组比较差异有统计学意义(P<0.15);3组间蛋白分解率比较差异无统计学意义(P>0.05).A组患者24 h腹透液蛋白定量与C组比较差异有统计学意义(P<0.05).A组患者体表面积与B、C组比较差异有统计学意义(P<0.0).A组患者促红素用量及医药费用最低.结论 (1)大多数患者使用6000 ml或6000 ml以下的透析剂量可以达到充分透析;(2)残肾功能好,体表面积小的患者,小剂量透析可以维持良好的营养状况,医疗费用越低;(3)透析时间长、残肾差、体表面积大的患者需要更高透析剂量才能维持充分透析,但腹膜透析液蛋白丢失增多,蛋白摄入不足,残肾对毒素清除减少可能使营养状况恶化.  相似文献   

2.
目的 比较腹膜透析患者不同透析剂量的临床疗效.方法 横断面调查西安交通大学医学院第一附属医院腹膜透析中心透析超过3个月但处于稳定状态的腹膜透析患者,根据透析剂量不同分为3组,A组≤4000ml,B组≤6000ml,C组≥8000ml.比较3组患者的透析充分性、血浆白蛋白、校正的蛋白分解率、24 h腹透液蛋白定量、体表面积、用尿尿素氮清除率与尿肌酐清除率的均值计算肾小球滤过率.结果 3组患者总尿素氮清除指数和总肌酐清除率比较差异无统计学意义(P>0.05);A组患者腹膜Kt/V和腹膜总肌酐清除率与B、C组比较差异有统计学意义(P<0.01);c组患者残肾Kt/V和残肾总肌酐清除率及肾小球滤过率与A、B组比较差异有统计学意义(P<0.01);A组患者白蛋白与C组比较差异有统计学意义(P<0.15);3组间蛋白分解率比较差异无统计学意义(P>0.05).A组患者24 h腹透液蛋白定量与C组比较差异有统计学意义(P<0.05).A组患者体表面积与B、C组比较差异有统计学意义(P<0.0).A组患者促红素用量及医药费用最低.结论 (1)大多数患者使用6000 ml或6000 ml以下的透析剂量可以达到充分透析;(2)残肾功能好,体表面积小的患者,小剂量透析可以维持良好的营养状况,医疗费用越低;(3)透析时间长、残肾差、体表面积大的患者需要更高透析剂量才能维持充分透析,但腹膜透析液蛋白丢失增多,蛋白摄入不足,残肾对毒素清除减少可能使营养状况恶化.  相似文献   

3.
目的 比较腹膜透析置管术中不同置管方法对置管成功率、导管通畅性及术后并发症、导管生存率的影响.方法 回顾性分析198例行腹膜透析置管术并长期随访的持续不卧床腹膜透析(CAPD)患者,其中应用导丝置管108例,卵圆钳置管90例.统计术中的置管重复次数、导管首次通畅率,观察术后腹腔出血发生率、腹壁渗液发生率、导管移位率以及导管生存率.结果 导丝置管重复次数为2.80±0.82次,卵圆钳置管重复次数为1.30 ±0.56次,差异有显著性(P<0.05);术中导管首次通畅率分别78.7%和91.1%.差异有显著性(P<0.05);术后腹腔出血发生率分别是7.41%和0,差异有显著性(P<0.05);腹壁渗液分别有2例和4例,差异无显著性(P>0.05);术后1年内导管移位发生率分别为11.5%和4.3%,差异有显著性(P<0.05);术后1年导管生存率分别为93.5%和100%,差异有显著性(P<0.05).结论 在腹膜透析置管手术中采用卵圆钳置管能够更为准确将导管置入目标位置,提高置管成功率,减少腹腔出血并发症,改善术后导管通畅性、降低术后导管移位以及提高导管生存率,值得推广应用.  相似文献   

4.
目的 比较Tenckhoff直管与卷曲管在维持性腹膜透析患者中的临床疗效.方法 对行腹膜透析置管术的133例成人慢性肾衰竭病例进行回顾性分析,根据其所使用的腹透置管类型不同,将患者分为末端直管组(68例)和卷曲管组(65例)两组,统计其腹膜透析引流速度、并发症、生存时间、退出透析或死亡等结局并进行比较.结果 两组患者腹膜透析的隧道口感染率、腹膜透析液引流速度、生存时间等无差别(P>0.05).术后2周内导管移位共5例,其中卷曲管4例,直管1例,两组比较有统计学意义(P<0.05).入液时疼痛,直管组7例,卷曲管组1例,两组比较有统计学意义(P<0.05).结论 Tenckhoff直管与卷曲管均适用于CAPD患者,各有优缺点,建议个体化选择腹膜透析用管.  相似文献   

5.
腹膜炎对CAPD患者腹膜小分子物质转运与超滤功能的影响   总被引:1,自引:1,他引:0  
目的观察了腹透时间、腹膜炎对连续非卧床腹膜透析(CAPD)患者腹膜转运与超滤功能的影响.方法观察对象为1998年~2001年在我透析中心行CAPD患者101例,其中发生腹膜炎者12例,为观察组;无腹膜炎发作史者89例,为对照组.于开始腹透后第1、6、12、18、24月分别进行腹膜平衡实验(PET),用于评价腹膜的小分子溶质转运(D/Pcreat)及超滤能力(UF).结果在无腹膜炎发作史的89例患者中,其D/Pcreat比值随腹透的进行而逐渐缓慢上升,至12个月时达到最大值(0.65±0.05),与透析第1个月相比无显著性差异(0.61±0.06,P=0.065);在伴有腹膜炎发作史者,其D/Pcreat比值上升幅度较大,并于腹透的第12个月也达到高峰值(0.74±0.056),与对照组相比有显著性差异(P<0.05);在开始CAPD后,所有患者超滤量(UF)随透析时间延长,呈快速下降过程,特别是在伴有腹膜炎发作史的患者更为明显.无腹膜炎发作史的患者于透析第18个月达到最低水平(351±48 ml),与透析第1个月相比有显著性差异(382±42 ml,P<0.05),而伴有腹膜炎发作史的患者则于开始透析后的第12个月达最低水平(326±57 ml),两组的差别具有统计学意义(P<0.05).经线性回归分析,累积腹膜炎发作时间与腹膜肌酐转运水平(D/Pcreat)呈明显正相关(r=0.83),与腹膜超滤量(UF)呈负相关(r=-0.75).结论以糖为基质的常规CAPD对腹膜转运功能与超滤功能具有一定的负面影响,而腹膜炎则明显加剧或恶化常规CAPD对腹膜功能的负面作用.因此,进一步提高CAPD技术与方法,降低腹膜炎发生率仍是肾科工作者所面临的主要问题之一.  相似文献   

6.
目的:探讨局麻下腹腔镜技术应用于腹膜透析置管术的可行性与临床疗效。方法:总结分析10例尿毒症患者局麻下行腹腔镜腹膜透析置管术的临床资料。脐上缘(A点)建立CO2气腹,置入5 mm腹腔镜,在腹腔镜监测下于脐下2 cm左旁开1.5 cm处(B点)向下隧道式穿刺入腹,由此置入腹膜透析管,再平B点向左7 cm垂直向下1.5 cm处(C点)置入弯分离钳,将一端准确置入膀胱直肠陷窝或子宫直肠陷窝,另一端经皮下隧道经C点引出体外。结果:腹膜透析管均放置成功,手术时间15~20 min,效果非常满意,并成功进行腹膜透析,未发生透析管漂浮、渗漏、堵管等并发症。结论:局麻下腹腔镜腹膜透析置管术是定位精确、安全可行的新方法。与传统开放手术相比,腹部切口更微创,患者痛苦轻,术后康复快,住院时间短,可尽早下床活动,值得临床推广应用。  相似文献   

7.
目的 探讨通过改进腹膜透析置管手术方法减少导管相关并发症的发生,提高腹膜透析质量.方法 2014年12月至2015年12月于本院住院的145例终末期肾脏病行腹膜透析置管的患者,随机分为观察组71例和对照组74例进行对照研究,观察并比较两组患者术后1年内漂管移位、网膜包裹、血块或纤维素阻塞、漏液、腹膜炎、隧道炎以及出口感染等并发症的发生率.结果 观察组患者采用改良腹膜透析置管术后1年内导管移位3例(4.22%),网膜包裹2例(2.81%);对照组1年内导管移位10例(13.51%),网膜包裹5例(6.75%),两组比较差异具有统计学意义(P<0.05).术后随访1年内两组患者总的导管相关并发症发生率,观察组为22.53%(16/71),对照组为40.55%(30/74),具有显著统计学差异(P<0.05).结论 改良后的腹膜透析置管术可有效降低导管相关并发症,进一步提高腹膜透析的质量,且手术操作简易、方便、安全,利于在基层医院开展运用,具有一定的临床应用价值.  相似文献   

8.
目的评估和总结腹膜透析(PD)治疗中合并腹壁疝治疗的临床经验。方法回顾性分析2000年5月到2010年12月连续性非卧床腹膜透析(CAPD)治疗中合并腹壁疝93例患者的临床资料。结果腹膜透析患者中,89例(95.7%)的患者行无张力疝修补术,术后无复发;行传统疝修补术4例(4.3%),复发3例,二次手术行无张力疝修补术,术后均未复发。术后住院天数3~11d,平均5.1d。结论腹膜透析治疗中合并腹壁疝宜尽早施行无张力疝修补术,术后早期有计划的逐步恢复CAPD是切实可行的。  相似文献   

9.
川芎嗪对不卧床连续性腹透的透析效能的影响   总被引:4,自引:1,他引:3  
目的将川芎嗪注射液(Lignstrazin,Lig)加至腹膜透析液中,观察其对腹透效能影响。方法将10例不卧床连续性腹膜透析(CAPD)患分成两组,每组5例病人,各观察不同处理的10个透析周期.其中5例病人腹透液中加入Lig,每2升40mg,另一组5例病人使用单纯腹透液透析,观察两组病人腹透时肌酐(Scr)尿素氮(BUN)尿酸(UA)的清除率。结果川芎嗪能显提高腹膜对BUN、Scr、UA清除率和超滤量。  相似文献   

10.
目的:探讨持续性不卧床腹膜透析(continuous ambulatory peritoneal dialysis,CAPD)合并腹茧症患者的诊断及治疗方法。方法:回顾分析14例CAPD并发腹茧症患者的临床资料。结果:14例腹茧症均经手术或腹腔镜探查确诊。腹腔镜探查时患者无死亡病例及并发症发生,术后发生并发症5例,死亡1例。随访2~10年,6例患者死于尿毒症及合并症,3例反复发作不完全性肠梗阻,均经非手术治疗痊愈。结论:CAPD并发腹茧症术前诊断困难,影像学检查及腹腔镜探查有助于明确诊断。手术并发症及死亡率较高,手术松解、解除梗阻是有效的治疗手段。  相似文献   

11.
Background: Continuous ambulatory peritoneal dialysis (CAPD) is an effective form of treatment for patients with end-stage renal disease. Open insertion of peritoneal dialysis (PD) catheters is the standard surgical technique, but it is associated with a relatively high incidence of catheter outflow obstruction and dialysis leak. Omental wrapping is the most common cause of mechanical problems. The purpose of this study was to determine the efficacy of the laparoscopic omental fixation technique to prevent the obstruction caused by omental wrapping and also to compare this laparoscopic technique with open peritoneal dialysis catheter insertion with respect to postoperative discomfort, complication rates, and catheter survival. Methods: Between March 1998 and October 2001, 42 double-cuff, curled-end CAPD catheters were placed in 42 patients. The outcomes of the 21 patients in whom the PD catheters were placed laparoscopically with omental fixation technique were compared with those of the 21 patients in whom the catheters were placed with open surgical technique. Recorded data included patient demographics, catheter implantation method, early and late complications, catheter survival, and catheter outcome. Results: Early peritonitis episodes occurred in 8 of 21 patients (38.0%) in the open surgical group (OSG) versus 2 of 21 patients (9.5%) in the laparoscopic omental fixation group (LOFG) (p < 0.05); late peritonitis episodes occurred in 3 of 21 patients (14.2%) in the OSG versus 1 of 21 patients (4.7%) in the LOFG (p < 0.05). Early exit site infection occurred in 8 of 21 patients (38.0%) in the OSG versus 4 of 21 patients (19.0%) in the LOFG (p < 0.05), with many catheter-related problems in the conventional surgical group. There was no outflow obstruction in the LOFG. The conventional procedure was faster than the laparoscopic omental fixation technique. Analgesic requirements and hospital stay were less in the laparoscopic group. Laparoscopic surgery also enabled diagnosis of intraabdominal pathologies and treatment of the accompanying surgical problems during the same operation. Occult inguinal hernia was diagnosed in 2 patients, inguinal hernioplasty was performed in 4 patients, adhesiolysis was performed in 8 patients who had previous abdominal surgery, and liver biopsy was taken in 2 patients. Ovarian cystectomy was performed in another patient during laparoscopic CAPD catheter placement. Conclusion: The laparoscopic omental fixation technique (described by Öünç and published in 1999) is a highly effective and successful method for preventing obstruction due to omental wrapping with a better catheter survival. Laparoscopic surgery also allows the diagnosis and treatment of the accompanying surgical pathologies during the same operation.  相似文献   

12.
BACKGROUND: Peritoneal fluid eosinophilia (PFE), which is classically associated with idiopathic eosinophilic peritonitis (EP), has been known as a common event in patients on continuous ambulatory peritoneal dialysis (CAPD). However, our recent retrospective study of CAPD patients following percutaneous catheter placement showed that PFE occurred rarely. The aim of this prospective study was to clarify the incidence and characteristics of idiopathic EP and PFE in patients on CAPD following percutaneous catheter placement. METHODS: Forty-eight patients on CAPD following percutanous catheter placement were recruited for the present study. Peritoneal dialysis was initiated immediately after catheter insertion without break-in period. A cytological study of dialysate was performed on days 1, 2, 3, 4, 5, 6, 7, 14 and 30 after initiation of CAPD, and then monthly for 6 months. In addition, a cytological study was performed also when a patient revealed abdominal pain or cloudy peritoneal effluent. RESULTS: PFE developed in three (6.3%) patients during the study period. The incidence of idiopathic EP and PFE without any clinical findings suggestive of PD-related peritonitis was 2.1% and 4.2% respectively. All cases of PFE, including idiopathic EP, developed on a mean of 13 day following initiation of CAPD and resolved spontaneously after a mean of 7 days. There was no significant difference in IgE levels or the occurrence of peripheral blood eosinophilia between patients with PFE and those without. CONCLUSION: Idiopathic EP is infrequent among patients on CAPD following percutaneous catheter placement, but should be differentiated from infectious PD-related peritonitis.  相似文献   

13.
Malfunction of a peritoneal dialysis (PD) catheter is common and usually occurs shortly after its insertion, due to omental wrapping. In fact, we have encountered this complication in 183 of 578 (31.6%) patients treated at our hospital since 1987. To overcome this problem, I have devised a new laparoscopic technique for catheter insertion. First, the omentum is fixed onto the peritoneum of the lateral abdominal wall at two points using a laparoscopic instrument (Pro Tack 5-mm Auto Suture, Norwalk, CT, USA) placed at the level of the umbilicus. The catheter is then introduced through the umblical trocar deep into the true pelvis. The cuff is positioned between the posterior rectus sheath and the rectus fibers, and the fascia is sewn. The catheter is then pulled through the 5-mm trocar site. This technique was successfully performed on ten patients with a median age of 46.1 years. There was no morbidity or any malfunction in continuous ambulatory peritoneal dialysis (CAPD) during follow-up periods ranging from 20 days to 9 months. Therefore, this new laparoscopic technique may prevent the obstruction caused by omental wrapping in CAPD. Received: October 13, 2000 / Accepted: May 15, 2001  相似文献   

14.
15.
Background. Starting continuous ambulatory peritoneal dialysis (CAPD) immediately after insertion of a peritoneal dialysis catheter is essential in end-stage renal disease (ESRD). In relation to the insertion methods, various mechanical and infectious complications may arise. In this study, we aimed to compare early complications of the laparoscopic tunneling method of CAPD placement that we developed recently in order to minimize the complications, with those of the conventional percutaneous method. Subjects and method. Included in this study were 12 consecutive patients with ESRD to whom we introduced catheters for CAPD by way of laparoscopic tunneling between April 2003 and July 2003 and followed up for at least 6 months, and 30 patients to whom the catheters were placed percutaneously in the same time period with the same follow-up time. The complications seen during the first 6 months after catheter placement with these two different methods were compared. Results. In all of the subjects, dialysis was started soon after catheter placement. No per-operative morbidity was seen in any of the patients. While with laparoscopic tunneling method no mechanical problem was seen, the percutaneous method resulted in early leakage in 10%, pericatheter bleeding in 3.3%, and hernia in 3.3% of the patients. As infectious complications, peritonitis occurred as one episode/36 patient-months in laparoscopic tunneling and one episode/22.5 patient-months in percutaneous method; catheter insertion site infection was seen in none in the laparoscopic method, while one episode/90patient-months was seen with the percutaneous method. Tunnel infection did not arise in any of the subjects. Conclusion. The authors of this study think that the peritoneal tunneling method for introducing CAPD, which has been recently developed and began to be routinely used by them, is rather safe in terms of early complications.  相似文献   

16.
A 40-year-old male underwent tube placement surgery for continuous ambulatory peritoneal dialysis (CAPD). A 2-cm skin incision was made, and the peritoneum was reflected enough to perform secure fixation. A swan-necked, double-felted silicone CAPD catheter was inserted, and the felt cuff was sutured to the peritoneum to avoid postoperative leakage. An adequate gradient for tube fixation to the abdominal wall was confirmed. The CAPD tube was passed through a subcutaneous tunnel. Aeroperitoneum was induced to confirm that there was no air leakage from the sites of CAPD insertion. Two trocars were placed, and we confirmed that the CAPD tube led to the rectovesical pouch. Tip position was reliably observed laparoscopically. Optimal patency of the CAPD tube was confirmed during surgery. Placement of CAPD catheters by laparoscopic-assisted surgery has clear advantages in simplicity, safety, flexibility, and certainty. Laparoscopic technique should be considered the first choice for CAPD tube insertion.  相似文献   

17.
BACKGROUND: Icodextrin dialysate used for peritoneal dialysis contains an iso-molar glucose polymer solution, which provides sustained ultrafiltration over long dwell times and is considered a valuable approach to reduce intraperitoneal glucose exposure. However, several side effects have been described, including abdominal pain and allergic and hypersensitivity reactions. Also, reactions compatible with chemical peritonitis have been reported. Over the period of a few months (January 2002-May 2002), a remarkable increase in the number of continuous ambulatory peritoneal dialysis (CAPD) patients using icodextrin dialysate diagnosed with sterile peritonitis was observed in our unit. METHODS: Five of the CAPD patients using icodextrin dialysate in our unit and diagnosed with sterile peritonitis were screened for leucocyte count and leucocyte differentiation during a follow-up period of 77 +/- 23 days. In addition, expression of CD14, a receptor for lipopolysaccharide (LPS), on the peripheral and peritoneal monocyte population was analysed. These results were compared to CAPD patients suffering from bacterial peritonitis. RESULTS: The peritoneal leucocyte count of CAPD patients using icodextrin dialysate and diagnosed with sterile peritonitis did not decrease significantly before treatment with icodextrin dialysate was interrupted, whereas it currently disappeared within 2-4 days in proven bacterial peritonitis. The sterile, cloudy icodextrin effluent contained an excess of macrophages on the day of diagnosis, whereas in bacterial peritonitis essentially an increase in the granulocyte population was observed. No elevation in the eosinophil population was observed. In contrast to bacterial peritonitis, we observed no increase in CD14 expression on the peripheral and peritoneal macrophages on the day of presentation and during the follow-up period. CONCLUSIONS: Specific batches of the icodextrin CAPD fluids contain a macrophage chemotactic agent, which causes a sustained inflammatory state in the peritoneal cavity. Because no increase in the expression of the LPS receptor CD14 could be observed, the increased peritoneal leucocyte count is probably not caused by LPS or LPS-like (possibly peptidoglycan-like) contamination.  相似文献   

18.
Bacillus licheniformis is a rare pathogen in continuous ambulatory peritoneal dialysis (CAPD) peritonitis. Only one case of B. licheniformis peritonitis has been previously reported but relapsing peritonitis by same species has not been reported. A 31-year-old man undergoing CAPD was admitted to our hospital with diarrhoea and turbid peritoneal effluent. Although B. licheniformis was cultured at his previous admission, we did not consider the species as a pathogen. After the same species was cultured twice consecutively at the subsequent admission, we confirmed that B. licheniformis was a pathogen of CAPD peritonitis. After appropriate intraperitoneal antibiotics therapy, the patient improved. He is currently undergoing CAPD without catheter removal.  相似文献   

19.
BACKGROUND: Plasma ghrelin exerts widespread bioactivities. Although it is effectively removed from the blood by a single course of haemodialysis, peritoneal clearance of ghrelin is uncertain. Our study aimed to determine (i) whether there is a correlation between plasma ghrelin levels and characteristics of peritoneal ghrelin clearance, and (ii) whether plasma ghrelin levels significantly impact markers of mortality or morbidity in continuous ambulatory peritoneal dialysis (CAPD) patients. METHODS: We enrolled 50 qualified CAPD patients. Blood was drawn during the fasting state and 2 h post-prandially. Also during these periods, peritoneal effluents were collected for radioimmunoassay of total plasma ghrelin level and measurement of other parameters. Twenty-four hour ascites were collected for determination of ghrelin daily mass transfer. RESULTS: Peritoneal ghrelin clearance was positively correlated with the dialysate-peritoneal creatinine (D/P(Cr)) ratio. Fasting plasma ghrelin levels were inversely correlated with the peritoneal/plasma (D/P(ghrelin)) ratio (P = 0.045). Plasma ghrelin levels were negatively correlated with body mass index, waist-hip ratio, fasting insulin and triglyceride level, and positively correlated with lean body mass. Plasma ghrelin levels were positively correlated with left ventricular mass (LVM), left ventricular mass index and blood pressure. CONCLUSIONS: Peritoneal transporter characteristics may modulate plasma ghrelin levels in CAPD subjects. By contributing to the level of plasma ghrelin, dwelling time may have an impact on LVM and associated morbidity in CAPD patients.  相似文献   

20.
Abstract: Peritoneoscopic surgery has been performed widely for a variety of abdominal surgical diseases. We describe here a safe and reliable technique of laparoscopic-assisted mesenterioadhesiotomy and peritoneal Tenckhoff catheter placement in patients who have previously undergone abdominal surgery. Five patients suffering from end-stage renal failure previously underwent single and/or polyabdominal surgery. The surgical procedures included hysterectomy, ovarian resection, appendectomy, and transabdominal right nephrectomy. Under general endotrachial anesthesia, a laparoscope was placed down through a direct cut made using a trocar. After CO2 gas insufflation, another one or two trocars were put in place for surgical procedures. To avoid intestinal injury, mesenterioadhesiotomy was performed carefully using a high-frequency hook electrode, forceps, and scissors forceps, and the Tenckhoff catheter was subsequently inserted with forceps directly into Douglas' fossa. Peritoneal equilibration tests performed 30–70 days after the initiation of continuous ambulatory peritoneal dialysis (CAPD) treatment revealed moderate to good peritoneal effectiveness. This procedure permits the surgeon to perform safe and exact catheter placement into Douglas' fossa even when there is a possibility that peritoneal and mesenterial adhesion are present. We believe that this technique of catheter placement may extend the indication for CAPD treatment in patients with predisposing lower abdominal surgery.  相似文献   

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