共查询到20条相似文献,搜索用时 640 毫秒
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Amr F. Mourad Hosam El-din G. Mohammad Mona M. Sayed Mohamed A. Ragae 《The Egyptian Journal of Radiology and Nuclear Medicine》2017,48(3):661-669
Objective
To evaluate the additional diagnostic value of diffusion and perfusion MRI in the differentiation of glioblastoma multiforme (GBM) and solitary brain metastasis.Patients and methods
This retrospective study included 24 patients with histologically proven brain tumors who underwent conventional MRI with analysis of diffusion (DWI) and perfusion (PWI) MRI findings of each tumor. The Apparent Diffusion Coefficient (ADC) values were calculated in the minimum (ADC-MIN), mean (ADC-MEAN), and maximum (ADC-MAX) in all the tumors and the peritumoral regions. The PWI data was expressed as maximum regional cerebral blood volume (rCBV) of the tumors and peritumoral regions.Results
After adding diffusion and perfusion to conventional MRI findings, we found that the accuracy of differentiation between glioblastoma multiforme (GBM) and solitary metastasis increased from 70% to 90%.There is a significant difference in DWI signal intensity between GBM and metastatic tumors (P < 0.05). The ADC values of GBM were lower than that of metastatic tumors. On perfusion MRI, the maximum rCBV of the peritumoral region (rCBVP) of GBM was higher than that of brain metastases (P < 0.001).Conclusion
The addition of diffusion and perfusion to the MRI protocol increases the accuracy of differentiation between GBM and solitary brain metastasis and should be considered routinely. 相似文献3.
Koji Ogomori Satoru Majima Yasuo Kuwabara Koichi Takano Masanari Nonokuma Kengo Yoshimitsu Ryoji Nishimura 《Annals of nuclear medicine》2013,27(4):371-377
Objective
The aim of this study was to clarify the difference between the morphological and perfusion changes occurring with the progression of Alzheimer’s disease (AD).Methods
The study focused on 37 patients who were clinically diagnosed with AD and were examined by both MRI and perfusion SPECT twice during a 1- to 2-year clinical observation period. Twenty-four of the 37 patients showed a progression of cognitive deterioration during the 1.2(±0.4)-year period of clinical observation (rapidly progressing group: initial mean MMSE score = 23.3; second mean MMSE score = 20.2), while 13 patients showed no apparent progression of cognitive deterioration (slowly progressing group: initial mean MMSE score = 21.2; second mean MMSE score = 22.2). The morphological changes were evaluated using a voxel-based morphometric technique with segmented MRI images. Cerebral perfusion was measured by Tc-99m ECD SPECT. Data analysis was performed by SPM on a MATLAB work space (2007.a).Results
There was no significant difference in either the perfusion or gray matter density between the rapidly progressing and slowly progressing groups at the initial examination. The rapidly progressing group showed an interval decrease of perfusion in the bilateral parieto-occipital cortex and a decrease of gray matter density in the bilateral temporal and cingulate cortex. The slowly progressing group did not show a significant interval change in either the cerebral perfusion or gray matter density.Conclusions
These results suggest that rapid symptomatic progression in AD patients accompanies rapid progression of both morphological and perfusion changes, although the regions of the changes differ between them. 相似文献4.
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Yeh BM 《Radiology》2006,241(3):633-634
Taillieu et al have shown that it is possible to noninvasively measure the placental blood flow, fractional volume of the maternal vascular placental compartment, and rate of transfer of contrast material between the maternal and fetal circulation in gravid mice through the use of dynamic contrast-enhanced MR imaging. Clearly, much work lies ahead before functional evaluation of the placenta becomes a clinical reality, but contrast-enhanced imaging shows promise for functional evaluation of placental disease. 相似文献
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A. Djuric-Stefanovic Dj. Saranovic D. Masulovic A. Ivanovic P. Pesko 《European journal of radiology》2013
Purpose
To estimate if CT perfusion parameter values of the esophageal cancer, which were obtained with the deconvolution-based software and maximum slope algorithm are in agreement, or at least interchangeable.Methods
278 esophageal tumor ROIs, derived from 35 CT perfusion studies that were performed with a 64-MDCT, were analyzed. “Slice-by-slice” and average “whole-covered-tumor-volume” analysis was performed. Tumor blood flow and blood volume were manually calculated from the arterial tumor-time–density graphs, according to the maximum slope methodology (BFms and BVms), and compared with the corresponding perfusion values, which were automatically computed by commercial deconvolution-based software (BFdeconvolution and BVdeconvolution), for the same tumor ROIs. Statistical analysis was performed using Wilcoxon matched-pairs test, paired-samples t-test, Spearman and Pearson correlation coefficients, and Bland–Altman agreement plots.Results
BFdeconvolution (median: 74.75 ml/min/100 g, range, 18.00–230.5) significantly exceeded the BFms (25.39 ml/min/100 g, range, 7.13–96.41) (Z = −14.390, p < 0.001), while BVdeconvolution (median: 5.70 ml/100 g, range: 2.10–15.90) descended the BVms (9.37 ml/100 g, range: 3.44–19.40) (Z = −13.868, p < 0.001).Both pairs of perfusion measurements significantly correlated with each other: BFdeconvolution, versus BFms (rS = 0.585, p < 0.001), and BVdeconvolution, versus BVms (rS = 0.602, p < 0.001). Geometric mean BFdeconvolution/BFms ratio was 2.8 (range, 1.1–6.8), while geometric mean BVdeconvolution/BVms ratio was 0.6 (range, 0.3–1.1), within 95% limits of agreement.Conclusions
Significantly different CT perfusion values of the esophageal cancer blood flow and blood volume were obtained by deconvolution-based and maximum slope-based algorithms, although they correlated significantly with each other. Two perfusion-measuring algorithms are not interchangeable because too wide ranges of the conversion factors were found. 相似文献7.
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Diagnosis of perfusion abnormality of the pulmonary artery in Takayasu’s arteritis using contrast-enhanced MR perfusion imaging 总被引:1,自引:0,他引:1
To determine the clinical efficacy of contrast-enhanced magnetic resonance (MR) perfusion imaging in the diagnosis of perfusion
abnormality in the pulmonary artery (PA) in Takayasu’s arteritis (TA). Twenty-one patients were evaluated. Pulmonary MR perfusion
images were acquired using a 2-dimensional (2D) fast spoiled gradient echo sequence with single-slice technique (TR/TE, 5.3/1.3;
flip angle, 30°; receiver bandwidth, 31.2 kHz/pixel; acquisition time, 0.7 s; and total acquisition time, 49 s). Seventy continuous
subtracted MR images were evaluated, and the presence of perfusion abnormality was determined in lobe-based (n=126) and patient-based (n=21) analyses. Sensitivity, specificity, positive predictive value (PPV), and negative predictive values (NPV) were calculated
using perfusion scintigraphy as a standard reference. For lobe-based analysis, sensitivity was 91.7–95.8%, specificity was
92.2–93.7%, and PPV and NPV were 73.3–76.7% and 97.9–99.0%, respectively. For patient-based analyses, sensitivity was 100%,
specificity was 72.7%, and PPV and NPV were 76.9% and 100%, respectively. Kappa values for each analysis were between 0.78–1.00.
In conclusion, MR perfusion imaging appears to be a valuable, noninvasive method to estimate PA involvement in patients with
TA. 相似文献
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Sander C. J. Verfaillie Sofie M. Adriaanse Maja A. A. Binnewijzend Marije R. Benedictus Rik Ossenkoppele Mike P. Wattjes Yolande A. L. Pijnenburg Wiesje M. van der Flier Adriaan A. Lammertsma Joost P. A. Kuijer Ronald Boellaard Philip Scheltens Bart N. M. van Berckel Frederik Barkhof 《European radiology》2015,25(10):3050-3059
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C Giuntini 《The quarterly journal of nuclear medicine》2001,45(4):281-286
The diagnostic strategy for pulmonary embolism, based on the mismatch of the ventilation/perfusion scan, was developed some 30 years ago on the following assumption: since the disorder involves the pulmonary vessels, it was surmised that in the embolized regions lung alveoli are unperfused or poorly perfused but well ventilated. Hence, it was inferred that this disorder was characterized, unlike parenchymal disease, by ventilation/perfusion mismatch in the affected lung zones and by an obvious increase of wasted ventilation, i.e., dead space. As matter of fact, experimental evidence on the redistribution of ventilation away from the vascular occluded lung had been already obtained in the early 60s of the last century. More recently, the behavior of regional pulmonary ventilation (V(A)) and blood flow (Q) in patients with acute pulmonary embolism (APE) has been studied by applying the multiple inert gas elimination technique (MIGET). It has been shown that the development of lung units with high V(A)/Q ratio (those with relative prevalence of perfusion obstruction) is accompanied by substantial redistribution of ventilation away from these units. Furthermore, radioisotopic techniques, used to visualize the topographic distributions of V(A) and Q in the same patients studied by MIGET, have shown reduced or absent V(A) in the embolized regions. This may occur by different mechanisms in the various stages of APE: bronchoconstriction mediated by local hypocapnia, atelectasis (occasionally hemorrhagic) related to alteration of surfactant production, bronchiolar obstruction and pulmonary infarction ascribed to degenerative and/or necrotic changes secondary to insufficient blood flow. In dogs and humans alike, the dead space measured by MIGET does not increase and that obtained from CO2 increases far less than the amount of unperfused lung in APE thus confirming a substantial redistribution of ventilation away from the embolized lung zones. Taken together, all these observations provide the pathophysiological explanation of the unacceptedly low level of sensitivity for the diagnostic strategy of APE based on the mismatch of the ventilation/perfusion scan. 相似文献
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《European journal of radiology》1998,26(3):297-303
Objective: Renal perfusion imaging may provide information about the hemodynamic significance of a renal artery stenosis and could improve noninvasive characterization when combined with angiography. It was proposed previously that diffusion sequences could provide useful perfusion indices based on the intravoxel incoherent motion (IVIM) model. Owing to motion artifacts, diffusion imaging has been restricted to relatively immobile organs like the brain. With the availability of single-shot echo-planar imaging (EPI) our purpose was to evaluate the IVIM model in renal perfusion. Methods and material: Eight volunteers underwent diffusion-sensitive magnetic resonance (MR) imaging of the kidneys using a spin echo (SE) EPI sequence. The diffusion coefficients determined by a linear regression analysis and fits to the IVIM function were calculated. Results and conclusion: Our preliminary experience does not support the possibility of obtaining perfusion information using the IVIM model in the kidneys. 相似文献
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Peng NJ Mar GY Liu CP Jao GH Lee D Liang HL Tsay DG Chen CC Liu RS 《Nuclear medicine communications》2001,22(6):625-629
The predictive accuracy of exercise myocardial perfusion scintigraphy (EMPS) in detecting coronary artery disease (CAD) in patients who fail to achieve an adequate level of exercise is not clear. This investigation was carried out in order to compare the sensitivity, specificity and accuracy of EMPS in adequate exercise patients with those in inadequate exercise patients. We have retrospectively compared the results of EMPS with coronary angiography (CAG). One hundred and forty-eight patients with both tests within 6 weeks were included. Adequate exercise was defined as > or = 85% maximally predicted heart rate for age. The overall sensitivity and specificity of EMPS to detect CAD were 92.5% (74/80) and 75%, (51/68), respectively. The sensitivity and specificity in adequate exercise patients were 94.1% (32/34) and 67.6% (23/34), whereas those in inadequate exercise patients were 91.3% (42/46) and 82.4% (28/34). The accuracy was 80.9% (55/68) and 87.5% (70/80), respectively. Patients with inadequate exercise had lower sensitivity but higher specificity of EMPS for detecting CAD, and achieved a higher accuracy than those with adequate exercise. 相似文献
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Okazawa H Tsuchida T Kobayashi M Arai Y Pagani M Isozaki M Yonekura Y 《European journal of nuclear medicine and molecular imaging》2007,34(1):121-129
Purpose: The aim of this study was to clarify whether decreases in baseline regional cerebral blood flow (rCBF) and in residual cerebral
vasoreactivity (CVR), assessed by the acetazolamide (ACZ) challenge, can detect misery perfusion in patients with chronic
cerebrovascular disease (CVD).
Methods: Oxygen extraction fraction (OEF) and other haemodynamic parameters were measured in 115 patients (64±9 years old) with unilateral
cerebrovascular steno-occlusive disease (>70% stenosis) using 15O-gas and water PET. A significant elevation of OEF, by greater than the mean+2SD compared with healthy controls, was defined
as misery perfusion. CBF, CVR determined by percent change in CBF after ACZ administration, OEF and other haemodynamic parameters
in the territories of the bilateral middle cerebral arteries were analysed. Diagnostic accuracy for the detection of misery
perfusion using the criteria determined by baseline CBF and CVR was evaluated in all patients and in only those patients with
occlusive lesions.
Results: Ten of 24 patients with misery perfusion showed a significant reduction in CVR. Using criteria determined by significant decreases
in CVR and baseline CBF, misery perfusion was detected with a sensitivity of 42% and a specificity of 95% in all patients.
In patients with occlusive lesions (n=50), sensitivity was higher but specificity was slightly lower. The diagnostic accuracy of the threshold determined by baseline
CBF alone was similar in all patients and in only those patients with occlusive lesions, and was higher than that achieved
using the asymmetry index of OEF.
Conclusion: Reductions in CVR and baseline CBF in the ACZ challenge for CVD would detect misery perfusion with high specificity. Reduction
in baseline rCBF is more accurate than reduction in CVR alone for the detection of misery perfusion. 相似文献
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Bauner KU Sourbron S Picciolo M Schmitz C Theisen D Sandner TA Reiser MF Huber AM 《European radiology》2012,22(1):73-82
Objectives
To determine the diagnostic value of magnetic resonance (MR) first pass perfusion in the differentiation of benign and malignant cardiac tumours. 相似文献18.
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Ami E. Iskandrian Vasken Dilsizian Ernest V. Garcia Rob S. Beanlands Manuel Cerqueira Prem Soman Daniel S. Berman Alberto Cuocolo Andrew J. Einstein Charity J. Morgan Fadi G. Hage Heinrich R. Schelbert Jeroen J. Bax Joseph C. Wu Leslee J. Shaw Mehran M. Sadeghi Nagara Tamaki Philipp A. Kaufmann Robert Gropler Sharmila Dorbala William Van Decker 《Journal of nuclear cardiology》2018,25(1):39-52
As the second term of our commitment to Journal begins, we, the editors, would like to reflect on a few topics that have relevance today. These include prognostication and paradigm shifts; Serial testing: How to handle data? Is the change in perfusion predictive of outcome and which one? Ischemia-guided therapy: fractional flow reserve vs perfusion vs myocardial blood flow; positron emission tomography (PET) imaging using Rubidium-82 vs N-13 ammonia vs F-18 Flurpiridaz; How to differentiate microvascular disease from 3-vessel disease by PET? The imaging scene outside the United States, what are the differences and similarities? Radiation exposure; Special issues with the new cameras? Is attenuation correction needed? Are there normal databases and are these specific to each camera system? And finally, hybrid imaging with single-photon emission tomography or PET combined with computed tomography angiography or coronary calcium score. We hope these topics are of interest to our readers. 相似文献