肝血管平滑肌脂肪瘤的超声造影与增强螺旋CT对比研究

Objective To observe the perfusion pattern of hepatic angiomyolipomas using contrastenhanced ultrasound(CEUS) and compare diagnostic efficacy of contrast-enhanced ultrasound with contrastenhanced helical CT(CECT).Methods Nineteen patients with 21 resected and pathologically proven hepatic angiomyolipomas were included in this study.Low mechanical index (mechanical index less than 0.2) realtime CEUS was performed in nineteen patients (5 patients with pulse inversion harmonic, 14 patients with contrast pulse sequencing, CPS) after 2.4ml bolus injection of contrast agent SonoVue.CECT was performed using 16-slice helical CT and contrast agent Ultravist.The diagnostic performance was calculated by considering histologic results as the reference standards.Results Fifteen tumors were correctly diagnosed as hepatic angiomyolipomas,4 tumors were misdiagnosed (including 1 hepatocellular carcinoma,2hepatic adenomas, 1 hemangioma) and 2 tumors were characterized as benign lesions by CEUS.Eight tumors were correctly diagnosed as hepatic angiomyolipomas, 13 tumors were misdiagnosed (including 7hepatocellular carcinoma, 1 liposarcoma, 2 lipomas, 1 hepatic adenomas, 2 hemangiomas) by CECT.The preoperative diagnostic accuracy was 71.4% for CEUS and 38.1 % for CECT(P＜0.05 ).Conclusions CEUS can demonstrate typical imaging characteristics of most hepatic angiomyolipomas, and has higher diagnostic performance than CECT in characterization of hepatic angiomyotipomas.     

肝血管平滑肌脂肪瘤的超声造影表现

Objective To investigate the features of hepatic angiomyolipoma(AML) on contrast enhanced ultrasound (CEUS). Methods Ten pathologically proved AML lesions in 9 patients were evaluated by using baseline ultrasound and CEUS. CEUS was performed with contrast pulse sequencing technique and the contrast agent of SonoVue. Results On baseline ultrasound, 7 lesions exhibited mixed echoic,which was obvious hyperechoic combined with partly of hypoechoie; 3 lesions exhitited obvious hypereehoic. On color Doppler flow imaging artery signals were detected in all lesions. And the lesions had plenty or slightly plenty of artery supply,with resistive index about 0.53 4±0.10 (0.48~0.62). On CEUS, in the arterial phase, 9 lesions exhibited hyper-enhanced. In the portal phase, 5 lesions exhibited iso-enhancement,1 lesion was slightly hyper-enhancement and 3 lesions was hypo-enhancement. In the late phase 6 lesions were iso-enhancement and 3 lesions were hypo-enhancement. One lesion was all hypo-enhancement in all three phases. Conclusions There are some characteristic manifestations of hepatic AML in CEUS, which are helpful for the diagnosis of hepatic AML in a way,but we still need more experiences.     

肝血管平滑肌脂肪瘤的超声造影表现

Objective To investigate the features of hepatic angiomyolipoma(AML) on contrast enhanced ultrasound (CEUS). Methods Ten pathologically proved AML lesions in 9 patients were evaluated by using baseline ultrasound and CEUS. CEUS was performed with contrast pulse sequencing technique and the contrast agent of SonoVue. Results On baseline ultrasound, 7 lesions exhibited mixed echoic,which was obvious hyperechoic combined with partly of hypoechoie; 3 lesions exhitited obvious hypereehoic. On color Doppler flow imaging artery signals were detected in all lesions. And the lesions had plenty or slightly plenty of artery supply,with resistive index about 0.53 4±0.10 (0.48~0.62). On CEUS, in the arterial phase, 9 lesions exhibited hyper-enhanced. In the portal phase, 5 lesions exhibited iso-enhancement,1 lesion was slightly hyper-enhancement and 3 lesions was hypo-enhancement. In the late phase 6 lesions were iso-enhancement and 3 lesions were hypo-enhancement. One lesion was all hypo-enhancement in all three phases. Conclusions There are some characteristic manifestations of hepatic AML in CEUS, which are helpful for the diagnosis of hepatic AML in a way,but we still need more experiences.     

肝血管平滑肌脂肪瘤的超声造影表现

Objective To investigate the features of hepatic angiomyolipoma(AML) on contrast enhanced ultrasound (CEUS). Methods Ten pathologically proved AML lesions in 9 patients were evaluated by using baseline ultrasound and CEUS. CEUS was performed with contrast pulse sequencing technique and the contrast agent of SonoVue. Results On baseline ultrasound, 7 lesions exhibited mixed echoic,which was obvious hyperechoic combined with partly of hypoechoie; 3 lesions exhitited obvious hypereehoic. On color Doppler flow imaging artery signals were detected in all lesions. And the lesions had plenty or slightly plenty of artery supply,with resistive index about 0.53 4±0.10 (0.48~0.62). On CEUS, in the arterial phase, 9 lesions exhibited hyper-enhanced. In the portal phase, 5 lesions exhibited iso-enhancement,1 lesion was slightly hyper-enhancement and 3 lesions was hypo-enhancement. In the late phase 6 lesions were iso-enhancement and 3 lesions were hypo-enhancement. One lesion was all hypo-enhancement in all three phases. Conclusions There are some characteristic manifestations of hepatic AML in CEUS, which are helpful for the diagnosis of hepatic AML in a way,but we still need more experiences.     

肝血管平滑肌脂肪瘤的超声造影表现

Objective To investigate the features of hepatic angiomyolipoma(AML) on contrast enhanced ultrasound (CEUS). Methods Ten pathologically proved AML lesions in 9 patients were evaluated by using baseline ultrasound and CEUS. CEUS was performed with contrast pulse sequencing technique and the contrast agent of SonoVue. Results On baseline ultrasound, 7 lesions exhibited mixed echoic,which was obvious hyperechoic combined with partly of hypoechoie; 3 lesions exhitited obvious hypereehoic. On color Doppler flow imaging artery signals were detected in all lesions. And the lesions had plenty or slightly plenty of artery supply,with resistive index about 0.53 4±0.10 (0.48~0.62). On CEUS, in the arterial phase, 9 lesions exhibited hyper-enhanced. In the portal phase, 5 lesions exhibited iso-enhancement,1 lesion was slightly hyper-enhancement and 3 lesions was hypo-enhancement. In the late phase 6 lesions were iso-enhancement and 3 lesions were hypo-enhancement. One lesion was all hypo-enhancement in all three phases. Conclusions There are some characteristic manifestations of hepatic AML in CEUS, which are helpful for the diagnosis of hepatic AML in a way,but we still need more experiences.     

肝血管平滑肌脂肪瘤的超声造影表现

Objective To investigate the features of hepatic angiomyolipoma(AML) on contrast enhanced ultrasound (CEUS). Methods Ten pathologically proved AML lesions in 9 patients were evaluated by using baseline ultrasound and CEUS. CEUS was performed with contrast pulse sequencing technique and the contrast agent of SonoVue. Results On baseline ultrasound, 7 lesions exhibited mixed echoic,which was obvious hyperechoic combined with partly of hypoechoie; 3 lesions exhitited obvious hypereehoic. On color Doppler flow imaging artery signals were detected in all lesions. And the lesions had plenty or slightly plenty of artery supply,with resistive index about 0.53 4±0.10 (0.48~0.62). On CEUS, in the arterial phase, 9 lesions exhibited hyper-enhanced. In the portal phase, 5 lesions exhibited iso-enhancement,1 lesion was slightly hyper-enhancement and 3 lesions was hypo-enhancement. In the late phase 6 lesions were iso-enhancement and 3 lesions were hypo-enhancement. One lesion was all hypo-enhancement in all three phases. Conclusions There are some characteristic manifestations of hepatic AML in CEUS, which are helpful for the diagnosis of hepatic AML in a way,but we still need more experiences.     

肝血管平滑肌脂肪瘤的超声造影表现

Objective To investigate the features of hepatic angiomyolipoma(AML) on contrast enhanced ultrasound (CEUS). Methods Ten pathologically proved AML lesions in 9 patients were evaluated by using baseline ultrasound and CEUS. CEUS was performed with contrast pulse sequencing technique and the contrast agent of SonoVue. Results On baseline ultrasound, 7 lesions exhibited mixed echoic,which was obvious hyperechoic combined with partly of hypoechoie; 3 lesions exhitited obvious hypereehoic. On color Doppler flow imaging artery signals were detected in all lesions. And the lesions had plenty or slightly plenty of artery supply,with resistive index about 0.53 4±0.10 (0.48~0.62). On CEUS, in the arterial phase, 9 lesions exhibited hyper-enhanced. In the portal phase, 5 lesions exhibited iso-enhancement,1 lesion was slightly hyper-enhancement and 3 lesions was hypo-enhancement. In the late phase 6 lesions were iso-enhancement and 3 lesions were hypo-enhancement. One lesion was all hypo-enhancement in all three phases. Conclusions There are some characteristic manifestations of hepatic AML in CEUS, which are helpful for the diagnosis of hepatic AML in a way,but we still need more experiences.     

肝血管平滑肌脂肪瘤的超声造影表现

Objective To investigate the features of hepatic angiomyolipoma(AML) on contrast enhanced ultrasound (CEUS). Methods Ten pathologically proved AML lesions in 9 patients were evaluated by using baseline ultrasound and CEUS. CEUS was performed with contrast pulse sequencing technique and the contrast agent of SonoVue. Results On baseline ultrasound, 7 lesions exhibited mixed echoic,which was obvious hyperechoic combined with partly of hypoechoie; 3 lesions exhitited obvious hypereehoic. On color Doppler flow imaging artery signals were detected in all lesions. And the lesions had plenty or slightly plenty of artery supply,with resistive index about 0.53 4±0.10 (0.48~0.62). On CEUS, in the arterial phase, 9 lesions exhibited hyper-enhanced. In the portal phase, 5 lesions exhibited iso-enhancement,1 lesion was slightly hyper-enhancement and 3 lesions was hypo-enhancement. In the late phase 6 lesions were iso-enhancement and 3 lesions were hypo-enhancement. One lesion was all hypo-enhancement in all three phases. Conclusions There are some characteristic manifestations of hepatic AML in CEUS, which are helpful for the diagnosis of hepatic AML in a way,but we still need more experiences.     

肝血管平滑肌脂肪瘤的超声造影表现

Objective To investigate the features of hepatic angiomyolipoma(AML) on contrast enhanced ultrasound (CEUS). Methods Ten pathologically proved AML lesions in 9 patients were evaluated by using baseline ultrasound and CEUS. CEUS was performed with contrast pulse sequencing technique and the contrast agent of SonoVue. Results On baseline ultrasound, 7 lesions exhibited mixed echoic,which was obvious hyperechoic combined with partly of hypoechoie; 3 lesions exhitited obvious hypereehoic. On color Doppler flow imaging artery signals were detected in all lesions. And the lesions had plenty or slightly plenty of artery supply,with resistive index about 0.53 4±0.10 (0.48~0.62). On CEUS, in the arterial phase, 9 lesions exhibited hyper-enhanced. In the portal phase, 5 lesions exhibited iso-enhancement,1 lesion was slightly hyper-enhancement and 3 lesions was hypo-enhancement. In the late phase 6 lesions were iso-enhancement and 3 lesions were hypo-enhancement. One lesion was all hypo-enhancement in all three phases. Conclusions There are some characteristic manifestations of hepatic AML in CEUS, which are helpful for the diagnosis of hepatic AML in a way,but we still need more experiences.     

肝血管平滑肌脂肪瘤的超声造影表现

Objective To investigate the features of hepatic angiomyolipoma(AML) on contrast enhanced ultrasound (CEUS). Methods Ten pathologically proved AML lesions in 9 patients were evaluated by using baseline ultrasound and CEUS. CEUS was performed with contrast pulse sequencing technique and the contrast agent of SonoVue. Results On baseline ultrasound, 7 lesions exhibited mixed echoic,which was obvious hyperechoic combined with partly of hypoechoie; 3 lesions exhitited obvious hypereehoic. On color Doppler flow imaging artery signals were detected in all lesions. And the lesions had plenty or slightly plenty of artery supply,with resistive index about 0.53 4±0.10 (0.48~0.62). On CEUS, in the arterial phase, 9 lesions exhibited hyper-enhanced. In the portal phase, 5 lesions exhibited iso-enhancement,1 lesion was slightly hyper-enhancement and 3 lesions was hypo-enhancement. In the late phase 6 lesions were iso-enhancement and 3 lesions were hypo-enhancement. One lesion was all hypo-enhancement in all three phases. Conclusions There are some characteristic manifestations of hepatic AML in CEUS, which are helpful for the diagnosis of hepatic AML in a way,but we still need more experiences.     

胰岛素瘤动态三期增强CT和18F-FDG PET/CT影像分析

目的 探讨胰岛素瘤MSCT动态三期增强及¹⁸F-FDG PET/CT显像的影像学特点。方法 回顾性分析我院6例经手术病理证实的胰岛素瘤的临床资料和¹⁸F-FDG PET/CT及同机MSCT动态三期增强影像资料。结果 6例患者均有不同程度低血糖发作病史和典型的惠普尔三联征,其中2例以精神症状首诊。全部病例空腹或发作时血糖均<2.8 mmol/L,胰岛素释放指数均>0.3。6例胰岛素瘤均为单发,1例位于胰尾,2例位于胰体,3例位于胰头,肿瘤直径0.8 cm×0.9 cm~3.0 cm×3.8 cm,平均1.6 cm×1.6 cm。CT平扫肿瘤呈均匀等或稍低密度,边界不清;增强扫描动脉期呈明显均匀强化,静脉期及延迟期强化程度逐渐减低,动脉期强化最为显著。6例患者中,5例肿瘤局部¹⁸F-FDG摄取未见增高,1例多发性内分泌肿瘤1型(MEN 1)相关胰岛素瘤局部¹⁸F-FDG摄取增高,SUV_max＝4.8。结论 MSCT动态三期增强扫描可清晰显示肿瘤的形态和位置,¹⁸F-FDG PET/CT对本病诊断价值有限。     

肝内胆管细胞癌超声造影与增强MRI表现对比分析

目的 分析肝内胆管细胞癌超声造影与增强MRI影像学表现特点.方法 8例经手术病理证实的肝内胆管细胞癌,术前行超声造影、增强MRI检查.结果 超声造影：动脉期5例周边环状高增强,1例整体均匀高增强,2例整体不均匀高增强;门脉期6例整体为低增强,2例内部呈低增强,周边仍见环状高增强;延迟期均呈低增强.增强MRI：动脉期8例环状高增强;门脉期及延迟期1例环状高增强,7例向心性增强.结论 肝内胆管细胞癌超声造影与增强MRI表现不同,可能与疾病的病理特点及两种造影剂在人体内的分布特点有关.     

肝肿瘤超声造影与增强CT的对比研究

目的比较超声造影(CEUS)和增强CT显示肝肿瘤的血流灌注特点,探讨对肝良恶性肿瘤的诊断价值。方法对92例肝占位性病变进行CEUS和增强CT检查,比较两种技术在不同时相的增强及灌注特征。结果原发性肝癌、血管瘤CEUS和增强CT的增强类型比较差异无显著性意义(χ2检验,P>0.05),肝转移癌两者比较差异有显著性意义(P<0.05)。其中30例肝恶性肿瘤CEUS显示的病灶数目为134枚,增强CT显示的病灶数目为118枚。结论CEUS和增强CT能敏感地显示肝良恶性肿瘤的血供特征,CEUS对肝转移癌微小血管的灌注情况及发现微小病灶方面优于增强CT,可有效地评价肿瘤血管化程度,为肝癌的早期诊断提供更多信息。     

超声造影与增强CT费用比较分析

目的了解超声造影和增强CT两种诊断方式对于肝脏局灶性占位性病变诊断的效价比。方法从2008年3月至2009年7月序贯入组159例需要做超声造影和增强CT的肝局灶性占位性病变患者,记录两种检查所用时间、人力和费用,并进行对比分析。结果与增强CT相比,超声造影诊断肝脏局灶性占位性病变的费用较低,消耗的时间、人力较少。结论在对肝脏局灶性占位性病变进行定性诊断时,超声造影检查是一种有效、高效价比的诊断工具。     

胆囊癌的超声造影和增强螺旋CT对比分析

目的评价超声造影和增强螺旋CT对胆囊癌的诊断价值。方法对比分析26例经手术、病理证实的胆囊癌的超声造影和CT增强的影像表现。结果超声造影和CT增强具有相似的表现。26例中,厚壁型14例,肿块型7例,腔内结节型5例。超声造影确诊23例,CT增强确诊22例,两者结合确诊25例,误诊1例。结论超声造影和CT增强扫描对于胆囊癌的诊断均很敏感且价值很高,结合两者可提高该病的确诊率。     

超声造影与增强CT对肾囊性病变诊断价值的Meta分析

Objective: Assess the diangostic value of contrast-enhanced ultrasonography and contrast-enhanced CT for benign and malignant renal cystic lesions identification based on Meta analysis.     

Dynamic contrast-enhanced MR imaging

Dynamic contrast-enhanced magnetic resonance imaging is a useful clinical tool in evaluation of soft tissue neoplasm and lymph nodes in head and neck. It is thought to be a useful predictor of response to radiotherapy for head and neck carcinoma and used to monitor the treatment and distinguish post-therapeutic changes from recurrent mass with greater confidence. It can be used to distinguish between normal and malignant tissue and to differentiate a malignant lymphoma from other lymph nodal enlargements. The technique utilizes relative differences in microvasculature and microcirculation between malignant and non-malignant tissue to achieve greater contrast in signal imaging following bolus contrast administration.This article explains the underlying principles and imaging techniques for this new diagnostic tool. The clinical applications and technical challenges are discussed. The future challenges and some contradictions in results are also outlined.     

超声造影与增强CT对胆囊占位性病变诊断的对比研究

摘要 目的 比较超声造影（CEUS）与增强CT（CECT）在胆囊占位性病变中的增强特征、诊断效能及一致性。方法 分析48例胆囊占位性病变患者CEUS与CECT的增强特征,比较二者诊断的敏感性、特异性、准确率,阴性预测值、阳性预测值,及诊断的一致性检验Kappa值。结果 CEUS与CECT对胆囊占位性病变各增强特征比较,差异均无统计学意义（P＞0.05）。CEUS与CECT诊断胆囊病变的敏感性分别为94.74%（18/19）和89.47%（17/19）（P=0.895）,特异性分别为90.48%（19/21）和95.24%（20/21）（P=0.905）,准确率分别为92.50%（37/40）和92.50%（37/40）（P=1.000）,阳性预测值分别为90.0%（18/20）和94.44%（17/8）,阴性预测值分别为95.0%（19/20）和90.91%（20/22）。CEUS、CECT与病理结果一致性检验Kappa值分别为0.850、0.849,二者之间诊断结果一致性检验 Kappa值为0.900。结论 CEUS与CECT对胆囊占位性病变的增强特征相似,二者诊断结果一致性良好且均具有较高的诊断效能。     

肝细胞腺瘤超声造影与增强CT表现对比分析

目的 明确CEUS和CECT对HCA的术前诊断价值。方法 回顾性分析病理确诊为HCA且术前行CEUS和CECT检查的21例患者共21个病灶资料，观察HCA的CEUS及CECT特征性影像学表现。结果 本组HCA病灶在CEUS和CECT动脉期均呈高增强100%（21/21），门脉期分别观察到14.3%（3/21）和19.1%（4/21）呈低增强；延迟期分别见33.3%（7/21）和42.9%（9/21）呈低增强，两者在显示“增强-减退”方面无统计学差异（P = 0.401）。CEUS对包膜下增强血管影的显示率高于CECT（McNemar，P = 0.028）。对比大体病理标本，CEUS、CECT对病灶内出血区的显示率均有统计学差异（CEUS vs 大体病理，P = 0.045；CECT vs 大体病理，P = 0.023），而且一致性均较低（CEUS vs 大体病理，Kappa值 = 0.327；CECT vs 大体病理，Kappa值 = 0.440）。以“快进不减退”和“包膜下增强血管影”为依据诊断HCA，CEUS显示率为47.6%，CECT显示率为33.3%，两者结合诊断率约52.4%。CEUS结合CECT诊断率与CEUS单独应用无统计学差异（P = 0.758）。根据免疫组化染色，共12个I-HCA病灶纳入研究。I-HCA在CEUS动脉期75.0%（8/12）呈整体增强，延迟期41.7%（5/12）呈低增强，41.7%（5/12）见包膜下增强血管影，16.7%（2/12）见灌注缺损区。I-HCA在CECT动脉期33.3%（4/12）呈不均匀增强，延迟期50.0%（6/12）呈低增强，16.7%（2/12）见包膜下增强血管影，25.0%（3/12）见灌注缺损区。“BMUS低回声、CEUS动脉期高增强、包膜下增强血管影”在I-HCA中的显示率约41.7%，出现该征象可提示I-HCA。结论 CEUS对HCA诊断符合率高于CECT，且CEUS对动脉期增强方式和包膜下增强血管影的显示较CECT更具有优势，CECT结合CEUS可提高HCA的术前诊断。