高分子材料在药物传递系统研究中的应用

新型高分子材料的不断出现,极大地促进了药物制剂技术的发展。笔者综述了高分子材料在新型药物传递系统中的应用,并应用高分子化学原理阐述了常用高分子材料的性能及其应用。     

高分子化学在药物传递系统研究中的应用

新型高分子材料的不断出现,极大地促进了药物制剂技术的发展。该文介绍了高分子化学在新型药物传递系统中的应用。并以高分子化学原理阐述了常用高分子材料的性能及其应用。     

药用高分子材料学教学内容与课程体系改革设想

药用高分子材料学是适应现代药学的发展和教学的需要,于20世纪90年代在我国建立起来的一门崭新学科,它在促进药物制剂的发展中起到了举足轻重的作用。可以说,没有新型的药用高分子材料的应用。就没有现代的药剂学。我院从上世纪90年代末开始在中药学研究生（制剂方向）中开设该门课程,之后在药物制剂、制药工程、中药学三个本科专业中开设,通过课程学习．学生可以较全面地掌握药用高分子材料的性质、特点以及实际应用情况,为中药新药的研制和开发打下基础。     

壳聚糖及其在药物制剂和生物技术中的应用

壳聚糖是世界上少见的天然带正电荷高分子电解质，具有良好的生物相容性和生物降解性。本文介绍它的性质，并着重介绍壳聚糖在药物制剂及生物技术方面的应用新进展。     

纳米高分子材料在生物医学领域的研究与应用

纳米高分子材料突破传统理念，发展迅猛，在生物技术、生命科学等高新技术中都有广阔应用前景。本文综述了纳米科学技术在高分子材料领域的研究现状，重点论述了纳米高分子材料在生物医学领域中的应用。并对其发展前景提出展望。     

几种测定秋水仙碱方法比较分析

秋水仙碱临床用以治疗癌症,特别对乳腺癌有一定疗效,对皮肤癌、白血病和何杰氏病等亦有一定作用。对原发痛风有特异作用,12～14小时内减轻炎症并迅速止痛。但是,秋水仙碱毒性过大,在一定程度上限制了它的应用。随着药学事业的迅猛发展,对高分子材料研究的不断深入,越来越多高分子材料被应用于药物制剂当中,许许多多的缓控释新型制剂被研制开发出来,以达到提高生物利用度。减小药物用     

《药物生物技术》征稿简则

《药物生物技术》是经国家科委批准出版公开发行的以应用生物技术为特征的技术性期刊(自2001年由季刊改为双月刊)。主要刊登生物技术在医药卫生、化学和食品工业、农业等诸领域中的研究、应用方面的文章,读者对象是从事生物技术、分离和纯化技术及药物制剂技术的科研、生产人员     

《药物生物技术》征稿简则

《药物生物技术》是1994年经国家科委批准公开发行的以应用生物技术为特征的技术性学术性期刊(双月刊)。主要刊登生物技术在医药卫生、化学和食品工业、农业等诸领域中的研究、应用方面的文章,读者对象是从事生物技术、分离和纯化技术及药物制剂技术的科研、生产人员、医药工作     

表面活性剂在药物制剂中的应用

表面活性剂是一类能够改变溶液性质的表面活性物质,由于表面活性剂的这一特性,其应用极广.表面活性剂在药物制剂中的应用,已有悠久的历史,但最初应用较少.20世纪80年代以来,随着合成化学工业的发展,具有各种性能的表面活性剂陆续问世,使其在药物制剂中的应用有了较为迅猛的发展.本文主要论述表面活性剂在药物制剂新的药物剂型以及新给药途径药物研究中的应用.     

生物技术制药与基因重组技术研究现状

1 生物技术药物 1.1 生物药物与生物技术药物的范畴 由于生物技术的崛起和基因工程的发展,提出了生物药物.20世纪90年代将生物药物分为:生化药物、生物制品、微生物药物和生物技术药物.     

The use of the terms ‘lifestyle medicines’ or ‘lifestyle drugs’

AIM: over the last 10 decades, 'lifestyle medicines' or 'lifestyle drugs' have been used with increasing frequency by journalists, politicians, authorities and to some extent by scientists. The objective of this paper is to analyse the quantity and quality of the use of these terms and discuss the implications associated with the labelling of indications and products as lifestyle medicines or lifestyle drugs. METHODS: The findings in this paper are based on an extensive literature review in the databases Medline, Pubmed, Embase and the two most frequently used search engines altavista.com and google.com, as well as the media database LexisNexis. RESULTS: In the period 1978 to August 2003, the term 'lifestyle medicines/drugs' has appeared 3174 times in English language media. In total, 23 different definitions are presented in the scientific literature. CONCLUSIONS: The review of the scientific literature shows that no widely accepted definition of the terms 'lifestyle medicines' or 'lifestyle drugs' exists. Nevertheless the terms have appeared more than 3000 times in the media (2600 times since 1998), which means that in most cases, the use of the terms 'lifestyle medicines' or 'lifestyle drugs' are based on the authors' own assumptions and values. This is problematic, not only in terms of a discourse, where no one knows what forms the basis of the discussion, but also because this at best leads to an uninformed discussion and at worst to harmful conclusions that might stigmatise and discriminate patients. Based on these findings, this paper argues that a clear, widely accepted definition of the terms 'lifestyle medicines' or 'lifestyle drugs' is essential to avoid potential misunderstandings that might lead to discrimination in the rationing of healthcare resources or stigmatisation of patients.     

包装标识的规范对非处方药合理使用的重要性

非处方药包装标识的规范对药物能否合理使用起决定性作用。结合目前国内药品标签、说明书存在的问题,就药品名称、不良反应、有效期、用法、适应证及注意事项进行分析,对完善和规范我国非处方药包装标识提出一些建议。     

新的芯片毛细管电泳及其联用技术研究应用进展

微流路芯片毛细管电泳是20世纪90年代才发展起来的用作微型毛细管电泳分离的新技术。微流路芯片毛细管电泳-质谱联用技术是众多仪器联用中的发展前沿。文章综述微流路芯片的制作，微流路芯片毛细管电泳的分离原理、装置和测定技术及微流路芯片毛细管电泳-质谱联用技术以及这类分析技术在生物技术和生命科学领域研究中的应用进展。     

疾病对药物体内代谢过程的影响

疾病可影响药物在体内的吸收、分布、代谢和排泄过程。本文基于Medline发表的相关研究,重点介绍短肠综合征、囊性纤维化和肝胆疾病等对药物体内代谢过程的影响。短肠综合征和囊性纤维化都显著影响药物的吸收和肠肝循环,而肾病、胆囊炎或胆囊手术可能影响药物的排泄。肝病影响药物代谢的肝药酶(P450同工酶)。疾病对药物代谢的影响,可能导致药物治疗无效或者中毒,引起严重后果。因此临床应该了解疾病对药物代谢影响的基本知识,治疗中主动调整给药方法和剂量,提高药物治疗效率,减少药源性的损害。     

水包油型乳剂作为佐剂的研究进展

随着现代生物技术的发展，重组蛋白疫苗、合成肽疫苗等新型疫苗不断涌现，迫切需要安全有效的佐剂来增强其免疫原性。水包油型乳剂是新型佐剂中的一个研发热点，如MF59和AS03已在欧盟和美国获批用于人用疫苗，且均被证实具有良好的效果和可靠的安全性。此文就水包油型佐剂的研究进展做一综述，以期为开发高效、低毒的新型佐剂提供参考。     

Multi- and single-target agents for major psychiatric diseases: therapeutic opportunities and challenges

There is growing pressure to find more effective therapies for major psychiatric disorders, such as schizophrenia and depressive disorder. The repeated disappointments that have been experienced with highly selective, single-target agents have prompted questions about their relative merits. In contrast, a multi-target agent (MTA) approach, discovered either by serendipity or by judicious design, might offer a more rational way to address the complex clinical demands of patients and their co-morbidities. Rather than being mutually exclusive, a balanced portfolio of the two approaches may offer a beneficial and synergistic outcome toward identification of novel antipsychotic and antidepressant therapies. With improvements in biomarker technology, translational biology and a growing understanding of psychopathology, there is optimism that the new generation of MTAs will finally shed the stigma of 'dirty drugs' and progress to the concept of intentionally designed and tailored psychopharmacological agents.     

印度生物技术产业成功的关键因素分析

印度生物技术产业2005年注册收入达到近11亿美元，2006年达到15亿美元，近年印度在该领域的发展取得了突飞猛进的成绩，联合国已把印度作为发展中国家生物工程技术培训中心，欧关等发达国家则将其作为生物技术试验基地，不少跨国公司和医药巨头也纷纷拥入。概要描述了印度生物技术产业的概况，对印度生物技术产业近年来高速发展的成功因素进行了重点阐述，并指出了其发展中存在的问题。     

Polydrug use at raves by a Western Australian sample

This study aimed to quantify the patterns of drug use among a group of participants in the rave scene in Perth, Western Australia. Interviews were conducted with 83 people who had recently been to a 'rave'. The study incorporated a semi-structured qualitative interview and a structured quantitative questionnaire. This paper reports on the quantitative data collected concerning patterns of drug use in association with the last rave attended. Use of 'dance drugs' (ecstasy, amphetamines or LSD) was reported by 86.8% of the 76 respondents who had used at least one drug in association with their last rave. Nearly 80% of these had also used at least one other drug on this occasion (mean number used = 2.4). Cannabis and inhalants were the drugs most commonly combined with the 'dance drugs', several respondents used more than one 'dance drug' concurrently and 16.7% had used alcohol. It seems that a significant proportion of those using 'dance drugs' in association with raves and dance parties are mixing these drugs with other substances despite harm reduction advice to the contrary. The need for more research in this area is discussed.     

一种新型抗体替代品——亲和体的研究进展

作为抗体的一种新型替代品,亲和体不仅以高亲和力与靶蛋白特异性结合,同时又具备相对分子质量小（~6 500）、穿透性强、免疫原性弱和制备过程简单等诸多特性。因此,亲和体在肿瘤靶向治疗、体内成像诊断和生物技术应用等方面具更突出的优势和可行性。此文对其特性和应用研究进展做一综述。     

Health security--GMOs in therapeutics

The recent progress in human therapeutics has been made possible thanks to molecular biology and its use in producing proteins having the same sequence and structure as that of human proteins. The use of GMOs allows production of proteins with high added value in therapeutics, which are of satisfactory quality. GMOs may also be directly administered to patients as gene therapy vectors. However, the use of GMOs in therapeutics must take into consideration some risks, particularly those of microbiological contamination, of neo-antigenicity as well as environmental risks with regard to the way of use of the GMO. Nevertheless, those risks are taken in due consideration in the development of these new medicinal products; solutions have been found to allow their use in therapeutics with a very positive benefit/risk ratio. Medicinal products from biotechnology have enabled considerable therapeutic progress without compromising health security.