腹股沟皮肤在整形外科的应用

1995年6月以来,作者于腹股沟部分别切取大张全厚皮片游离移植,制备旋髂浅血管轴型皮瓣、腹壁浅血管轴型皮瓣和随意型真皮下血管网薄皮瓣带蒂移植,修复头颈部及四肢皮肤软组织缺损.报告如下:     

腹部双叶皮瓣修复手部软组织缺损

应用腹壁浅动脉及旋髂浅动脉的双叶共蒂皮瓣,带蒂修复手部软组织缺损15例,疗效满意。根据受区的需要,皮瓣远端可修薄成真皮下血管网皮瓣,皮下脂肪仅达2mm厚,移植后血运建立良好,外观不臃肿,质地柔软,供区隐蔽,尤其是修复手部二处软组织缺损的理想供应。     

轴型髂腹部真皮下血管网皮瓣修复手部皮肤缺损

为了解髂腹部真皮下血管网皮瓣的解剖及临床应用,采用髂腹部真皮下血管网皮瓣带蒂修复４３例手部皮肤缺损患者,结果４３例皮瓣术后２周断蒂全部成活,且外观优良。认为用轴型髂腹部真皮下血管网皮瓣修复手部皮肤缺损,操作简单,易掌握,成活率高,值得推广应用。     

改良的带蒂含真皮下血管网薄型髂腹股沟皮瓣在手外科手术中的应用

目的通过对改良的带蒂含真皮下血管网薄型髂腹股沟皮瓣(以下简称改良的髂腹股沟皮瓣)在手外科手术中的应用,进一步完善该皮瓣的应用技巧,丰富临床上在皮肤软组织缺损上的治疗手段和方法。方法以旋髂浅动脉体表投影即腹股沟韧带中点至同侧髂前上棘连线为轴,以选用的血管蒂为轴心,延长两侧的切口,形成皮瓣,修复手部皮肤缺损。结果该皮瓣手术修复手部的创伤和皮肤缺损,疗程提前,外形满意,活动自如。结论改良的髂腹股沟皮瓣,明显缩短治疗周期,降低了住院费用,提高了手术修复治疗,适合临床进一步的推广和应用。     

髂腹股沟骨皮瓣Ⅰ期修复前臂手部骨皮肤缺损

目的探讨带旋髂浅血管蒂髂腹股沟骨皮瓣修复前臂、手部复合组织缺损的方法。方法2000年5月～2006年5月,收治急诊入院的23例前臂、手部皮肤合并骨缺损,皮肤缺损范围2.0cm×4.5cm～14.0cm×10.0cm;骨缺损2～7cm。清创后应用以旋髂浅动、静脉为皮瓣轴型血管蒂的骨皮瓣进行修复,皮瓣切取范围4.0cm×2.5cm～17.0cm×11.0cm。结果术后骨皮瓣全部成活,创面Ⅰ期愈合。随访3～24个月,平均6个月,皮瓣质地良好,外观及功能满意,骨缺损达临床愈合时间5～9w,平均7w。结论带旋髂浅血管蒂髂腹股沟骨皮瓣切取简便、血供丰富、供区隐蔽,且均能直接缝合,是修复前臂、手部复合组织缺损的一种较理想的方法。     

髂腹部真皮下血管网皮瓣修复爪形手的体会

应用髂腹部真皮下血管网皮瓣 (以下简称薄皮瓣 )修复爪形手 33例 ,效果均满意。笔者对随意型和轴型两种薄皮瓣的临床解剖特点、适用范围、断蒂时间、临床中的使用价值等作了分析 ,认为有较强的实用性。　　髂腹部真皮下血管网皮瓣包括随意型和轴型两种薄皮瓣(前者不含轴型血管 ,后者含腹壁浅动脉和 /或旋髂浅动脉 )。该薄皮瓣含真皮下血管网丰富 ,血供良好 ,成活率高 ,位置隐蔽 ,修复手部创面外形好 ,断蒂时间短 ,具有较强的实用性[1 ] 。自 1996年以来 ,应用髂腹部真皮下血管网皮瓣修复爪形手33例 :随意型薄皮瓣 2 3例 ,轴型薄皮瓣 10例 ,…     

髂腹股沟皮瓣修复急诊手外伤46例报告

目的　应用髂腹股沟带蒂皮瓣修复急诊手外伤引起的手及前臂皮肤软组织缺损。方法　以股动脉搏动点与髂前上棘顶点的连线为轴心线 ,以旋髂浅动、静脉为皮瓣血管蒂 ,皮瓣面积 (6～ 2 5 )cm× (4～ 10 )cm。结果　 46例皮瓣全部成活 ,手及前臂外观较为满意。结论　髂腹股沟皮瓣是修复急诊手外伤引起的皮肤软组织缺损的有效方法之一。该手术操作简便 ,安全可靠 ,在基层医院尤为适用     

内踝上皮支皮瓣在足踝部组织缺损修复中的应用

目的观察应用带胫后动脉内踝上皮支为血管蒂岛状皮瓣修复足踝部皮肤软组织缺损效果。方法自2002～2009年来应用带胫后动脉内踝上皮支为血管蒂岛状皮瓣修复足踝部皮肤软组织缺损32例,皮瓣面积最小4cm×7cm,最大为7cm×14cm。均为带血管蒂转移。结果 30例皮瓣术后全部存活,术后随访6个月～1年,效果满意。其中1例皮瓣术后坏死,行游离髂腹股沟皮瓣移植修复,1例部分坏死,行植皮术创面修复。结论内踝上皮支皮瓣带蒂转移是修复足踝部皮肤软组织缺损有效方法之一。     

手外伤修复中真皮下血管网皮瓣的应用研究

目的探讨真皮下血管网皮瓣修复手外伤创面的手术方法及效果。方法2004年10月～2008年10月,应用胸、腹部带蒂真皮下血管网皮瓣修复手部皮肤软组织缺损创面45例。结果术后43例皮瓣完全成活,仅2例皮瓣远端小部分皮肤坏死,经换药后愈合。术后随访6个月～3年,伤手受区皮肤外形美观、色泽好,功能恢复满意。结论应用胸腹部带蒂真皮下血管网皮瓣修复手部皮肤软组织缺损是一种较理想的修复方法。     

探讨带旋髂浅血管蒂髂腹股沟骨皮瓣移位修复手部复合组织缺损的疗效

目的:探讨带旋髂浅血管蒂髂腹股沟骨皮瓣移位修复手部复合组织缺损的临床疗效。方法:选取2017年1月-2018年6月我院急诊收治的25例手部复合组织缺损患者纳入本次研究,患者的皮肤缺损范围最小3.3cm×1.8cm;最大15.4cm ×9.2cm。先行清创处理,3-7天后将旋髂的浅动静脉作为皮瓣轴型血管蒂的骨皮瓣实施修复,皮瓣的切取范围略大于皮肤缺损的范围,评估临床疗效。结果:所有患者的骨皮瓣全部成活,24例患者创面Ⅰ期愈合、1例Ⅱ期愈合。随访1年,患者的手部外观和功能良好。骨缺损的愈合时间为5-9周,平均在7周左右。结论:在手部复合组织缺损的临床治疗中,采用带旋髂浅血管骶想:腹股沟骨皮瓣移位修复,能够直接缝合,具有切取简单、供区隐蔽、血供良好的优势,值得推广。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.