复方皂矾丸对非小细胞肺癌患者化疗后骨髓抑制的防护作用

[目的]观察复方皂矾丸(主要由西洋参、海马、皂矾、大枣、核桃仁、肉桂等中药组成)对铂类化疗方案治疗非小 细胞肺癌的骨髓保护作用。[方法]将65例中晚期肺癌患者随机分为两组,即治疗组(化疗+复方皂矾丸)和对照组(单 纯化疗),观察两组化疗后骨髓毒性分级情况以及治疗后白细胞恢复正常所需的时间。[结果]治疗组两个疗程化疗的完成 率为91.6％(33／36),高于对照组的68.9％(20／29)(P<0.01)。治疗组未出现Ⅲ、Ⅳ期骨髓抑制,Ⅰ、Ⅱ期骨髓抑制也 少于对照组(P<0.01);治疗组白细胞恢复正常所需时间也短于对照组(P<0.01)。[结论]复方皂矾丸可以防治化疗导 致的骨髓抑制,缩短骨髓恢复正常时间,有利于化疗按时完成。     

复方皂矾丸治疗食道癌化疗引起的白细胞减少疗效观察

目的 :观察复方皂矾丸对食道癌化疗引起的白细胞减少的治疗作用。方法 :食道癌化疗的 5 6例中 ,治疗组2 9例服用复方皂矾丸 ,对照组 2 7例未服任何升白细胞药 ,观察两组白细胞在化疗前及化疗后第 3天、第 6天、第 14天、第 2 1天的变化情况 ,并进行t检验 ,分析结果。结果 :治疗组与对照组在化疗前 1天 ,白细胞均值 6 5 3± 1 43与 6 49±1 41无差异 ,而化疗开始后第 3天、第 6天、第 14天、第 2 1天 ,白细胞均值分别为 4 3 5± 0 76与 3 77± 0 71,4 0 2±0 45与 3 5 2± 0 5 1,5 3 2± 0 68与 4 2 3± 0 5 3 ,5 7± 0 78与 4 5 2± 0 47,P <0 .0 1及P <0 .0 5有显著性差异。结论 :复方皂矾丸对骨髓造血系统损伤有较好的保护作用     

复方皂矾丸减轻晚期非小细胞肺癌化疗副反应临床观察

目的观察复方皂矾丸减轻晚期非小细胞肺癌化疗副反应的疗效。方法94例晚期非小细胞肺癌患者随机分为两组,治疗组48例给予TP方案化疗联合复方皂矾丸;对照组46例仅单纯TP方案化疗。观察两组毒副反应、体重变化、KPS评分变化。结果治疗组Ⅲ-Ⅳ度骨髓抑制发生率低于对照组（P〈0．05）。对照组治秀后体重下降及KPS下降发生率与治疗组比较有统计学显著性差异（P〈0．05）。结论复方皂矾丸联合TP方案化疗能减轻晚期非小细胞肺癌患者毒副反应,改善体重及生活质量。     

复方皂矾丸在放射治疗中的临床疗效观察

目的：观察复方皂矾丸加放疗治疗恶性肿瘤改善生存质量、升高白细胞作用与不良反应。方法：采用随机对照方法将120例患者分为复方皂矾丸加放疗的治疗组55例，单纯放疗的对照组65例。结果：治疗组升白有效率为74．5％，对照组为13．8％，两组有显著性差异（P〈0．01）。两组患者治疗前后症状改善，卡氏评分和体重变化均有显著差异（P〈0．05）。结论：复方皂矾丸可明显升高白细胞并改善生存质量，且不良反应小。     

复方皂矾丸治疗肿瘤患者化疗后血小板减少

目的 对肿瘤患者经化疗治疗出现血小板减少后应用复方皂矾丸治疗的临床效果进行分析.方法 将我院门诊治疗的化疗后出现血小板减少的76例患者,随机分为治疗组（41例,予复方皂矾丸）和对照组（35例,予益血生胶囊）两纽,观察两组患者治疗前、治疗后4,8,12天血小板计数和不良反应.结果 与治疗前相比,治疗组和对照组治疗后患者血小板计数均有不同程度的增加（P＜0.05）;与对照组比较,治疗组患者治疗前、治疗后4天血小板计数均无差异性（P＞0.05）,而治疗后的第8天、第12天后,治疗组患者血小板均有增加（P＜0.05）;两组患者腹胀、腹泻不良反应发生率无差异（P ＞0.05）.结论 复方皂砚丸对治疗化疗后的血小板减少疗效好于益血生胶囊,且不良反应较少,值得临床推广应用.     

补肾复方冲剂影响再生障碍性贫血患者造血祖细胞研究

在探讨补肾复方冲剂治疗肾阳虚型再生障碍性贫血 (简称再障 )临床疗效基础上 ,观察其对于再障患者骨髓造血祖细胞影响。以补肾复方冲剂治疗 30例 ,复方皂矾丸、康力龙各治疗 15例。采用甲基纤维素培养法观察 3组病例治疗前、后骨髓造血祖细胞水平变化 ,并与正常献血员对照。结果示补肾复方组临床有效率为 80 % ,明显高于复方皂矾丸 ( 4 0 % )与康力龙组 ( 4 6 67% ) ;且补肾复方组治疗有效病例的骨髓造血祖细胞 (BFU E及CFU GM )恢复明显优于复方皂矾丸与康力龙组 ;3组间无效者骨髓BFU E及CFU GM水平无明显变化。说明补肾复方冲剂治疗肾阳虚型再障疗效不仅高于复方皂矾丸和康力龙组 ,且其有效者血液学恢复更为完全。     

复方皂矾丸治疗再生障碍性贫血临床疗效评价

【目的】探讨复方皂矾丸 (西洋参、海马、皂矾等组成 )对再生障碍性贫血的临床疗效。【方法】采用前瞻性随机对照方法 ,观察复方皂矾丸加康力龙联合治疗 36例再生障碍性贫血患者血红蛋白、白细胞、血小板上升变化情况。【结果】复方皂矾丸联合治疗组总有效率为 86 % ,明显高于基础治疗组的 53.5%(两组比较P <0 .0 0 5)。【结论】复方皂矾丸是治疗再生障碍性贫血安全、廉价、效果满意的药物。     

复方皂矾丸在鼻咽癌放疗中的临床应用

目的探讨复方皂矾丸在鼻咽癌患者放疗中的临床应用价值。方法选择我院放疗的鼻咽癌患者63例，随机分组，治疗组（an用复方皂矾丸）32例，对照组31例；观察两组外周血的变化及CRP等情况。结果治疗组的白细胞、血小板降低发生率、CRP升高比率和放疗中断率分别为18．75％（6／32）、15．6％（5／32）、18．75％（6／32）、9．35％（3／32），对照组为67．7％（21／31）、45．2％（14／31）、67．7％（21／31）、35％（11／31），两组差异有显著统计学意义（P〈0．01）。结论复方皂矾丸在鼻咽癌放疗中有明显的骨髓保护功能，能有效地减少因WBC、PLT下降或H腔黏膜炎症引起的放疗中断，对病程预后和患者的生活质量的改善有一定的临床意义。     

白细胞介素-11合维血宁治疗白血病化疗后血小板减少

目的：观察重组白细胞介素-11（rhIL-11）、维血宁干扰预防白血病化疗后血小板下降的临床疗效。方法：急性白血病患者共27例，观察组15例，化疗后应用巨和粒、维血宁治疗；对照组12例单纯化疗，观察两组对血小板下降的影响。结果：观察组血小板最低值明显高于对照组，血小板恢复亦明显快于对照组，骨髓巨细胞数明显高于对照组（P〈0.05）。结论：rhIL-11结合维血宁在预防白血病化疗后血小板下降有明显的提升作用，能减少血小板输注的次数。     

复方皂矾丸加康力龙治疗慢性再生障碍性贫血的临床探讨

目的：观察复方皂矾丸加康力龙治疗慢性再生障碍性贫血（CAA）的疗效。方法：对48例CAA患者随机分为两组：治疗组28例，用复方皂矾丸加康力龙等西药治疗；对照组20例，单用康力龙等西药治疗。结果：治疗组总有效率达75％，对照组总有效率达45％，两组疗效有显著性差异（P＜0．01）。结论：复方皂矾丸加康力龙治疗CAA有良好疗效。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.