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Histologic evaluation of resection specimens obtained at 293 endoscopic resections in Barrett's esophagus 总被引:1,自引:0,他引:1
Peters FP Brakenhoff KP Curvers WL Rosmolen WD Fockens P ten Kate FJ Krishnadath KK Bergman JJ 《Gastrointestinal endoscopy》2008,67(4):604-609
BACKGROUND: Evidence-based selection criteria for endoscopic resection (ER) of Barrett's neoplasia are scarce. OBJECTIVE: To study the histopathology of ER specimens of Barrett's neoplasia and correlate this with endoscopic characteristics to make recommendations for patient management. DESIGN, SETTING, INTERVENTIONS: Histology and correlating endoscopy reports of specimens obtained at 293 consecutive ERs performed at a Dutch tertiary referral center between 2000 and 2006 were reviewed. MAIN OUTCOME MEASUREMENTS: Histologic findings in ER specimens and their relation with endoscopic characteristics. RESULTS: A total of 150 ERs were performed for focal lesions: 16% type 0-I, 23% 0-IIa, 7% 0-IIb, 3% 0-IIc, 9% 0-IIa-IIb, and 42% 0-IIa-IIc; and 143 for flat mucosa. Histology revealed no dysplasia in 57 ERs, low-grade intraepithelial neoplasia in 52, high-grade intraepithelial neoplasia in 104, T1m in 61, and T1sm in 17; in two cancers, infiltration depth was not assessable because of artifacts. Type 0-I and 0-IIc lesions significantly more often penetrated the submucosa (P = .009): 60% were G1 cancers, 23% were G2 cancers, and 18% were G3 cancers. G2-G3 cancers significantly more often invaded the submucosa (P < .001) or had positive vertical margins (P = .015). Histology of ER specimens led to a change in diagnosis in 49% of the focal lesions and a relevant change in treatment policy in 30%. LIMITATIONS: A retrospective study. CONCLUSIONS: ER is a valuable diagnostic tool that frequently leads to a change in treatment policy. Most endoscopically resected early Barrett's neoplasia are 0-II type, G1 mucosal neoplasia. Submucosal infiltration is more often encountered in type 0-I and 0-IIc lesions and in G2-G3 cancers. 相似文献
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Nicholas J. Shaheen Bruce D. Greenwald Anne F. Peery John A. Dumot Norman S. Nishioka Herbert C. Wolfsen J. Steven Burdick Julian A. Abrams Kenneth K. Wang Damien Mallat Mark H. Johnston Alvin M. Zfass Jenny O. Smith James S. Barthel Charles J. Lightdale 《Gastrointestinal endoscopy》2010,71(4):680-685
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Ganz RA Overholt BF Sharma VK Fleischer DE Shaheen NJ Lightdale CJ Freeman SR Pruitt RE Urayama SM Gress F Pavey DA Branch MS Savides TJ Chang KJ Muthusamy VR Bohorfoush AG Pace SC DeMeester SR Eysselein VE Panjehpour M Triadafilopoulos G;U.S. Multicenter Registry 《Gastrointestinal endoscopy》2008,68(1):35-40
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