特比萘芬治疗念珠菌性外阴阴道炎、龟头炎临床观察

为观察特比萘芬治疗念珠菌性外阴道炎、龟头炎的疗效及不良反应，采用特比萘芬0.25g，日1次，连服1周对23例包皮龟头炎、37例外阴阴道炎患者进行了治疗。结果：停药1周后，外阴阴道炎的有效率为97.30%，包皮龟头炎的有效率为100%；真菌清除率达96.67%。结果口服特比萘芬治疗念珠菌性外阴阴道炎、包皮龟头炎疗效显著。     

特比萘芬治疗复发性念珠菌性阴道炎56例临床观察

目的观察特比萘芬治疗复发性念珠菌性阴道炎的疗效.方法选择门诊复发性念珠菌性阴道炎患者,随机分为治疗组(口服特比萘芬)和对照组(口服酮康唑),各56例.治疗后2用、8周、12周,随访观察疗效.结果治疗组与对照组治疗效果比较,差异无显著性(χ2=0,P＞0.05),但不良反应明显较对照组轻.结论口服特比萘芬治疗复发性念珠菌性阴道炎效果良好.     

特比萘芬与氟康唑治疗念珠菌性阴道炎的对照观察

为探讨特比萘芬（兰美抒）治疗念珠菌性阴道炎（vaginalcandidosis，VC）的疗效，与治疗VC常规用药氟康唑（三维康）作对比，笔者将１２３例VC患者随机分组，给予兰美抒和三维康治疗，进行临床对照研究，现将结果报告如下。１对象与方法１．１病例入选标准：２００１年１月～２００２年７月笔者医院妇科和皮肤科门诊患者；阴道分泌物湿片镜检为菌丝相和（或）培养为念珠菌；年龄１８～６５岁；首次诊断为念珠菌性阴道炎，且１个月内未系统用过抗真菌药，半个月内未用过外用抗真菌药物。１．２病例排除标准：妊娠或哺乳期妇女，肝、肾功能…     

特比萘芬治疗复发性念珠菌性外阴阴道炎临床观察

目的观察特比萘芬治疗复发性念珠菌性外阴阴道炎的疗效。方法选择复发性念珠菌性外阴阴道炎患者,随机分为治疗组(口服特比萘芬)和对照组(口服酮康唑)各60例。治疗后2,8,12周,随访观察疗效。结果2周后,治疗组和对照组有效率分别为85.00%和82.00%,两组差异无显著性(χ2=0.573,P=0.903);8周和12周时两组的复发率比较差异亦无显著性(前者χ2=0.194,P=0.659;后者χ2=0.192,P=0.661);治疗组不良反应明显较对照组轻(χ2=4.728,P=0.03)。结论口服特比萘芬治疗复发性念珠菌性外阴阴道炎效果良好,不良反应少。     

特比萘芬治疗念珠菌性外阴阴道炎疗效和安全性评价

目的观察特比萘芬治疗念珠菌性外阴阴道炎的疗效及安全性。方法选择本院念珠菌性外阴阴道炎患者,随机分为治疗组34例,口服特比萘芬250mg,1次/d;对照组31例,口服伊曲康唑200mg,1次/d。两组均连用10天。结果治疗组和对照组有效率分别为67.65%和87.10%,真菌清除率分别为82.35%和83.87%,两组有效率和真菌清除率比较差异均无显著性意义(P均>0.05)。结论口服特比萘芬治疗念珠菌性外阴阴道炎疗效肯定,安全性高。     

特比奈芬治疗念珠菌性阴道炎疗效观察

目的观察特比萘芬治疗念珠菌性阴道炎的疗效。方法选择本所STD门诊念珠菌性阴道炎患者160例,随机分为治疗组(口服特比萘芬)和对照组(口服伊曲康唑),每组80例,两组患者均连用14天。结果治疗组和对照组有效率分别为87.5%和93.75%,两组差异无显著性意义意义(χ2=1.839,P>0.05);两组不良反应发生率差异亦无显著性意义(P>0.05)。结论口服特比萘芬治疗念珠菌性阴道炎疗效较好,安全性高。     

特比萘芬与伊曲康唑治疗念珠菌性阴道炎疗效比较

目的：比较特比萘芬与伊曲康唑治疗念珠菌性阴道炎的疗效。方法：134例患分为两组，治疗组作真菌镜检及培养，A组口服特比萘芬0．25g，1次／d，连服7d，B组口服伊曲康唑0．2g，1次／d，连服7d；停药时、停药2周后复诊、作真菌镜检，判定疗效。结果：A组停药时及2周后有效率分别为79．4％，85．3％；B组停经时及2周后有效率分别为81．8％，83．3％，两组比较有效率无显性差异(P＞0．05)。结论：特比萘芬与伊曲康唑均对念珠菌性阴道炎有较好的疗效。     

特比萘芬治疗头癣36例疗效观察

我们于１９９７年３～８月应用瑞士诺华公司生产的盐酸特比萘芬（疗霉舒）治疗观察头癣４７例，现将其中资料完整的３６例报告如下。１一般情况：３６例患者中３５例为门诊患者，１例为住院患者，女２７例，男９例，年龄最小为８个月，最大８１岁，平均１１．２岁。病程最...     

伊曲康唑与特比萘芬联合治疗念珠菌性阴道炎、龟头炎的疗效观察

我们于2001年1月～2003年2月对我院皮肤科门诊确诊的66例念珠菌性阴道炎、龟头炎患者，采用伊曲康唑与特比萘芬联合疗法，取得了很好的疗效，现将结果报道如下：     

口服特比萘芬治疗外阴阴道念珠菌病疗效观察

目的：观察特比萘芬治疗外阴阴道念珠菌病的临床及真菌学疗效。方法：选择外阴阴道念珠菌病患者150例，口服特比萘芬250mg，每日1次，连续口服2周，停药时及停药后4周、8周复诊，观察疗效。治疗前后作真菌镜检及培养，鉴定菌种，观察真菌清除率，并作抑菌试验，测定MIC值。结果：口服特比萘芬治疗外阴阴道念珠菌病，总有效率及真菌清除率均达到94％。结论：口服特比萘芬治疗外阴阴道念珠菌病，方法简单、疗效高。     

特比萘芬治疗浅部真菌病的临床应用

该文综述了近年来抗真菌药特比萘芬在临床应用的进展,包括特比萘芬的体外抗真菌活性,治疗儿童头癣及老年甲真菌病的疗效及不良反应,为临床医生选用抗真菌药治疗浅部真菌病提供参考。     

One-week therapy with oral terbinafine in cases of tinea cruris/corporis

The use of oral terbinafine in the treatment of superficial dermatophyte infections has been extensively studied, using different treatment regimens. To evaluate the efficacy of short-term therapy with oral terbinafine in cases of tinea cruris/corporis. 22 patients (21 male and one female) with mycologically proven tinea cruris/corporis, were included in the present study. Each patient received one tablet of terbinafine 250 mg daily for 1 week. Patients were followed-up for 6 weeks after completion of treatment. Clinical and mycological assessments were performed at the end of treatment, and at the end of the follow-up period. The mean sum of scores of signs and symptoms in all patients decreased significantly from 12-36 before treatment to 0 at the end of the follow-up period, and mycological investigations were negative in all patients at the end of the follow-up period. Our results show that 1-week therapy with oral terbinafine is highly effective in the treatment of tinea cruris/corporis.     

Treatment of chromoblastomycosis with terbinafine: a report of four cases

This report is about four cases of chromoblastomycosis confirmed by direct examination, histopathology and cultures. The duration of disease infection varied from 5 to 12 years. By culture, Cladosporium carrionii was isolated in two cases and Fonsecaea pedrosoi in the other two cases. Terbinafine 0.25 g twice daily for 1 month and 0.25 g once daily for maintenance therapy were given to three patients. Terbinafine 0.25 g once daily was given to one patient. After 4-8 months of therapy, all cases were cured without relapse when followed up for 6 months. The total dosage of terbinafine was 37.5-60 g. No relevant side effects showed during treatment.     

100例银屑病肤纹图型调查

我们就银屑病患者100例作了肤纹图型初步调查,现将结果报告如下:一、方法:用打印油墨将患者的指、掌及肠纹压印在白纸上;并对每例的指纹、猿线、atd角、大鱼际纹、小鱼际纹、指间区纹和拇区历纹七项指标进行分析.     

IFN-γ、GM-CSF增强巨噬细胞抗白念珠菌活性的研究

目的: 确定小鼠重组γ-干扰素(rmuIFN-γ)和小鼠重组粒巨噬细胞集落刺激因子(rmuGM-CSF)对巨噬细胞抗白念珠菌活性的调节.方法: 分别将不同浓度的rmuIFN-γ、rmuGM-CSF与小鼠腹腔渗出巨噬细胞共同培养2天,然后测定巨噬细胞的抗白念珠菌活性.结果: 两种细胞因子都有增强巨噬细胞抗白念珠菌活性的作用,rmuGM-CSF对巨噬细胞抗白念珠菌活性的增强效应强于rmuIFN-γ(其抑菌率分别为44.49%、35.77%,P<0.01).结论: IFN-γ与GM-CSF均有增强巨噬细胞抗白念珠菌活性的作用,两者联合应用有协同效应.