Isolated pancreatic metastasis of extremity myxoid liposarcoma: Report of a case

Myxoid liposarcoma (ML) has a high predilection for extrapulmonary sites of metastases, including intra-abdominal metastases, but pancreatic involvement is extremely rare. Here, we report the case of a 66-year-old male patient, who underwent pancreaticoduodenectomy for isolated pancreatic metastasis of ML of the left lower extremity that had been excised 6 years before. Completion pancreatectomy was necessitated afterwards for a delayed haemorrage associated with pancreatic fistula. Currently the patient is alive with no evidence of disease. Highly selected patients with isolated pancreatic metastasis of soft tissue sarcoma may benefit from a curative surgical resection.     

Myxoid liposarcoma mimicking fluid density

A case of liposarcoma of the liver capsule initially presenting as massive pleural effusion and ascites is reported. The chest radiograph, computed tomographic scan, and sonogram are emphasized.     

Primary liposarcoma of the mediastinum in a child

A case of primary anterior mediastinal liposarcoma occurring in a child is reported. A 5-year-old male child complained of exertional dyspnea and left chestpain. The chest roentgenogram showed a complete opacity of the left pleural space. After thoracotomy, the histological examination revealed mediastinal myxoid-pleomorphic liposarcoma. Surgical resection was performed and chemotherapy was given; 10 months later a recurrence was noted in the mediastinum. The child died 17 months after establishing the diagnosis.     

Primary Ewing's sarcoma family tumors of the lung a case report and review of the literature

Ewing's sarcoma family tumors (ESFT) have been reported to originatein a variety of sites, most commonly in the extremities. Weherein report a case of a primary ESFT of the lung presentingin an 8-year-old boy. A histological examination of hematoxylin–eosinstained sections showed a homogeneous population of closelypacked small neoplastic cells. The tumor cells were stronglypositive for CD99/MIC2 and negative for the leukocyte commonantigen, myoglobin, desmin, epithelial membrane antigen, AE1/AE3and synaptophysin. The patient was treated with neoadjuvantchemotherapy and surgery. Nine months later, he is in good conditionand chest CT scans have revealed no evidence of either localrecurrence or distant metastasis. Cases of ESFT of the lunghave been reported in recent years but there are still few reportsof primary ESFT of the lung. To date, only eight cases of ESFTof the lung have been reported in the literature. This is thefirst report of an ESFT of the lung occurring in a patient under10 years of age. The clinical course and therapeutic managementof ESFT are also discussed.     

The prognostic impact of dedifferentiation in retroperitoneal liposarcoma: a series of surgically treated patients at a single institution

BACKGROUND.

A series of patients with well differentiated (WD)/dedifferentiated (DD) retroperitoneal liposarcoma (RLS) was studied to evaluate the prognostic value of the presence, extension, and grade of the DD component.

METHODS.

Among 148 patients with RLS who underwent surgery over 20 years, the authors retrieved data on patients who had localized WD/DD RLS. For the current analysis, patients were included only if they had primary disease or a first recurrence at their initial presentation. The DD component, when present, was graded according to National Federation of Centers in the Fight Against Cancer (FNCLCC) criteria, and the extension of the DD component was described as a percentage. Univariate and multivariate analyses were carried out for local recurrence‐free survival (LRFS), event‐free survival (EFS), and disease‐specific survival (DSS).

RESULTS.

Of 93 patients who were identified, 36 patients (39%) had WD RLS, and 57 patients (61%) had DD RLS. The median follow‐up was 71 months (range, 28‐132 months). Seven patients (7.5%) developed distant metastases, including 5 patients who had DD RLS. The 5‐year DSS rate was 42% in patients with DD RLS and 71.6% in patients with WD RLS (P = .018). The corresponding rates for LRFS were 22% and 43.3%, respectively (P = .007). The presence of the DD component and its FNCLCC grade were independent prognostic factors for DSS and LRFS. The administration of radiation therapy was associated independently with better LRFS.

CONCLUSIONS.

Patients with high‐grade DD RLS had a worse prognosis in terms of both DSS and LRFS. The extension of the DD component and its mitotic index were relevant for EFS. The results indicated that radiation therapy may improve LRFS. These data may help stratify the risk of recurrence for patients with RLS. Clinical studies on new multimodality approaches are warranted. Cancer 2008. © 2008 American Cancer Society.     

Challenging surgical treatment of giant retroperitoneal liposarcoma: A case report

Liposarcoma is a rare malignant tumor type and surgical resection is the gold standard treatment. The present study reported on the case of a 51-year-old woman who presented with a mass in the left upper abdomen. Computed tomography revealed a 32-cm giant retroperitoneal liposarcoma. Complete tumor resection was performed without the removal of other organs. Postoperative pathological examination indicated retroperitoneal well-differentiated liposarcoma and immunohistochemistry revealed S-100(−), MDM2(+), vimentin(+), CDK4(+), p16(+) and STAT6(+) results. The patient recovered well after the surgery. Complete tumor resection during the first surgery is key to cure liposarcoma. The present case report will be helpful for clinical oncologists to fully understand giant retroperitoneal liposarcoma and treat it accordingly.     

Clinicopathological characteristics and experience in the treatment of giant retroperitoneal liposarcoma: A case report and review of the literature

Retroperitoneal liposarcoma (RPLS) is a rare tumor, especailly those over 20 kg that are called “giant liposarcoma," whose characteristics and treatments remain relatively unknown. Herein, we report a giant RPLS measuring 65 × 45 × 30 cm in diameter and 31 kg in weight, which we successfully performed complete excision through interdisciplinary cooperation. The patient had an uneventful postoperative course and was discharged without complications. Afterwards he underwent radiotherapy and had no evidence of tumor recurrence or symptoms of metastasis at 3-month CT scan and 8-month follow-up. We also first review the 13 cases reported in literature published in PubMed regarding giant RPLS. Giant RPLS commonly occurs in adults aged 40–60 y and presents atypical clinical manifestations. CT scan is the most useful examination and preoperative biopsy is controversial. Complete surgical resection still remains the principal treatment. Giant RPLS can also be removed, even reach to R0 excision, by a multidisciplinary team in a specialized center after meticulous planning even though its gigantic tumor size. Local radiotherapy following surgery may improve the rate of recurrence. Besides, closely follow-up and routine examinations are required.     

A dedifferentiated liposarcoma of the anterior mediastinum

Dedifferentiated liposarcoma was first described in 1979, and its definition has been recently extended. We found an undiagnosed anterior mediastinal mass in a 56- year-old man for whom we performed a complete tumor resection through median sternotomy. Microscopic examination revealed that the mass was primarily a low-grade, dedifferentiated liposarcoma, with a partial high-grade area. Occurrence of dedifferentiated liposarcoma in the anterior mediastinum is rare. We did not perform any adjuvant therapy. Three years after the surgery, the patient is alive without disease. In lipoma-like, well-differentiated liposarcoma cases, we should consider the possibility of dedifferentiated liposarcoma if a mild, atypical spindle cell component is found.     

Imaging features of primary pulmonary liposarcoma

Primary liposarcoma of the lung is extremely rare. We report a 28‐year‐old pregnant woman who complained of dyspnoea during the third trimester. Chest radiography, thoracic ultrasound, CT and MRI showed a huge heterogeneous tumour involving all the left lung and the mediastinum. The tumour was composed of soft tissue, and fatty and cystic components with calcifications. Diagnosis was made on core biopsy under CT guidance. Surgical excision was performed but unfortunately the patient died during the operation.     

Primary osteosarcoma of the lung: a case report and review of the literature

Primary osteosarcoma of the lung is exceedingly rare. A 72-year-old man was admitted to our hospital; a primary osteosarcoma of the lung was diagnosed following computed tomography-guided needle biopsy. He died of rapidly progressing respiratory insufficiency without effective treatment seven months after the onset of symptoms. Macroscopic findings at autopsy showed typical histologic features of osteosarcoma without any bony lesion. Here we present a rare case and review the clinicopathological features of 20 previously reported cases.     

Dedifferentiated liposarcoma of the small bowel mesentery presenting as a submucosal mass

Dedifferentiated liposarcoma(DDLPS) is a variant of liposarcoma but with a more aggressive course.It occurs most commonly in the retroperitoneum and rarely in any other anatomical location.We describe a case of DDLPS arising from the small bowel mesentery presenting as submucosal mass of the small bowel.The current case is unusual as the tumor originated from the small bowel mesentery and a dedifferentiated component transmurally invaded the small bowel wall,including the small bowel submucosa.     

Diffuse peritoneal liposarcoma—Report of one case

A rare case of diffuse peritoneal liposarcoma is reported. The patient, a man aged 45, was admitted with ascites; laboratory and instrumental studies were all negative. Ascites was unresponsive to conservative treatment, so an explorative laparotomy was planned. Parietal and visceral peritoneum showed numerous gelatinous gray-yellow nodules. Diagnosis was only histologic.     

Successful treatment of advanced pancreatic liposarcoma with apatinib: A case report and literature review

Pancreatic liposarcoma is a malignant tumor originated from the pancreas mesenchymal tissue and mostly presented in skin, subcutaneous, periosteum, and long bone on both sides. Both conventional chemotherapy and radiotherapy have limited efficacy and poor prognosis for advanced pancreatic liposarcoma. Here, we reported a case of advanced pancreatic liposarcoma and reviewed the literature specific for liposarcoma of the pancreas and discuss the emerging options of treatment. The patient was treated with apatinib and a cross-line rescue therapy combined with paclitaxel after progressive disease. The therapeutic effect of the combination regimen has been evaluated. Apatinib is an oral tyrosine kinase inhibitor targeting the intracellular domain of vascular endothelial growth factor receptor-2 (VEGFR-2), which has dual effects of anti-angiogenesis and anti-tumor cell proliferation. To our knowledge, this is the first case to report the successful use of apatinib for advanced pancreatic liposarcoma.     

转移性心包黏液样脂肪肉瘤1例报道并文献复习

原发性心包恶性肿瘤较为少见,以心包恶性间皮瘤居多,原发性心包脂肪肉瘤极为罕见,目前国内外报道甚 少[1-2],而继发性心脏恶性病变的患病率是原发性心脏恶性肿瘤的20～40倍.为进一步提高对原发性心包恶性肿瘤的认识,避免临床漏诊及误诊,现结合相关文献,就1例转移性心包黏液样脂肪肉瘤(myxoid liposarcoma,...