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偏头痛(Migraine)作为一种发作性血管神经性疾病不仅严重危害着人们的身体健康,同时也对社会医疗经济产生巨大影响。针刺作为一种安全有效的治疗措施,在预防和缓解偏头痛急性发作方面被众多临床及动物实验证明是卓有成效的。然而,针刺治疗偏头痛的机制尚未完全明确。目前,围绕偏头痛的发生机制有3种较为主流的学说,分别是血管源性学说、神经源学说和三叉神经血管学说。近10年来相关研究针刺治疗偏头痛的文献表明,针刺可能通过减轻神经炎症、降低神经元致敏与调节脑功能网络连接等方式缓解疼痛,故探讨相关可能机制从而提出新的研究方向,有利于充实针刺治疗偏头痛的理论体系。 相似文献
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针刺少阳经穴对慢性偏头痛患者脑内葡萄糖代谢的影响 总被引:6,自引:2,他引:6
目的:观察人脑对循经取穴针刺的响应特征,探讨循经取穴的中枢神经取效机制。方法:对6例慢性偏头痛患者进行针刺治疗。选取少阳经穴风池、外关、阳陵泉作为治疗穴位,应用正电子发射计算机断层显像(PET-CT)进行扫描,用统计参数图软件(SPM2)对重建图像进行数据分析并与健康人脑功能成像进行比较,观察针刺前后偏头痛患者脑内葡萄糖代谢变化。结果:针刺后患者的脑干、脑岛等疼痛矩阵脑区的兴奋区明显减少,脑功能减低区以右侧颞叶为主转变为双侧颞叶对称区域。结论:针刺少阳经对慢性偏头痛镇痛作用的可能靶点是脑桥、脑岛、额叶前部等脑区,针刺后引起双侧颞区脑代谢减低的转变可能是针刺足少阳经穴治疗偏头痛的机制之一。针刺可能通过对脑内能量代谢的协调再分配起到整体、良性的治疗效应。 相似文献
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目的:偏头痛是一种临床常见的神经血管功能障碍性疾病,在世界范围内有很高的患病率,也是全球第二大致残因素。既往磁共振成像(MRI)研究表明偏头痛患者存在大脑结构和功能的异常,作为一种非药物疗法,针刺治疗偏头痛可调节这些异常改变。目前由于偏头痛发病机制尚不明确,本研究拟利用基于体素的形态学分析(VBM)和基于种子点的功能连接(FC)方法探讨偏头痛患者脑内异常结构和功能改变,为后期研究针刺治疗偏头痛的调节脑区提供基础。方法:该研究招募了34名偏头痛患者和38名健康对照者,均行结构和静息状态功能磁共振成像扫描。使用VBM方法比较灰质体积的组间差异,将具有显著改变的灰质体积作为种子区域,进一步计算差异脑区和全脑之间的功能连接,并将脑结构或功能变化与临床特征之间做相关性分析。结果:研究结果显示偏头痛患者的左枕叶灰质体积高于健康对照组。基于种子点的功能连接分析显示,左侧枕叶和右侧额下回之间的功能连接减少,涉及前扣带皮层(ACC)和右侧脑岛。左侧ACC的FC下降与视觉模拟量表(VAS)和焦虑自评量表(SAS)呈正相关。结论:本研究提示偏头痛患者较健康受试者存在异常变化脑区,为偏头痛的神经病理学基础提供... 相似文献
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阿尔茨海默病是严重的神经退行性疾病,认知障碍是其核心症状。近年来的研究发现,脑源性神经营养因子介导的信号通路及其相关受体在神经传导中有选择性的激活与表达,进而改善认知功能。本研究基于脑源性神经营养因子研究针刺治疗认知障碍的作用机理,以期为针刺治疗认知障碍的机制提供新的思路。 相似文献
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《结合医学学报(英文版)》2014,(3)
Objective: Acupuncture has been commonly used for preventing attacks and relieving pain, although there is limited knowledgeon the physiological mechanism behind this method.The objectives of this study were to compare the differences in brain activities evoked by active acupoints and inactive acupoints and to investigate the possible correlation between clinical efficacy and brain responses.Methods: Eighty migraineurs without aura were enrolled to receive either active acupoint acupuncture or inactive acupoint acupuncture treatment for 8 weeks.Twenty patients in each group were randomly selected for a resting-state fMRI examination.The treatment schedule lasted for 8 weeks.VAS score, frequency of the migraine attack, number of days with migraine, and HIT-6 score were employed to evaluate the efficacy of acupuncture treatment, and ReHo value was used to detect brain activity.Results: The decrease in the VAS score in the active acupoint group was significantly greater than that in the control group after treatment(P0.05).However, there were no significant differences between the two groups in others(P0.05).The neuroimaging data indicated that long-term active acupoint therapy elicited a more extensive and remarkable cerebral response compared with acupuncture at inactive acupoints.The decrease in the VAS score was significantly related to the increased average ReHo values in the ACC in the two groups(P=0.0020, P=0.0015).Moreover, the decrease in the VAS score was associated with the increased average ReHo values in the insula(P=0.0003), and SMA(P=0.0130), which could be detected in the active acupoint group.Conclusion: Active acupoints were significantly superior to inactive acupoints in alleviating pain intensity for migraineurs.The efficacy of acupuncture at active acupoints might result partly from regulating some disease-affected key regions and the pain circuitry for migraine, promoting reintegration of several dimensions of the inner body, and establishing psychophysical pain homeostasis. 相似文献
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针刺治疗头痛历史悠久,安全有效,其有效率为50%左右,如何筛选针刺有效人群对于优化针刺治疗方案、节约医疗成本、减轻病人负担意义重大。运用神经影像学技术进行疗效预测是目前的神经影像学研究热点之一,因此本文综述近年针刺治疗偏头痛的相关研究,并对针刺治疗偏头痛的疗效预测研究的现状和研究思路进行探讨。 相似文献
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《结合医学学报(英文版)》2014,(3)
Neuroimaging plays a critical role in future acupuncture research.To date, many esteemed researchers have shown that acupuncture modulates many key areas of the brain using fMRI, including the primary and secondary somatosensory cortices, limbic regions, insula, and prefrontal cortex.Such findings help to shed light on at least part of the physiological processes involved in acupuncture conducted on healthy subjects.They also pointed that neuroimaging has the potential to testify acupuncture's therapeutic effectiveness.Although several recent studies have used neuroimaging to demonstrate acupuncture's effect in various conditions, there remains a need for more clinically oriented neuroimaging research.However, in designing trials that include neuroimaging outcomes, the stakes are high due to the elevated costs involved using fMRI.This presentation introduces the emerging field of neuroanthropology as a potential methodological framework for designing richly informative, high-value acupuncture trials.Neuroanthropology focuses on the triangulation of neuroimaging data with qualitative data obtained through in-depth ethnographic interviews and fieldwork in order to test neuroscientific findings in natural human environments.Beyond simply validating basic neuroscientific findings about the general functions of the human brain with qualitative observational and interview data, neuroanthropology can also play a role in clinical neuroimaging research by linking changes in specific brain networks to changes in the experience of emotional, physical, and even spiritual symptoms.It is especially appropriate for acupuncture research focusing oneffectiveness as well as efficacy.This presentation thus examines potential strategies for the incorporation of neuroanthropological methods in clinical acupuncture research, including a discussion of how neuroanthropology fits within specific research design models such as whole systems and/or comparative effectiveness research.It further invites a deeper conversation about the challenges involved with organizing, funding, and conducting such deeply interdisciplinary and mixed-methods studies. 相似文献
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[目的]观察无先兆偏头痛患者脑功能网络的拓扑属性改变,探究针刺治疗无先兆偏头痛的中枢效应机制。[方法]纳入20例无先兆偏头痛患者和20例匹配的健康受试者,患者在针刺疗程前后分别进行1次功能磁共振扫描,采用基于全脑体素水平的度中心度(DC)分析方法和基于图论理论的大尺度脑功能网络分析方法,对比无先兆偏头痛患者与健康受试者、患者针刺前后拓扑指标的变化特点。[结果]与健康受试者相比,无先兆偏头痛患者DC降低的脑区有左侧辅助运动区、边缘叶、额回内侧面、左侧扣带回中部,无DC升高脑区,且无先兆偏头痛患者的聚类系数和局部效率明显下降,最短路径、小世界指数、全局效率呈下降趋势。与针刺前相比,无先兆偏头痛患者针刺后的聚类系数、局部效率、小世界指数、全局效率有升高趋势。[结论]针刺治疗能改善无先兆偏头痛患者下降的聚类系数和局部效率等拓扑指标。 相似文献
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Introduction:Obstructive sleep apnea syndrome(OSAS) is considered a major public health issue due to its high prevalence and severe consequences.Several published studies have revealed that electroacupuncture may relieve OSAS symptoms.However,the mechanism of electro-acupuncture in the treatment of patients with OSAS remains unclear.Methods and analysis:We evaluated the efficacy and mechanism of electro-acupuncture in the treatment of patients with OSAS.This was a two-group parallel randomized c... 相似文献
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近年来,脑科学是国际交叉科学研究的热点和前沿领域。技术是推动学科发展的重要工具。立足科学前沿及国家需求,脑科学技术也不断推动中医药现代化发展及脑科学研究与中医药特色疗法的紧密结合。针刺疗法是传统中医疗法中不可或缺的组成部分,“针刺治神”奠定了针刺疗法通过中枢整合体表刺激信息调制机体内环境稳态以发挥治疗作用的中医理论基础。探究针刺治疗疾病的中枢效应机制十分必要。目前,在针刺研究领域中,无论是临床研究还是基础研究,脑科学相关技术均得到了广泛应用。因此,本文主要以神经示踪、光遗传、化学遗传、膜片钳、脑微透析、功能磁共振成像、脑电技术为例,梳理了脑科学技术在针刺研究中的应用,旨在总结现有脑科学技术的特点,为脑科学技术创新及应用探究针刺的中枢效应机制提供新思路。 相似文献