胰腺内副脾误诊为神经内分泌肿瘤病例特点及误诊分析（附 10例报道）

目的 探讨胰腺内副脾患者的病例特点及误诊原因，以提高对该病的认识，减少误诊及不必要的手术。方法 回顾性收集术前诊断为胰腺神经内分泌肿瘤，经术后病理确诊为胰腺内副脾的患者10例(共12 个病灶)，分析其CT、MRI、Ga68-dotatatePET-CT图像、病理特点及临床资料。结果 10例患者中9例为单发，1例有3个病灶；12个病灶均位于胰尾、均与周围组织边界清晰、均为富血供结节；病灶最大径0.3~3 cm, 平均1.43 cm。MRI表现：T1W1均呈低信号，T2W1 8例呈高信号（80%），DWI 7例呈高信号（70%）；增强扫描动脉期6例呈均匀强化，只有 1例呈 “花斑样”不均匀强化。3例行Ga68-dotatatePET-CT检查的患者病灶均呈高代谢，SUVmax约为脾脏SUV的一半。结论 IPAS一般位于胰尾，病灶小于3cm，边界清晰；在MRI T1W1序列上呈低信号，T2W1及DWI多呈高信号，增强扫描动脉期很少见到典型的“花斑样”不均匀强化，静脉期及延迟期多为均匀强化，68Ga标记生长抑素受体PET/CT检查时可能会出现高代谢。     

胰腺伴破骨细胞样巨细胞未分化癌的影像学特征分析

目的探讨胰腺伴破骨细胞样巨细胞未分化癌(UPC-OGC)的计算机断层扫描(CT)和磁共振成像(MRI)特征。方法回顾性纳入2015年4月至2019年11月在复旦大学附属中山医院经病理确诊为UPC-OGC、术前行上腹部CT或MRI检查且临床和病理资料完整的11例患者。分析所有UPC-OGC患者的CT、MRI图像特征, 包括病灶位置、数目、形态、大小、边界, 平扫、强化特点, 周围侵犯、转移情况等。采用独立样本t检验进行统计学分析。结果 11例UPC-OGC患者的肿瘤病灶均为单发, 病灶最大径(范围)为(4.84±2.96) cm(2.00～12.80 cm)。7例UPC-OGC患者肿瘤病灶位于胰头, 2例位于胰体, 1例位于胰尾, 1例位于胰体尾部。3例UPC-OGC患者肿瘤病灶形态为类圆形, 8例患者肿瘤病灶形态为椭圆形伴分叶。8例UPC-OGC患者肿瘤病灶边界清晰, 3例患者肿瘤病灶边界不清。7例UPC-OGC患者行CT平扫和增强扫描检查, CT平扫检查示肿瘤实性区CT值与正常胰腺实质相近[(37.14±6.10) HU比(43.14±4.55) HU], 差异无统计学意义(t=-2...     

MRI、CT与PET/CT在老年胰腺神经内分泌肿瘤中的影像特点

目的探讨核磁共振成像(MRI)、电子计算机断层扫描(CT)及正电子发射计算机断层显像(PET/CT)在老年胰腺神经内分泌肿瘤(NETP)中的诊断价值。方法选取通过病理及免疫组化确诊为NETP的老年患者17例,其中12例为无功能性NETP,5例为功能性NETP。结果磁共振检查病变位于胰腺,T1WI表现低信号或等信号,T2WI表现高或低混杂信号,DWI均显示高信号;CT平扫检查显示等或低混杂密度,实性部分病变平扫平均CT值45.9HU。增强CT及磁共振扫描检查均表现"快进快出",囊性病变不呈现强化;1例功能性NETP经PET/CT检查不存在高代谢灶,1例无功能性NETP经PET/CT检查存在等密度结节,病灶大小为1.2 cm,SUVmax为4.1。结论 CT、磁共振两者共同影像学特点表现为老年NETP境界清晰和显著增强,PET/CT检测采取合适的示踪剂对体积较小的功能性NETP有重要意义,可以全面预测是否存在转移。     

应用18F-FDG PET/CT检查评价肝泡型包虫病肝内病灶活性研究*

目的 观察¹⁸-氟脱氧葡萄糖(¹⁸F-FDG)PET/CT检查对肝泡型包虫病(HAE)患者治疗前后肝内病灶活性的评价作用。方法 2016年6月～2018年6月我院收治的109例HAE患者,按体质量服用阿苯达唑脂质剂10 mg·d^-1·kg^-1,治疗6个月。所有患者均于治疗前后行¹⁸F-FDG PET/CT检查,分析病灶边缘带最大标准放射性摄取值(SUV_max)。结果 在109例患者中,治疗前PET/CT检查显示HAE病灶多呈混杂密度占位灶,形状不规则,内见钙化灶、液化性坏死区,边界不清晰,多呈侵袭性生长,病灶边缘带见放射性药物分布影,且高于肝脏,病灶内部未见明显放射性分布;在阿苯达唑脂质剂治疗后6个月,PET/CT检查显示75例病灶周边放射性浓聚现象消失或明显降低,34例病灶边缘带放射性分布较治疗前轻度变淡;109例患者在阿苯达唑治疗后病灶边缘增殖浸润带SUV_max值为(3.6±1.4),显著低于治疗前【(4.9±1.9),P＜0.05】。结论 应用¹⁸F-FDG PET/CT检查能够帮助评估HAE病灶活性,从而指导药物治疗。     

SAP的CT-MRI表现

正常胰腺从胰头到胰尾逐渐变小,横行于腹膜后,胰头、钩突位置较低,胰体和胰尾部位置略高,胰颈部略有狭窄,其周围可见低密度的脂肪组织,其前上方是胃后壁,后方是脾静脉,胰头最大径约3.0 cm,胰体约2.5 cm,尾部约2.0 cm,老年人的正常胰腺实质萎缩,体积缩小.CT平扫时正常胰腺实质密度均匀,与脾脏相似,轮廓规则,边缘清楚,CT值40~50 HU;CT增强扫描胰腺实质呈均匀性强化,CT值达70~80 HU.磁共振T1加权像胰腺表现为与肝脏相似的信号强度,T2加权像信号强度与肝脏相似或略高,胰腺后脂肪的短T1长T2高信号勾画出胰腺轮廓.     

胰腺异位副脾1例报告并文献复习

胰腺异位副脾临床发病罕见,术前诊断困难,易误诊为胰腺神经内分泌肿瘤。本文报告1例胰腺异位副脾病例,患者因上腹部胀痛不适就诊,完善腹部磁共振检查和CT检查示胰尾部大小约1.4 cm×1.1 cm占位,术前辅助检查结果示：胰腺占位性病变？胰腺神经内分泌肿瘤？胆囊结石伴慢性胆囊炎;胆总管结石伴胆管炎;肝功能不全。择期行内窥镜逆行性胆管胰管造影术+内镜乳头括约肌切开取石术+胆囊切除术+胰腺体尾部切除术,术后病理示：胰腺异位副脾;胆囊结石伴慢性胆囊炎。给予对症处理后患者出院,随访正常。     

胰腺3T磁共振弥散加权成像的临床应用研究

目的 探讨胰腺组织3T磁共振(MR)扩散加权成像(DWI)的可行性及其在胰腺肿瘤定性诊断中的价值。方法 应用3T MR成像仪对20名健康志愿者和47名胰腺肿块患者(胰腺癌21例,肿块型胰腺炎7例,胰腺囊性肿瘤19例)行胰腺常规MRI及两组不同扩散梯度因子(b值,500和1000 mm2/s)DWI检查,测量病灶、病灶旁胰腺DWI信号强度(signal intensity,SI)及病灶表观扩散系数(apparent diffusion coefficient,ADC)值。结果 在b=500和1000 mm2/s DWI图像上,正常胰腺实质信号均匀,胰头、体、尾各部分的ADC值差异均无统计学意义;而胰腺癌、肿块型胰腺炎均显示为高信号,且在b=1000mm2/s的DWI上胰腺癌的相对SI1000值显著高于肿块型胰腺炎(1.238 +0.448比0.371±0.293,P＜0.01)。胰腺癌与肿块型胰腺炎ADC500和ADC1000均显著低于正常胰腺(P＜0.01),且胰腺癌ADC1000显著低于肿块型胰腺炎[(1.087±0.175) mm2/s比(1.279 +0.213) mm2/s,P＜0.01]。胰腺囊性病变在b= 500 mm2/s时显示为高信号,在b=1000mm2/s的DWI上表现为低或等低信号,其ADC500和ADC1000均显著高于正常胰腺(P值均＜0.01)。结论 3T磁共振胰腺DWI有助于胰腺肿块型病变的鉴别诊断,高b值DWI对胰腺病变定性诊断更有价值。     

胰腺实性假乳头状瘤27例临床诊疗分析

目的探讨胰腺实性假乳头状瘤（SPT）的临床病理特点、影像学特点,总结诊疗经验。方法对2008年9月至2012年9月我院单中心收治的27例SFF患者的临床资料进行回顾性分析。结果全部27例患者行手术切除,行胰十二指肠切除4例,保留十二指肠胰头肿瘤切除6例,胰腺中段切除5例,保留脾脏胰体尾切除5例,胰体尾＋脾切除7例。27例患者中有12例合并不同程度的胰漏及发热,其中有1例术后出现脾动脉出血。全部患者随访中有1例术后2年出现复发并再次手术切除,余均未出现复发及转移,无死亡。结论胰腺SPT常见于青年女性,为交界性恶性潜能肿瘤,预后好。CT及MRI是最主要的影像学检查方法。治疗原则建议行根治性手术切除,同时争取保留周边脏器结构功能完整。     

胰腺囊性肿瘤15例诊治分析

目的探讨胰腺囊性肿瘤的临床病理特点及诊治方法。方法对2004～2009年我院收治的均经手术和病理检查证实为胰腺囊性肿瘤的15例临床资料进行回顾性分析。结果 15例病人中浆液性囊腺瘤3例,黏液性囊腺瘤7例,囊腺癌5例。浆液性囊腺瘤较黏液瘤和囊腺癌小(P<0.05)。5例血清CAl99明显升高(胰腺囊腺癌4例,胰腺黏液性囊腺瘤1例)(正常参考范围1～39 u/L),提示CAl99是鉴别胰腺囊性肿瘤良恶性的较好标志物。5例肿物位于胰头部,1例肿物位于胰体部,2例肿物位于胰体尾部,7例肿物位于胰尾部。全部病人均接受了手术治疗。肿物位于胰头者行胰、十二指肠切除术5例;肿物位于胰体者行胰腺节段切除加胰腺远端空肠Roux-en-Y吻合术1例;肿物位于胰体尾者行肿物摘除术2例;肿物位于胰尾者行肿物摘除术2例,胰体尾切除术2例,胰体尾及脾切除术2例,胰体尾切除、脾切除及肝转移瘤切除术1例。与病理诊断相比,术前诊断误诊率26.7%,手术术中诊断误诊率20%。全组无围手术期死亡者,预后良好。结论临床中胰腺囊性肿瘤的病史询问,病理学特征,B超及CT检查,囊液分析及组织活检有助于明确诊断,手术切除是唯一有效的治疗方法,疗效满意。     

自身免疫性胰腺炎的CT和MRI影像学征象

目的 探讨自身免疫性胰腺炎(autoimmune pancreatitis,AIP)的CT及MRI影像学表现特征.方法 回顾性分析14例经组织学和(或)类固醇激素治疗证实的AIP患者的CT及MRI资料.10例行CT检查,7例行MRI检查(其中3例同时做CT和MRI检查).结果 11例AIP表现为胰腺弥漫性肿大,3例为胰腺局限性肿大.10例CT平扫见胰腺病变区密度均降低,5例显示节段性胰管,5例见胆总管胰头段狭窄;7例在胰腺病变区周围可见环绕包膜样结构;动态增强后出现延迟均匀强化.7例MRI的抑脂T1WI显示胰腺病变后信号均匀降低(3例)或不均匀降低(4例),抑脂T2WI信号均匀增高(3例)或不均匀增高(4例);4例MRI显示胰管,MRCP见1例胰头部胰管局限性狭窄,2例胰管节段性狭窄;5例MRI见胆总管胰头段狭窄,MRCP见3例胆总管胰头段呈鸟嘴样狭窄;6例见胰腺病变区周围环绕包膜样结构.14例AIP均未见胰腺实质钙化,胰管均未见明显扩张(＞3 mm).结论 AIP的CT、MRI表现具有特征性,主要为胰腺呈腊肠样改变,胰周出现包膜样结构,胰管弥漫性或局限性狭窄,胆总管胰头段炎性狭窄.     

妊娠高血压综合征致后部可逆性脑病综合征的影像学表现

目的 探讨妊娠高血压综合征(pregnancy-induced hypertension,PIH)致后部可逆性脑病综合征(posterior reversible encephalopathy syndrome,PRES)的影像学特点.方法 3l例PHI患者均行CT平扫,MPd平扫+弥散加权成像(diffusion-weighted imaging,DWI).结果 31例PIH患者CT平扫均可见顶枕叶分水岭区低密度影,CT值19～23 Hu;其中11例MRI表现为T1稍低信号,T2稍高信号,液体衰减反转恢复序列旱高信号,DWI旱等信号,表观弥散系数不下降;临床症状恢复时间早于MRI影像学恢复时间.结论 PIH妊娠晚期发生的PRES的CT和MRI病变部位具有一定特征性,结合病史可明确诊断.     

CT and MR Imaging Findings of Pancreatic Paragangliomas: A Case Report

Previous studies on pancreatic paraganglioma, a rare neoplasm, have primarily reported its ultrasound and routine and contrast-enhanced computed tomography (CT) findings. To our knowledge, we are the first to report the contrast-enhanced magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) sequence findings of pancreatic paraganglioma.A male patient, ages 41 years, was admitted to our hospital due to a pancreatic space-occupying lesion that had been present for more than 10 days. The patient had no obvious discomfort. He had a history of hypertension and hyperthyroidism. Physical examination revealed upper abdominal tenderness without a palpable mass. Routine and contrast-enhanced abdominal CT showed a soft tissue mass at the pancreatic head/uncinate process, with patchy calcification within the lesion. On a contrast-enhanced CT scan, severe enhancement of the mass in the arterial phase was noted, as was slightly reduced but still marked enhancement in the venous phase. The celiac trunk and superior mesenteric artery segment were wrapped by the tumor. Thickened, tortuous vessels were observed at the lesion edges, around which there were multiple enlarged lymph nodes. The main pancreatic duct was markedly dilated. Routine and contrast-enhanced pancreatic MRI demonstrated an abnormal nodular signal in the pancreatic head/uncinate process that was approximately 4.3 × 6.4 cm² in size. T1-weighted imaging (T1WI) revealed hypointensity, whereas T2-weighted imaging (T2WI) revealed nonhomogeneous, slight hyperintensity. Patchy hypointensity on both T1WI and T2WI was observed within the lesion. DWI showed slight hyperintensity. Grossly heterogeneous enhancement of the mass was observed on a contrast-enhanced MRI scan, with the tumor wrapped around the adjacent vasculature, and multiple enlarged lymph nodes were observed peripherally. After preoperative preparation, the patient underwent pancreatoduodenectomy. Histopathology and immunohistochemistry of the resected tumor indicated pancreatic paraganglioma. After surgery, the patient recovered well, without presenting any recurrence or metastasis during short-term follow-up.For hypervascular pancreatic tumors on contrast-enhanced CT or MRI, and particularly those occurring in the pancreatic head, with a clear display of draining veins, the possibility of pancreatic paraganglioma should be considered. These tumors usually exhibit necrosis or cystic changes and are occasionally accompanied by calcification.     

肝局灶性结节增生的MRI诊断及鉴别诊断价值

目的探讨肝脏局灶性结节增生的MRI诊断及鉴别诊断价值。方法回顾性分析16例肝脏局灶性结节增生的MRI平扫及动态增强表现。结果平扫15例T1W1呈稍低信号,1例呈低信号;T2WI16例均呈稍高信号,14例可见中心斑痕;动态增强16例动脉期均明显均匀强化,静脉期及延迟期呈等及稍高信号,中心斑痕延迟强化。结论MRI平扫及动态增强对其诊断具有一定临床意义。     

Imaging findings of splenic hamartoma

AIM: To assess CT and MR manifestations and their diagnostic value in splenic hamartoma with review of literatures. METHODS: We described a woman who was accidentally found to have a splenic tumor by ultrasound of the abdomen. CT and MR findings of this splenic hamartoma were proved by pathology retrospectively. RESULTS: The CT and MR findings in this case included a ball-like mass with homogeneous mild-hypodensity lesions on non-enhanced CT scans or isointensity on T1-weighted images and mild hypointensity on T2-weighted images, progressive homogeneous enhancement on multiple-phase spiral CT and MR enhanced scans, and isodense enhancement on delayed post-contrast CT scans and obvious hyperintensity relative to the spleen on delayed MR images. CONCLUSION: Splenic hamartoma has some specific radiological features. However, the diagnosis of this disease must be based on clinical features and confirmed by pathology.     

Dermatofibrosarcoma Protuberans: Computed Tomography and Magnetic Resonance Imaging Findings

The aim of this study was to analyze the computed tomography (CT) and magnetic resonance imaging (MRI) findings of dermatofibrosarcoma protuberans (DFSP), with a view to improving the diagnosis of this kind of tumor.A total of 27 cases of histopathologically confirmed DFSP were analyzed retrospectively. Of these, 18 patients underwent a CT scan and 9 patients underwent an MRI. All patients underwent unenhanced and contrast-enhanced examinations; 1 patient underwent multiphrase CT enhancement examination. Imaging characteristics, including location, shape, size, number, edge, and attenuation or intensity of each lesion, both unenhanced and contrast enhanced, were analyzed.Of the 27 cases, 24 were solitary, 2 had 2 nodules, and 1 had multiple confluent tumors. The lesion with multiple confluent tumors was ill defined and irregular; the other lesions were oval or round, well-defined nodules or masses. The unenhanced CT images showed 19 homogenous isodense lesions. There was no calcification in any of the patients. The contrast-enhanced CT images showed intermediate and marked nonhomogeneous enhancement in 13 lesions, intermediate homogeneous enhancement in 4 lesions, and a mild heterogeneous enhancement in 2 lesions. MR T1-weighted images revealed 1 ill-defined and 9 well-defined homogeneous isointense lesions. T2-weighted images showed homogeneous hyperintensity to the muscles in 6 lesions, 3 mild hyperintense lesions with hypointense lesions, and 1 mixed, mild hyperintense and isointense lesion. Contrast-enhanced T1-weighted images demonstrated intermediate and marked nonhomogeneous enhancement in 9 lesions and intermediate homogeneous enhancement in 1 lesion.DFSP is characterized by a subcutaneous well-defined soft tissue nodule or mass on plain CT/MR scans, and shows intermediate-to-marked enhancement on contrast-enhanced CT/MR scans. The imaging findings for DFSP are nonspecific, but may help to define the diagnosis in an appropriate clinical setting.Dermatofibrosarcoma protuberans (DFSP) is a rare low-grade malignant cutaneous tumor. It was first reported by Darier and Ferrand and called “progressive and recurrent skin fibroma” in 1924.¹ In 1925, Hoffman named it as DFSP.² DFSP often occurs in the dermis and subcutaneous layers. Typical DFSP shows superficial skin nodules or masses, and often protrudes from the skin surface. DFSP is often misdiagnosed, especially for larger tumors with deep tissue invasion and atypical manifestations, which often results in improper treatment leading to vulnerability to relapse. DFSP is often superficial; therefore, there are few reports focusing on imaging findings of DFSP.^3–12 Herein, we provide a retrospective review of the imaging findings of 27 cases of DFSP with the aim to improve our knowledge of DFSP.     

肝脏局灶性结节增生CT、MRI征象和病理特点的综合分析

目的探讨肝脏局灶性结节增生（FNH）的CT、MRI征象和病理特点。方法回顾性分析经手术切除病理证实为FNH病例15例,其中7例术前行多层螺旋CT平扫及多期增强扫描,另8例行MR平扫及多期增强扫描。结果15例病灶多呈类圆形、椭圆形,少数呈分叶状;病灶直径3．0～8．0cm;病灶的边界在平扫时显示模糊,增强后显示清楚;CT平扫病灶多呈稍低或等密度,中心部分瘢痕结构呈更低密度,增强后动脉期病灶实质部分多明显均匀强化,瘢痕结构未见强化,门静脉期和延迟期实质部分强化程度下降呈稍低或等密度,瘢痕结构延迟强化,其中4例瘢痕结构可见;MRI平扫病灶呈稍长或等T1WI及T2WI信号,瘢痕结构于T2WI上呈特征性高信号,增强后三期信号变化特点类似CT三期增强特点,其中5例瘢痕结构可见;9例增强后病灶内或周围可见增粗、扭曲的动脉,在T2WI上表现为血管流空。结论熟悉FNH多种影像征象,可提高FNH术前诊断率。CT和MRI能够反映FNH病理特点及血供血管情况,可为临床选择手术方案提供重要参考。     

Solitary Necrotic Nodules of the Liver: Histology and Diagnosis With CT and MRI

Background

A solitary necrotic nodule (SNN) of the liver is an uncommon lesion, which is different from primary and metastatic liver cancers.

Objectives

To analyze the classification, CT and MR manifestation, and the pathological basis of solitary necrotic nodule of the liver (SNN) in order to evaluate CT and MRI as a diagnosing tool.

Patients and Methods

This study included 29 patients with liver SNNs, out of which 14 had no clinical symptoms and were discovered by routine ultrasound examinations, six were found by computed tomography (CT) due to abdominal illness, four had ovarian tumors, and five had gastrointestinal cancer surgeries, previously. Histologically, these SNNs can be divided into three subtypes, i.e., type I, pure coagulation necrosis (14 cases); type II, coagulation necrosis mixed with liquefaction necrosis (five cases); and type III, multi-nodular fusion (10 cases). CT and magnetic resonance imaging (MRI) patterns were shown to be associated with SNN histology. All patients were treated surgically with good prognosis.

Results

CT and MRI appearance and correlation with pathology types: three subtypes of lesions were hypo-density on both pre contrast and post contrast CT, 12 lesions were found the enhanced capsule and 1 lesion of multi- nodular fusion type showed septa enhancement. The lesions were hypo-intensity on T2WI and the lesions of type II showed as mixed hyperintensity on T2WI. The capsule showed delayed enhancement in all cases, and all lesions of multi- nodular fusion type showed delayed septa enhancement on MR images. 15 cases on CT were misdiagnosed and Four cases on MRI were misdiagnosed and the accuracy of CT and MRI were 48.3% and 86.2% respectively.

Conclusions

In conclusion, CT and MRI are useful tools for SNN diagnosis.     

超急性及急性脑梗塞的磁共振弥散成像

目的 评价磁共振弥散加权成像在老年人超急性、急性脑梗塞中的应用及与常规磁共振序列、CT之间的比较。方法共收集61例疑似超急性、急性脑梗塞患者（平均年龄70岁）,在发病24h内进行磁共振T1WI、T2WI、水抑制序列、弥散加权扫描以及CT扫描。结果 共有36例患者确诊为超急性或急性脑梗塞,弥散加权序列准确显示了35例,敏感性为97％、特异性为99％;水抑制序列加T2WI为56％、57％,CT为44％、48％。结论 弥散加权对于24h内超急性、急性期脑梗塞的显示明显优于常规磁共振序列及CT,并且可以很好地区分急性与慢性梗塞病灶。     

Assessment of hepatocellular carcinomas using conventional magnetic resonance imaging correlated with histological differentiation and a serum marker of poor prognosis

Purpose

To establish a method of assessing the malignant potential of hepatocellular carcinoma (HCC) using magnetic resonance imaging (MRI).

Methods

For 69 nodules [12 Edmondson (Ed)-I, 48 Ed-II, 9 Ed-III] in 54 HCC patients, signal intensity patterns and enhancement patterns of gadopentate dimeglumine (Gd-DTPA) dynamic studies were correlated with histological differentiation and serum lens culinaris agglutinin-reactive alpha-fetoprotein (AFP-L3) level, which is an indicator of poor prognosis.

Results

Hypointensity on T1-weighted imaging was seen in 17, 72, and 89% of Ed-I, Ed-II, and Ed-III HCCs, respectively (P < 0.001). Meanwhile, hyperintensity on T2-weighted imaging was seen in 42, 88, and 89% (P < 0.005). Tumor stain during the arterial phase of Gd dynamic MRI was seen in 75, 86, and 89%. Tumor stain washout during the portal phase was seen in 43% of Ed-II and 100% of Ed-III HCCs (P < 0.005). In the Ed-II and Ed-III HCCs, hypointensity on T1-weighted imaging was seen in 65% of AFP-L3-negative HCCs and 90% of AFP-L3-positive HCCs (P = 0.071). Washout of tumor stain during the portal phase was seen in 39% of AFP-L3-negative HCCs and 75% of AFP-L3-positive HCCs (P < 0.05).

Conclusions

Although hyperintensity of tumor on T2-weighted imaging and arterial hypervascularity of tumor are considered to be useful for differential diagnosis between well differentiated HCCs and moderately/poorly differentiated HCCs, hypointensity of tumor on T1-weighted imaging and tumor stain washout during the portal phase of Gd-DTPA dynamic MRI reflected poorer histological differentiation of HCCs and correlated with AFP-L3 levels.