共查询到20条相似文献,搜索用时 250 毫秒
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1 临床资料患者女,56岁.因右腰背部褐色斑片10余年就诊.10余年前无明显诱因右腰背部出现褐色斑丘疹,无明显自觉症状.后皮损渐增多,面积增大,部分皮损相互融合大致呈环状.曾在多家医院就诊,一直未明确诊断,亦未曾治疗.否认家族中有类似症状患者.体检:一般情况好,系统检查无见异常. 相似文献
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临床资料患儿男,6个月.全身发棕褐色斑5月余就诊.患儿于出生半月时胸腹部、颈项部出现不规则片状浅褐色斑疹、斑丘疹,未经治疗,皮疹渐增多,并延及全部躯干、四肢及头面部.皮疹颜色随时间推移而逐渐加深,由浅褐色变为棕褐色斑疹或斑丘疹. 相似文献
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患者女,42岁.因右侧腋部、右乳外上象限和右腹部丘疹10年,于2011年7月6日来我科就诊.10年前患者发现右侧腋部、右乳外上象限和右腹部斑片,不痛不痒,逐渐扩大.患病以来,未接受治疗.既往体健,无其他病史,家族中无类似病史.
体格检查:一般情况好,各系统检查未发现异常.皮肤科检查:右腋部皮损由瓷白色互不融合的丘疹形成,周边有色素减退斑和色素沉着斑(图1A);右乳外上象限旁淡褐色斑片,皮损中央大部分为瓷白色,轻度萎缩,无明显硬化;右腹部两处淡红色斑片,有蜡样光泽,皮损中央萎缩,皮革样硬度,周边有红晕(图1B).躯干四肢、肛门、生殖器及黏膜部位未见皮损. 相似文献
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《中国皮肤性病学杂志》2020,(2)
正1临床资料例1女,51岁,皮肤褐色斑片、丘疹伴痒20年余,泛发全身1年。患者20余年前背部出现褐色斑疹伴痒,外院考虑"鱼鳞病",外用止痒药物(具体不详)无效,皮损渐增多。至2016年泛发全身,弥漫分布棕褐色斑片,瘙痒剧烈,遂来本科就诊。 相似文献
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患者男,34岁,因面颈、躯干、上肢红丘疹及褐色斑6年就诊.患者6年前无明显诱因于颈部、双腋下、腹股沟陆续出现红色丘疹,炎症消退后呈现棕褐色斑片或斑丘疹,反复发作,之后累及前额、胸腹及后背,部分融合成网状,对称分布,有时瘙痒.体检:各系统检查未见明显异常.皮肤科检查:患者前额、颈部、躯干见成片棕褐色斑疹、斑丘疹,夹杂散在红色丘疹、斑丘疹,皮疹扁平,表面无鳞屑,孤立损害似脂溢性角化样;前额及颈部皮疹密集分布,融合呈网状;双腋下及腹股沟可见绿豆大小红色丘疹,呈密集网状分布,腰腹部皮肤可见弥漫性点状色素减退斑. 相似文献
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汤爱民 《国际皮肤性病学杂志》1986,(4)
本文报道2例类似先天性色素痣的先天性平滑肌错构瘤。一例年龄7周,白种人,男婴;另一例年龄5岁,混血男孩。疑患先天性色素痣而做皮肤磨平术。体检:例1右中背部有一70×25mm的淡褐色斑片,边缘不规则,表面有淡白色的毳毛。例2左下背、胁腹部和腹股沟区有一边界不规则的150×120mm棕褐色斑片,表面被有淡色毳毛。整个皮损均可见毛囊性丘疹,亦可见少数棕褐色卫星斑。二 相似文献
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43岁男性患者,阴阜和阴茎多发褐色丘疹、斑块及斑片伴鸡冠状赘生物4年余。右侧阴阜见聚集3枚黑褐色扁平丘疹,上覆鱼籽样小突起;左侧阴阜有一豌豆大淡红色鸡冠状赘生物,质软;阴茎背近端见棕褐色斑疹、斑块及斑片,上附散在黑褐色粟粒大扁平丘疹,质硬、表面光滑。依次取阴茎背色素斑块、右侧阴阜褐色丘疹及左侧鸡冠状赘生物,共3处皮损行组织病理检查,分别符合肛门生殖器鳞状上皮内瘤和尖锐湿疣的诊断。 相似文献
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Dowling-Degos disease--a heat aggravated variant 总被引:2,自引:0,他引:2
A 22-year-old woman presented with a 5-year history of a micropapular eruption localized to the flexor aspect of her limbs as well as persistent reticulate pigmentation of her neck and upper chest resembling Darier's disease. The eruption was associated with pruritus that was precipitated by heat and was worse in summer. The axillae, groins and inframammary areas had multiple papules but lacked reticulate pigmentation. Multiple biopsies showed an epidermis with club- and antler-like rete ridges but no acantholysis or dyskeratosis. This distinct clinical presentation may represent an unusual heat aggravated variant of Dowling-Degos disease that clinically shares features with Darier's disease and transient acantholytic dermatosis. 相似文献
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Dowling–Degos disease with dyschromatosis universalis hereditaria-like pigmentation in a family 总被引:1,自引:0,他引:1
K Sandhu A Saraswat AJ Kanwar 《Journal of the European Academy of Dermatology and Venereology》2004,18(6):702-704
Dowling-Degos disease is a rare autosomal dominant inherited pigmentary disorder characterized by reticulate pigmentation of the flexures, prominent comedone like lesions and pitted scars. Dyschromatosis universalis hereditaria is characterized by the presence of hypopigmented as well as hyperpigmented macules. We report a family showing features of both these diseases. 相似文献
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Cutaneous and systemic plasmacytosis (CSP) is an exceedingly rare condition arising primarily in patients of Japanese descent. Herein, we describe a patient of mainland Chinese origin suffering CSP. A 49-year-old Chinese male had asymptomatic brownish-red plaques and papules of the face and trunk for 6 years. Physical examination revealed innumerable symmetric red-brownish macules on face and trunk with fewer red-brownish papules scattered among the macules. Chemical analysis revealed hypergammaglobulinemia. Computerized tomography scan discovered some lymphadenopathy in the axillary, paratracheal and pulmonary regions. Histological examination showed focal perivascular and periadnexal infiltrate of mainly plasma cells in the superficial and deep dermis. Immunohistochemical study showed that a great number of the infiltrating cells were CD20-positive. The infiltrated polyclonal plasma cells expressed both kappa and lambda light chains. Topical therapy with tacrolimus 0.1% ointment for 2 months reduced the thickness and pigmentation of the facial skin lesions. The lesions resumed the original appearance 3 weeks after discontinuing the therapy. To the best of our knowledge, this is the first case of CSP from mainland China. 相似文献
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Dowling-Degos disease (DDD) is a rare autosomal dominant trait characterized by numerous, symmetrical, progressive and pigmented macules over the axillae, groins, face, neck, arms and trunk as well as scattered comedo-like lesions (dark dot, follicles) and pitted acneiform scars. Histopathology is diagnostic testing using a distinctive form of acanthosis, characterized by an irregular elongation of thin branching rete ridges, with a concentration of melanin at the tips. We report cases of generalized DDD in a single family with autosomal dominant penetrance. DDD can be presented in a generalized form with hypopigmented lesions instead of reticulate hyperpigmentation confined to the flexor areas. This form can be differentiated from DUH by histopathology. 相似文献
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Zimmermann CC Sforza D Macedo PM Azulay-Abulafia L Alves Mde F Carneiro SC 《Anais brasileiros de dermatologia》2011,86(5):979-982
Dowling-Degos disease (DDD) is a rare genetic disease of the skin (reticulate pigmented anomaly), clinically characterized by flexural brown pigmented reticulate macules, comedo-like papules on the back, neck and pitted perioral or facial scars. We present the case of a 51 year-old man with macrocomedo-like lesions, pitted scars, cysts, hyperpigmented macules in his back, chest, axillae, neck, groin and face. The patient reported having two children, three brothers and a father with a similar condition. The histopathology of the skin biopsies was very characteristic of Dowling-Degos disease, showing dilated follicular, fingerlike projections called rete ridges (dermal pegs), with thinning of the suprapapillary plates, resulting in an "antler-like" pattern and increased pigmentation of the basal layer. 相似文献
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Howard A. Oriba M.D. Jacob S. Lo M.D. Jacob W. E. Dijkstra M.D. Wilma F. Bergfeld M.D. 《International journal of dermatology》1991,30(1):39-42
ABSTRACT: A 26-year-old white woman had reticulate nonmelanocytic hyperpigmentation anomaly characterized by partially blanching red-brown papules and macules and a histologic picture of digitate epithelial budding proliferation with lightly pigmented rete ridges. Except for the classically described hyperpigmentation at the rete ridge tips, the patient has Dowling-Degos disease. This case of a reticulate nonmelanocytic hyperpigmentation anomaly is probably a variant of Dowling-Degos disease. 相似文献
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Laila El Shabrawi‐Caelen Angelika Hofer Helmut Kerl 《Journal der Deutschen Dermatologischen Gesellschaft》2007,5(8):645-646
Galli‐Galli disease is usually characterized by reticulate hyperpigmentation of the flexures. Rare patients may present without this finding, instead having only localized erythematous papules and brown, lentigo‐like macules on the trunk and extremities. Histological changes consist of elongated and in part hyperpigmented rete ridges and areas of acantholysis. 相似文献
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Byung Soo Kim MD Sang‐Hee Seo MD Hong Dae Jung MD Kyung‐Sool Kwon MD Moon‐Bum Kim MD 《International journal of dermatology》2010,49(4):421-425
Background X‐Linked reticulate pigmentary disorder is a very rare cutaneous condition characterized by different clinical manifestations according to sex. Methods We report a 31‐year‐old woman with X‐linked reticulate pigmentary disorder. Results On examination, there were multiple, asymptomatic, brownish macules in linear and whorled patterns over the trunk, axillae, groin, and extremities. The woman had not experienced any systemic manifestations involving the gastrointestinal, pulmonary, or ocular systems. Her hair, teeth, and nails were normal on close observation. All laboratory data were within the normal range. A genetic study was not performed. Conclusions Although a genetic study was not performed, we believe that our patient can be diagnosed with X‐linked reticulate pigmentary disorder according to the clinical and histopathologic findings. 相似文献