前列清瘀汤治疗慢性前列腺炎78例

目的:观察前列清瘀汤治疗慢性前列腺炎的临床疗效特点.方法:78例慢性前列腺炎患者给予前列清瘀汤煎服,观察疗效特点.结果:6周后,所有患者中医症候均得到明显改善,NIH - CPSI评分、EPS镜检WBC不同程度降低,有效率为96.9％.结论:前列清瘀汤治疗症候复杂性慢性前列腺炎疗效显著.     

前列清瘀汤配合中药保留灌肠治疗慢性前列腺炎临床观察

目的:观察前列清瘀汤配合中药保留灌肠治疗湿热夹瘀型慢性前列腺炎临床疗效。方法:选取符合标准的64例慢性前列腺炎患者给予前列清瘀汤口服,并配合中药保留灌肠,4周为1个疗程,连续治疗2个疗程。结果:64例患者治疗后痊愈19例、显效26例、有效11例、无效4例、脱落4例,总有效率为87.50%。第1个疗程结束后自身前后对照,中医症候改善、临床疗效、前列腺炎症状指数NIH-CPSI评分、EPS镜检WBC计数方面差异具有统计学意义(P0.05);第2个疗程结束后差异具有显著统计学意义(P0.01)。结论:前列清瘀汤配合中药保留灌肠对慢性前列腺炎具有较好疗效。     

银屑病的中医治疗研究进展

银屑病是一种慢性迁延性皮肤病,该病易复发难治愈。中医运用多种内外治法,在治疗银屑病方面取得较好疗效。本文就中医治疗银屑病的研究进展作一综述。     

从痰瘀互结理论论治梗阻性无精子症

笔者从痰瘀互结理论出发,分析梗阻性无精子症的病因,将化痰通络方运用于临床实践,通过化痰通络法治疗梗阻性无精子症,取得了一定疗效.     

银屑病中医辨证的规律探讨

通过分析银屑病中医辨证的特点,总结出本病中医辨证的规律为"病证论治,辨血为主,全面反映"。根据对血的辨证把本病分为血热、血瘀和血燥证,并在此基础上加用其他多种辨证方法,以反映本病的复杂情况。     

湿热消外敷热导入疗法治疗慢性前列腺炎的临床研究

目的:观察湿热消外敷热导入疗法对慢性前列腺炎的疗效。方法:将213例慢性前列腺炎患者分型后随机分为治疗组和对照组,治疗组予以湿热消外敷热导入疗法治疗,对照组予以前列安栓,两组均以30天为1疗程。结果:1疗程后,治疗组与对照组比较,在总体疗效方面差异有统计学意义(P<0.05,P<0.01),治疗组疗效优于对照组;在NIH-CPSI和中医证候学评分方面比较,差异有统计学意义(P<0.05,P<0.01),治疗组优于对照组。结论:湿热消外敷热导入疗法对慢性前列腺炎有较好的作用。     

清淋合剂治疗慢性前列腺炎(湿热下注型)的临床疗效研究

目的观察清淋合剂治疗慢性前列腺炎(湿热下注型)的临床疗效。方法选取2017年3月至2017年9月重庆市中医院泌尿外科诊治的慢性前列腺炎(湿热下注型)患者72例作为研究对象。随机分为治疗组(清淋合剂组)和对照组(八正散组),两组疗程为4周,观察两组患者治疗前后美国国立卫生研究院慢性前列腺炎症状评分(NIH-CPSI)、中医症状评分及前列腺液常规的变化。结果治疗组总有效率80.6%,对照组总有效率66.7%;两组患者治疗前后的前列腺液常规无明显变化,差异无统计学意义(P0.05),NIH-CPSI评分、中医症状评分均有明显改善,差异均具有统计学意义(均P0.05),且治疗组明显优于对照组,差异具有统计学意义(P0.05)。结论清淋合剂治疗慢性前列腺炎(湿热下注型)临床疗效优于传统八正散组方,能更好地改善患者临床症状。     

重症银屑病的治疗

银屑病是常见的慢性炎症性皮肤病，主要治疗方法包括外用药物、物理治疗、系统用药以及心理治疗等。泛发性脓疱型银屑病、红皮病型银屑病和关节病型银屑病等重症银屑病的治疗是皮肤科临床工作中的难点之一，本文简要介绍如下。     

名老中医治疗银屑病经验分享

<正>银屑病又名"牛皮癣",是慢性复发性炎症性皮肤病。因有大小不等的红斑,覆盖银白色鳞屑,刮之可见点状出血等特征,中医学又称之为"白疕"、"干癣"、"松皮癣"。该病病因不明,近年来发病率逐年增多,已被世界卫生组织列为21世纪人类十大顽症之一。该病初起多因风寒或风热之邪侵袭肌肤,以致营卫不和,气血不畅,阻于肌表而发病;或因湿热蕴积,外不能宣泄,内不可利导,阻于肌表而发病;病久     

曲蛇消银汤治疗寻常型银屑病血热证的临床疗效观察及对相关代谢指标的影响

目的观察自拟曲蛇消银汤治疗寻常型银屑病血热证的临床疗效及对相关代谢指标的影响。方法将60例寻常型银屑病血热证患者随机分为曲蛇消银汤治疗组和消银颗粒对照组(每组各30例),对治疗前后银屑病面积和严重程度指数标准(PASI)积分和疗效及相关代谢指标进行比较。结果治疗组PASI积分优于对照组(P0.05),治疗组总有效率90.0%,对照组总有效率66.7%,2组患者总有效率差异有统计学意义(P0.05)。治疗8周后,治疗组血清TC、TG水平与对照组相比明显降低,差异有统计学意义(P0.01)。结论曲蛇消银汤治疗寻常型银屑病血热证临床疗效确切,其作用机制可能与调节患者血脂等相关代谢指标紊乱、改善微循环有关。     

迈之灵片联合连翘败毒片治疗湿热瘀阻型下肢血栓性浅静脉炎36例

目的探讨迈之灵片联合连翘败毒片治疗湿热瘀阻型下肢血栓性浅静脉炎的临床疗效。方法将67例符合纳入条件的患者随即分为2组，治疗组36例，予口服迈之灵片和连翘败毒片；对照组31例，予口服肠溶阿司匹林片和头孢拉定胶囊或左氧氟沙星片，疗程均为4周，每周复诊1次，观察各组的临床疗效。结果治疗组临床治愈率及有效率分别为77．8％、94．5％，对照组分别为48．4％、83．9％；治疗组在退红、消肿、止痛时间方面均短于对照组。结论迈之灵片联合连翘败毒片治疗湿热瘀阻型下肢血栓性浅静脉炎疗效确切、可靠。     

基于网络药理学探讨蛇莓-白英治疗银屑病的作用机制

目的 探讨"蛇莓-白英"药对治疗银屑病的作用机制.方法 文本挖掘方式检索中药分子作用机制网络药理学在线分析平台(Batman-TCM)数据库,收集蛇莓所含有的有效成分及靶点基因,通过设置Score cutoff≥10和P≥0.05为条件进行筛选.在中国知网上进行文献检索,找出白英的主要化学成分.通过化学成分靶点预测和注...     

Comparison of Treatment Goals for Moderate-to-Severe Psoriasis between Korean Dermatologists and the European Consensus Report

BackgroundThe development of therapies for psoriasis has led to the need for a new strategy to the treatment of patients with moderate-to-severe psoriasis. New consensus guidelines for psoriasis treatment have been developed in some countries, some of which have introduced treatment goals to determine the timing of therapeutic regimens for psoriasis.ObjectiveTo investigate the opinions held by Korean dermatologists who specialize in psoriasis about treatment goals, and to compare these with the European consensus.MethodsKorean dermatologists who specialize in psoriasis were asked 11 questions about defining the treatment goals for psoriasis. The questionnaire included questions about the factors used to classify the severity of psoriasis, defining the induction and maintenance phases of psoriasis treatment, defining treatment responses during the induction phase, and defining treatment responses during the maintenance phase.ResultsThe Korean consensus showed responses that were almost similar to the European consensus, even without using the Delphi technique, which uses repeated rounds of questions to reach a consensus. Only one response that related to psoriasis severity in the context of the quality of patients'' lives differed from the European consensus.ConclusionThe concept of using treatment goals in the treatment of moderate-to-severe psoriasis can be applied to Korean psoriasis patients. Since a tool for assessing the quality of patients'' lives is not commonly used in Korea, the development of a simple, rapidly completed, and region-specific health-related quality of life assessment tool would enable treatment goals to be used in routine clinical practice.     

银屑病皮损鳞屑中两种微生物的检测及外用派瑞松效果

目的探讨银屑病发病与金黄色葡萄球菌(简称金葡菌)、糠秕孢子菌感染的关系及观察外用派瑞松治疗效果。方法对银屑病病人皮损进行细菌培养及真菌真接镜检,并外用派瑞松治疗。结果银屑病患者金葡菌和糠秕孢子菌带菌率均高于正常对照(P<0.01;P<0.05),治疗后带菌率明显下降;治愈率和有效率分别为18.0%,72.0%。结论金葡菌、糠秕孢子菌在银屑病的发病和发展中起一定作用,派瑞松是治疗银屑病较好的药物之一。     

养血解毒药对组合治疗银屑病的分子机制预测

目的探讨养血解毒药对组合干预银屑病的作用靶点及分子网络机制。方法参考《中药大辞典(第2版)》找到当归、鸡血藤、槐花、土茯苓的化学成分,应用Pub Chem数据库检索这些成分对应的靶蛋白;以"Psoriasis"为关键词,在Pub Med gene数据库中检索银屑病的相关基因;然后将上述数据集导入分子网络分析平台,分别构建中药靶蛋白和银屑病相关基因的分子网络及生物学通路;再通过网络映射、比较,可视化呈现养血药对、解毒药对及它们的组合干预银屑病的作用靶点和分子网络机制。结果养血解毒药对组合针对核因子-κB、细胞外信号调节激酶1/2、泛素和26s蛋白酶体分子靶点,以及通过调控芳香烃受体信号通路、雄激素信号通路、内皮型一氧化氮合酶信号通路和磷脂酰肌醇-3激酶/丝氨酸-苏氨酸蛋白激酶信号通路对银屑病发挥协同效应。结论分子网络分析技术是探索中药治疗疾病靶点及机制的有效方法。     

局部静电疗法治疗银屑病临床疗效及机理研究

目的　探讨局部静电疗法治疗静止期斑块型银屑病的临床疗效和机理。方法　应用局部静电疗法对 2 7例静止期斑块型银屑病患者进行临床疗效观察 ,并与外用激素疗法作自身对照 ;运用免疫组化SP法及计算机图像分析法检测部分患者表皮中热休克蛋白HSP2 7和HSP70 的表达情况。结果　局部静电疗法总有效率 77.78% ,经Ridit检验 ,与外用激素疗法相比疗效无显著性差异 (u =0 .5 93 1,P >0 .0 5 ) ;患者皮损处表皮细胞中HSP2 7和HSP70 表达缺失 ,疗后恢复表达。结论　局部静电疗法是治疗静止期斑块型银屑病有效而安全的方法 ,其机理可能为诱导表皮热休克蛋白的表达 ,调节细胞的增生和分化 ,发挥其应激保护作用。     

槐香乌蛇颗粒联合NB-UVB治疗寻常型银屑病(血热证)的临床疗效及对T细胞亚群水平的影响

目的 观察槐香乌蛇颗粒联合窄谱中波紫外线(NB-UVB)治疗寻常型银屑病(血热证)的临床疗效及对T细胞亚群水平的影响.方法 将80例寻常型银屑病(血热证)患者按就诊顺序编号,并采用随机表法分为研究组和对照组,各40例.对照组单独给予NB-UVB治疗,研究组在对照组基础上联合槐香乌蛇颗粒治疗,同时设立健康对照组40例.分...     

[Translated article] Practical Update of the Recommendations Published by the Psoriasis Group of the Spanish Academy of Dermatology and Venereology (GPs) on the Treatment of Psoriasis with Biologic Therapy. Part 1. Concepts and General Management of Psoriasis With Biologic Therapy

Background and objectivesA new, updated AEDV Psoriasis Group (GPs) consensus document on the treatment of moderate to severe psoriasis was needed owing to the approval, in recent years, of a large number of new drugs and changes in the treatment paradigm.MethodologyThe consensus document was developed using the nominal group technique and a scoping review. First, a designated coordinator selected a group of Psoriasis Group members for the panel. The coordinator defined the objectives and key points for the document and, with the help of a documentalist, conducted a scoping review of articles in Medline, Embase, and the Cochrane Library up to January 2021. The review included systematic reviews and meta-analyses as well as clinical trials not included in those studies and high-quality real-world studies. National and international clinical practice guidelines and consensus documents on the management of moderate to severe psoriasis were also reviewed. Based on these reviews, the coordinator drew up a set of proposed recommendations, which were then discussed and modified in a nominal group meeting. After several review processes, including external review by other GPs members, the final document was drafted.ResultsThe present guidelines include general principles for the treatment of patients with moderate to severe psoriasis and also define treatment goals and criteria for the indication of biologic therapy and the selection of initial and subsequent therapies. Practical issues, such as treatment failure and maintenance of response, are also addressed.     

活血化瘀联合温阳生肌法治疗青斑样血管炎临床分析

目的分析青斑样血管炎的临床特征及中医证候特点,提高对本病的诊断及中医辨证水平。方法对12例确诊的青斑样血管炎患者的临床表现、组织病理、中医证候、中医治则、方药、预后进行回顾性分析。结果12例患者中男3例,女9例,年龄15~45岁,平均年龄20.17岁,中医药治疗时间为14~70 d,平均时间为54.60 d。12例患者均为对称皮疹,均伴有疼痛;皮损特点均为红斑、水疱、紫癜、坏死、水肿、溃疡,呈现线状或放射状分布;皮损痊愈后见色素沉着斑或线状象牙白色萎缩性瘢痕。所有患者经过组织病理确诊。12例患者均符合寒凝血瘀证。坏死期选用活血化瘀法,应用桃红四物汤加减;溃疡期选用温阳生肌法,应用自拟方温阳生肌汤加减。局部使用黄连膏换药。12例患者经中医药治疗后皮损均完全消退,溃疡愈合,遗留色素沉着斑及象牙白色萎缩性瘢痕。停药后随访6个月无1例复发。结论活血化瘀联合温阳生肌法为中医治疗青斑样血管炎提供了新的思路,并能明显降低复发率,值得进一步研究。