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1.
Mahwash Kassi Venkateshwar Polsani Robert C. Schutt Solomon Wong Faisal Nabi Michael J. Reardon Dipan J. Shah 《The Journal of thoracic and cardiovascular surgery》2019,157(5):1912-1922.e2
Background
The purpose of this analysis is to describe the differences in cardiac magnetic resonance characteristics between benign and malignant tumors, which would be helpful for surgical planning.Methods
This was a prospective cohort study of 130 patients who underwent cardiac magnetic resonance imaging for evaluation of a suspected cardiac mass. After excluding thrombi and tumors without definitive diagnosis, 66 tumors were evaluated for morphologic features and tissue composition.Results
Of the 66 patients, 39 (59.0%) had malignant tumors and 27 (41.0%) had benign tumors. Patients with malignant tumors were younger when compared with those with benign tumors (age 51 years [42.8-60.0] vs 65 years [60.0-71.0] median). Malignant tumors more often demonstrated tumor invasion (69% vs 0% P < .001) and were more often associated with pericardial effusion (41% vs 7.4% P = .004). Presence of first-pass perfusion (100% vs 33% P < .001) and late gadolinium enhancement (100% vs 59.2%, P < .001) were significantly higher in malignant tumors. In logistic regression modeling, tumor invasion (P < .001) and first-pass perfusion (P < .001) were independently associated with malignancy. Furthermore, using classification and regression tree analysis, we developed a decision tree algorithm to help differentiate benign from malignant tumors (diagnostic accuracy ～90%). The algorithm-weighted cost of misclassifying a malignant tumor as benign was twice that of classifying a benign tumor as malignant.Conclusions
Our study demonstrates that cardiac magnetic resonance imaging is a useful noninvasive method for differentiating malignant from benign cardiac tumors. Tumor size, invasion, and first-pass perfusion were useful imaging characteristics in differentiating benign from malignant tumors. 相似文献2.
Zhongyang Li Fei lei Peng Xiu Xi Yang Lei Wang Ganjun Feng Limin Liu Yueming Song Chunguang Zhou 《Journal of orthopaedic science》2019,24(1):68-74
Background
Spinal tuberculosis accounts for more than 50% of bone tuberculosis cases. This study compared clinical, radiological and functional outcomes between anterior and posterior approaches for treatment of middle or lower thoracic spinal tuberculosis in elderly patients.Methods
We retrospectively examined middle or lower thoracic spinal tuberculosis (T5–T12) in patients over 65 years. All procedures included debridement, decompression, autologous bone graft and fixation. Surgical procedure, surgical duration, estimated blood loss during surgery and laboratory results were recorded. Pleural effusion volume, thoracic cavity volume, Oswestry Disability Index score, neurological status, radiological parameters and complication rate were evaluated.Results
No significant difference was found in surgical duration, blood loss, kyphosis angle correction, loss of correction, thoracic cavity volume, or complication rate between the two groups (P > 0.05). Average postoperative pleural effusion volumes were 605.9 ± 209.5 mL (377–1074 mL) and 262.9 ± 228.1 mL (0–702.4 mL) in the anterior and posterior groups, respectively (P = 0.004). Average hospitalization durations were 26.4 ± 10.5 days (17–53 days) and 19.2 ± 5.0 days (14–30 days) (P = 0.04). Average postoperative serum albumin levels were 24.19 ± 3.84 g/L (19–29.5 g/L) and 28.24 ± 2.52 g/L (24.4–31.6 g/L) (P = 0.01). No relapse or reinfection was observed in either group at the final follow-up. Surgical revision was not required in either group.Conclusions
Both anterior and posterior surgeries can be used to treat middle or lower thoracic spinal (T5-T12) tuberculosis in elderly patients. In general, the posterior approach might be superior, especially for patients with poor general health. 相似文献3.
Anwen Williams Arfon G.M.T Powell Izabela Spernaes Pallavi Basu Stephen Edwards Paul Edwards 《The surgeon》2019,17(1):15-18
Background
The influence of patient demographics and mode of admission on the ‘weekend effect’ remains unclear. This study examins the relationship between day of admission, patient demographics, mode of presentation and survival.Methods
Hospital admissions over a three-year period were studied. Patients with an inpatient stay less than 24 h and those who were discharged from the emergency department were excluded. In-hospital mortality was correlated with day of admission, age, gender and mode of presentation in a binary logistical regression analysis.Results
There were 448,827 admissions, of which 350,648 (85.7%) occurred during a weekday. 256,777 (62.7%) were emergency presentations, which was closely related to a weekend admission (92.3% vs 57.8%, p < 0.001). There were 8099 deaths of which 6336 (78.2%) related to a weekday admission and 1736 (21.4%) related a weekend admission. Mortality for elective admissions was 78 (0.05%) compared to 8021 (3.12%), p < 0.001 in emergency admissions. Univariable regression analysis revealed a weekend admission (Odds Ratio (OR) 1.68 (95% confidence interval (CI) 1.60–1.78, p < 0.001) and emergency presentation (OR 63.02 (95%CI 50.42–78.77), p < 0.011) were associated with weekend mortality. On multivariable analysis the OR for weekend admission reduced to 1.07 (95%CI 1.01–1.13), p = 0.013 and the OR for emergency presentation increased to 76.68 (95%CI 61.40–96.00), p < 0.001.Conclusion
This study highlights that higher weekend mortality rates are a consequence of a lower proportion of elective admissions. Extending the working week to seven days might reduce weekend mortality without reducing the total number of deaths. 相似文献4.
Gong Long Sun Suqin Zhang Hu Zhao Yan Yao Huixin Li Tianwang Yu Yang Wang Zhenhu 《Journal of orthopaedic science》2019,24(1):116-120
Background
Sleep disorder after total knee arthroplasty (TKA) is complex as it greatly differs from patient to patient. Thus, it can be seen that we should further know the detail in sleep disorders following TKA to find well solutions to achieve satisfactory sleep and better recovery.Methods
Between October 2011 and January 2016, 965 patients accepted primary TKA. We reviewed each patient's data. Sleep disorder was evaluated via subjective instruments. The Sleep Questionnaire in the present study is a 12-item instrument that evaluates sleep in terms of three dimensions: sleep quality; disruptive factors; and specific forms. Patients were identified and confirmed as at least 1 kind of sleep disorders according to the Second Edition of the International Classification of Sleep Disorders (ICSD-2). And we compare the clinical characteristics and difference in postoperative recovery of different types of sleep disorders.Results
Sleep disturbances persisted approximately 2 months postoperatively. 75.9% patients was classified into primary insomnias, while 24.1% was secondary insomnias. There was the largest number of those who were adjustment sleep disorder. Pains, mental elements, and factors intrinsic to the patients were the most significant causes of insomnia of patients. There were significant differences in VAS pain score (P < 0.001*), active ROM (P < 0.001*) and LOS in hospital (P < 0.001*) among varied forms of insomnias.Conclusions
Our data revealed that adjustment insomnia ranked first. Specifically, the factors affecting sleep quality postoperatively included pains, mental elements, and factors intrinsic to the patients etc. In addition, we found that patients with difficulty in staying asleep and non-restorative sleep has increased pain scores and LOS in hospital with decreased active ROM in comparison to difficulty in falling asleep and too early awakening. Our data may be of a certain benefit to rational use of medication to improve diverse insomnias and to make patients recover better. 相似文献5.
Yeqian Huang Nayef A. Alzahrani Oliver M. Fisher Terence C. Chua Mathew A. Kozman Winston Liauw Arief Arrowaili Sarah J. Valle David L. Morris 《American journal of surgery》2019,217(4):704-712
Background
This study examines the impact of intraoperative macroscopic tumour consistency on short-term and long-term outcomes after cytoreductive surgery (CRS) with intraperitoneal chemotherapy (IPC) for appendiceal adenocarcinoma with peritoneal metastases.Methods
Macroscopic intraoperative tumour consistency was classified in three groups as soft (jelly-like geltatinous tumours), hard (hard tumour nodules without gelatinous features) and intermediate (both soft and hard features). In-hospital mortality, major morbidity, intensive care unit (ICU), high dependency unit (HDU) and total hospital stay, disease-free survival (DFS) and overall survival (OS) were compared.Results
The three groups had similar perioperative short-term outcomes. Patients with soft, intermediate and hard tumours revealed differences in OS (p?<?0.001) and DFS (p?=?0.03). Multivariable analysis revealed a shorter OS for patients with hard versus soft tumours (HR for hard tumours?=?4.43, 95%CI 2.19–9.00).Conclusions
Intraoperative macroscopic tumour consistency may be used as a prognostic marker for survival in patients with appendiceal adenocarcinoma with peritoneal metastases. 相似文献6.
7.
Ya-Peng Qi Jian-Hong Zhong Zhi-Yin Liang Jie Zhang Bin Chen Chang-Zhi Chen Le-Qun Li Bang-De Xiang 《American journal of surgery》2019,217(4):739-744
Background
Microvascular invasion (MVI) has recently been reported to be an independent prognostic factor in patients with hepatocellular carcinoma (HCC). This study compared the outcomes of adjuvant transarterial chemoembolization (A-TACE) after hepatic resection (HR) in patients with HCC involving MVI.Methods
This prospective study involved 200 consecutive patients with MVI-HCC who underwent HR alone (n?=?109) or HR with A-TACE (n?=?91).The Kaplan-Meier method was used to compare disease-free survival (DFS) and overall survival (OS).Results
The two groups showed similar DFS at 1, 2, and 3 years (P?=?0.077). The A-TACE group showed significantly higher OS than the HR-only group (P?=?0.030). Subgroup analysis showed that A-TACE was associated with significantly higher DFS and OS among patients with a tumor diameter >5?cm or with multinodular tumors.Conclusions
A-TACE may improve postoperative outcomes for MVI-HCC patients, especially those with tumor diameter >5?cm or multinodular tumors. 相似文献8.
Jeffrey D. Howard Mickey S. Ising Megan E. Delisle Robert C.G. Martin 《American journal of surgery》2019,217(1):156-162
Background
Appropriate postoperative readmission rates and modifiable risk factors for readmission have yet to be defined for many operations. This systematic review and meta-analysis attempt to define these parameters for pancreaticoduodenectomy.Materials and methods
The main outcomes were readmission rate, risk factors, and reasons for readmission. Meta-analyses were performed when data was homogeneous, otherwise, a qualitative review was performed.Results
The 30-day, 90-day, and overall readmission rates were 17.63%, 26.14%, and 27.18%, respectively. In the meta-analysis, chronic pancreatitis (OR, 1.44, p?=?0.04), operative length (MD, 26.1; p?<?0.01), wound infection (OR, 1.9, p?<?0.01), intra-abdominal abscess (OR, 3.79, p?<?0.01), VTE (OR, 2.27, p?=?0.01), and LOS (MD, 1.66, p?<?0.01) where associated with readmission.Conclusion
Hospital readmission will continue to be a quality metric and will influence reimbursement models. Thirty and 60-day readmission data underestimate the true readmission rate. Chronic pancreatitis, operative length, and several post-operative complications were associated with greater readmission. More uniform reporting is necessary to identify modifiable risk factors associated with readmission. 相似文献9.
E. Cholongitas N. Antoniadis I. Goulis E. Theocharidou G. Ιmvrios O. Giouleme D. Filis E. Mouloudi E. Akriviadis I. Fouzas 《Transplantation proceedings》2019,51(2):450-453
Purpose
Everolimus, a mammalian target of rapamycin inhibitor, may have a protective role on hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT), but data regarding the impact of its trough serum levels on HCC recurrence are missing.Methods
Fifty-five patients (43 men, age 55 ± 8 years) who underwent LT for HCC were evaluated. Several demographic and clinical variables were recorded, including radiological and histological characteristics of HCC as well as dosages and trough levels of immunosuppressive regimens.Results
HCC recurrence occurred in 11 (20%) patients: 5 (25%) of 20 patients under calcineurin inhibitors and 6 (17%) of the 35 patients under everolimus (P = .48). The patients with HCC recurrence (n = 11, group 1), compared to those without recurrence (n = 44, group 2), had significantly more frequent HCC in the explant: outside Milan criteria (P = .001), microvascular invasion (P < .001), and higher number of nodules (P = .001). In multivariate analysis, microvascular invasion was the only independent factor significantly associated with HCC recurrence (OR: 2.3, 95% CI: 1.4–10.5, P = .03). Among the patients who received everolimus-based immunosuppression, the recipients with HCC recurrence, compared to those without HCC recurrence, had significantly lower mean trough levels of everolimus at 7–12 months post-LT (3.9 vs 5.9 ng/mL, P = .001), while the patients with mean trough levels of everolimus >6 ng/mL had decreased HCC recurrence rates (log rank: 2.3, P = .007).Conclusions
We found for the first time mean concentrations of everolimus between 7–12 months post-LT as the only modifiable variable related with HCC recurrence in LT recipients. However, larger studies are needed for final conclusions. 相似文献10.
Francesco Muratori Filippo Frenos Leonardo Bettini Davide Matera Nicola Mondanelli Maurizio Scorianz Pierluigi Cuomo Guido Scoccianti Giovanni Beltrami Daniela Greto Lorenzo Livi Giacomo Baldi Giuliana Roselli Rodolfo Capanna Domenico Andrea Campanacci 《Journal of orthopaedic science》2018,23(6):1038-1044
Background and objectives
Liposarcoma (LPS) is a malignant mesenchymal tumor and the most common soft tissue sarcoma. Four different subtypes are described: well differentiated (WD) LPS or atypical lipomatous tumor (ALT), dedifferentiated (DD) LPS, myxoid LPS, and pleomorphic LPS (PLS). The objective of the study was to investigate prognostic factors and clinical outcome of liposarcoma.Methods
We retrospectively examined the clinico-pathological features of a series of 307 patients affected by Liposarcoma at a mean follow-up of 69 months (range 6–257). ALT/WD LPS were analyzed separately. The influence of site, size, type of presentation, grading, histotype and local recurrence on local and systemic control and survival was assessed.Results
The statistical analysis indicated that only surgical margins represented a significant prognostic factor for local recurrence in ALT/WD LPS (P = 0.0007) and other subtypes of LPS (P = 0.0055). In myxoid, PLS and DD LPS, significant prognostic factors for metastasis free survival (MFS) were surgical margins (P = 0.0009), size of the tumor (P = 0.0358), histology (P = 0.0117) and local recurrence (P = 0.0015). In multivariate analysis, surgical margins (0.0180), size (0.0432) and local recurrence (0.0288) correlated independently with MFS. Margins (P = 0.0315), local recurrence (P = 0.0482) and metastases (P < 0.0001) were prognostic factors for overall survival (OS).Conclusion
Marginal surgery can be an accepted treatment for ALT/WD LPS. In other liposarcoma subtypes (Myxoid, DD, PLS) wide or radical surgery is recommended as the margins significantly influence local recurrence-free survival (LRFS), metastasis-free survival (MFS) and overall survival (OS). Local recurrence and metastases were significant prognostic factors for OS. 相似文献11.
Zhisen Gao Yinqiao Du Shang Piao Jingyang Sun Xiang Li Yonggang Zhou 《Journal of orthopaedic science》2019,24(1):109-115
Background
Staphylococcus species are major pathogens of peri-prosthetic joint infection (PJI). Coagulase-positive staphylococci and coagulase-negative staphylococci have different intrinsic virulences. However, few studies have specifically compared the clinical manifestations and two-stage revision outcomes of PJI caused by these two species.Methods
We retrospectively collected 260 arthroplasty patients who underwent a two-stage revision because of PJI from January 2003 to June 2015 in our institute because of PJI. Sixty-four patients (36 hips and 28 knees) and 23 patients (13 hips and 10 knees) were infected by coagulase-negative staphylococci (CoNS) and SA, respectively.Results
The preoperative mean ESR value of the SA group was higher than that of the CoNS group (median, 60.9 VS 35.9; P < 0.001). Seventeen (73.9%) of the 23 SA infected patients had a sinus tract, while only 12 (18.8%) of the 64 CoNS-infected patients had this symptom (73.9% VS 18.8%; P < 0.001). At the time of follow-up, 58 (90.6%) of the 64 CoNS-infected patients had successfully controlled the infection. In the SA group, 20 (87.0%) patients ultimately acquired successful control (90.6% VS 87.0%; P = 0.923). Surgical history was identified as a potential risk factor (OR = 6.2, 95%CI 1.17–32.4) for prognosis when potential covariates were adjusted.Conclusions
SA infection has a higher ESR value and a more frequent occurrence of sinus tract. The infection control rate of the two-stage revision protocol was close to 90% for both SA and CoNS species, and there is no statistically significant difference in the eradication rate of infection between the SA and CoNS groups. Surgical history may be a good predictor of failure for PJI patients treated with two-stage revision. 相似文献12.
Yusuke Hori Akira Matsumura Takashi Namikawa Minori Kato Shinji Takahashi Shoichiro Ohyama Tomonori Ozaki Akito Yabu Hiroaki Nakamura 《Journal of orthopaedic science》2019,24(2):224-229
Background
The degenerative lumbar scoliosis (DLS) patients who mainly complained about neurogenic claudication due to spinal canal stenosis are well-indicated for short segment fusion (SSF) at the affecting levels. However, it is unclear whether we should consider global sagittal balance or not. The aim of this study was to evaluate the impact of sagittal balance on the surgical outcomes of degenerative lumbar scoliosis (DLS) patients who underwent SSF.Methods
We retrospectively reviewed 70 DLS patients who underwent SSF (less than 3 levels) and could be followed for at least 2 years. The PI-LL, PT, SVA, and T1 pelvic angle (TPA) were measured using standing whole spine X-rays preoperatively (PreO) and at final follow-up (FFU). Surgical outcomes were assessed with the improvement in Japanese Orthopaedic Association score (JOAs) for low back pain (LBP), and the level of LBP was measured using the visual analogue scale (LBP-VAS). We analysed the relationships between the radiographic parameters and the surgical outcomes.Results
We divided the patients into the three groups (poor/fair/good) based on the JOAs. The analysis with the Jonckheere-Terpstra trend test indicated that the following radiographic parameters had a significant trend with surgical outcomes in each group: (poor/fair/good; p value); PreO PI-LL (26/20/17°; P = 0.04), SVA (46/75/35.5 mm; P = 0.02), TPA (28/27/23°; p = 0.04), FFU PI-LL (33/25/8.5°; P = 0.004), SVA (93/90.5/32.5 mm; P = 0.001), and TPA (33/29/25°; P = 0.007). Additionally, LBP-VAS had a significant correlation between the three groups at final follow-up (P = 0.004). There were significant correlations between improvement in JOAs and PI-LL, SVA, and TPA both PreO and at FFU (P < 0.05).Conclusions
Sagittal spinal imbalance and spinopelvic malalignment significantly impact the surgical outcomes of SSF for DLS. Preoperative evaluation of spinopelvic alignment and sagittal balance is of critical importance when SSF are performed for DLS patients. 相似文献13.
Brian C. Wengerter Kevin Y. Pei David Asuzu Kimberly A. Davis 《American journal of surgery》2018,215(1):37-41
Background
The overall utility of the Rothman Index (RI), a global measure of inpatient acuity, for surgical patients is unclear. We evaluate whether RI variability can predict rapid response team (RRT) activation in surgical patients.Methods
Surgical patients who underwent RRT activation from 2013 to 2015 were matched to four control cases. RI variability was gauged by maximum minus minimum RI (MMRI) and RI standard deviation (RISD) within a 24-h period before RRT. The primary outcome measured was RRT activation, and our secondary outcome was in-hospital mortality.Results
Two hundred seventeen (217) patients underwent RRT. RISD (odds ratio, OR, 1.31, 95% confidence interval, CI, 1.23–1.38, P < 0.001; area under receiver operating characteristic, AUROC, curve 0.74, 95% CI 0.70–0.77) and MMRI (OR 1.10, 95% CI 1.08–1.12, P < 0.001; AUROC 0.76, 95% CI 0.72–0.79) predicted increased likelihood of RRT.Conclusions
RISD is predictive of RRT. 相似文献14.
Susan M. Nedza Donald E. Fry Michael Pine Agnes M. Reband Pan Chen Gregory Pine 《American journal of surgery》2018,215(3):367-370
Background
Preoperative emergency department (ED) visits may reflect the patient's biliary disease, or may signal unstable comorbid conditions that have relevance following inpatient laparoscopic cholecystectomy (ILC) and outpatient laparoscopic cholecystectomy (OLC) in Medicare patients.Methods
We used the Medicare inpatient and outpatient Limited Datasets to identify elective laparoscopic cholecystectomy patients from 2011 to 2014. ED visits for 30-days before the surgical event were identified and correlated with the probability of patients returning to the ED in the 30-days following the procedure.Results
A total of 129,377 inpatient and 235,339 outpatient LCs were identified. A total of 20,021 (15.5%) of ILCs and 52,025 (22.1%) of OLCs had 30-day preoperative ED visits. ILCs with any 30-day ED visit preoperatively had an Odds Ratio (OR) that predicted a post-discharge ED visit of 1.85 (95% CI = 1.78–1.92; P < 0.0001). OLCs with any 30-day ED visit preoperatively had an OR for post-discharge ED visit of 1.50 (95% CI = 1.46–1.54; P < 0.0001).Conclusion
Preoperative ED visits predict postdischarge ED visits for laparoscopic cholecystectomy in Medicare patients. 相似文献15.
Background
Postoperative nausea and vomiting (PONV) may lead to extended hospital stay due to severe discomfort and restriction of patient activity. We retrospectively studied PONV incidence following total hip arthroplasty (THA) to evaluate the effect of opioid administration via epidural catheter.Methods
Our study included 155 affected joints in 136 patients who underwent a first THA from 2011 to 2016. For postoperative analgesia, an epidural catheter was preoperatively placed and used for continuous analgesic delivery into the epidural space up to 2 days after surgery. We analyzed patient age, sex, body mass index (BMI), opioid use via epidural catheter, amount of opioid used intraoperatively, amount of opioid used immediately before the end of the operation, anesthesia duration, and amount of opioid used postoperatively.Results
PONV was reported for 51 affected joints. Opioid was infused via epidural catheter in 114 affected joints, but not in 41 affected joints. Logistic regression analysis for PONV occurrence revealed a significant difference according to sex (P < 0.05), BMI (P < 0.01), and opioid use via epidural catheter (P < 0.05). Correlation analysis evaluating the occurrence of PONV and BMI using the χ2 test demonstrated a significantly higher incidence of PONV in the subgroup of patients with a BMI ≤20 kg/m2 (P < 0.01).Conclusions
These results indicate that without using opioid or other action should be considered when epidural catheter is used in female patients with a BMI ≤20 kg/m2. 相似文献16.
Hyeon Jang Jeong Bong Young Kong Sung Min Rhee Joo Han Oh 《Journal of orthopaedic science》2019,24(1):95-102
Background
This retrospective study was designed to compare the hemodynamics among the types of shoulder arthroplasty and to evaluate predictors of transfusion in the Asian population.Methods
A total of 212 shoulder arthroplasties (26 fracture hemiarthroplasty (fHA), 49 anatomical total shoulder arthroplasty (aTSA), 132 reverse total shoulder arthroplasty (rTSA), and 5 revision surgery) from August 2004 to January 2016 were retrospectively reviewed. Demographics, surgical factors, and perioperative hemodynamic factors among the types of arthroplasty were compared. Multivariate analysis was conducted to determine predictors of transfusion.Results
Preoperative hemoglobin and hematocrit levels were lower in the fracture hemiarthroplasty group (p < 0.001, 0.001). The overall transfusion rate of shoulder arthroplasties in Asian population was 11.3%, and transfusion rate was significantly different among the types of arthroplasty (fHA 30.8%, aTSA 10.2%, rTSA 7.6%, revision 20.0%; p = 0.010). The predictors of transfusion were preoperative hemoglobin levels <12.15 g/dL (OR = 7.404, 95% C.I. 2.420–22.653, p < 0.001) and <10.0 g/dL at postoperative day 1 (OR = 5.499, 95% C.I. 1.929–15.671, p = 0.001).Conclusion
The best predictors of transfusion were hemoglobin levels of perioperative periods, furthermore, total amount of drainage could not represent the quantity of perioperative hemorrhage. Therefore, careful monitoring of hemoglobin level is more crucial than monitoring the amount of drainage. Hemodynamics according to the type of arthroplasty should be considered in shoulder arthroplasty.Level of evidence
Level IV, retrospective case series. 相似文献17.
I.D. Kostakis N. Machairas A. Prodromidou P. Stamopoulos Z. Garoufalia I. Fouzas G.C. Sotiropoulos 《Transplantation proceedings》2019,51(2):433-436
Introduction
Repeat liver resection (RLR) has been adopted by surgeons as the first-line treatment in the case of intrahepatic recurrence of hepatocellular carcinoma (HCC), whereas salvage liver transplantation (SLT) is considered a second-line option. The aim of our study was to evaluate the results of SLT and RLR for HCC.Methods
We searched for articles published up to December 1, 2017, in the PubMed database that compared SLT with RLR for HCC. We extracted data about patient and tumor characteristics, operative and postoperative outcomes, and survival and performed a meta-analysis.Results
Patients who underwent SLT had somewhat larger liver lesions (mean difference: 0.73 cm, 95% confidence interval [CI]: 0.29–1.18, P = .001; I2: 0%, P = .82). Moreover, salvage liver transplantation resulted in higher blood loss, longer operating time, longer hospital stay, and higher postoperative morbidity (risk ratio [RR]: 2.45, 95% CI: 1.6–3.75, P < .0001; I2: 0%, P = .58) than RLR, whereas there was no significant difference in terms of postoperative mortality (RR: 6.48, 95% CI: 0.51–82.54, P = .15; I2: 61%, P = .08). On the other hand, SLT led to longer disease-free survival (DFS) than RLR (HR: 0.42, 95% CI: 0.25–0.7, P = .0009; I2: 63%, P = .03), but there was no significant difference in regard to overall survival (OS) (HR: 0.82, 95% CI: 0.55–1.23, P = .34; I2: 0%, P = .62).Conclusions
SLT seems to be inferior to RLR regarding operative and postoperative results but presents a significant advantage in terms of DFS over RLR. 相似文献18.
Teena Shetty Joseph T. Nguyen Anita Wu Mayu Sasaki Eric Bogner Alissa Burge Taylor Cogsil Esther U. Kim Kelianne Cummings Edwin P. Su Stephen Lyman 《The Journal of arthroplasty》2019,34(1):151-156
Background
Postsurgical acute nerve injury is rare but potentially devastating following total hip arthroplasty (THA). Previous literature suggests a wide range of incidence from 0.1% to 7.6%. Confirmed risk factors for these injuries remain unclear.Methods
THA patients at our institution who developed nerve injury during their admission for THA between January 1, 1998, and December 31, 2013, were systematically identified and matched with 2 control subjects by surgical date. Relevant patient and surgical data were obtained through review of patient charts and electronic health records. We identified potential risk factors and calculated odds ratios (OR) using a conditional logistic regression model with a parsimonious stepwise approach.Results
We identified 93 nerve injuries in 43,761 THAs (0.21%). The mean age of cases was 63 years. Adjusting for other factors in the model, patients <45 years were found to be at increased risk of developing nerve injury (OR, 7.17; P = .033). Similarly, patients with a history of tobacco use (OR, 1.90; P = .030) and a history of spinal surgery or disease (OR, 10.06; P < .001) were also associated with increased risk of nerve injury. For every 30-minute increase in surgery time after 1 hour, risk of nerve injury risk increased (OR, 1.48; P = .034). Assignment as first operative case of the morning was associated with a decreased risk of nerve injury (OR, 0.37, P = .043).Conclusion
This study demonstrates that nerve injury is a rare complication following THA at our institution. We found risk factors that are possibly modifiable factors such as lumbar spine disease, smoking, and time of surgical scheduling. 相似文献19.
Momotaro Kawai Atsushi Tanji Takayuki Nishijima Koichi Tateyama Yuhei Yoda Ai Iizuka Yusaku Kamata Tadahisa Urabe 《Journal of orthopaedic science》2018,23(6):987-991
Background
It remains unclear whether early surgical intervention can reduce mortality after surgery in hip fracture patients. The aim of this study was to investigate the association between time from injury to surgery and mortality rate within 90 days after hip fracture surgery.Methods
We retrospectively identified 1827 patients who underwent hip fracture surgery in a tertiary care center in Japan between April 2007 and March 2017. After applying exclusion criteria (patients with spontaneous fracture, multiple fractures, revision surgery, total hip arthroplasty, or a refusal to participate), 1734 patients were included. We extracted data concerning patients’ age, race, sex, operative procedure, American Society of Anesthesiologists (ASA) score, days from injury to surgery (injury-surgery days), and days from admission to surgery (admission-surgery days), which could affect 90-day mortality after surgery. Variables associated with 90-day mortality were determined using multivariate logistic regression analysis.Results
The 90-day postoperative mortality rate was 3.5% (60 of 1734). Multivariable analysis showed that injury-surgery days were not associated with 90-day mortality (odds ratio [OR], 0.91; 95% confidence interval [CI], 0.80 to 1.05; P = 0.19), and that older age (OR, 1.06; 95% CI, 1.02 to 1.10; P = 0.005), male sex (OR, 3.62; 95% CI, 1.86 to 7.03; P < 0.001) and high ASA score (OR, 2.10; 95% CI, 1.06 to 4.18; P = 0.034) significantly increased 90-day mortality. In addition, admission-surgery days were not associated with 90-day mortality (OR, 0.95; 95% CI, 0.83 to 1.09; P = 0.45).Conclusion
Our results demonstrated that time from injury to surgery was not associated with mortality within 90 days after surgery after adjusting for age, sex, operative procedure, and ASA score. 相似文献20.
Ravil Sharifulin Alexander Bogachev-Prokophiev Sergey Zheleznev Igor Demin Alexey Pivkin Alexander Afanasyev Alexander Karaskov 《The Journal of thoracic and cardiovascular surgery》2019,157(1):134-141.e3