Effect of surgical treatment on stage IV melanoma

One hundred eighty patients with hematogenous metastases from malignant melanoma were reviewed. Complete resection of the gross tumor was technically feasible in 33 percent of the cases. Patients who had complete resection of the gross tumor had an estimated median survival time of 11.4 months and an estimated 5 year survival rate of 14 percent. Patients with solitary lesions removed had a median survival time of 22.8 months and a 5 year survival rate of 23 percent. Patients with distant subcutaneous metastases completely removed had a median survival time of 31.9 months and a 5 year survival rate of 29 percent. Surgical resection of distant metastases, when technically feasible, particularly for solitary lesions and subcutaneous locations, increases the length of survival of patients with disseminated melanoma.     

Incisional hernia in Day Surgery: our personal experience

Incisional hernia is one of the most common complications of laparotomy. Its repair with prosthesis has enabled a considerable improvement in the outcome, significantly reducing recurrences. This study analyses the results of open hernioplasty with mesh performed as a Day Surgery procedure in 42 patients between November 2008 and October 2010. The results were good, with low postoperative morbidity and recurrences (2.4%).     

Primary tumor resection in patients with stage IV breast cancer: 10-year experience

The role of surgery in the management of stage IV breast cancer is controversial. Existing studies in Stage IV breast cancer have not closely evaluated the role of patient response to induction systemic therapy (IST) in its relationship to survival outcomes. We identified all patients with a diagnosis of de novo stage IV breast cancer who underwent surgery of their primary tumor from January 2008 to December 2018. Patients were grouped according to their response in the primary disease site into progression (progressive primary disease) or no progression (nonprogressive primary; comprising complete, partial and stable response). We identified a total of 45 stage IV breast cancer patients who underwent operative intervention of their primary breast tumor. Prior to surgical intervention, progression in the primary site during IST was identified in 13/42 patients (31%), of whom four patients also had progression in the distant disease. The 5-year survival was higher in the nonprogressive primary (74%) than the progressive primary disease group (52%) which did not reach statistical significance (p = 0.08). Age, pathologic tumor size, clinical nodal status, number of positive lymph nodes, and distant disease response to systemic therapy were significantly associated with survival. In this single institution experience, select patients with stage IV breast cancer at initial diagnosis who underwent resection of the primary tumor following systemic therapy achieved favorable overall and distant progression-free survival. Surgery is reasonable to consider for local palliation or in selected patients who have excellent response to systemic therapy and good performance status.     

Organizational model and clinical evaluation in Day Surgery: our experience

Surgical treatments in Day Surgery (DS) are characterised by limited hospitalisation during daytime on the base of an organizational model established by appropriate protocols. According to it, the patient at low operational risk and the patient whose post-operative management is easy is admitted to the programme. The Authors report their experience of DS focusing on the surgical and anaesthesiological qualifications that help to control the risk factors reducing the complications and thus guaranteeing the safety and effectiveness of the service.     

Videolaparoscopic surgery in the treatment of colorectal disease: our experience with 200 patients

In this article we examine our experience over the last 4 years, from 1998 to 2001, in the surgical treatment of colorectal disease using the laparoscopic approach. We treated 200 patients, 54 of whom presented benign disease and 146 malignancies. The operations were performed by a team of surgeons and nurses experienced in advanced laparoscopy. Over this period, the duration of the surgical intervention was gradually reduced by 17%. The conversion rate from laparoscopy to open procedures was also reduced (mean rate 11%). Canalization and the resumption of walking and nutrition were reasonably fast. Postoperative complications occurred in 22% of cases The number of fistulas and anastomotic dehiscences was high (10/200 = 5%), due both to evaluation errors and the choice of surgical material. At present, on applying the criteria of traditional open surgery, this figure is also coming down. Bleeding complications (12/200 = 6%) can also be ascribed to the learning curve (2 bleeds in the trocar site and 2 haematomas in the Pfannenstiel laparotomy site) and are therefore likely to be reduced. Bleeding during the surgical procedures, however, was very low, with a mean value of 69.6 ml. Laparoscopic surgery for colorectal disease is well standardized and we believe there should be no doubts as to its use in benign disease. Its use in oncological surgery, though theoretically correct, needs to be confirmed by the trials currently in progress. The results we have obtained in our experience, after completion of the learning curve, agree with the figures reported in the literature.     

Comparison of phenol and argon beam coagulation as adjuvant therapies in the treatment of stage 2 and 3 benign-aggressive bone tumors

Argon beam photocoagulation has gained popularity as an adjuvant therapy for the treatment of giant cell tumors of bone and other stage 2 or 3 benign-aggressive bone tumors. Although argon beam photocoagulation has been considered a safe and reasonable adjuvant treatment with acceptable recurrence rates, it has never been directly compared with the commonly described phenol as adjuvant. The purpose of this study was to determine whether argon beam photocoagulation is as effective as phenol in preventing recurrence without affecting functional outcome as an adjuvant to surgical curettage. We retrospectively reviewed 93 consecutive patients with a minimum 10-month follow-up between 1992 and 2007 who were treated with curettage and either phenol or argon beam photocoagulation. Functional outcomes and complications were recorded. Overall, 16 (17.2%) of 93 patients who were initially treated with 1 of the adjuvants had pathologically confirmed recurrences. No additional recurrences were noted after retreatment, leading to an overall recurrence rate of 17.1% with phenol and 14.8% with argon beam photocoagulation (P=.726). While avoiding the toxic effects of phenol, argon beam photocoagulation provides for statistically equivalent recurrence rates, functional outcomes, and complication rates in the treatment of benign-aggressive bone tumors.     

Critical analysis of treatment of stage II and stage III melanoma patients with immunotherapy.

Over the past 8 years, 244 patients with Stage II or III melanoma have been treated by cutaneous injection of a crude acellular homogenate of allogeneic melanoma cells (V-I) or a more concentrated fraction (V-II), followed in most patients by exchanges of WBC between paired partners. Patients with Stage III disease exhibited an overall response rate of 24% and prolongation of survival compared with control data. Stage II patients also had prolonged survival and reduced rate of recurrence over historic peers' data. Breakdown of subgroup data revealed that V-II plus exchange of WBC is similar to V-I plus exchange or V-II alone. However, recent experience of LTF suggests a higher response rate than in either V-I or V-II groups, particularly when autochthonous tumor is used for cross-immunization. The most meaningful immunologic data resulted from analysis of DNCB and MIF data. Patients negative to DNCB rarely respond to immunotherapy. A positive pretreatment MIF or positive conversion following treatment correlates with response, whereas, conversion of positive to negative predicts poor clinical performance.     

Trigeminal neurinomas: clinical features and surgical experience in 84 patients

Trigeminal neurinomas are the second most common intracranial neurinomas next to the vestibular neurinomas. Eighty-four patients with trigeminal neurinomas were treated between 2003 and 2007. There were 40 women and 44 men (mean age 43 years). The most frequent symptoms were headache or numbness of the ipsilateral hemiface. There were 24 type A, nine type B, 45 type C, and six type D tumors. Dextroscope virtual reality technology was used for preoperative planning in recent eight cases. Gross total resection was achieved in 63 patients. We found that the major impediments to complete removal were adherent to the brainstem and skull base vascular structure, the frontotemporal approach with zygomatic or orbitozygomatic osteotomy or subtemporal approach could offer excellent exposure of the middle fossa and access to the posterior fossa, and Dextroscope virtual reality technology was a very useful tool to identify surgical and anatomic nuances and enhance preoperative planning in trigeminal neurinomas resection.     

The prognostic significance of chemotherapy for stage IV gastric cancer patients: A single-institution experience

Purpose  

The significance of aggressive chemotherapy for stage IV gastric carcinoma was retrospectively examined.     

"Low-pressure" laparoscopic cholecystectomy in high risk patients (ASA III and IV): our experience

The insufflation pressure used for laparoscopic cholecystectomy is usually 12-15 mm Hg, and a pneumoperitoneum with carbon dioxide has a significant effect on both cardiovascular and respiratory function. These effects are transient in young, healthy patients, but may be dangerous in ASA III and IV patients with a poor cardiac reserve. This study was designed to assess the feasibility of performing laparoscopic cholecystectomy at 6.5-8 mm Hg insufflation pressure in "high-risk" patients. Thirteen patients, 10 ASA III and 3 ASA IV, with cholelithiasis, were included in this study The insufflation pressure was 6.5-8 mm Hg, with a 10 degrees anti-Trendelenburg position. The cardiovascular and blood gas variables studied were: mean arterial blood pressure, heart rate, respiratory rate, and end-tidal CO2 pressure. The authors reported no conversions and no intra- or postoperative complications. During insufflation heart rate and mean arterial blood pressure increased minimally if compared with laparoscopic cholecystectomy at 12-15 mm Hg. Pa CO2 increased after insufflation (+5 mm Hg), and the end-tidal CO2 pressure gradient was moderate (3.5 mm Hg) and unchanged during surgery. A low-pressure pneumoperitoneum is feasible for laparoscopic cholecystectomy and minimizes the adverse haemodynamic effects of peritoneal insufflation.     

Surgical treatment of varicocele in day-surgery: our experience

Varicocele has been recognized as a treatable cause of male infertility. Recently, new techniques have been described for varicocele repair, including microsurgery, embolization and laparoscopy. The aim of this study is to evaluate the results of a group of patients who underwent subinguinal varicocelectomy using local anaesthesia in Day Surgery, after a careful ultrasonographic study to evaluate the degree and the quality of the reflux in the spermatic vein. The study shows that outpatient subinguinal varicocelectomy is a safe and reliable procedure. This approach is performed in local anaesthesia, has minimal morbidity and recurrences and, in our experience, has led an improvement in the quality of seminal fluid.     

Minilaparotomy versus laparoscopy in the treatment of cholelithiasis: our experience

The traditional biliary surgery has undergone some transformations to patient's advantage. Nowadays the open-surgery of cholelithiasis is inclined to reduce the incision to 5-6 cm and to perform a transverse one to respect the anatomy of abdominal wall. From July 2002 to April 2006, 82 cholecystectomy (53 minilaparotomy cholecystectomy, and 29 laparoscopic cholecystectomy) have been performed in our institution. The two groups are homogeneous for age, sex, BMI, ASA. Among the patients who underwent a minilaparotomy cholecystectomy we observed a quick recovery of normal activities already 24 hours from the operation, a hospital stay of 24-48 hours and an excellent esthetic result. The minilaparotomy approach is, in our opinion, similar to laparoscopic for short and long time results. Nevertheless, according to medical literature, our first choice is for laparoscopic approach and we prefer laparotomy approach in selected clinical conditions.     

Surgical treatment of primary hyperparathyroidism: our experience

The Authors report their experience on 136 patients with primary hyperparathyroidism. Nephrolitiasis was proven in 56 patients (41.3%), 20 patients (14.7%) were asyntomatic. Acute primary hyperparathyroidism was detected in 12 cases (8.8%). The preoperative localization of the diseased glands permits to minimize the procedure in terms of length and region of incision, extent of exploration and morbidity. 91.3% of the lesions were single adenoma, 7.3% double adenomas and 1.4% hyperplasia in MEN 1. The intraoperative PTH assay, performed in 90 patients (66.2%), showed a sensibility of 93.4%. Surgical treatment was successful in 93.4% of cases ( 127/136 patients), increasing to 97.0% (132/136patients) if only recurrent hyperparathyroidism was considered, with no mortality and morbidity of 4.4%.     

Surgical treatment of carotid chemodectoma: our experience

Carotid chemodectoma is a tumor that affects the bifurcation of the carotids. It is not a frequent event, but it has great importance for surgical and diagnostic problems involved. In this article three cases of chemodectoma observed and surgically treated are reported.