昏迷合并重症肺部感染患者应用纤维支气管镜灌洗治疗的临床效果评价

目的：分析昏迷合并重症肺部感染患者应用纤维支气管镜灌洗治疗的临床效果。方法：选取2014年3月4日至2014年8月20日期间收治的60例合并重症肺部感染的昏迷患者,分为应用组（30例）和对照组（30例）。给予对照组患者常规对症治疗,在其基础上给予应用组患者纤维支气管镜灌洗治疗,观察并比较两组患者治疗后效果。结果：应用组的治疗有效率（96．67％）高于对照组（43．00％）,P＜0．01,具有显著统计学差异;应用组的体温恢复正常时间（4．12±2．10）d优于对照组（9．21±3．13）d,P＜0．05,具有统计学差异;应用组的肺啰音消失时间（8．54±2．87）d优于对照组（14．98±3．21）d,P＜0．05,具有统计学差异。结论：纤维支气管镜灌洗治疗在合并重症肺部感染的昏迷患者的临床治疗中效果好,症状改善时间短,值得临床应用与推广。     

昏迷合并重症肺部感染患者应用纤维支气管镜灌洗治疗的临床效果

目的：探讨应用纤维支气管镜灌洗方式对昏迷合并重症肺部感染患者进行治疗的临床效果。方法选择66例昏迷合并重症肺部感染患者随机平分为对照组和观察组,各33例。对照组给予常规对症治疗,观察组在对照组的治疗基础上加用纤维支气管镜灌洗进行治疗,并对比分析2组患者的治疗效果。结果观察组的治疗总有效率为93.94%、明显高于对照组（72.73%）,差异具有统计学意义（P＜0.05）;观察组患者体温恢复时间、肺部症状消失时间、住院时间等各项指标均明显优于对照组,差异具有统计学意义（P＜0.05）。结论在常规治疗的基础上加用纤维支气管镜灌洗对昏迷合并重症肺部感染患者进行治疗可促进治疗效果得到显著提高,加快患者康复速度。     

纤维支气管镜灌洗治疗昏迷合并重症肺部感染40例临床效果观察

目的:探讨纤维支气管镜灌洗治疗昏迷合并重症肺部感染的临床效果.方法:我院2015年1月-2016年1月收治的昏迷合并重症肺部感染患者80例,随机分为观察组和对照组,每组40例患者.对照组患者给予常规对症治疗;在对照组的基础上,观察组患者给予纤维支气管镜灌洗治疗.对比分析两组患者临床症状恢复正常时间、机械通气时间、血气指标、C反应蛋白和白细胞计数.结果:治疗后,观察组患者体温恢复正常时间、血象恢复正常时间、湿啰音消失时间、机械通气时间、PaO2、PaCO2,以及C反应蛋白和白细胞计数的改善情况均明显优于对照组,组间比较差异具有统计学意义(P<0.05).结论:纤维支气管镜灌洗治疗昏迷合并重症肺部感染效果较为理想,能明显改善患者临床症状和血气指标,以及减轻炎症反应,具有较高的临床推广价值.     

纤维支气管镜在重症肺部感染治疗中的临床价值

目的:观察经纤维支气管镜行吸痰、灌洗及局部用药在重症肺部感染治疗中的疗效。方法:将40例重症肺部感染患者随机分为治疗组和对照组。治疗组在常规治疗基础上加经纤维支气管镜行吸痰、灌洗及局部用药,同时取深部痰培养,根据药敏试验结果选择敏感抗菌药物治疗,对照组单纯全身抗感染治疗,观察和比较两组临床疗效、平均住院日和发热时间。结果:治疗组患者经纤维支气管镜治疗后临床症状明显改善,住院及发热时间缩短,疗效优于对照组,差异有统计学意义(P0.05)。结论:纤维支气管镜应用于重症肺部感染患者的治疗有肯定的临床价值,且安全、创伤小,值得广泛推广。     

经纤维支气管镜灌洗治疗重型颅脑损伤合并肺部感染疗效观察

目的:总结经纤维支气管镜灌洗治疗重型颅脑损伤合并肺部感染的临床意义和效果。方法:采用纤维支气管镜灌洗治疗重型颅脑损伤合并肺部感染患者,分两组进行治疗,观察组采用纤维支气管镜灌洗治疗,对照组采用化痰、平喘、气道湿化及抗感染等常规疗法,对两组治疗效果进行对比观察。结果:观察组总有效率高于对照组,观察组患者肺部感染控制时间明显少于对照组。结论:纤维支气管镜支气管肺泡灌洗术治疗重型颅脑损伤合并肺部感染,安全、有效,值得在基层医院大力推广。     

纤维支气管镜支气管肺泡灌洗治疗重症肺部感染疗效观察

目的:探究重症肺部感染使用纤维支气管镜支气管肺泡灌洗治疗的疗效。方法:选取80例重症肺部感染患者为研究对象,其中40例重症肺部感染患者实施常规治疗,作为对照组,另40例患者在对照组基础上使用纤维支气管镜支气管肺泡灌洗治疗,作为观察组,比较两组效果。结果:比较两组患者的治疗有效率,观察组明显高于对照组;比较两组患者的恢复时间,观察组患者明显短于对照组,差异有统计学意义(P<0.05)。结论:纤维支气管镜支气管肺泡灌洗治疗重症肺部感染能够提高患者治疗效果,帮助患者症状及时缓解,促进其恢复,值得临床推广。     

重症肺部感染经纤维支气管镜支气管肺泡灌洗治疗临床观察

目的：观察使用纤维支气管镜支气管肺泡灌洗治疗重症肺部感染的临床疗效。方法选取2010年2月-2015年10月收治经纤维支气管镜肺泡灌洗治疗的重症肺部感染患者30例作为观察组,另选取同期未经纤支镜治疗的该病患者30例作为对照组,对比两组临床疗效。结果观察组治疗显效率及总有效率高于对照组,且临床症状消失时间、机械通气时间及住院时间均明显短于对照组,P＜0.05,差异有统计学意义。结论使用纤支镜对重症肺部感染患者进行支气管肺泡灌洗治疗,能够有效提高临床疗效,改善临床症状,且能有效缩短治疗时间,具有良好的临床应用效果及价值。     

支气管镜下肺泡灌洗法治疗老年支气管扩张合并感染临床疗效观察

目的：观察分析应用支气管镜下肺泡灌洗法治疗老年支气管扩张合并感染的临床疗效。方法：选取78例老年支气管扩张合并感染患者,根据治疗方法随机分成两组,对照组39例行包括抗感染、祛痰、引流等常规治疗,实验组在常规治疗基础上应用支气管镜下肺泡灌洗治疗,比较疗效、血气等指标。结果：实验组疗效明显高于对照组达100％,咳嗽、咳痰等症状缓解时间较对照组大大缩短,住院花费等也少于对照组,差异显著,P＜0．05。结论：应用支气管镜下肺泡灌洗方法治疗老年支气管扩张合并感染的效果优于常规治疗方法,具有一定的临床推广意义。     

纤维支气管镜下治疗慢性阻塞性肺疾病急性发作合并严重肺部感染的效果

目的：探讨纤维支气管镜下治疗慢性阻塞性肺疾病急性发作（AECOPD）合并严重肺部感染的效果。方法：收集本院38例AECOPD合并严重肺部感染患者,分为观察组（20例）和对照组（18例）,观察组在抗感染、营养支持等治疗基础上运用纤维支气管镜吸痰、药物灌洗,而对照组只给予常规抗感染、平喘、化痰、止咳治疗,观察两组治疗前后患者呼吸频率、心率、血气分析及胸部x线的变化以评定纤维支气管镜的辅助治疗的效果。结果：研究组显效13例,有效5例,无效2例,总有效率为90％（18／20）。对照组显效8例,有效4例,无效6例,总有效率66．7％（12／18）,差异有统计学意义（P〉0．05）。结论：应用纤维支气管镜治疗AECOPD合并严重肺部感染的患者是安全有效的方法。     

纤维支气管镜吸痰治疗重症肺部感染疗效观察

目的:观察经纤维支气管镜吸痰治疗重症肺部感染的临床疗效.方法:将住院诊断为重症肺部感染的病例随机分组,治疗组用经纤维支气管镜吸痰联合常规抗感染治疗,对照组用常规抗炎综合治疗,观察疗效并进行统计学分析.结果:经纤维支气管镜吸痰联合常规抗感染治疗的方法,能缩短住院时间,更快地改善症状,提高治愈率.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.