共查询到20条相似文献,搜索用时 15 毫秒
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Elena Galli Virginie Le Rolle Otto A. Smiseth Jurgen Duchenne John M. Aalen Camilla K. Larsen Elif A. Sade Arnaud Hubert Smitha Anilkumar Martin Penicka Cecilia Linde Christophe Leclercq Alfredo Hernandez Jens-Uwe Voigt Erwan Donal 《Journal of the American Society of Echocardiography》2021,34(5):494-502
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《Journal of the American Society of Echocardiography》2022,35(4):355-365
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Bharat Nandakumar Shaji K. Kumar Angela Dispenzieri Francis K. Buadi David Dingli Martha Q. Lacy Suzanne R. Hayman Prashant Kapoor Nelson Leung Amie Fonder Miriam Hobbs Yi Lisa Hwa Eli Muchtar Rahma Warsame Taxiarchis V. Kourelis Stephen Russell John A. Lust Yi Lin Wilson I. Gonsalves 《Mayo Clinic proceedings. Mayo Clinic》2021,96(3):677-687
ObjectiveTo evaluate the clinical outcomes of patients with primary plasma cell leukemia (pPCL) defined by 5% or greater clonal circulating plasma cells on peripheral blood smear and treated with novel agent induction therapies.Patients and MethodsA cohort of 68 patients with pPCL diagnosed at the Mayo Clinic in Rochester, Minnesota, from January 1, 2000, to December 31, 2019, and treated with novel agent induction therapies was evaluated.ResultsThe median follow-up was 46 (95% CI, 41 to 90) months. The median bone marrow plasma cell content was 85% (range, 10% to 100%) and median clonal circulaitng plasma cell percentage on the peripheral blood smear was 26% (range, 5% to 93%). There was a preponderance of t(11;14) primary cytogenetic abnormality in this cohort. The median time to next therapy (TTNT) and overall survival (OS) for all patients with pPCL patients in this cohort was 13 (95% CI, 9 to 17) and 23 (95% CI, 19 to 38) months, respectively. However, when stratified by cytogenetic risk, the median TTNT and OS were 16 and 51 months for standard risk vs 9 and 19 months for high risk (P=.01 for OS).ConclusionPrimary plasma cell leukemia remains an aggressive disease with poor prognosis despite novel agent–based therapies. Some patients have better than expected survival and this phenomenon may be influenced by the absence of high-risk cytogenetics. Newer treatment regimens are needed to improve the prognosis of this devastating disease. 相似文献