钩虫感染与周围环境的关系

１９９０年７－９月在淮阳县３个自然村采用加藤法观察人群钩虫感染率和感染程度，用贝氏分离法检查土壤中含钩虫卵数、钩虫幼虫数，用饱和硝酸甘油离心法检查蔬菜瓜类表面的钩虫卵数，以了解钩虫感染与周围环境的相互关系。结果共检查１４２１人，其感染率为５４．６％，...     

钩虫的感染和免疫

本文综述了钩虫病流行的现状、宿主对钩虫感染免疫应答及钩虫的免疫逃逸机制,为钩虫病的免疫防治提供依据。     

钩虫感染的免疫

钩虫感染的免疫张仁刚川北医学院寄生虫学教研室南充６３７００７冯瑞元华西医科大院寄生虫教研室成都６１００４１钩虫感染引起的贫血是一些非洲和亚洲国家的主要公共卫生问题。我国经过多年的积极防治，１９９１年调查南方各省区农村人体钩虫感染仍高达２４．３－７７．...     

信阳市农村居民钩虫感染调查分析

我国北方以十二指肠钩虫感染为主,南方以美洲钩虫感染为主,为了解地处南北交界的大别山区信阳市3县农村钩虫感染情况,现将2001-08所作的调查结果报道如下。1对象与方法采用整群随机抽样的方法,根据各县、区经济情况、卫生条件和文化水平,以3县区14乡常住人口为对象,每乡调查550     

Gastrointestinal bleeding in hookworm infection

Digestive Diseases and Sciences -     

山东省人群钩虫感染情况调查

1960年代,山东省人群钩虫感染率多在20％～40％,个别地区高达61％以上。为进一步掌握钩虫病在全省的流行状况,根据卫生部《关于开展全国人体寄生虫病现状调查的通知》,我们于2001～2003年,对在流行钩虫病的10个县（市、区）进行了钩虫病调查。     

Mucosal antibody responses in experimental hookworm infection

Hookworms are bloodfeeding nematodes that reside in the intestinal mucosa. These parasites secrete proteins that induce robust systemic immune responses in humans and experimental animals. By contrast, mucosal immune responses in and around the site of attachment are not described as well. This paper presents data from studies aimed at examining hookworm-specific mucosal antibody responses in a hamster model of Ancylostoma ceylanicum infection. Intestinal flush prepared from infected hamsters was analysed by ELISA and shown to be enriched in IgA-specific for A. ceylanicum excretory-secretory (ES) products. Evaluation of mucosal IgA responses by immunoblot demonstrated that infected hamsters recognized a broad range of ES proteins. Hamsters repeatedly exposed to drug-terminated infections were shown to have enhanced serum IgG and mucosal IgA responses, as well as a high level of protection from challenge infection. Parasite-specific IgA was also detected in the faeces of hamsters undergoing a primary infection, and increasing faecal IgA responses were coincident with significant reductions in intestinal worm burdens and faecal ES output over time. Together these results suggest that secretory IgA may act in concert with other components of the mucosal and systemic immune response to promote protective immunity against hookworm infection and/or disease.     

甲苯达唑药盐防治钩虫病的研究

1984～1987年,在广西壮族自治区5401人口范围内,用甲苯达唑伴食盐(简称药盐)供全民服用。平均每人每天服甲苯达唑40mg,连服15～20d后,钩虫卵阴转率为92.3～94.4％;50、100和200mg/d×30d各剂量组的钩虫卵阴转率均达100％。试点居民服2个疗程后钩虫感染率从原来的57.9～71.1％下降到1％以下。上述一次剂量蛔虫卵阴转率高达99.1～100％;100mg/d×30d的鞭虫卵阴转率为97.6％。药盐副反应轻微,无需药物处理。