穿通性毛母质瘤1例

报告1例穿通性毛母质瘤。患者女,60岁。因背部结节4个月就诊。皮肤科检查示背部有一突出皮面的紫红色结节,直径0.9cm结节中心有破溃。予以手术切除。组织病理检查示穿通性毛母质瘤。     

穿通性毛母质瘤

报告1例穿通性毛母质瘤.患儿女,10岁.左上臂外侧出现一红色丘疹,偶有疼痛,逐渐增至玉米粒大,中央破溃1年.皮肤科检查:左上臂后外侧见一玉米粒大的紫红色半球形结节,质硬,中央破溃呈脐窝状.经皮损组织病理检查诊断为穿通性毛母质瘤.     

穿通性毛母质瘤1例报告

穿通性毛母质瘤１例报告胡亚莹（江苏省泰县溱湖医院，２２５５０８）毛母质瘤又称钙化上皮瘤。为一较少见的毛源性肿瘤，而穿通性毛母质瘤更为罕见，今遇到１例，特报告如下：患者男，６７岁，因“头顶部出现碗豆大结节，微痒，搔抓易出血４年”而就诊。自诉４年前头顶部...     

毛母质瘤一例

正临床资料患者,男,24岁。主因颈后肿物2年余,于2015年3月6日就诊。2年前,患者颈后中部皮下出现一小指大肿物,无不适,缓慢生长,未诊治。既往体健;否认局部有外伤史;无此类疾病家族史。体格检查:各系统无异常。皮肤科情况:颈后中部可见一皮肤稍隆起区域,表皮正常,皮下可扪及一直径约3cm的深在结节,质地较硬,稍有弹性,可移动,无波动感,表面皮肤触觉、痛温觉正常。实验室检查:     

水疱型毛母质瘤一例

正临床资料患儿,女,13岁。因右侧肩部结节5个月,出现水疱样外观1个月,于2015年7月29日就诊。5个月前,患儿右侧肩部出现一蚕豆大小淡红色质硬结节,缓慢增大;1个月前结节表面出现水疱样外观,无自觉症状。自起病以来,患儿无发热、肌无力、肌肉酸痛及肌肉萎缩等全身症状。患儿既往体键,无传染病及遗传病史,家族成员中无类似疾病患者。皮损局部无外伤史或蚊虫叮咬史。体格检查:一般情况可,     

毛母质瘤1例

患者女．70岁。困左面颊出现紫红色结节伴瘙痒、破溃4个月余,于2006年3月27日来我中心门诊就诊。4个月前无明显诱冈患者左面颊部出现一绿豆大红色丘疹,无明显瘙痒及疼痛,曾自行使用细绳结扎皮损,结果皮损迅速增大至鸽蛋大,质地稍硬,自觉瘙痒不适,搔抓后皮损中心破溃、出血、结痂。发病前无外伤史．家族中无类似疾病患者。[第一段]     

毛母质瘤

毛母质瘤临床表现多样,无特征性,极易误诊,但其组织病理学改变具有特征性。现报告1例。     

毛母质瘤1例

1临床资料患者,女,43岁,左侧颧部淡黄色结节伴瘙痒半年,于2007年9月13日就诊。半年前无明显诱因左侧颧部出现一米粒大丘疹伴轻度瘙痒,未予治疗,后     

水疱样毛母质瘤一例

患者男,75岁.因颈后部肿物3月余,于2009年11月来我科就诊.就诊前3个月摸到颈后部一绿豆大小硬结,无明显不适,未予处理.此后自觉皮损迅速增大,但无局部与全身不适感.否认发疹前局部有外伤史.既往体键,否认心、肺、肝、肾、脑重要脏器疾病史.家族中无遗传性疾病史及类似疾病患者.     

水疱样毛母质瘤一例

报告1 例水疱状毛母质瘤。患儿女, 16 岁。左肩部出现一渐增大水疱6月。皮肤科检查：左肩部见约2x1x1cm大小的皮色半球形、半透明的水疱状新生物,表面光滑,质韧,未见破溃。经皮损组织病理检查诊断为毛母质瘤。     

A case of perforating pilomatricoma

Pilomatricoma is a rare skin neoplasm, most commonly seen in the head and neck region, and occurring in the first two decades of life. It is usually solitary and varies from 0.5 to 2 cm in diameter. Its etiology is unknown. Perforating pilomatricoma is a rare clinical variant that presents as a draining, crusted nodule or ulcer, and is reported to arise faster than the classic pilomatricoma. Herein, we report a case of 35-year-old female, who had a 4-month history of a growing mass on her leg. On physical examination, a 4-cm diameter, asymptomatic, erythematous, ulcerated mass was noted on the left anterio-lateral upper leg. The first histopathological analysis of a punch biopsy from the lesion was reported as basal cell carcinoma. Therefore, the lesion was totally excised. There were shadow cells, squamoid cells, and basaloid aggregations more prominently in the one area in the tumor. In addition, calcification, foreign body giant cells and inflammatory cells were present. Punch or excisional biopsies are preferred as a method of diagnosis for the majority of cutaneous neoplasms. If total excision is not the method of choice, multiple punch biopsies should be made from different areas in large skin tumors for correct diagnosis.     

儿童穿通型毛母质瘤四例

毛母质瘤又称Malherbe钙化上皮瘤,首先由Malherbe和Chenantais于1880年报道[1]。临床上偶可见到穿通型毛母质瘤、水疱型毛母质瘤及巨大型毛母质瘤等罕见类型[2]。我科自2012—2014年共收治4例穿通型毛母质瘤患儿,现报告如下。临床资料病例1,女,4岁7个月。主因右侧颈部肿物2年、破溃1.5年,于2012年12月24日就诊。2年前无明     

面部毛母质瘤一例

患儿女,9个月,因发现左下睑包块3个月就诊。患儿3个月前左下睑不慎被撞击出现皮肤淤斑,未予特殊处理,1个月前感冒后原撞击部位出现一个质硬包块,突出皮面,无破溃,伴轻压痛。至我院就诊。初诊为血管瘤？建议活检,组织病理报告：表皮大致正常,真皮浅中层局限性区域胶原纤维间隙明显增宽,血管轻度增生,有散在扩张的淋巴管,小血管周围少量淋巴细胞、浆细胞浸润。 AB染色阴性。疑为横纹肌肉瘤。彩超检查,结果：肿块血管丰富,初步诊断为血管瘤？鉴于临床表现、彩超与病理报告明显不符合,建议患者行肿块切除后再行组织学检查。患儿既往体健,家族中无遗传性疾病史及类似疾病患者……     

儿童穿通型毛母质瘤29例临床病理特点分析

目的:分析儿童穿通型毛母质瘤的临床及病理特点,探讨其发生机制。方法:回顾2014—2020年就诊于北京儿童医院皮肤科的29例穿通型毛母质瘤患儿资料,分析其临床及组织病理学特点。结果:29例中男11例,女18例,男女比例为1∶1.64。发病年龄3个月至14岁10个月,中位发病年龄4.58岁。病程2个月至2年,平均8.72...     

Six cases of perforating pilomatricoma: Anetodermic changes with expression of matrix metalloproteinases

Perforating pilomatricoma (PP) is a rare clinical variant of pilomatricoma presenting as a crusted or ulcerated nodule. Previous reports have suggested that the tumor cells perforate the epidermis through a process of transepithelial elimination. Here, we report six cases of PP and examine the mechanism of transepithelial elimination in PP. Histologically, the dermis above or around the tumor nest exhibited edema, dilated vascular spaces, sparse collagen bundles and absence of elastic fibers, suggesting anetodermic changes in all cases. Immunohistochemistry demonstrated many CD68-positive macrophages around the tumor nests. Matrix metallopeptidase (MMP)-9 and MMP-12 were expressed in the inflammatory cells and tumor cells, and were also present in the epidermis and fibroblasts in all cases. We speculate that in PP anetodermic change caused by MMP and elastases including MMP-9 and MMP-12 may precede elimination of the tumor.     

反应性穿通性胶原病一例

患者男,35岁,因四肢发生瘙痒性丘疹4个月就诊。4个月前无明显诱因于四肢出现散在分布的淡红色、粟粒火丘疹．伴有明显瘙痒,皮损逐渐扩大、增多,形成绿豆至黄豆大丘疹,经一个月后部分皮疹消退,但陆续有新发皮疹出现．患者平素体健,无不良嗜好,无口腔、外阴溃疡史,无关节、肌肉疼痛,饮食、大小便正常。父母非近亲结婚,家庭成员中无类似病患者。     

反应性穿通性胶原病一例

反应性穿通性胶原病（reactive perforating collagenosis,RPC）是一种以变性胶原被排出体外为特征的穿通性皮肤病, 临床少见,多累及儿童, 有一定遗传倾向。而成人期发病的患者多并发系统疾病, 现将我科诊治的l 例并发糖尿病、乙型肝炎等系统疾病的成人反应性穿通性胶原病报道如下……