创伤失血性休克限制性液体复苏的临床同察

目的评价创伤失血性休克(HTS)采用限制性液体复苏的治疗效果,以提高存活率.方法总结1997年-2004年急诊收治常规液体复苏和限制性液体复苏的创伤失血性休克病人60例,对病人的年龄、创伤严重度评分、休克程度、复苏开始时间、输入液体量进行统计学分析,对比常规液体复苏组(n＝30)和限制性液体复苏组(n=30)的疗效和存活率.结果限制性液体复苏组输液量为(2089±328)ml,治愈率86.4%,死亡率为13.6%;常规液体复苏组输液量(2965±524)ml,治愈率77.8%,死亡率22.2%.两组间比较有显著性差异(P＜0.05).结论在出血未控制的情况下,限制性液体复苏可提高治愈率,降低死亡率,为后续治疗提供有力条件.     

创伤失血性休克限制性液体复苏的临床观察

目的评价创伤失血性休克(HTS)采用限制性液体复苏的治疗效果,以提高存活率。方法总结1997年-2004年急诊收治常规液体复苏和限制性液体复苏的创伤失血性休克病人60例,对病人的年龄、创伤严重度评分、休克程度、复苏开始时间、输入液体量进行统计学分析,对比常规液体复苏组(n=30)和限制性液体复苏组(n=30)的疗效和存活率。结果限制性液体复苏组输液量为(2089±328)ml,治愈率86.4%,死亡率为13.6%;常规液体复苏组输液量(2965±524)ml,治愈率77.8%,死亡率22.2%。两组间比较有显著性差异(P<0.05)。结论在出血未控制的情况下,限制性液体复苏可提高治愈率,降低死亡率,为后续治疗提供有力条件。     

重度颅脑损伤合并失血性休克救治探讨

目的探讨重度颅脑损伤合并失血性休克患者的救治。方法对深圳市南山区人民医院2010年10月～2013年10月收治的90例重度颅脑损伤合并失血性休克患者进行回顾性分析，其中，44例采用常规液体复苏，46例采用限制性液体复苏，比较2组液体复苏的治疗效果。结果常规液体组44例患者的平均输液量为（2646．1±182.5）mL，限制性液体组44例患者的平均输液量为（1673.2±33．8）mL，2组输液量差异有统计学意义（P〈0.05）。常规液体组患者死亡率为65．6％，限制性液体组死亡率为41.3％，2组死亡率比较差异有统计学意义（P〈0.05）。结论早期诊断和及时准确处理是挽救重度颅脑损伤合并失血性休克患者生命的关健，限制性液体复苏可以提高重度颅脑损伤合并失血性休克患者的治愈率。     

颅脑损伤并创伤失血性休克早期限制性液体复苏的疗效评价

目的:本科将针对使用早期限制性液体复苏治疗的颅脑损伤并创伤性休克的患者进行疗效检验,进而提高颅脑损伤并创伤失血性休克的治疗效果。方法:收集2015年1月至2016年1月本科115名患者的病例,对患者的颅脑损伤性程度、失血性休克的程度,以及对患者进行液体复苏的开始时间,患者进行早期限制性液体的输入性程度进行统计学处理,从而分析常规性的液体复苏治疗与早期限制性的液体复苏治疗的不同。结果:常规性的液体复苏输入量是(2630±636)毫升,治愈率为61.8%,死亡率为38.2%;而采用早期限制性液体复苏治疗的输入量是(1635±535)毫升,治愈率为78.2%,死亡率是21.8%。具有显著差异。结论:采用早期限制性液体复苏可以提高颅脑损伤并创伤失血性休克的治疗效果。     

不同补液方式对创伤合并失血性休克患者早期急救的影响

目的 探讨不同补液方式对创伤合并失血性休克患者早期急救的影响.方法 选择创伤合并失血性休克患者98例,按治疗顺序分为两组,各49例.对照组实施充足液体补充,研究组实施限制性液体补充.对两组患者的输液量、输血量、平均动脉血压、心率、并发症发生率及死亡率进行观察.结果 研究组患者输液量、输血量、平均动脉血压、心率分别为(1294.5±25.1)mL、(346.1±17.6)mL、(51.3±12.3)mmHg、(79.1±8.5)次/min;对照组患者输液量、输血量、平均动脉血压、心率分别为(2894.5±42.9)mL、(599.3±22.8)mL、(71.3±7.5)mmHg、(129.1±9.6)次/min,组间比较差异有统计学意义(P<0.05);研究组与对照组总并发症发生率分别为14.3%、36.7%,两组比较差异有统计学意义(P<0.05);研究组患者死亡率为16.3%,对照组患者死亡率为38.8%,组间比较差异有统计学意义(P<0.05).结论 限制性液体补充可有效提高创伤合并失血性休克患者的临床疗效,降低患者并发症发生率及死亡率,值得临床推广.     

创伤失血性休克急诊早期限制性液体复苏的探讨

目的 探讨限制性液体复苏-高渗液体复苏-出血未控制前允许性低血压状态对创伤失血休克急诊早期的救治效果.方法 将56例创伤失血性休克患者随机分成常规液体复苏组(29例),限制性液体复苏组(27例).常规组在止血前早期、快速、足量输入平衡液,维持平均动脉压(MAP)达70～90 mm Hg,限制组在止血前输入7.2%氯化钠的右旋糖酐溶液(晶:胶3:1)4 ml/kg,平均速度20 ml/min,维持MAP在50～70 mm Hg.比较两组患者的输液量、凝血酶原时间(PT)、治愈率及死亡率.结果 与常规液体复苏比较,限制性液体复苏组输液量明显减少,PT明显缩短,治愈率明显升高,死亡率降低,差异均有统计学意义(P<0.05).结论 限制性液体复苏可避免过分扰乱机体的代偿机制和内环境,改善脏器灌注和氧供,提高创伤失血性休克患者的治愈率,降低死亡率,改善预后.     

创伤失血性休克早期限制性液体复苏的应用

目的：探讨创伤失血性休克（HTS）采用限制性液体复苏的治疗效果,以提高存活率。方法：将85例创伤失血性休克患者随机分为常规液体复苏组（42例）、限制性液体复苏组（43例）。常规组在止血前早期、快速、足量输入平衡液及胶体液,维持平均动脉压（MAP）达（60－90）mmHg,限制组在手术止血前以平均20mL／min的速度输入平衡液及胶体液,维持MAP在（40—60）mmHg。比较两组患者的平均输液量、凝血酶原时间（PII）及治愈率。结果：限制性液体复苏组输液量为（20554-232）mL,PT（12．5±1．7）s,治愈率90．7％;常规液体复苏组输液量（2741±430）mL,PT（14．5±1．9）s,治愈率73．8％。与常规液体复苏组比较,限制液体复苏组术前输液量明显减少,明显著降低,治愈率提高,两组比较差异具有统计学意义（P〈0．05）。结论：限制性液体复苏能调动机体凝血机制及其他代偿机制。可保证重要器官的血流灌注,提高创伤失血性休克患者的治愈率,改善预后。     

限制性液体复苏治疗失血性休克56例临床分析

目的探讨限制性液体复苏治疗创伤失血性休克的临床效果。方法回顾分析救治创伤失血性休克118例患者临床资料,随机采用常规液体复苏(常规组)和限制性液体复苏(限制组)两种方法复苏,其中常规组62例,限制组56例,对两组患者凝血酶原时间(PT)、红细胞压积(HCT)、血清乳酸(BL)、血气剩余碱(BE)、病死率及输液量进行统计学分析,比较疗效。结果常规组术前输液量为2830±268ml、入院24h内病死率为24.19%,限制组术前输液量为830±228ml、病死率为8.93%,两组比较差异有高度显著性(P均<0.01)。两组患者MAP、PT、HCT、BE比较差异也有显著性(P<0.01或0.05)。结论限制性液体复苏可维持重要器官的血流灌注,为争取进一步治疗赢得时间,改善预后及降低病死率。     

早期限制性液体复苏对急诊失血性休克的影响

目的:讨论限制性液体复苏对急诊创伤患者的影响,寻求高效的液体复苏方法。方法:对2010年7月~2013年2月在我科就诊的79例创伤性休克患者的临床资料进行回顾性分析。对比常规液体复苏组(n=28)和限制性液体复苏组(n=51)的疗效和存活率。结果:限制性液体复苏组输液量为2098±315ml,治愈率86.4%,死亡率为13.6%;常规液体复苏组输液量2980±512ml,治愈率77.8%,死亡率22.2%。2组间比较有显著性差异(P<0.05)。结论:在创伤早期出血未控制的情况下,限制性液体复苏可提高治愈率,降低死亡率,为后续高级生命支持创造了条件。     

限制性液体复苏对急性创伤失血性休克的临床意义

目的:通过限制性液体复苏及充分性液体复苏对急性创伤失血性休克患者的救治效果,探讨限制性液体复苏对急性创伤失血性休克患者的临床意义。方法:分析2011-09~2013-09我院急诊科80例急性创伤失血性休克患者早期液体复苏,通过对患者的年龄、创伤严重度评分、复苏开始时间、输入液体量、治愈率、死亡率进行统计学分析,对比限制性液体复苏和常规性液体复苏对急性创伤失血性休克的救治效果。结果:80例急性创伤失血性休克患者中,常规性液体复苏组死亡率高于限制性液体复苏组(P0.05)。结论:限制性液体复苏能降低急性创伤失血性休克患者死亡率,改善预后。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Electro-Acupuncture Combined with the Trigger Point Needle-Embedding for Treatment of Primary Trigeminal Neuralgia in 31 Cases

In recent years, the author of this essay has applied electro-acupuncture combined with the trigger point needle-embedding for treatment of primary trigeminal neuralgia in 31 cases, yielding satis- factory results as reported in the following.     

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Objective： To explore the role of matrix metalloproteinase-1,2 （MMP-1, MMP-2） and tissue inhibitor of matrix metalloproteinases-1 （TIMP-1） in endometriosis. Methods： The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.endometria from 40 subjects （excluding endometriosis） were collected and examined by in situ hybridization technology and western blot assay. Results： Both expressions of MMP-1 and -2 were stronger in ectopic endometrium and eutopic endometrium than in normal endometrium. On the contrary, the expression of TIMP-1 in ectopic endometrium and eutopic endometrium was lower. The differences were significant （P 〈 0.01 ）. Moreover, there was no relationship among the expressions of MMP-1, 2 and TIMP-1 in ectopic endometrium. Conclusion： The expressions of MMP-1, 2 and TIMP-1 lose balance and lack of periodic changes in ectopic endometrium , which explains the biological invasive behavior of endometriosis. It was suggested-that regulating the balance between the MMPs and TIMP-1 should be an ideal therapeutic target to endometriosis.     

Shi Da-zhuo (史大卓) —An outstanding cardiologist of integrative medicine

Prof. SHI Da-zhuo, Ph.D., male, was born on March 20, 1960. Prof. SHI entered the Ph.D. program in 1990 at the China Academy of Chinese Medical Sciences under the supervision of Prof. CHEN Ke-ji, majoring in the treatment of cardiovascular diseases. After receiving his Ph.D. degree in 1993, Prof. SHI started working at the Cardiovascular Center in Xiyuan Hospital affiliated to China Academy of Chinese Medical sciences.     

Persist in and Carry Forward the Integrative Medical Research——Speech at the 6th National General Congress of Chinese Association of Integrative Medicine by Academician CHEN Zhu,Minister of Ministry of Health

The 6th National General Congress of Chinese Association of Integrative Medicine （CALM） was convened at 19-20, April 2008 in Beijing. Academician CHEN Zhu, the minister of Ministry of Health indicated at the congress that the integration of Chinese and Western medicine is very well in keeping with the situation of our country and the general rule of development in medical science; and as a good integration of Chinese medicine and Western medicine, it is mutually beneficial and advantageous to both of them. Seeing the creativity shown in integrative medical investigation in theoretic and methodological sides, we should and must persist in and develop it.