CO2 embolism during hysteroscopy

During CO2 hysteroscopy the intracavitary pressure increases up to 80 mmHg. This can result in a CO2 embolism, especially after injury/lesion of the endometrium. A 49-year-old female Caucasian patient underwent curettage, and the following day while a hysteroscopy was being performed in general anesthesia a CO2 embolism occurred, with bradyarrhythmia, drop of arterial blood pressure, superior vena cava syndrome, metallic heartsound and hypercapnia. It was possible to achieve recompensation of the right heart failure with drug therapy. Other causes (lung embolism, hypoventilation, increased CO2 production, cardiac causes) could be excluded.     

CO(2) embolism during minimally invasive vein harvesting.

CO(2) embolism is a known, though rare, complication of procedures using CO(2) insufflation. We report massive cardiac right atrial CO(2) embolism during minimally invasive harvesting of a varicose great saphenous vein. The patient's hemodynamics deteriorated significantly and needed to be stabilized by emergency institution of cardiopulmonary bypass. Causes of this rare but potentially lethal complication are discussed, as well as its prediction, diagnosis, and prevention.     

Carbon dioxide embolism during endoscopic vein harvesting

Endoscopic vein harvesting (EVH) is becoming common for the patients undergoing coronary artery bypass grafting. Using carbon dioxide insufflations during the vein harvest can produce rare but catastrophic CO(2) embolism. We report a case of massive right atrial CO(2) embolism due to femoral vein injury which occurred during the performance of a routine EVH procedure.     

Capnography in the early diagnosis of carbon dioxide embolism during laparoscopy

Venous embolism of carbon dioxide occurred during elective diagnostic laparoscopy in a healthy adult female. The diagnosis of gas embolism was made on the basis of the sudden abrupt onset of systolic and diastolic murmurs. The continuously recorded end-tidal carbon dioxide concentration (FETCO2) increased abruptly from 3.8 to 4.2 per cent and then slowly decreased to 4.0 per cent over the subsequent 30 seconds. CO2 insufflation was terminated immediately following the establishment of the diagnosis. The patient recovered uneventfully. A transient but rapid rise in FETCO2 is suggested as a useful early sign of venous CO2 embolism during laparoscopy.     

Carbon dioxide embolism during endoscopic saphenous vein harvesting in coronary artery bypass surgery

OBJECTIVES: Our objectives were to determine the incidence and severity and the time course of the CO(2) embolism during endoscopic saphenous vein harvesting with CO(2) insufflation in coronary artery bypass surgery with transesophageal echocardiography monitoring. METHODS: Four hundred three consecutive patients scheduled for off-pump coronary artery bypass grafting surgery or femoral-to-popliteal artery bypass grafting surgery were prospectively studied. Multiplane transesophageal echocardiography with a new transgastric view was used to monitor CO(2) bubbles in the inferior vena cava and hepatic vein. RESULTS: CO(2) embolisms occurred in 17.1% of patients. Minimal, moderate, and massive CO(2) embolisms occurred in 13.1%, 3.5%, and 0.5%, respectively. The occurrence of moderate and massive CO(2) embolisms was frequently associated with the surgical manipulation of branches of saphenous veins. No significant risk factors were identified in multiple logistic regression analysis. CONCLUSION: The incidence of significant CO(2) embolism during endoscopic saphenous vein harvesting with CO(2) insufflation procedures was more than 4%. Continuous transesophageal echocardiographic monitoring of the CO(2) bubbles in the inferior vena cava is essential in early detection and can help to prevent the development of significant CO(2) embolisms in these patients.     

Cardiac catheters for diagnosis and treatment of venous air embolism: a prospective study in man

One hundred consecutive patients undergoing neurosurgical procedures in the seated position were monitored for venous air embolism with a Swan-Ganz pulmonary artery (PA) catheter, precordial Doppler ultrasound device, and continuous end-tidal CO2 (FETCO2) analysis. Simultaneous determinations of right atrial and pulmonary capillary wedge pressures were also performed during each operation. Although 80 episodes of air embolism were detected by changes in Doppler sounds, only 36 were associated with increased PA pressure, and only 30 developed a decrease in FETCO2. Changes in PA pressure and FETCO2 agreed closely (r = 0.86), and only marked changes were associated with systemic hypotension. Air was recovered from the right atrium and PA only in small amounts (2 to 20 ml) during air embolism, although it was possible to aspirate large quantities of blood. Twenty-nine patients were found to have right atrial pressures that were higher than pulmonary capillary wedge pressures. Paradoxical air embolism from a probe-patent foramen ovale was possible in these patients, and one developed signs and symptoms of systemic air embolism postoperatively. We conclude that noninvasive monitoring with the combination of a precordial Doppler device and end-tidal CO2 analysis is satisfactory for rapid detection of clinically significant venous air embolism. The unique advantage of Swan-Ganz monitoring, however, is that it permits identification of patients who may sustain paradoxical air embolism, and that it differentiates the hemodynamic effects of brain-stem manipulation from those caused by air embolism.     

CO2– Gasembolie nach akzidenteller Gefäßpunktion bei laparoskopischer Cholezystektomie

We report a case of carbon dioxide (CO(2)) embolism in a 52-year-old man during a laparoscopic cholecystectomy, which caused an accidental CO(2)-insufflation in a vessel despite exact control of the Verres needle. The first manifestations were two drops of the partial pressure of endtidal carbon dioxide (Petco(2)) from 34 mmHg to 13 mmHg and again from 37 mmHg to 11 mmHg, followed by pulseless ventricular tachycardia. It was possible to achieve resuscitation and a recompensation of the right heart failure with drug therapy. After successful resuscitation and restoration of a stable hemodynamic situation, an abrupt increase in the Petco(2) from 11 mmHg to 52 mmHg was noted. This increase of Petco(2) could be interpreted as the reinstallation of circulation and the amount of CO(2) in the organism after carbon dioxide embolism.     

Possible venous air embolism during open eye surgery in a child

PURPOSE: Although venous air embolism is a well recognized complication within most surgical subspecialties, it has only been reported recently during eye surgery in one adult, and never before in a child. We describe the case of a 17-month-old boy who sustained a possible air embolism during repair of an open trauma of his right eye. CLINICAL FEATURES: A vitrectomy through the pars plana with air-fluid exchange of the posterior chamber was performed under general anesthesia to remove a foreign body which had impaled the optic nerve. A few minutes after removal of the foreign body, a notable decrease in end-tidal CO(2), oxygen saturation and arterial blood pressure occurred, requiring administration of a high inspired oxygen fraction and vasopressors. Venous air embolism was strongly suspected after other causes of a decrease of end-tidal CO(2) and hypoxemia had been excluded. An arterial blood gas confirmed hypoxemia and respiratory acidosis. CONCLUSION: Although venous air embolism is a rare complication of eye surgery, it should nevertheless be considered as a possible complication during air-fluid exchange vitrectomy in children.     

Gas embolism during hysteroscopy

PURPOSE: Gas embolism during hysteroscopy is rare but sometimes fatal. A fatal case of gas embolism during diagnostic hysteroscopy using carbon dioxide (CO2) is presented. CLINICAL FEATURES: A 68 yr old woman was admitted for treatment of myoma and cancer of the uterus. Hysteroscopy using CO2 was performed without monitoring or anesthesia on the ward. At the end of the examination, just after the hysteroscope was removed, she developed tonic convulsions, lost consciousness, and her pulse was impalpable. Cardiac massage was started, anesthesiologists were called and the trachea was intubated. She was transferred to the intensive care unit with continuous cardiac massage. Cardiac resuscitation was successful. A central venous line was inserted into the right ventricle under echocardiography in an attempt to aspirate gas with the patient in the Trendelenberg position, but the aspiration failed. Positive end expiratory pressure and heparin for emboli, midazolam for brain protection, and catecholamines were administered. Fifteen hours after resuscitation, the pupils were enlarged and she died 25 hr after resuscitation. CONCLUSION: Gas embolism is a rare complication of hysteroscopy. The procedure should be performed with monitoring of blood pressure, heart rate, oxygen saturation and end-tidal CO2 concentration.     

Gas embolism during radical nephrectomy by retroperitoneal laparoscopy

A case of CO2 gas embolism occurring during retroperitoneal laparoscopic right radical nephrectomy in a 70-year-old-woman is reported. Patient's outcome was excellent after venous clamping, fluid loading and application of a positive and expiratory pressure. Gas embolism is a well documented complication of laparoscopic surgery, but has been rarely described in retroperitoneal laparoscopy for urologic procedure. The retroperitoneal surgical site, the major surgical procedure with vessel manipulation and the left lateral position seem to be the risk factors for gas embolism in this case.     

Volumetric capnography in the mechanically ventilated patient

Expiratory capnogram provides qualitative information on the waveform patterns associated with mechanical ventilation and quantitative estimation of expired CO2. Volumetric capnography simultaneously measures expired CO2 and tidal volume and allows identification of CO2 from 3 sequential lung compartments: apparatus and anatomic dead space, from progressive emptying of alveoli and alveolar gas. Lung heterogeneity creates regional differences in CO2 concentration and sequential emptying contributes to the rise of the alveolar plateau and to the steeper the expired CO2 slope. The concept of dead space accounts for those lung areas that are ventilated but not perfused. In patients with sudden pulmonary vascular occlusion due to pulmonary embolism, the resultant high V/Q mismatch produces an increase in alveolar dead space. Calculations derived from volumetric capnography are useful to suspect pulmonary embolism at the bedside. Alveolar dead space is large in acute lung injury and when the effect of positive end-expiratory pressure (PEEP) is to recruit collapsed lung units resulting in an improvement of oxygenation, alveolar dead space may decrease, whereas PEEP-induced overdistension tends to increase alveolar dead space. Finally, measurement of physiologic dead space and alveolar ejection volume at admission or the trend during the first 48 hours of mechanical ventilation might provide useful information on outcome of critically ill patients with acute lung injury or acute respiratory distress syndrome.     

Detection of venous air embolism

A clinical report on the detection of venous air embolism during neurosurgery is presented. The use of end-tidal CO2 monitoring is described.     

Cardiopulmonary changes during laparoscopy and vessel injury: comparison of CO2 and helium in an animal model

BACKGROUND: Injury of venous vessels during elevated intraperitoneal pressure is thought to cause possible fatal gas embolism, and helium may be dangerous because of its low solubility. METHODS: Twenty pigs underwent laparoscopy with either CO2 (n=10) or helium (n=10) with a pressure of 15 mm Hg and standardized laceration (1 cm) of the vena cava inferior. After 30 s, the vena cava was clamped, closed endoscopically by a running suture and unclamped again. During the procedure changes of cardiac output (CO), heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), pulmonary artery pressure (PAP), pulmonary artery wedge pressure (PAWP), end tidal CO2 pressure (PETCO2), and arterial blood gas analyses (pH, pO2 and pCO2) were investigated. RESULTS: No animal died during the experimental course (mean blood loss during laceration: CO2, 157+/-50 ml; helium, 173+/-83 ml). MAP and CO values showed a decrease after laceration of the vena cava in both groups that had already been completely compensated for before suturing. PETCO2 increased significantly after CO2 insufflation (P<0.01), while helium showed no effect. Laceration of the vena cava caused no significant changes in PETCO2 values in either group. Significant acidosis and an increase of pCO2 were only found in the CO2 group. CONCLUSIONS: The incidence of gas embolism during laparoscopy and accidental vessel injury seems to be very low. With the exception of acidosis and an increase of PETCO2 in the CO2 group, there were no differences in cardiopulmonary function between insufflation of CO2 and helium.     

The absence of arterial oxygen desaturation during massive oxygen embolism after hydrogen peroxide irrigation

For decades, water-mill murmur, decrease in end-tidal CO(2) (Petco(2)), hypotension, and hypoxemia have been accepted as diagnostic criteria for gas embolism. In this case report, a 19-yr-old male patient developed a sudden reduction in Petco(2) and profound circulatory collapse 15 min after intramedullary irrigation with H(2)O(2). However, arterial oxygen desaturation never developed throughout the entire course of resuscitation from presumed massive oxygen embolism.     

Severe hypercapnia due to pulmonary embolism of polymethylmethacrylate during vertebroplasty

Pulmonary polymethylmethacrylate embolism is a rare but potentially fatal complication of percutaneous vertebroplasty. Clinical signs are typical for pulmonary embolism: they include respiratory distress, hypotension, and decreases in end-tidal CO(2). We report a case of fatal pulmonary polymethylmethacrylate embolism during percutaneous vertebroplasty that initially presented with hypertension (arterial blood pressure 190/90 mm Hg), normocardia, and hypercapnia (PaCO(2) 96 mm Hg), along with loss of consciousness. Several pieces of polymethylmethacrylate were found in the pulmonary vasculature at autopsy. IMPLICATIONS: Osteoporotic spine fractures are increasingly treated by injection of bone cement into the vertebral body. Polymethylmethacrylate embolism is a rare but potentially fatal complication. We report on a case of polymethylmethacrylate embolism that was at first unrecognized because of uncharacteristic signs and symptoms.     

Air embolism during operative hysteroscopy: TEE-guided resuscitation

During hysteroscopic surgery there are concerns about potential complications such as venous air and gas embolism. The incidence of subclinical air emboli events during operative hysteroscopy is significantly underestimated. The manifestations of this complication may range from an unnoticeable decrease in P(ET)CO(2) to the need for resuscitation. Three cases of air embolism with variable outcomes occurring during general anesthesia for operative hysteroscopy in otherwise healthy patients are presented.     

Experimental study of effect of embolism of different laparoscopy insufflation gases

BACKGROUND AND PURPOSE: Whilst carbon dioxide is the gas generally used for insufflation during laparoscopy, several studies have reported adverse effects specifically associated with its use. These effects may be attributable to chemical, metabolic, or immunologic effects specific to CO2. Because helium is chemically, physiologically, and pharmacologically inert, it has been suggested as a possible substitute insufflation gas. However, there has been concern about the potential implications of venous gas embolism during helium insufflation. The aim of this study was to examine the physiological effect of the intravenous injection of He and CO2 in an experimental model. MATERIALS AND METHODS: Eleven domestic white pigs were randomly allocated to receive multiple intravenous injections of increasing volumes of either CO2 or He gas. Cardiorespiratory function was measured, and the intravenous volumes of gas that resulted in cardiac arrest were determined. RESULT: Cardiorespiratory functional measures returned to normal quicker after CO2 than after He injection. Helium injection quickly overwhelmed the animal's ability to compensate and resulted in death at a lower volume than did CO2 injection. CONCLUSIONS: Gas embolism during He insufflation is more likely to be lethal than is CO2 embolism. This scenario is most likely following Veress needle insertion into a large vein. Therefore, if He is to be used for insufflation during clinical laparoscopy, the possibility of venous injection should be minimized by avoiding Veress needle use. Further investigation of the safety of He insufflation is warranted before a role during clinical laparoscopy can be recommended.     

A case of ligation of the left pulmonary artery during total arch replacement for aortic arch aneurysm

Pulmonary artery embolism is one of the most severe complications that can occur in the perioperative period. We report a case of left pulmonary artery obstruction during total arch replacement, which occurred during cardiopulmonary bypass (CPB) for severely invasive procedures. A 59-year-old male was anesthetized for total arch replacement using a double-lumen endobronchial tube (Bronco-Cath 39 F left) in the supine position. The surgery was performed under deep hypothermic circulatory arrest and CPB. When the CPB was finished and mechanical ventilation was started, PaCO2 was unusually elevated. Furthermore, end-tidal CO2 was decreased and no CO2 was expired from the left side of the double-lumen tube. Left pulmonary embolism was highly suspected and pulmonary artery angiography was performed. As the complete obstruction of the left pulmonary artery was demonstrated, pulmonary artery reconstruction was performed. The reason for the obstruction was the surgical ligation during CPB. The wall of the aneurysm was attached to the left pulmonary artery and when it was removed, the left pulmonary artery was injured. The systemic circulation remained stable, however, despite reports that pulmonary embolism was very dangerous and often caused the patient's death.     

Carbon dioxide and argon gas embolism during laparoscopic hepatic resection

During laparoscopic hepatic resection, an abrupt decrease in FE'CO(2) (from 28 mmHg to 9 mmHg) associated with near cardiac arrest occurred concomitantly with hepatic vein laceration and the use of an argon beam coagulator system. During venous gas embolism, transesophageal echocardiography (TEE) proved the transpulmonary passage of the gas. In the post-operative period, the patient developed pulmonary edema and made a full recovery after 5 days. This is a case report of a possible paradoxic carbon dioxide (CO(2)) and argon gas embolism by transpulmonary passage during laparoscopic hepatic resection.     

羟乙基淀粉130/0.4、低分子肝素对脂肪栓塞综合征的防治作用

目的 在用同种异体家兔骨髓脂肪建立脂肪栓塞综合征(FES)动模模型基础上,观察羟乙基淀粉130/0.4、低分子肝素对FES的防治作用.方法 将42只家兔随机分3组.对照组予0.8ml/kg骨髓脂肪,从股静脉以0.05ml/min速度注射.羟乙基淀粉130/0.4治疗组在注射骨髓脂肪之前3 h及之后12 h分别静脉滴注30 ml/kg羟乙基淀粉130/0.4.低分子肝素治疗组在注射骨髓脂肪之前3 h及之后12 h分别皮下注射300 U/kg低分子肝素.对3组家兔连续观察24 h,观察计算死亡率,检测存活家兔动脉血氧分压、二氧化碳分压,血浆游离脂肪酸(FFA),行肺组织形态及病理学检查.结果 跟对照组比较羟乙基淀粉130/0.4干预治疗组,死亡率降低,动脉血氧分压、二氧化碳分压下降值减小,FFA浓度升高值减小,差异有统计学意义(P＜0.01).跟对照组比较低分子肝素干预治疗组以上指标观察数值变化小,差异无统计学意义(P＞0.05).3组死亡率分别为57%、14%、43%.干预治疗组肺组织病理病变均较对照组减轻,但羟乙基淀粉130/0.4比低分子肝素组减轻更明显.结论 羟乙基淀粉130/0.4对脂肪栓塞综合征有较好的预防治疗作用.

Abstract：

Objective On the basis of fat embolism syndrome animal model injected with homologous rabbit bone marrow fat, to observe prevention and treatment of fat embolism syndrome (FES) by hydroxyethyl starch 130/0. 4 and low molecular weight heparin. Methods Forty-two rabbits were divided into three groups. The rabbits in control group were injected with bone marrow fat 0. 8 ml/kg (0. 05 ml/min) via femoral vein. In hydroxyethyl starch 130/0. 4 group, the rabbits were intravenously injected with hydroxyethyl starch 130/0. 4 (30 ml/kg), 3 h before and 12 h after embolism respectively. In low molecular weight heparin group, the rabbits were hypodermically injected with low molecular weight heparin (300 U/kg), 3 h before and 12 h after embolism respectively. After observation for 24 h, mortality rate was calculated, the levels of O2 pressure, CO2 pressure and plasma free fatty acid (FFA) were measured, and morphological and pathological changes of the lung were observed. Results As compared with control group, mortality rate, O2 pressure, CO2 pressure and the increase in FFA were reduced in hydroxyethyl starch 130/0. 4 group ( P ＜0. 01 ). There was no significant difference between low molecular weight heparin group and control group. Mortality rate in three groups was respectively 57％, 14％ and 43％ respectively. The pathological changes of the lung in two experimental groups demonstrated mild injuries than in control group, more significantly in hydroxyethyl starch 130/0. 4 group. Conclusion Hydlroxyethyl starch 130/0. 4 could effectively prevent and treat fat embolism syndrome.