捆绑式胰肠吻合术预防胰肠吻合口漏

胰肠吻合口漏(胰漏)是胰十二指肠切除术(PD)后最危险的并发症,其发生率一般为8%~19%,相关死亡率高达8%~40%。如何有效地预防胰漏是施行胰十二指肠切除术的关键。1996年1月,彭淑牖等[1]设计了捆绑式胰肠吻合术,以捆绑取代缝合,避免遗留针孔,保证吻合口的密封性,经一系列临床证实,有效地避免了胰漏的发生[2-4],得到国内外学者的赞誉。本文再谈谈捆绑式胰肠吻合术的若干关键问题。一、捆绑式胰肠吻合术预防胰肠吻合口漏的机理为了预防胰肠吻合口漏的发生,60多年来,众多外科学者致力于设计新的术式,从胰管结扎、胰管栓塞、到各种各样的胰肠吻合…     

捆绑式胰肠吻合术51例报告

胰肠吻合口瘘是胰十二指肠切除术中极其严重的并发症,迄今尚无一种能够完全杜绝胰漏的标准术式.1996年1月,作者设计了一种简易、安全的吻合方式,称之为捆绑式胰肠吻合术.至今连续施行了51例,没有1例发生胰瘘.最初11例、28例的初步经验已作过介绍,现进一步报告近年来的经验.     

捆绑式胰肠吻合术在预防胰十二指肠切除术后胰瘘发生中的临床应用

目的 探讨捆绑式胰肠吻合术在预防胰十二指肠切除术后胰肠吻合口漏的可行性及临床应用价值. 方法我院在2002年3月至2006年10月期间对32例胰十二指肠切除术患者采用捆绑式胰肠吻合术.结果 32例患者手术均顺利,无一例发生胰瘘,无手术死亡病例. 术后发生胆瘘2例,经腹腔引流治愈.结论 捆绑式胰肠吻合术操作简便,预防胰瘘效果可靠,值得推广.     

腹腔镜胰十二指肠切除术后引流液淀粉酶含量在临床相关胰瘘中的预测价值

目的 探讨腹腔镜下胰十二指肠切除术(LPD)后引流液淀粉酶含量及其他危险因素对临床相关术后胰瘘(CR-POPF)的预测价值.方法 按纳入及排除标准回顾性收集2017年1月至2019年12月期间于徐州医科大学附属医院普外科行LPD患者的临床资料,分析影响LPD后CR-POPF发生的独立影响因素,同时使用受试者操作特征(R...     

贯穿缝合式胰肠吻合术

目的 评价一种新的胰肠吻合方法的可行性和安全性.方法 总结该院普外科2005年5月至2010年11月间46例应用贯穿缝合式胰肠吻合术行胰肠吻合的临床经验和手术方法.结果 贯穿缝合式胰肠吻合术胰断端空肠仅需贯穿缝合6～8针.全组46例均无出现胰肠吻合口漏和吻合口出血.结论 应用贯穿缝合式胰肠吻合术行胰肠吻合操作安全、简单、吻合可靠,值得推荐.     

双层连续套入式胰肠吻合在胰十二指肠切除术中的应用

目的 对胰肠吻合缝合技术进行改进，预防胰漏的发生。方法 28例胰十二指肠吻合手术采用4-0 proene线双层连续胰肠套入式吻合。结果 双层连续胰肠套入式吻合时间平均11min，明显缩短了手术时间，全部病例均未出现胰肠吻合口漏，没有手术死亡。结论 双层连续套入式胰肠吻合，操作简便、省时、并发症少，是胰肠吻合术的一种有效改进。     

捆绑式胰肠吻合与传统胰肠吻合术后并发症的比较

目的：探讨捆绑式胰肠吻合术在防止胰漏、减少并发症方面的临床价值。方法：回顾性分析１９９８年１月～２００１年８月我院施行捆绑式胰肠吻合术（同时行半胃切除）（捆绑组）３２例,并与同期传统胰肠吻合法（对照组）５１例作对比。观察术后胰漏、胆漏、胃排空障碍、消化道出血等并发症的发生率。结果：胰漏、胆漏、胃排空障碍和消化道出血发生率在捆绑组中分别为０％、６．３％（２／３２）、３．１％（１／３２）和３．１％（１／３２）,以对照组中分别为１５．７％（８／５１）、１７．６％（９／５１）、１５．７％（８／５１）和１１．８％（６／５１）。术后平均住院天数捆绑组（２６．０５ｄ）较对照组（３８．２４ｄ）显著缩短。结论：捆绑式胰肠吻合术有助于避免胰漏的发生,以及由此所致的各种其他并发症。同时,半胃切除有助于减少吻合口溃疡或应激溃疡出血的产生。     

彭氏捆绑式胰肠吻合术在胰十二指肠切除术中的应用

目的 总结彭氏捆绑式胰肠吻合术的临床应用经验,并将经改进的捆绑式吻合术(Ⅱ型)与原吻合术(Ⅰ型)的临床资料进行比较,评价其效果。方法 2001年1月至2003年1月共有69例患者在我院行胰十二指肠切除,所有患者均顺利切除了十二指肠,并采用Ⅱ型捆绑式胰肠吻合术进行消化道重建,术后进行随访和B超检查。并将69例患者的临床资料与57例行Ⅰ型捆绑式吻合术患者的病例资料对比。结果 两组患者均没有发生胰肠吻合口漏,Ⅱ型捆绑式胰肠吻合术手术操作较Ⅰ型简单,吻合所需时间平均为也短于Ⅰ型吻合术。结论 Ⅱ型捆绑式胰肠吻合术能有效防止胰肠吻合口漏。且与Ⅰ型比较具有操作简单、节省时间、能对吻合口进行检测等优点。     

胰肠吻合术式百年变迁

胰肠吻合术是胰十二指肠切除术消化系重建最重要的一环。自第1例胰十二指肠切除术报道至今,关于胰肠吻合术的改进及研究已经历了100多年的探索。胰肠吻合手术的死亡率已从20世纪70年代的20%～40%下降到21世纪初的5%以下,但仍无法从根本上杜绝并发症特别是胰瘘的发生。胰瘘是最常见的严重并发症之一,发生后死亡率极     

胰肠吻合术式百年变迁

胰肠吻合术是胰十二指肠切除术消化系重建最重要的一环。自第1例胰十二指肠切除术报道至今,关于胰肠吻合术的改进及研究已经历了100多年的探索。胰肠吻合手术的死亡率已从20世纪70年代的20%～40%下降到21世纪初的5%以下,但仍无法从根本上杜绝并发症特别是胰瘘的发生。     

胰十二指肠切除术中两种胰肠吻合方式疗效比较

目的 比较胰十二指肠切除术中采用胰肠套入吻合与胰管-空肠黏膜对黏膜吻合术后胰漏发生率、住院时间和费用的差异。方法 回顾2009年3月至2013年5月126例接受胰十二指肠切除术治疗病例,采用胰肠套入吻合67例,胰管-空肠黏膜对黏膜吻合59例。分析两种胰肠重建方式术后胰漏发生率及严重程度的差异,同时对两组平均住院时间及费用进行比较分析。结果 套入式胰肠重建组术后胰漏发生率为31.34%（21/67）,黏膜对黏膜胰肠重建组为13.56%（8/59）;两组术后胰漏严重程度（A、B、C级）情况分别为10.45%（7/67）,14.93%（10/67）,5.97%（4/67）和8.47%（5/59）,3.39%（2/59）,1.69%（1/59）。两组平均住院时间为（24.15 d vs 16.86 d）,费用分别为（49 882.73元 vs 38 047.80元）。两组患者术后胰漏发生率和严重程度B级所占比例、平均住院时间和费用差异均有统计学意义（P均＜0.05）。结论 采用胰管-空肠黏膜对黏膜吻合的胰肠重建方式术后胰漏发生率和严重程度（B级）、平均住院时间和费用明显低于采用胰肠套入吻合,该法可能更有利于患者术后恢复。     

两种胰肠吻合术式与胰瘘关系探讨

目的分析比较粘合式胰肠吻合方式与双层套入式吻合方式发生胰瘘并发症的差异。方法对1999年1月至2006年1月期间57例胰十二指肠切除术病例资料进行回顾性分析研究,依据术中胰肠吻合方式的不同,分为粘合式胰肠吻合组和双层套入式吻合组,比较两组间手术时间、出血量、平均住院时间和胰瘘发生率的差异。结果无手术死亡。两组手术时间、出血量和平均住院时间无统计学差异。套入式吻合组发生胰肠吻合口瘘1例(2.9%)、单纯性胰瘘6例(17.6%),粘合式吻合组无胰瘘发生。两组胰肠吻合口瘘差异无统计学意义(P>0.05),套入式吻合组单纯性胰瘘显著高于粘合式吻合组(P<0.05)。胰瘘经保守治疗均治愈。结论胰肠吻合术式对胰瘘发生率有一定的影响,粘合式胰肠吻合术式可以有效地降低胰瘘发生率。     

胰十二指肠切除术不同胰肠吻合方式的选择与效果评价

目的评价不同胰肠吻合方式在胰十二指肠切除术中的临床疗效,探讨不同胰肠吻合方式的适用性。方法回顾性分析2012年1月至2014年8月收治的117例行胰十二指肠切除术患者临床资料,按吻合方式不同分为胰管空肠黏膜吻合(A组,61例)和捆绑式胰肠吻合(B组,56例),比较两种不同胰肠吻合方式术后胰漏及相关并发症的发生率。结果胰肠黏膜吻合组胰腺残端直径明显大于捆绑式胰肠吻合组(t=7.441,P0.05),捆绑式胰肠吻合组胰肠吻合时间明显小于胰肠黏膜吻合组(t=3.085,P0.05)。两组患者术后胰漏、腹腔出血、腹腔感染、胃潴留、肺部感染、平均住院时间及费用,差异无统计学意义(x2=0.257,0.308,0.737,0.896,1.096;t=1.211,1.477;P0.05)。结论胰管空肠黏膜吻合法和捆绑式胰肠吻合法是胰十二指肠切除术两种主要吻合方法,都能有效降低胰漏的发生率,应根据术中探查结果,合理灵活选择不同吻合方式。     

改良胰肠荷包套入式吻合方式的临床应用

[摘 要] 目的 探讨改良胰腺空肠端侧荷包套入式吻合方式在消化道重建中的应用价值。方法 回顾性分析2016年4月至2017年3月河北省沧州市中心医院收治的37例胰十二指肠切除术患者行改良胰腺空肠荷包套入式吻合术的临床资料。观察术中胰肠吻合时间、术中出血量,检测术后第3、5、7天胰肠吻合口周围引流物淀粉酶浓度。术后患者每3个月复查上腹部增强CT,随访1年,随访截止时间2017年7月。结果 所有患者均顺利完成手术。胰肠吻合时间（11±3）min,术中出血量（465±161）mL,术后第3、5、7天胰肠吻合口周围引流物淀粉酶浓度[M（Q）]分别为18.0（64.5）U、16.0（112.2）U、7.0（19.5）U,引流液淀粉酶呈逐渐减少趋势（F=18.104,P<0.05）。术后并发症：生化漏1例;腹腔内出血1例,再次剖腹探查发现为空肠切开处黏膜出血。36例患者获得随访,无胰管结石及急慢性胰腺炎,无腹泻等胰腺外分泌功能不足的表现。结论 改良胰腺空肠荷包套入式吻合方式操作简便、省时、可靠,在胰十二指肠切除术中具有临床应用价值。     

根据胰管直径等因素选择不同胰肠吻合方式对患者术后恢复的影响

目的 评价根据胰管直径等因素选择的不同胰肠吻合方式对患者术后恢复的影响,为胰肠吻合方式的选择决策提供依据.方法 回顾性分析我院在2010年1月至2013年1月间行胰十二指肠切除术305例患者的临床资料.对于胰管直径≥3 mm的患者采用胰管空肠黏膜吻合（胰管空肠吻合组,120例）;对于胰管直径＜3 mm者,进一步比较胰腺残端与空肠管径的直径大小,若胰腺残端较粗大,且大于空肠管径者采用改良Child胰肠吻合（改良Child胰肠吻合组,80例）,若胰腺残端直径小于空肠管径者选择捆绑式胰肠吻合（捆绑式胰肠吻合组,105例）.比较不同胰肠吻合方式术后并发症的发生率,评价临床疗效.结果 胰管空肠黏膜吻合组胰管直径显著大于其他两组（P＜ 0.05）,改良Child胰肠吻合组胰腺残端直径明显大于捆绑式胰肠吻合组（P＜0.05）.本组研究总体胰瘘发生率为11.1％ （34/305）.比较三组患者术后胰瘘、腹腔出血、腹腔感染、消化功能异常、平均住院时间及术后死亡,差异无统计学意义（χ^2=1.51,2.78,1.16,3.75,1.94,F=2.13,P＞0.05）.结论 在行胰十二指肠切除术时,可以根据胰管直径、胰腺残端直径及空肠管径合理选择不同的胰肠吻合方式.     

A comparison of pancreaticogastrostomy and pancreaticojejunostomy following pancreaticoduodenectomy

This retrospective study compares the results of pancreaticogastrostomy (PG) and pancreaticojejunostomy (PJ) in our institution, which has extensive experience in both techniques. Between the years of June 1995 and June 2001, 214 patients underwent pancreaticoduodenectomy (PD) at our institution. Of these 177 had PG and 97 had pancreatojejunostomy (PJ). There were 117 (54.6%) males and 97 (45.3%) females with a mean age of 64.2 ± 12.4 years. Indications for surgery were pancreatic adenocarcinoma in 101 (47.2%), ampullary adenocarcinoma in 36 (16.9%), distal bile duct adenocarcinoma in 22 (10.2%), duodenal adenocarcinoma in 9 (4.2%), and miscellaneous causes in 46 (21.4%) of patients. Preoperatively, significant differences in the groups were that the patients undergoing PJ were significantly younger than those undergoing PG. Also noted preoperatively, was that the patients undergoing PG had a significantly lower direct bilirubin than those undergoing PJ. With regard to intraoperative parameters, operative time was significantly shorter in the PJ group when compared to the PG group. When the patients who did not develop fistula (N = 186) were compared to those who developed fistula (N = 28) the significant differences were that the patients who developed fistula were more likely to have hypertension preoperatively and a higher alkaline phosphatase. They also showed a significantly higher drain amylase and were likely to have surgery for ampullary, distal bile duct or duodenal carcinoma rather than pancreatic adenocarinoma. In addition, those patients who developed fistula had a significantly longer postoperative stay, a larger number of intraabdominal abscesses and leaks at the biliary anastomosis. Thirty-day mortality was significantly higher in the PJ group compared to the PG (4 vs. 0, P = 0.041). There was a significantly larger number of bile leaks in the PJ group when compared to the PG (6 vs. 1, P = 0.048). In addition, the PJ group required a significantly larger number of new CT guided drains to control infection (8 vs. 2,P = 0.046) and the PJ group required a larger number of re-explorations to control infection or bleeding (5 vs. 0, P = 0.018). However, the pancreatic fistula rate was not different between the two groups (12% [PG] vs. 14% [PJ]). This retrospective analysis shows that safety of PG can be performed safely and is associated with less complications than PJ and proposes PG as a suitable and safe alternative to PJ for the management of the pancreatic remnant following PD.     

Impact of the highest amylase level in drain fluid on surgical outcomes and postoperative interventions in patients undergoing pancreaticoduodenectomy

ObjectivesThe clinical significance of the highest drain fluid amylase (DFA) level beyond pancreaticoduodenectomy (PD) postoperative day three (POD 3) remains unclear. This study investigated the impact of highest DFA level beyond POD 3 on postoperative pancreatic fistula (POPF) severity and outcomes of patients undergoing PD with POPF.MethodsPatient demographics of biochemical POPF and clinically relevant POPF (CR-POPF) were compared. Predictive factors were assessed using binary logistic regression. Receiver operating characteristic curve analysis was performed to determine the optimal cutoff value of highest DFA (beyond POD 3). We compared length of hospital stay, surgical mortality rates, and need for postoperative interventions by highest DFA level.ResultsPatients with CR-POPF had an older age (p = 0.039), required intraoperative blood transfusion (p = 0.006), and had greater highest DFA levels (p = 0.001) than those with biochemical POPF. The optimal highest DFA cutoff was 2014.5 U/L. Multivariate analysis showed that percentage of patients with intraoperative blood transfusion (p = 0.011; odds ratio, 3.716) and a highest DFA > 2014.5 U/L beyond POD 3 (p = 0.001; odds ratio, 5.722) was predictive of CR-POPF.ConclusionHighest DFA > 2014.5 U/L beyond POD 3 is an independent predictor for CR-POPF. At a highest DFA >2014.5 U/L, 30-day surgical mortality rate, length of stay, and need for postoperative interventions did not differ.     

Laparoscopic side-to-side pancreaticojejunostomy (Partington-Rochelle) for chronic pancreatitis

Intractable pain in chronic pancreatitis has been treated by several different procedures, including resection and drainage, or a combination of the two. We describe the technique of laparoscopic side-to-side pancreaticojejunostomy for chronic pancreatitis in five patients. The procedure is performed using five trocars. Stapling and direct suturing are required. Careful selection of patients is important. Preoperative and intraoperative ultrasound is necessary to assess the dilated pancreatic duct. In one of the five patients, the laparoscopic technique was converted to an open procedure because the preoperative findings were not confirmed at exploration. Four of the five patients are pain-free, with 5- to 30-month follow-up. Laparoscopic pancreaticojejunostomy can be performed safely, and it is a procedure that should be considered in the treatment of appropriate patients with chronic pancreatitis. Received for publication on Aug. 17, 1998; accepted on June 10, 1999