我国第一例HIV阳性尸解病例淋巴结的组织病理学和免疫组织病理学

本文研究了1例HIV阳性男孩的19个淋巴结的病理组织学和免疫组织化学改变。根据Stutte等HIV相关淋巴结病5期分类,84%淋巴结在Ⅲ期和Ⅳ期,相应于临床ARC/AIDS。发现淋巴滤泡萎缩、血管增生、组织细胞增生和正常网状纤维支架的破坏。免疫组织化学证实残留的淋巴细胞绝大多数是T细胞。S-100阳性细胞的正常分布发生改变。Kil阳性细胞主要存在于第Ⅱ期淋巴结。对这些改变的意义本文进行了讨论。     

自杀与幸福感关系的研究进展

自杀是全球都关注的严重公共卫生问题。数据报告表明,我国自杀率尤其是农村自杀率明显下降,分析认为与我国农村城市化进程加快,农村女性幸福感上升有关。幸福感作为自杀的保护因素,为自杀预防提供一条全新的出口。本文试图综合评述国内外有关自杀与幸福感的关系研究文献,为自杀的预防干预和自杀遗族的创伤治疗及家庭功能研究提供文献依据和未来方向。     

A Literature Review of Laboratory-Acquired Brucellosis

Brucellosis is a bacterial zoonotic disease which has been associated with laboratory-acquired infections. No recent reviews have addressed the characteristics of laboratory-acquired brucellosis (LAB). English-language literature was reviewed to identify reports of laboratory exposures to Brucella spp. and LAB cases between 1982 and 2007. Evaluation of 28 case reports identified 167 potentially exposed laboratory workers, of whom 71 had LAB. Nine reports were identified that summarized an additional 186 cases of LAB. Only 18 (11%) exposures were due to laboratory accidents, 147 (88%) exposures were due to aerosolization of organisms during routine identification activities, and the circumstances of 2 (1%) exposures were unknown. Brucella melitensis was the causative agent in 80% (135/167) of the exposures. Workers with high-risk exposures were 9.3 times more likely to develop LAB than workers with low-risk exposures (95% confidence interval [CI], 3.0 to 38.6; P < 0.0001); they were also 0.009 times likelier to develop LAB if they took antimicrobial PEP than if they did not (95% CI, 0 to 0.042; P < 0.0001). The median incubation period in case and summary reports was 8 weeks (range 1 to 40 weeks). Antimicrobial PEP is effective in preventing LAB. The incubation period may be used to identify appropriate serological and symptom surveillance time frames for exposed laboratory workers.     

Systemic Mastocytosis: Case Report and Literature Review

A case of systemic mastocytosis is reported and the literature reviewed. Although the dermatological manifestation of this rare disease, in the form of urticaria pigmentosa, is well recognized and goes along with the osteosclerotic changes that can be seen with systemic mastocytosis, it is imperative to rule out malignancy as a cause for a new onset of ascites and newly discovered sclerotic osseous changes.     

当代前列腺动脉栓塞术的文献回顾

前列腺动脉栓塞术作为一种崭新的放射介入技术,用于治疗良性前列腺增生继发下尿路症状的患者。良性前列腺增生症是一种常见于中老年男性患者的临床病症,它常导致典型的下尿路症状,包括夜尿、尿频、尿急、尿流率下降、排尿踌躇、不完全排空感等。通常在排除肿瘤、炎症、中枢神经系统疾病等病因后,由良性前列腺增生所引起的轻中度下尿路症状可行观察疗法或药物治疗,而对于中重度症状患者,则多建议手术治疗。自早期偶然发现选择性地前列腺动脉栓塞术能治疗因前列腺增生继发的恶性出血,且可缓解下尿路症状之后,该方法被越来越多的临床学者所接受,并积极探索该技术的实用性、安全性及有效性。目前,前列腺动脉栓塞术仍未成为良性前列腺增生症的标准疗法。本文将重点回顾关于前列腺动脉栓塞术的相关文献,包括个案、动物研究、回顾性或前瞻性队列研究等,对该技术进行总结。     

ULTRASTRUCTURAL CHARACTERISTICS OF DUODENAL SOMATOSTATINOMAS

Ultrastructural findings of granules and vesicles appearing in tumor cells of somatostatinoma are reported. Except for D granules, one granule and four kinds of vesicles were discerned. Some tumor cells had granules of the exocrine type which were similar to those of the chief cells of the stomach. Very small clear vesicles (YO and KO) had accumulated mainly in the apical region of the somatostatinoma cells. Both vesicles were round, unit–membrane bounded and clear in the center, each measuring about 90 and 30 nm in diameter. The cored vesicles normally seen in the sympathetic system were revealed. Doughnut vesicles characterized by double contour membranes were detected together with the cored vesicles.
A mixutre of exocrine cells of the chief cell–type in the paraneuroma has not been previously reported. And we have as yet very little information as to the doughnut vesicle. ACTA PATHOL. JPN. 33: 359–366, 1983.