2型糖尿病及其肾病与血管生成素2基因多态性的关联分析

目的 研究2型糖尿病(type 2 diabetes mellitus,T2DM)及其肾病(diabetic nephropathy,DN)发生、发展与血管生成素2(angiopoietin-2,Ang-2)基因多态性的关联性.方法 应用等位基因特异聚合酶链反应检验无亲缘关系汉族人群的2型糖尿病及其肾病患者221例、正常对照104名Ang-2基因单核苷酸多态性(single nucleotide polymorphism,SNP)759T/G、1078A/G、1233A/G在病例组中的频率,并用尿白蛋白排泄率、炎症标志物单核细胞趋化蛋白浓度变化探讨上述SNP与T2DM、DN发生发展的关联.结果 (1) Ang-2 759 T/G、1078 A/G基因型频率和等位基因频率在各组中的差异无统计学意义,而1233 A/G基因型频率和等位基因频率的差异有统计学意义(P＜0.05);(2)在校正年龄和性别等因素后,1233A/GSNP G等位基因患T2DM和DN的风险分别是A等位基因的2.265倍(95％ CI:1.223～1.402,P=0.031)和1.789倍(95％ CI:0.889～1.021,P=0.012);(3) Ang-2 1233A/G G等位基因与DN发生相关(r=1.321,OR=1.427,95％ CI:2.324～4.177,P=0.034).结论 Ang-2 1233A/G SNP与2型糖尿病的发生有关;AG+ GG基因型和等位基因G可能是DN发生、发展的风险因素.     

血管紧张素原基因M235T分子变异与2型糖尿病肾病的关系

目的　探讨血管紧张素原（ａｎｇｉｏｔｅｎｓｉｎｏｇｅｎ , Ａ Ｇ Ｔ） 基因 Ｍ２３５ Ｔ 分子变异与中国人无肾病并发症的２ 型糖尿病（ｄｉａｂｅｔｅｓ ｍ ｅｌｌｉｔｕｓ , Ｄ Ｍ） 、２ 型糖尿病肾病（ｄｉａｂｅｔｉｃ ｎｅｐｈｒｏｐａｔｈｙ , Ｄ Ｎ） 的关系。方法　用 Ｐ Ｃ Ｒ及 Ｒ Ｆ Ｌ Ｐ 方法对８４ 例 Ｄ Ｍ、９６ 例 Ｄ Ｎ 及９８ 名正常对照进行了 Ａ Ｇ Ｔ 基因 Ｍ２３５ Ｔ 多态性的检测。结果　 Ｄ Ｎ 组 Ｔ 等位基因频率０８２ , Ｔ Ｔ 基因型频率０７０ ,与对照组（０６３ ,０４３） 比较有显著差异（ Ｐ＝ ０００３ , Ｐ＝００００４） ;校正了 Ｄ Ｎ 的几种危险因素后, Ｔ Ｔ 基因型对 Ｄ Ｎ 的 Ｏ Ｒ 为３４７（９５ ％ Ｃ Ｉ 为１５１ ～７９４ , Ｐ＝０００３３） 。 Ｄ Ｍ 组基因型频率分布与对照组比较无显著差异（ Ｐ＞ ００５） 。结论　 Ａ Ｇ Ｔ 基因 Ｔ Ｔ 型可能是中国人群２ 型糖尿病肾病的独立危险因素之一。     

PPP1R3基因多态性与中国汉族人群2型糖尿病的相关性研究

目的　旨在研究 1型蛋白磷酸酶骨骼肌特异的糖原靶向调节亚单位基因 (PPP1R3)Asp90 5Tyr以及 3′ -UTR5bpD/I多态性与安徽省汉人群的 2型糖尿病 (T2DM )相关性。方法　运用PCR -RFLP法对安徽省合肥地区 36 6例汉族受试者 (T2DM患者 2 6 2例 ,健康成人 10 4例 )进行基因型测定。结果　 (1)PPP1R3基因Asp90 5Tyr以及 3′ -UTR 5bpD/I多态性的基因型及等位基因频率在T2DM与健康对照组间分布均没有显著性差异 (P >0 .0 5 )。 (2 )PPP1R3基因Asp90 5Tyr以及3′ -UTR 5bpD/I多态性间呈连锁不平衡 ,其分布频率在不同人群中不尽相同。结论　PPP1R3基因Asp90 5Tyr以及 3′ -UTR 5bpD/I多态性可能在安徽省合肥地区 2型糖尿病发病中不起重要作用。两种多态性的分布表现明显的种族性。     

Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy: a meta-analysis

Investigations into the association between diabetic nephropathy (DN) and MTHFR C677T gene polymorphism in several case–control studies has yielded contradictory results. To shed light on these inconclusive findings, a meta-analysis of all available studies relating the C677T polymorphism to the risk of developing DN was conducted. The PubMed database was searched, and case–control studies investigating the association between MTHFR C677T gene polymorphism and DN were included in the meta-analysis. The meta-analysis included 15 studies, of which 8 involved Caucasians and 5 East Asians; 11 studies involved subjects with type 2 diabetes and 4 with type 1 diabetes. The main analysis (all studies) revealed significant heterogeneity between the studies (P _Q < 0.01) and a marginal association between the 677T allele and the risk of developing DN; the random effects (RE) pooled odds ratio (OR) was 1.30 (1.03–1.64). However, the sensitivity analysis (exclusion of studies not in Hardy–Weinberg equilibrium) produced non-significant results. The recessive model derived significant results in main analysis [fixed effects (FE) OR = 1.32 (1.10–1.58), P _Q = 0.27], and in type 2 diabetes [FE OR = 1.30 (1.06–1.60), P _Q = 0.38]. The additive model produced significant association in main analysis [RE OR = 1.65 (1.13–2.42), P _Q < 0.01] in Caucasians [FE OR = 1.48 (1.11–1.98), P _Q = 0.17] and in type 2 diabetes [RE OR = 1.65 (1.03–2.67), P _Q < 0.01]. However, sensitivity analysis diminished the significant results in type 2 diabetes. There is no differential magnitude of effect in large versus small studies. In conclusion, although there is some evidence of association between MTHFR C677T gene polymorphism and DN, the above findings reinforce the need for further and more rigorous association studies.     

磺脲类受体基因多态性与新疆地区2型糖尿病相关性研究

目的　研究磺脲类受体 (sulfonylureareceptor,SUR1)基因第 2 4内含子 3tc多态性与新疆地区 2型糖尿病的相关性。方法　利用PCR -RFLP法对新疆地区 72例受试者 (2型糖尿病患者 4 2例 ,正常对照 30例 )磺脲类受体基因第 2 4内含子 - 3t→c多态性进行研究。结果　SUR1基因第 2 4内含子“c”等位基因频率在患者及对照中无显著差异 (77 5 %比 6 3 5 % ,P =0 0 6 5 3) ,“cc”基因型频率分别为 6 1 9% ,4 0 % ,也无显著差异 (P =0 0 6 6 2 )。结论　SUR1基因第 2 4内含子 - 3t→c多态性可能在新疆地区 2型糖尿病发病中不起重要作用。     

Leptin基因甲基化与糖尿病的相关性研究

目的 探讨瘦素基因启动子区甲基化及蛋白表达与糖调节受损(impaired glucose regulation,IGR)以及2型糖尿病(type 2 diabetes mellitus,T2DM)的相关性.方法 采用甲基化特异性PCR对不同血糖水平的个体进行Leptin基因启动子区甲基化检测.用双抗体夹心ABC-酶联免疫吸附法检测血液标本中的瘦素蛋白表达量.结果 与正常对照组(59.2％)相比,T2DM和IGR组Leptin基因的甲基化率偏低(分别为31.5％和43.6％),差异具有统计学意义(x2分别为22.499,5.109,P值均＜0.05).T2DM与IGR组相比甲基化率偏低(x2=3.962,P＜0.05),差异具有统计学意义.患者的瘦素含量相对于正常人均偏高,但仅T2DM组与正常人差异具有统计学意义(q=6.81,P＜0.01).直线回归分析提示,瘦素含量随DNA甲基化程度的降低有增高的趋势,两者呈显著负相关(r=-0.95,P＜0.01).结论 Leptin基因启动子区甲基化与瘦素代谢紊乱可能参与糖尿病的发生和发展.检测IGR和T2DM患者Leptin基因启动子区的甲基化状态和基因蛋白表达,对于早期干预、延缓病程具有一定的参考价值.     

Insights about interventions to address food insecurity in adults with type 2 diabetes: Valuable lessons from the stories of African Americans living in the inner city

ObjectivesThis qualitative study aimed to gain insight from the perspectives of food insecure African Americans living in an inner city regarding important diabetes intervention strategies and components.MethodsUsing a grounded theory approach, two focus groups (totaling 16 individuals) were conducted in Milwaukee, Wisconsin. Purposive, convenience sampling was used to identify food insecure adults with diabetes. Questions were asked using a moderator guide to explore challenges and barriers to managing diabetes within the context of food insecurity, and facilitators or resources that helped participants improve diabetes management. Questions were open ended and followed by probes asking for additional perspectives and personal experiences related to the overarching topic, and questions asking to clarify statements.ResultsOverarching concepts and themes specific to possible interventions discussed during the focus groups included group education, peer support, access to community resources and programs, stress management, and faith-based programs as desired intervention outcomes.ConclusionsKey findings from the current study show that inner-city African Americans with diabetes desire interventions that foster social and community support systems.Practice ImplicationsGiven this insight, more robust and comprehensive interventions are needed to account for the multifaceted experience of food insecurity and diabetes within the inner-city environment.     

Association of FADS2 rs174575 gene polymorphism and insulin resistance in type 2 diabetes mellitus

BackgroundMany risk factors contribute to the pathogenesis of diabetes. Gene and lifestyle factors are considered to be the major contributors. A dietary pattern is attributed to be one of the lifestyle risk factors favoring diabetes. The present study aims to find an association between fatty acid desaturase (FADS) gene polymorphism and glycemic profile in type 2 diabetes mellitus (T2DM).MethodologyA total of 429 subjects were included in the study on the basis of inclusion and exclusion criteria, of which 213 and 216 subjects were diabetic and control, respectively. Body mass index was calculated. Fasting plasma glucose, glycated hemoglobin (HbA1c) and insulin were measured using commercially available kits. rs174575 of FADS2 was selected based on previous publications and identified using the dbSNP database. To compare the biochemical parameters with the genotype, the following three models were used: additive model (CC vs CG vs GG), dominant model (CC + CG vs GG), and recessive model (CC vs CG + GG).Results and DiscussionFBS, HbA1c, insulin, HOMA-IR, and HOMA-B exhibited a high and statistically significant difference between subjects and controls. The three models exhibited a statistically significant difference between FBS, HOMA-IR, and HOMA- B (p<0.05).ConclusionThe distribution of rs174575 genotype differed significantly between the subjects and controls in the present study. The study revealed that genetic variation in FADS2 is an additional facet to consider while studying the risk factors of T2DM.     

HLA-DRB基因启动子区多态性与肺结核合并2型糖尿病的相关性

目的研究HLADRB基因启动子区序列与肺结核合并2型糖尿病的相关性。方法用PCRSSP法进行HLADRB基因分型,启动子区扩增产物直接测序。结果病例组DRB109等位基因的频率显著高于对照组(P<0.05)。病例组中DRB基因启动子区-65位碱基T和-8位AG杂合子的频率明显增加(P<0.05)。病例组中DRB109阳性标本-65位碱基T的频率明显增加,G明显减少(P<0.01);+39位碱基C明显增加,T明显减少(P<0.01)。结论DRB109等位基因及HLADRB启动子区多态性与肺结核合并2型糖尿病密切相关。     

Association of polymorphisms in monocyte chemoattractant protein-1 promoter with diabetic kidney failure in Korean patients with type 2 diabetes mellitus

Monocyte chemoattractant protein-1 (MCP-1) is suggested to be involved in the progression of diabetic nephropathy. We investigated the association of the -2518 A/G polymorphism in the MCP-1 gene with progressive kidney failure in Korean patients with type 2 diabetes mellitus (DM). We investigated -2518 A/G polymorphism of the MCP-1 gene in type 2 DM patients with progressive kidney failure (n=112) compared with matched type 2 DM patients without nephropathy (diabetic control, n=112) and healthy controls (n=230). The overall genotypic distribution of -2518 A/G in the MCP-1 gene was not different in patients with type 2 DM compared to healthy controls. Although the genotype was not significantly different between the patients with kidney failure and the diabetic control (p=0.07), the A allele was more frequent in patients with kidney failure than in DM controls (42.0 vs. 32.1%, p=0.03). The carriage of A allele was significantly associated with kidney failure (68.8 vs. 54.5%, OR 1.84, 95% CI 1.07-3.18). In logistic regression analysis, carriage of A allele retained a significant association with diabetic kidney failure. Our result shows that the -2518 A allele of the MCP-1 gene is associated with kidney failure in Korean patients with type 2 DM.     

Association between the GLUT1 gene polymorphism and the risk of diabetic nephropathy: a meta-analysis

The association between diabetic nephropathy (DN) and the XbI polymorphism in the GLUT1 gene has been investigated in several case-control studies. These studies rendered contradictory results: the allele XbI(–) was shown either to be a risk factor or neutral, or even protective for the development of the disease. To shed some light on these inconclusive findings, a meta-analysis of all available studies relating the XbI polymorphism to the risk of developing DN was conducted. Five out of six identified studies included Caucasian populations, and only one involved samples from an Asian population. Overall, the meta-analysis suggested large heterogeneity between studies (P<0.01, I²=68%) and lack of association between allele XbI(–) and the risk of developing DN relative to allele XbI(+): random effects odds ratio (OR)=1.26 [95% CI (0.93, 1.69)]. Excluding one study with the controls not in Hardy–Weinberg equilibrium, the sensitivity analysis revealed that heterogeneity (P=0.28, I²=21%) could be explained, and then, there is an overall association: fixed effects OR=1.34 [95% CI (1.13, 1.60)]. Then, significant ORs were also found on analysis of subgroups: for the Caucasian population, fixed effects OR=1.29 [95% CI (1.08, 1.56)] and for the type 2 diabetic patients fixed effects OR=1.69 [95% CI (1.09, 2.63)]. In type 1 diabetes, there is a moderate heterogeneity (P=0.19, I²=41%) with fixed effects OR=1.29 [95% CI (1.06, 1.56)] and random effects OR=1.32 [95% CI (1.01, 1.71)]. There is a source of bias in the selected studies: large studies failed to show association while small studies claimed an association. Although there is evidence of association between GLUT1 and DN, the above findings reinforce the need for further and more rigorous association studies.     

The polymorphism of manganese superoxide dismutase is associated with diabetic nephropathy in Japanese type 2 diabetic patients

 We evaluated the relationship of an alanine or valine polymorphism at amino acid sequence 16 [Val(16)Ala] of manganese superoxide dismutase (Mn-SOD) with diabetes and diabetic nephropathy in Japanese type 2 diabetic patients. Val(16)Ala genotyping of Mn-SOD was done by polymerase chain reaction-restriction fragment length polymorphism with a restriction enzyme (Bsaw I) in 478 Japanese type 2 diabetic patients and 261 nondiabetic Japanese healthy subjects. The genotype distribution of diabetic and nondiabetic subjects was then compared, and the association of genotype with diabetic nephropathy was evaluated in the diabetic patients. The allele frequency and genotype of the diabetic patients were not different from those of the healthy nondiabetic subjects. The VV type showed a significantly higher frequency in the diabetic patients with nephropathy than did the AA or VA type [VV type: normoalbuminuria 70.8%, microalbuminuria 84.8% (P = 0.0057), macroalbuminuria 84.1% (P = 0.0128)]. Furthermore, logistic regression analysis showed that this polymorphism is associated with diabetic nephropathy independently (odds ratio = 0.461925, P = 0.03). Accordingly, the Val(16)Ala polymorphism of Mn-SOD may be unrelated to the etiology of type 2 diabetes, but it seems to be associated with diabetic nephropathy in Japanese type 2 diabetic patients. Received: August 5, 2002 / Accepted: December 3, 2002 Correspondence to:Y. Tanaka     

A common functional exon polymorphism in the microsomal triglyceride transfer protein gene is associated with type 2 diabetes, impaired glucose metabolism and insulin levels

The microsomal triglyceride transfer protein (MTP) is required for the assembly and secretion of apolipoprotein B-containing lipoproteins. Emerging evidence has indicated that the functional MTP exon polymorphism I128T is associated with dyslipidemia and other traits of the insulin-resistance syndrome, and the T128 variant seems to confer a reduced stability of MTP, resulting in reduced binding of LDL particles. The aim of the study was to elucidate the association of this MTP polymorphism with parameters of postprandial metabolism. A total of 716 male subjects from a postprandially characterized cohort (MICK) and a nested case–control study (EPIC) of 190 incident type 2 diabetes cases and 380 sex- or age-matched controls were genotyped for the I128T exon polymorphism. In comparison to homozygote subjects of the wild allele, carriers of the less common allele of the MTP T128 genotype showed significantly lower postprandial insulin levels (P=0.017), lower diastolic blood pressure (P=0.049) and had a lower prevalence of impaired glucose metabolism and diabetes type 2 (P=0.03) in the MICK. Consistent with this, we found a lower incidence of type 2 diabetes in male subjects of the nested case–control study in the T128 genotype (P=0.007). These results suggest that the rare allele of the MTP I128T polymorphism may be protective against impaired glucose tolerance, type 2 diabetes and other parameters of the metabolic syndrome.     

The relationship between C677T methylenetetrahydrofolate reductase gene polymorphism and retinopathy in type 2 diabetes: a meta-analysis

The association between retinopathy in type 2 diabetes [diabetic retinopathy (DR)] and the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene has been investigated in several case-control studies. These studies rendered contradictory results, some indicating that the polymorphism is associated with the risk of developing DR whereas others concluded there is no association. To shed light on these inconclusive findings, a meta-analysis of all available studies relating the C677T polymorphism to the risk of developing DR was conducted. Four out of five identified studies included populations of East Asian descent, and only one involved samples from European descent (Caucasians). Overall, the meta-analysis suggested large heterogeneity between studies (p = 0.08, I² = 52%) and marginal association between C677T transition and the risk of developing DR: random effects odds ratio (OR) = 1.39 [95% CI (1.05, 1.83)]. The sensitivity analysis [exclusion of one East Asian study with the controls not in Hardy–Weinberg equilibrium (HWE)] showed no heterogeneity (p = 0.25, I² = 27%) and no significant association: fixed effects OR = 1.22 [95% CI (0.99, 1.51)] and random effects OR = 1.24 [95% CI (0.96, 1.60)]. The sub-group analysis for the East Asian population produced a significant association: fixed effects OR = 1.48 [95% CI (1.20, 1.83)] and random effects OR = 1.52 [95% CI (1.14, 2.03)]. However, sensitivity analysis in East Asians revealed that the association is marginal: fixed effects OR = 1.33 [95% CI (1.04, 1.70)] and random effects OR = 1.36 [95% CI (1.01, 1.83)]. There is a source of bias in the selected studies: the largest studies failed to show association while the smallest study claimed an association. The above findings reinforce the need for larger and more rigourous studies in this area.     

Ghrelin基因多态性与2型糖尿病的相关性

目的探讨ghrelin基因多态性与2型糖尿病之间的关系。方法进行ghrelin基因C408A和G346A的多态性分析,同时进行生化指标和临床参数的检测。结果正常对照组(NGT组)C408A基因型CC、CA、AA的基因型频率分别为75.4%、24.0%及0.6%。2型糖尿病组(DM组)中CC、CA及AA的基因型频率分别为70.8%、28.2%及1.0%。NGT组CC基因型者总胆固醇水平明显高于CA AA基因型者(P<0.05);DM组CC基因型者血尿酸水平明显高于CA AA基因型者(P<0.05)。在所有的受试者中未发现G346A多态性存在。结论Ghrelin基因C408A分布与等位基因频率没有明显的差异;本组人群中未发现ghrelinG346A多态性存在;C408A多态性与总胆固醇和尿酸水平相关。     

Variants in Intron 13 of the ELMO1 Gene are Associated with Diabetic Nephropathy in African Americans

Variants in the engulfment and cell motility 1 (ELMO1) gene are associated with nephropathy due to type 2 diabetes mellitus (T2DM) in a Japanese cohort. We comprehensively evaluated this gene in African American (AA) T2DM patients with end-stage renal disease (ESRD). Three hundred and nine HapMap tagging SNPs and 9 reportedly associated SNPs were genotyped in 577 AA T2DM-ESRD patients and 596 AA non-diabetic controls, plus 43 non-diabetic European American controls and 45 Yoruba Nigerian samples for admixture adjustment. Replication analyses were conducted in 558 AA with T2DM-ESRD and 564 controls without diabetes. Extension analyses included 328 AA with T2DM lacking nephropathy and 326 with non-diabetic ESRD. The original and replication analyses confirmed association with four SNPs in intron 13 (permutation p-values for combined analyses = 0.001–0.003), one in intron 1 (P = 0.004) and one in intron 5 (P = 0.002) with T2DM-associated ESRD. In a subsequent combined analysis of all 1,135 T2DM-ESRD cases and 1,160 controls, an additional 7 intron 13 SNPs produced evidence of association (P = 3.5 × 10⁻⁵– P = 0.05). No associations were seen with these SNPs in those with T2DM lacking nephropathy or with ESRD due to non-diabetic causes. Variants in intron 13 of the ELMO1 gene appear to confer risk for diabetic nephropathy in AA.     

2型糖尿病胰岛素抵抗和胆固醇酯转运蛋白基因多态性的关联研究

目的 探讨胆固醇酯转运蛋白(cholesteyl ester transfer protein，CETP)基因多态性与2型糖尿病胰岛素抵抗的关系。方法 采用聚合酶链反应和酶切电泳方法对108例2型糖尿病患者进行CETP-TaqIB基因型分型，同时测定血脂、空腹胰岛素、胰岛素敏感指数和胰岛素抵抗指数。结果 正常对照组与2型糖尿病组等位基因频率和基因型分布无统计学意义；2型糖尿病甘油三酯(triglyceride，TG)、总胆固醇(total cholesterol，TC)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol，LDL-C)和载脂蛋白B(apolipoprotein B，apoB)浓度各基因型间差异无统计学意义，而高密度脂蛋白胆固醇(high density lipoprotein cholesterol，HDL-C)、载脂蛋白A1(apolipoprotein A1，apoA1)、空腹胰岛素(fasting insulin，FINS)、胰岛素敏感性指数(insulin sensitivity index，ISI)和HOMA模型胰岛素抵抗指数(homeostasis model assessment-insulin resistance，HOMA-IR)各基因型间差异有统计学意义，HDL-C、apoA，和ISI B2B2型显著高于B1B1型，FINS和HOMA-IR B2B2型显著低于B1B1型；以胰岛素敏感性指数和HOMA-模型胰岛素抵抗指数为因变量进行多元回归分析，ISI和HOMA-IR与体重指数、收缩压、TC、HDL及基因型分型密切相关。结论 CETP-Taq IB基因多态性与2型糖尿病脂代谢及胰岛素抵抗密切关联，可能是胰岛素抵抗的重要遗传因素。     

C反应蛋白表达在2型糖尿病大血管病变中意义

目的:探讨C反应蛋白(CRP)与2型糖尿病(T2DM)大血管病变发生的关系。方法:将T2DM患者60人随机分为合并大血管并发症组与无大血管并发症组,每组各30例,正常对照组30例。检测病人血清中血脂、糖化血红蛋白(HbA1c)和CRP水平。结果:2型DM患者的CRP水平明显高于正常对照组(P<0.05),其中有大血管并发症组显著高于无大血管并发症组(P<0.05),Logstic回归分析显示,CRP水平是T2DM患者大血管并发症发生的独立危险因素。结论:CRP与T2DM的发生相关,升高的CRP是促使T2DM并发大血管病变的独立危险因素。     

NAT2基因多态性与2型糖尿病的关系

目的探讨NAT2基因多态性与2型糖尿病易感性的关系,为糖尿病的有效防治提供科学依据。方法采用PCR及测序技术对174例2型糖尿病患者和174例健康者的NAT2基因4个常见突变位点进行检测。结果糖尿病组中NAT2等位基因频率分别为：Wt（69.54%）,M2（16.37%）,M3（10.63%）,M1（3.44%）。与正常对照组比较差异无显著性。NAT2基因型（WT/WT,WT/Mx,Mx/Mx）在糖尿病组中分布频率分别为44.82%,49.42%,5.74%,两组间比较差异显著。糖尿病组中快乙酰化者164例（占94.25%）,慢乙酰化者10例（占5.75%）,两组间比较有差异。携带NAT2快乙酰化基因型者患2型糖尿病的风险是携带NAT2慢乙酰化基因型者的3.98倍。结论本研究提示快乙酰化代谢表型可能是糖尿病的一个遗传易感因素,而慢乙酰化代谢表型可能对糖尿病的发生具有一定保护作用。