血友病性关节病的MRI分析

目的:探讨血友病性关节病的MRI表现及临床价值.方法:回顾性分析11例22个膝关节血友病性关节病患者的MRI表现.结果:22个膝关节均有积血,表现为关节腔、骨骼和/或软组织血肿,早期血肿在T1WI为等信号、T2WI呈高信号;中期血肿在T1WI呈略高信号或混杂信号,T2WI呈高信号或混杂信号;晚期血肿在T1WI和T2WI均表现为混杂信号,血肿逐渐被吸收.病变早期关节结构基本保持正常,中晚期关节结构均有损害,表现为关节软骨、骨皮质破坏吸收,关节间隙狭窄,骨端或骨骺增大变形.早中期滑膜、关节囊、肌肉及韧带肿胀,而晚期则萎缩、退变.结论:MRI能准确显示血友病性关节病的病理改变,对疾病分期、指导临床治疗及同位素放射治疗效果评价具有重要意义.     

Hemophilic arthropathy: assessment with MR imaging

Fifteen patients with hemophilia, 14 of whom had hemophilic arthropathy, were examined with magnetic resonance (MR) imaging to determine if it could be used to assess hemophilic arthropathy, especially synovial hypertrophy and the status of the articular cartilage. Thirty-five joints of the appendicular skeleton were imaged. Four joints in two patients were clinically normal. Synovial hypertrophy was detected in 28 joints and appeared as areas of low to intermediate signal intensity on T1- and T2-weighted images, with foci of increased signal intensity on T2-weighted images (presumed to be due to areas of fluid or inflammation) in 16 joints. Abnormal articular cartilage was demonstrated in 26 joints; bone lesions, fluid collections, and joint space narrowing could also be seen. MR imaging appears to be useful in depicting the components of hemophilic arthropathy.     

A compartmental approach to the radiographic evaluation of soft-tissue calcifications

Musculoskeletal radiology, like most areas of diagnostic radiology, has seen a dramatic increase in the use of cross-sectional imaging techniques over the last decade. However, conventional radiography remains a vital role in the evaluation of disease involving the spine and extremities. Given its widespread availability and low cost, radiography should be the initial examination obtained when imaging is clinically indicated. Therefore it is essential that the practicing radiologists be able to maximize the diagnostic value of this common study to aid the clinicians with a focused differential diagnosis, if not a definitive diagnosis. While much emphasis has been placed on radiographic interpretation of osseous lesions, similar diagnostic yield can be often obtained about calcified or ossified soft-tissue lesions. Detailed evaluation of the distribution and morphology of the soft-tissue calcifications, combined with a thorough knowledge of the entities that may occur at the site of the noted abnormality, provides significant interpretive value to provide a definitive diagnosis or accurately recommend the next most effective management step. We provide a compartmental-based approach to the interpretation of soft-tissue calcifications.     

Periarticular calcifications. A little-known sign of psoriatic arthritis

The hands of 40 patients with psoriasis were examined by conventional and direct magnification radiograms. In 5 cases the hands showed typical psoriatic arthropathy. In 5 other cases only small calcifications in the soft tissues at distal interphalangeal joints were visible: according to clinical and laboratory data, these lesions could be in connection with psoriatic arthritis.     

Ochronotic arthropathy in alkaptonuria. Radiological manifestations and physiopathological signs

Alkaptonuria is a rare autosomal recessive metabolic disease, due to the lack of homogentisic acid oxidase. The following accumulation of homogentisic acid brings about a black discoloration of both the urine (alkaptonuria) and connective tissue (ochronosis). The ochronotic alterations into joint cartilages cause degenerative arthropathy and osteopenia. The radiological features of three unrelated cases of alkaptonuria are reported. Radiographic abnormalities of ochronotic arthropathy are found in both the spine and the extraspinal joints. In the spine, the progressive calcification and "vacuum" phenomenon of disc spaces are the most characteristic findings. Disc space narrowing is associated with calcification and marginal sclerosis of vertebral bodies and is accentuated by osteopenia. Osteophytes are usually absent or of small size; nevertheless progressive formation of marginal intervertebral bridges and obliteration of disc spaces at multiple levels ("pseudoblock vertebrae") may occur. In extraspinal sites, space narrowing, bone sclerosis and fragmentation may also be observed. Diagnosis of ochronotic arthropathy is often suggested by radiographs of the spine, and it is confirmed afterwards by clinical and laboratory findings. The characteristic radiological findings of ochronotic spondylitis, in the final stage, include narrowing of at least four lumbar disc spaces, associated with their calcification and "vacuum" phenomenon, "pseudoblock vertebrae", marginal sclerosis and osteopenia of vertebral bodies.     

Roentgenologic and nuclear medicine findings in alkaptonuric ochronosis

In alkaptonuria, a recessively inherited disturbance of amino acid metabolism, deposits of oxydation products of homogentisinic acid result in the disease pattern of ochronosis. Due to the enhanced brittleness of the supporting and gliding tissue, ochronotic arthropathy develops at the vertebral column and later at the major joints with typical roentgenological changes especially in the intervertebral space and the intervertebral disk, as well as the adjacent vertebral bodies. The bone scintigram shows enhanced accumulation in the base and tectorial plates as well as in the adjacent sclerosing zones in the spongiosa of the affected vertebral bodies.     

MR Arthrography of the Hip

Magnetic resonance imaging (MRI) of the hip has been valuable in the diagnosis of occult osseous abnormalities and of periarticular soft tissue disorders. MRI has been less useful in the evaluation of acetabular labral tears and other intra-articular abnormalities. Image optimization is more technically challenging in the hip than in smaller joints because the overlying soft tissues are thicker, resulting in decreased spatial and contrast resolutions that may not be adequate to distinguish the acetabular labrum from subchondral bone, articular cartilage, and joint capsule. MR arthrography (MRA) extends the capabilities of conventional MRI because contrast solution separates intra-articular structures and outlines abnormalities. In hips with suspected acetabular labral injury, arthrographic MR images demonstrate the location and length of tears and the presence of associated capsular defects. Arthrographic MR images may also enable the accurate diagnosis of cartilage lesions and intra-articular loose bodies. This article illustrates normal arthrographic MR features of the hip as well as pathologic disorders of the acetabular labrum, capsule, and articular cartilage     

膝关节退行性骨关节病的MRI表现

目的 :探讨MRI对膝关节退行性骨关节病的诊断价值。方法 :对手术、关节镜或临床证实的 2 1例 2 6个膝关节退行性骨关节病的MRI表现进行回顾性分析。结果 :MRI能较好地显示膝关节病变的关节软骨、半月板、韧带、骨质等改变 ,还能对关节软骨、半月板损伤和退变进行分级 ,明显优于传统X线检查。结论 :MRI检查能清楚显示退行性骨关节病的病变特点和严重程度 ,为临床选择合适的治疗方案提供了依据。     

Radiographic and MRI features of deferiprone-related arthropathy of the knees in patients with beta-thalassemia

OBJECTIVE: This study was undertaken to describe the radiographic and MRI appearances of arthropathy of the knees in 14 patients with beta-thalassemia major undergoing chelation therapy with deferiprone (L1). MATERIALS AND METHODS: All available radiographs and MRI studies of the knees in 14 beta-thalassemia major patients (mean age, 16.3 years; age range, 7-33 years) undergoing chelation therapy with L1 were retrospectively assessed for changes in the synovium, cartilage, and bone. Imaging findings and signs of knee arthropathy were correlated with chelation therapy and average serum ferritin concentration. RESULTS: Nine (64%) of the 14 patients developed arthralgia of the knees during treatment with L1. Abnormal imaging findings were present in all symptomatic and two asymptomatic patients (12/14, 86%) and included joint effusion, subchondral bone irregularity, and patellar beaks. Additional MRI findings were thickening and enhancement of the synovium; hypointense bands in the synovium; irregularly thickened epiphyseal and articular cartilage overlying subchondral bone defects; and, on T2-weighted sequences, hyperintense articular cartilage lesions. The degree of knee symptoms at the time of imaging did not reflect the severity of cartilage and subchondral bone changes. CONCLUSION: Radiologic changes can be seen in L1-related arthropathy and should be recognized. MRI of the knees should be considered in symptomatic children and young adults with thalassemia undergoing L1 chelation therapy for iron overload.     

Indirect magnetic resonance arthrography of the shoulder; a reliable diagnostic tool for investigation of suspected labral pathology

Purpose

Indirect magnetic resonance arthrography (I-MRA) confers significant logistical advantages over direct MRA and does not require articular injection. In this study, we determined the diagnostic performance of I-MRA in relation to conventional MRI and arthroscopy or surgery in detecting tears of the glenoid labrum, including Bankart lesions and superior labral antero-posterior (SLAP) tears in a standard clinical setting.

Patients and methods

Ninety-one symptomatic patients underwent conventional MRI and I-MRA of the affected shoulder, followed by either arthroscopy or open surgery. The scans were interpreted independently by two experienced radiology consultants with a special interest in musculoskeletal radiology. Using the surgical findings as the standard of reference, sensitivity, specificity, and diagnostic accuracy of conventional non-contrast MRI and I-MRA in the detection of labral tears were calculated.

Results

The sensitivity of I-MRA was 95 and 97 %, respectively, for two radiologists as opposed to 79 and 83 % for conventional MRI. For both radiologists, the specificity of I-MRA, as well as MRI, was 91 % for detection of labral tears of all types. Accuracy of diagnosis was 93 and 95 %, respectively, for two radiologists with indirect MRA, compared to 84 and 86 % with non-contrast MRI.

Conclusions

This retrospective study shows that I-MRA is a highly accurate and sensitive method for the detection of labral tears. The data obtained supports the use of I-MRA as standard practice in patients with shoulder instability due to suspected labral pathology where further investigative imaging is indicated.     

强直性脊柱炎骶髂关节的CT诊断价值

目的探讨强直性脊柱炎（AS）患者骶髂关节病变的CT表现,并评价其对早期诊断的意义。方法对46例经临床证实AS患者骶髂天节病变的CT表现进行了回顾性分析,并参照修订的AS纽约标准（5级分类法）对全部患者的骶髂关节病变进行了分级。结果研究证实,本组46例均有异常CT表现。其中,Ⅱ级（早期,7例）CT表现为骶髂关节受累,关节面轻度硬化、毛糙,皮质白线消失,关节面细小囊变,但关节间隙仍正常;Ⅲ级（进展期,35例）CT表现为骶髂关节面呈虫蚀状侵蚀,软骨钙化,关节面骨质增生硬化,关节间隙略增宽或不均匀变窄;Ⅳ级（晚期,4例）CT表现为关节骨性强直,关节间隙消失。结论CT能清晰显示骶髂关节的微细结构及其病理改变,极有利于诊断AS患者早期骶髂关节病变。     

Contribution of meniscal extrusion and cartilage loss to joint space narrowing in osteoarthritis.

OBJECTIVE: This study was undertaken to determine the contribution of meniscal extrusion and cartilage loss to joint space narrowing on conventional radiographs by correlation with magnetic resonance imaging (MRI). SUBJECTS AND METHODS: Sixty-two consecutive patients, 32 patients with osteoarthritis and 30 without osteoarthritis, over the age of 60 years that were referred for both radiographic and MRI of the knee were included in the study. In each case, relative joint space narrowing on conventional AP radiographs was assessed utilizing the Kellgren-Lawrence scoring system. Subsequently, the degree of meniscal extrusion and the integrity of articular cartilage were evaluated from MR in the same patients. RESULTS: Each of 30 patients with normal joint space (Kellgren Grade 0) were noted to have normal articular cartilage, grade 1 meniscal extrusion was identified in only three of these patients. In comparison, meniscal extrusion was identified in all 32 patients with joint space narrowing (Kellgren Grades 1-4). Definite thinning or loss of articular cartilage was identified in only 15 of the 32 cases. In 17 patients with radiographic joint space narrowing (Kellgren Grades 1-3) and meniscal extrusion, no loss of articular cartilage was observed. A statistically significant correlation (P<0.001) was observed between Kellgren Grade and degree of meniscal extrusion and cartilage thinning on MRI. CONCLUSION: Conventional radiographs are an unreliable method of evaluating for articular cartilage loss in patients with early osteoarthritis. Initial joint space narrowing on conventional radiographs is secondary to meniscal extrusion rather than thinning of articular cartilage in most cases.     

头颈部椎周间隙良性肿瘤的MR成像研究

目的：分析头颈部椎周间隙良性肿瘤MR成像特征及病变的诊断与鉴别诊断。方法：18例头颈椎周间隙良性肿瘤均经Philips0.5T超导型MR成像仪扫描,包括12例神经鞘瘤、2例神经纤维瘤和4例脊索瘤,其中13例行Gd-DTPA增强,结果：18例良性肿瘤于T2加权像上均呈高信号（大多数接近脑脊液）,增强后显著强化。6例神经鞘瘤、1例神经纤维瘤和4例脊索瘤信号不均匀,所有病例均位于椎周间隙椎前部分。其中7例位于舌骨上,结论：MR成像可清晰显示椎周间隙病变,划分椎周间隙在一定程度上能进行病变的定性诊断和鉴别诊断。     

Magnetic resonance in the diagnosis of bone infections

Skeletal infections represent a variety of clinical and pathological conditions in which both an early diagnosis and the precise evaluation of disease extent are very important in planning proper therapy. To determine MRI capabilities and limitations in the evaluation of skeletal infections 21 patients--12 with a clinical diagnosis of osteomyelitis of the lower limbs and 9 with a clinical diagnosis of spondyloscitis--were studied with this technique. All patients were examined with conventional X-rays; conventional tomography was performed in 3 cases, and CT in 6. Signal intensities and morphological aspects were then evaluated with MRI. MRI diagnoses were compared with surgical findings or clinical follow-up, after antibiotic therapy: 19 true-positives were observed, together with 1 true-negative, 1 false-positive, and no false-negatives. MRI findings were correlated with those of conventional radiology: MRI identified the lesions and their nature in 100% of cases, whereas conventional radiology did the same in 85% of cases; in 50% of cases only the latter was able to define the nature of the process. Four patients underwent MRI follow-up. MRI was highly sensitive in determining the presence of lesions in an early stage and in demonstrating lesion regression. Moreover, MRI was able to identify the complications occurring in some cases of osteomyelitis and spondyloscitis. In all cases MRI allowed the extent of the disease to be accurately determined and, in osteomyelitis of the lower limbs, it was extremely useful to differentiate soft-tissue infections from bone marrow involvement.     

MRI of atypical focal nodular hyperplasia of the liver: radiology-pathology correlation

OBJECTIVE: The purpose of our study was to determine the MRI features of atypical focal nodular hyperplasia of the liver and to compare them to pathology findings. MATERIALS AND METHODS: We retrospectively reviewed MRI and pathology findings in 27 focal nodular hyperplasia lesions with atypical MRI features. Six criteria for typical focal nodular hyperplasia were required: iso- or hypointensity on T1-weighted sequences and iso- or slight hyperintensity on T2-weighted sequences; homogeneous signal intensity; central hyperintense area on T2-weighted sequences; marked lesion contrast enhancement; accumulation of gadolinium chelates within the central area on delayed contrast-enhanced T1-weighted sequences; and absence of capsule. RESULTS: The most common atypical radiology features included absence of, or an atypical, stellate area; heterogeneity on both T1- and T2-weighted images; and high-intensity signal on T1-weighted sequences. MRI-pathology correlation showed that T1 hyperintensity with no other atypical MRI feature (n = 3) could be explained by steatosis, sinusoidal dilatation, or hemorrhage. In addition, in two patients with lesions smaller than 3 cm in diameter, the only atypical MRI feature was absence of a stellate area. CONCLUSION: These findings suggest a lesion that is hyperintense on T1-weighted sequences or that lacks a stellate area but is smaller than 3 cm in diameter can be diagnosed as focal nodular hyperplasia provided all other MRI criteria for this diagnosis are present. In such cases, close monitoring on MRI without invasive diagnostic procedures may be warranted. However, in large lesions (> 3 cm) without a stellate area and in lesions with heterogeneity, histopathology examination is mandatory to rule out other diagnoses.     

低场MRI在膝关节退行性骨关节病中的诊断价值

目的探讨低场MRI对膝关节退行性骨关节的诊断价值。方法对经手术、关节镜或临床证实的60例(65个)膝关节退行性骨关节病的低场MRI表现进行回顾性分析。结果低场MRI能较好地显示膝关节关节软骨、半月板、骨质及韧带等变性、损伤,较传统X线检查有明显优势。结论低场MRI对膝关节退行性骨关节病的诊断有重要价值。     

MRI of articular cartilage: revisiting current status and future directions

OBJECTIVE: The purpose of this article is to review the current understanding of the MRI appearance of articular cartilage and its relationship to the microscopic and macroscopic structure of articular cartilage, the optimal pulse sequences to be used in imaging, the appearance of both degenerative and traumatic chondral lesions, the appearance of the most common cartilage repair procedures, and future directions and developments in cartilage imaging. CONCLUSION: Articular cartilage plays an essential role in the function of the diarthrodial joints of the body but is frequently the target of degeneration or traumatic injury. The recent development of several surgical procedures that hold the promise of forming repair tissue that is hyaline or hyalinelike cartilage has increased the need for accurate, noninvasive assessment of both native articular cartilage and postoperative repair tissue. MRI is the optimal noninvasive method for assessment of articular cartilage.     

骨良性肿瘤与肿瘤样病变的MR诊断

目的：探讨磁共振在骨良性肿瘤与肿瘤样病变诊断中的价值。材料和方法：搜集骨良性肿瘤与肿瘤样病变３４例，分析其磁共振表现。全部病例均做磁共振检查。采用常规ＳＥ序列，Ｔ１Ｗ及Ｔ２Ｗ成像。其中２０例同时做了脂肪抑制成像。结果：磁共振诊断正确率为９４．１％（３２／３４）。磁共振征象包括：骨质破坏（３０／３４）；软组织肿块（３／３４）；关节侵犯（１／３４）；骨壳（１０／３４）；硬化缘（１７／３４）；钙化（３／３４）；骨间隔（７／３４）；囊变坏死（８／３４）；出血（７／３４）；软组织水肿（３／３４）；髓腔水肿（３／３４）；关节积液（３／３４）。结论：磁共振是骨良性肿瘤与肿瘤样病变的有效辅助诊断方法。磁共振与平片、ＣＴ相结合有利于提高定性诊断正确率。     

T1 mapping联合常规MRI扫描方案评估膝关节软骨损伤

目的评估在常规MRI扫描方案中加入T1 mapping成像能否提高对膝关节软骨损伤的诊断效能。方法选取86例患者的88个膝关节接受了膝关节MRI检查和关节镜检查。MRI检查采用常规方案并加入T1 mapping成像。术前2位影像科医师对所有MRI检查图像进行一致的诊断,评估是否存在软骨损伤并进行软骨损伤MRI分级,首先评估常规MRI扫描方案的图像,然后评估T1 mapping联合常规MRI扫描方案的图像。由1位骨科医师在关节镜下进行软骨损伤关节镜分级并作为金标准。计算两种MRI扫描方案评估软骨损伤的敏感度和特异度,统计分析两种扫描方案的诊断结果是否存在差异。结果关节镜检出的256个软骨损伤,常规MRI扫描方案的敏感度、特异度分别为59.0%和98.6%,T1 mapping联合常规MRI扫描方案的敏感度、特异度分别为85.9%和93.2%。T1 mapping联合常规MRI扫描方案显著提高了MRI扫描诊断早期关节软骨损伤的敏感度,关节镜1级软骨损伤的敏感度从18.6%提高至71.2%,关节镜2A级软骨损伤的敏感度从74.3%提高至94.3%。上述两种扫描方案的结果差异均有统计学意义(P<0.05)。结论常规MRI扫描方案中加入T1 mapping成像,可提高对膝关节软骨损伤的敏感度,为临床诊断早期膝关节软骨损伤提供影像学依据。     

中肾管囊肿的CT与MRI诊断

目的：通过回顾分析手术病理证实的中肾管囊肿的CT或MRI表现,提高中肾管囊肿CT与MRI的影像诊断水平。方法：回顾分析25例手术病理证实的中肾管囊肿的CT或MRI表现,5例行CT平扫加增强,21例行MRI平扫加增强,其中1例同时行CT和MRI平扫加增强。结果：本组病例全部为女性,单发23例,多发2例,位于输卵管系膜内19例,其中双侧2例;子宫正后方1例,腹膜后3例,下腹部2例。CT表现为圆形或卵圆形,低密度薄壁囊性肿块,边界清楚,1例腹膜后中肾管囊肿壁见多发钙化并右肾下垂、旋转不良、右侧输尿管异位;MRI表现为长T1长T2薄壁囊性肿块,1例腹膜后中肾管囊肿后壁可见一小囊;增强扫描,4例位于输卵管系膜内中肾管囊肿表现为囊壁部分弧线状强化,其余病例囊壁及囊内未见强化。结论：中肾管囊肿有其典型的发病部位,结合临床,CT或MRI可以提示中肾管囊肿的诊断,显示钙化方面CT优于MRI,显示病灶囊变结构及与周围结构之间关系,MRI检查优于CT。