耳科开放式术腔的容量测量及术腔处理技术的选择

目的 :测量耳科开放式术腔的大小 ,探讨术腔处理技术的选择和应用 ,并对疗效进行评价。方法 :在 15 0耳开放式手术中 ,术腔处理组 10 5耳 ,用生理盐水灌注法测量术腔的大小 ,对于中小术腔选择三瓣法耳道耳甲成形术 ,对于大术腔则选择五瓣法耳道耳甲成形术或三瓣法耳道耳甲成形术加部分乳突腔充填术进行术腔处理。并与 4 5耳传统开放式手术作对照。结果 :10 5耳开放式术腔中 ,中等术腔最多 ,占 4 2 .9% ,其次为小术腔 ,占 36 .2 % ,大术腔最少 ,仅占 2 0 .9%。术后 3个月和 6个月复诊 ,术腔处理组干耳率分别为 93.3%和 95 .2 % ,术腔上皮化率分别为 89.5 %和 92 .4 %。对照组干耳率分别为 77.8%和82 .2 % ,术腔上皮化率分别为 73.3%和 80 .0 %。术腔处理组干耳率 (P <0 .0 1)和上皮化率 (P <0 .0 5 )均高于对照组。随访 1～ 5年 ,术腔处理组有 3耳 (2 .84 % )复发 ,对照组有 5耳 (11.1% )复发。结论 :根据术腔大小选择相应的耳道耳甲成形术或乳突腔充填术是促进术后干耳的重要步骤之一 ,生理盐水灌注法是测量术腔大小的简便方法 ,可作为选择术腔处理技术的依据     

耳甲腔成形术在开放式乳突手术中的临床价值

目的：探讨耳甲腔成形术在开放式乳突手术中的价值。方法：对220耳行耳甲腔成形术（成形组）及61耳未做耳甲腔成形术（对照组）的患者进行疗效比较。结果：随访1－5年，成形组术后干耳率93．64％，术腔上皮化率88．64％，术腔肉芽发生率为5．45％，7例术后复发；对照组术后干耳率68．85％，术腔上皮化率62．30％，术腔肉芽发生率29．50％，9例术后复发。结论：耳甲腔成形术可提高开放式乳突手术术后干耳率，降低肉芽发生率，促进乳突腔上皮化，对提高开放式乳突手术的疗效具有一定的临床价值。     

乳突腔充填术及耳甲腔成形术对乳突根治术效果的影响

目的　探讨乳突腔充填术及耳甲腔成形术对乳突根治术的效果。方法　对 49例行乳突腔充填术及耳甲腔成形术 (成形组 )及 3 7例未做乳突腔充填术及耳甲腔成形术 (对照组 )的患者 ,进行疗效对比。结果　术后 3个月和半年 ,乳突腔明显缩小或消失率、干耳率、术腔上皮化率均明显高于对照组 (P <0 .0 1或 0 .0 5 ) ;随访 1～ 5年 ,对照组复发再手术 5耳 (13 .5 % ) ,成形组复发再手术 1耳 (2 .4% )。结论　乳突腔充填术及耳甲腔成形术可缩小乳突腔 ,促进乳突腔的通气引流及上皮化 ,提高乳突根治术的效果     

耳甲腔成形及耳后带蒂肌骨膜瓣乳突填塞对开放式乳突根治术疗效分析

目的探讨耳甲腔成形及耳后带蒂肌骨膜瓣乳突填塞对开放式乳突根治术疗效的影响。方法 2004年2月～2008年8月间在我院接受手术治疗的122例（122耳）患者中,57耳采用乳突根治术（改良乳突根治术）＋改良耳甲腔成形术及耳后带蒂肌骨膜瓣填塞根治腔（实验组）,65耳行常规手术方法,即采用乳突根治＋经典耳甲腔成形术,未做耳后肌骨膜瓣填塞（对照组）。术后随访时间为0.5～1年,观察两组患者术后干耳率和复发率情况。结果实验组干耳率为96.5%,明显高于对照组（80.0%）（P〈0.05）。实验组术后复发率（1.85%）低于对照组（7.7%）,但差异无统计学意义（P〉0.05）。结论两种术式的患者其术后复发率的差异不明显,改良耳甲腔成形术＋耳后带蒂肌骨膜瓣填塞开放式乳突根治腔,不但扩大了外耳道口,且缩小术后根治腔,促进乳突腔的上皮化及通气引流,提高术后干耳率,从而提高开放式乳突根治术的疗效。     

耳甲腔成形术对乳突根治术疗效的影响

目的 探讨耳甲腔成形对开放式乳突根治术疗效的影响.方法 60例慢性化脓性中耳炎患者行开放式乳突根治术,对32例行耳甲腔成形术(成形组)及28例未行耳甲腔成形术者(对照组)进行随访和疗效的相关分析.结果 成形组术后干耳平均时间为4.3周,肉芽生长发生率为6.25%;对照组术后干耳平均时间为5.5周,肉芽生长发生率为35.7%,两组比较差异均有统计学意义.两组术后复发、头晕、耳鸣、耳部不适等的发生率比较差异无统计学意义.结论 耳甲腔成形术方法简便,可有效改善术腔引流通气,缩短干耳时间,降低肉芽发生率,缩短上皮化时间,对提高乳突根治术的疗效有促进作用.     

ORM联合耳甲腔成形术、乳突腔填充术治疗中耳胆脂瘤的价值分析

目的:探讨开放式乳突根治术(open radical mas-toidectomy,ORM)联合耳甲腔成形术、乳突腔填充术治疗中耳胆脂瘤的价值。方法:回顾性分析2014年6月-2017年7月于本院确诊并行中耳胆脂瘤根治术患者60例,按照手术方式将患者分为ORM组(n=31)及联合组(n=29),其中ORM组手术方式为单纯ORM治疗,而联合组给予ORM联合耳甲腔成形术及乳突腔填充术,比较两组患者术后治疗效果、耳道及相应结构恢复情况、手术前后听力情况、并发症发生情况及随访1年内中耳胆脂瘤复发率的差异。结果:联合组患者治疗总有效率显著高于ORM组(P0.05);联合组患者干耳率及鼓膜存活率均显著高于ORM组,干耳时间及耳道上皮化时间均显著短于ORM组(P0.05);联合组术后6个月PTA及ABG均显著低于ORM组(P0.05);两组患者术后并发症发生率比较,差异无统计学意义(P0.05);联合组患者术后复发率显著低于ORM组(字2=4.251,P0.05)。结论:ORM联合耳甲腔成形术、乳突腔填充术治疗中耳胆脂瘤效果较好,且能促进患者术后耳道相关结构愈合,同时改善其听力情况,降低术后复发率,且安全性相对较好。     

耳道耳甲腔成形术在开放式乳突术中的应用

开放式乳突手术 ,包括乳突根治术及其改良术式 ,是胆脂瘤型和骨疡型中耳炎主要的手术方法 ,但要获得好的疗效 (获得干耳 ) ,妥善的术腔处理是至关重要的 ,我们自 1999年通过对 2 3例开放式乳突手术的术腔处理—耳道耳甲腔成形术 ,取得了较好的疗效 ,现报告如下。临床资料和方法　 2 3例胆脂瘤型和骨疡型中耳炎 ,男 13例 ,女 10例 ,年龄最大 55岁 ,最小 8岁 ,平均 30 6岁。病程量长 31年 ,最短 3年 10个月 ,平均 6 8年。其中单耳 2 1例 ,双耳 2例 ,共计 2 5耳。2 5耳均在局部加强化麻醉下作开放式乳突手术 ,术腔处理采用耳道耳甲腔成形术 ,…     

耳甲腔成形及乳突腔充填术在乳突根治术中的应用价值

目的：探讨耳甲腔成形术及乳突腔充填术在乳突根治术中的应用价值。方法：25例、25耳行乳突腔充填术及耳甲腔成形术，分别于术后3、6个月观察乳突腔缩小情况、干耳时间、术腔上皮化及术后是否出现前庭症状等。结果：经随访1～2年，患者巨大乳突术腔明显变小，皮肤光滑，色泽正常，全部病例均获干耳，干耳时间平均为6周，l例术后出现头晕，耳鸣症状，4耳同期行鼓室成形术，术后实用气导听力提高15～25dB。结论：耳甲腔成形术及乳突腔充填术可以缩小乳突腔，促进乳突腔的通气引流及上皮化，提高乳突根治术的效果，同时有利于鼓室成形术。     

耳后多种自体中胚层软组织及皮质骨粉填充乳突修复耳道后壁在开放式手术中的临床应用

目的：探讨在开放式鼓室成形术治疗慢性化脓性中耳炎和胆脂瘤型中耳炎中,采用耳后多种自体中胚层软组织和乳突皮质骨粉填充乳突术腔、修复耳道后壁以恢复耳道生理状态的临床应用。方法慢性化脓性中耳炎和胆脂瘤型中耳炎患者21例,借助于原有开放式鼓室成形术的手术基础,设计采用耳后多种自体中胚层软组织及乳突皮质骨粉,填充乳突术腔、修复外耳道后壁,以恢复耳道生理状态。结果术后随访6个月以上,除1例愈合后虽获干耳但仍遗留鼓膜小穿孔外,其余病例鼓膜均愈合,新外耳道较原耳道略宽敞,无明显分泌物积聚,无胆脂瘤复发,耳道干燥,后壁光滑,后内上角未形成钝角鼓膜,干耳率100％,鼓膜愈合率95．2％。结论在开放式鼓室成形术手术基础上,采用耳后多种中胚层组织和自体骨粉填充乳突术腔修复外耳道后壁,取材方便、修复方式简便,术后修复组织无液化坏死,愈合良好。远期随访观察,术后耳道后壁形态稳定,上皮化良好,皮肤色泽正常,耳道管腔略大且更趋近于术前正常生理状态,对恢复耳道生理结构和功能具有积极意义。     

开放式乳突根治术应用耳甲腔成形术

开放式乳突根治术，是胆脂瘤型和骨疡型中耳炎主要的手术方法。术中清除中耳病灶，防止颅内外并发症，以获得干耳。但术后不干耳常有发生，分析其原因，术中彻底处理术腔固为重要；临床采用扩大外耳道亦有利于乳突术腔早日上皮化。且提高了干耳率。我科2004--2006年共行乳突根治术及耳甲腔成形术13耳。取得良好效果，现报告如下。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Electro-Acupuncture Combined with the Trigger Point Needle-Embedding for Treatment of Primary Trigeminal Neuralgia in 31 Cases

In recent years, the author of this essay has applied electro-acupuncture combined with the trigger point needle-embedding for treatment of primary trigeminal neuralgia in 31 cases, yielding satis- factory results as reported in the following.     

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Objective： To explore the role of matrix metalloproteinase-1,2 （MMP-1, MMP-2） and tissue inhibitor of matrix metalloproteinases-1 （TIMP-1） in endometriosis. Methods： The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.endometria from 40 subjects （excluding endometriosis） were collected and examined by in situ hybridization technology and western blot assay. Results： Both expressions of MMP-1 and -2 were stronger in ectopic endometrium and eutopic endometrium than in normal endometrium. On the contrary, the expression of TIMP-1 in ectopic endometrium and eutopic endometrium was lower. The differences were significant （P 〈 0.01 ）. Moreover, there was no relationship among the expressions of MMP-1, 2 and TIMP-1 in ectopic endometrium. Conclusion： The expressions of MMP-1, 2 and TIMP-1 lose balance and lack of periodic changes in ectopic endometrium , which explains the biological invasive behavior of endometriosis. It was suggested-that regulating the balance between the MMPs and TIMP-1 should be an ideal therapeutic target to endometriosis.     

Shi Da-zhuo (史大卓) —An outstanding cardiologist of integrative medicine

Prof. SHI Da-zhuo, Ph.D., male, was born on March 20, 1960. Prof. SHI entered the Ph.D. program in 1990 at the China Academy of Chinese Medical Sciences under the supervision of Prof. CHEN Ke-ji, majoring in the treatment of cardiovascular diseases. After receiving his Ph.D. degree in 1993, Prof. SHI started working at the Cardiovascular Center in Xiyuan Hospital affiliated to China Academy of Chinese Medical sciences.     

Persist in and Carry Forward the Integrative Medical Research——Speech at the 6th National General Congress of Chinese Association of Integrative Medicine by Academician CHEN Zhu,Minister of Ministry of Health

The 6th National General Congress of Chinese Association of Integrative Medicine （CALM） was convened at 19-20, April 2008 in Beijing. Academician CHEN Zhu, the minister of Ministry of Health indicated at the congress that the integration of Chinese and Western medicine is very well in keeping with the situation of our country and the general rule of development in medical science; and as a good integration of Chinese medicine and Western medicine, it is mutually beneficial and advantageous to both of them. Seeing the creativity shown in integrative medical investigation in theoretic and methodological sides, we should and must persist in and develop it.