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南海蓖麻海绵Biemna fortis化学成分的研究(一) 总被引:1,自引:1,他引:0
通过柱层析,色-质联用和波谱技术(IR,~1HNMR,_(13)CNMR)等方法,从南海蓖麻海绵Biemnafortis中分离鉴定出三个甾醇:(22E)-3β-羟基胆甾-5,8,22-三烯-7-酮(1),(22E,24ξ)-3β-羟基-24-甲基胆甾-5,8,22-三烯-7-酮(2)和(22E,24ξ)-3β-羟基-24-乙基胆甾-5,8,22-三烯-7-酮(3)。 相似文献
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女贞子化学成分的研究(Ⅱ) 总被引:3,自引:0,他引:3
继前报,作者又从女贞子(LiguslrumLucidumAil.)乙醇提取物的石油醚萃取部分和乙酸乙酯萃取部分分离鉴定了4个化合物.化合物Ⅵ为19α-羟基-3-乙酰乌索酸(19α-hydroxy-3-acetyl-ursolicacid),化合物Ⅸ为对羟基苯乙醇-β-D-葡萄糖甙(p-hydroxyphenethyl-β-D-glucoside),化合物X为芹菜素-7-O-β-D-葡萄糖甙(cosmossin),化合物Ⅺ为甘露醇(mannitol).其中化合物Ⅵ为一新天然产物. 相似文献
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自蛇毒(DuchesneaindicaFock)全草中分离出6个化合物,其中,2个为新化合物,分别命名为蛇莓甙A(duchesideA)和蛇莓甙B(duchesideB),经化学及光谱(UV,1R,1HNMR,13CNMR,NOEDS和MS)分析确定,蛇莓甙A的结构为3'-O-甲基-鞣花酸-4-O-β-D-吡喃木糖甙(Ⅰ),蛇莓甙B的结构为3'-O-甲基-鞣花酸-4-O-α-L-呋喃阿拉伯糖甙(Ⅱ)。另外4个化合物为已知三萜类化合物:3β-羟基-乌苏烷-12-烯-28-羧酸(Ⅲ),2α,3β,19α-三羟基-乌苏烷-12-烯-28-羧酸(Ⅳ),2α,3β,19α-三羟基-乌苏烷-12-烯-28-羧酸-28-O-β-D-吡喃葡萄糖甙(Ⅴ),2α,3α,19α-三羟基-乌苏烷-12-烯-28-羧酸-28-O-β-D-吡喃葡萄糖甙(Ⅵ)。其中化合物Ⅳ,Ⅴ和Ⅵ为首次从该属植物中分离得到。 相似文献
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南海蓖麻海绵Biemna fortis化学成分的研究(二) 总被引:4,自引:0,他引:4
从南海蓖麻海绵Biemna fortis中分离出4个有机化合物,经IR,~1HNMB,~13CNMR,EIMS,GC-MS等方法确定它们的化学结构分别为:正十八酸(1),鲨肝醇(2),5α, 8β.环二氧-24ξ-甲基胆甾-6, 22-二烯-3β-醇(3), 24ξ-甲基胆甾-7,22-二烯-3β,5α-二醇6-酮(4)。 相似文献
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目的研究中药地梢瓜果实的化学成分。方法利用硅胶、Sephadex LH-20柱色谱及HPLC等方法进行分离纯化,根据理化性质和波谱数据进行结构鉴定。结果分离得到6个三萜类化合物,分别鉴定为β-香树脂醇乙酸酯(1)、羽扇豆醇乙酸酯(2)、α-香树脂醇正辛烷酸酯(3)、α-香树脂醇(4)、β-香树脂醇(5)、齐墩果酸(6)。结论化合物4、5、6为首次从该植物中分离得到,化合物4、6为首次从该属植物中分离得到。 相似文献
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女贞子化学成分的研究(Ⅱ)1) 总被引:4,自引:0,他引:4
继前报,作者又从女贞子(Ligustrum Lucidum Ait。)乙醇提取物的石油醚萃取部分和乙酸乙酯萃取部分分离鉴定了4个化合物。化合物Ⅵ为19a-羟基-3-乙酰乌索酸(19a-hydroxy-3-acetyl-ursolic acid),化合物Ⅸ为对羟基苯乙醇-β-D-葡萄糖甙(p-hydroxyphenethyl-β-D-glucoside),化合物X为芹菜素-7-O-β-D-葡萄糖甙( 相似文献
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本文报道了胆甾烷-3β,5α,6β-三醇、胆甾烷-3β,5α,6α-三醇、胆甾-4-烯-3β,6β-二醇、胆甾-4-烯-3β,6α-二醇及其琥珀酸单酯和它们的钠盐的合成,体外试验的初步结果表明:胆甾烷-3β,5α,6β-三醇-3-琥珀酸单酯钠(17),胆甾烷-3β,5α,6α-三醇-3,6-双琥珀酸单酯钠(18),胆甾-4-烯-3β,6β-二醇-3,6-双琥珀酸单酯钠(19)及胆甾-4-烯-3β,6α-二醇-3,6双琥珀酸单酯钠(20)具有较明显的抗癌活性。 相似文献
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Three sesquiterpene lactone compounds, two novel(1β, 3β-dihydroxy-6β, 11β, 4α, 5α, 7αH-eudesm-12,6-olide-1-O-β-D-glucopyranoside, 1β, 3β-dihydroxy-6β, 4β, 5α, 7αH-eudesm-11 en-12,6-olide-1-O-β-D-glucopyranoside) and 1β, 3β-dihydroxy-6β, 11β, 4α, 5α, 7αH-eudesm-12,6-olide were isolated from the aqueous fraction of MeOH extract of the roots fromTaraxacum hallaisanensis (Compositae) employing Amberlite XAD-2, ODS-gel, silica gel and Sephadex LH-20 column chromatographics. Another known compound, (?)-epicatechin, was isolated from the aqueous fraction of the MeOH extract. The total MeOH extract also contained phytosterol and a mixture of β-amyrin acetate, α-amyrin acetate and lupeol acetate. Structures of isolated compounds were elucidated by spectroscopic parameters of IR, Mass,13C-NMR,1H-NMR,1H-1H COSY,13C-1H COSY and HMBC. 相似文献
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目的: 追踪分离牛奶菜的化学成分,并对分离得到的单体化合物进行抗肿瘤活性测试。方法: 以体积分数70%乙醇回流提取,采用各种色谱技术对提取物进行分离纯化,通过理化性质和光谱数据确定所得单体化合物的结构。结果: 从牛奶菜根的提取物中分离并鉴定了10个化合物,分别鉴定为α-香树脂醇乙酸酯 (1)、α-香树脂醇 (2)、3β, 24-二羟基乌苏烷-12-烯 (3)、补骨脂素 (4)、β-胡萝卜苷 (5)、异香草酸 (6)、α-单棕榈精 (7)、亚油酸 (8)、二十四烷酸 (9)、十六烷醇 (10)。结论:化合物3、4、6、7为首次从该植物中分离得到。 相似文献
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目的 研究卫矛科卫矛属植物肉花卫矛 (Euonymus carnosus Hemsl.) 的化学成分。方法 采用正相硅胶和 Sephalex LH-20 凝胶柱色谱等分离方法对肉花卫矛的乙酸乙酯萃取部位进行分离纯化,根据理化性质和波谱数据进行结构鉴定。结果 分离得到 5 个三萜类化合物,分别鉴定为 β-香树脂醇棕榈酸酯(Ⅰ)、β-香树脂醇(Ⅱ)、齐墩果酸(Ⅲ)、3β, 22α-二羟基-12-齐墩果烯-29-羧酸(Ⅳ)、山海棠萜酸(Ⅴ)。所有化合物均为首次从肉花卫矛中分离得到。 相似文献
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夏枯草皂苷A的结构鉴定 总被引:28,自引:1,他引:27
目的:研究夏枯草(Prunella vulgaris L.)果穗中的化学成分。方法:用色谱法分离夏枯草的化学成分,并用化学及波谱法鉴定其结构。结果:从夏枯草中分离得到6个化合物,根据理化性质和波谱数据鉴定其结构分别为β-香树脂醇(1),α-波甾醇(2),豆甾醇(3),豆甾-7-烯-3β-醇(4),咖啡酸(5)和2α,3α,24-三羟基-齐墩果-12-烯-28-酸-28-β-D-吡喃葡糖酯苷(6)。并将其亲脂性部分甲基化后用气质联用方法进行分析,从中分离鉴定了8个脂肪酸类化合物。 结论:化合物6为新化合物,命名为夏枯草皂苷A,化合物2~5为首次从夏枯草获得。 相似文献
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Alliumonoate, a new cyclopentane derivative, has been isolated from the chloroform-soluble fraction of the ethanolic extract of Allium victorialis, along with β-amyrin acetate, β-sitosterol acetate, 22-cyclohexyl-1-docosanol, β-amyrin, β-sitosterol, and β-sitosterol 3-O-β-D-glucopyranoside, reported for the first time from this species. Their structures were elucidated on the basis of spectral data including mass spectra and 2D NMR experiments. 相似文献
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Nkeoma Nkasi Okoye Daniel Lotanna Ajaghaku Henry Nnaemeka Okeke Emmanuel Emeka Ilodigwe Chukwuemeka Sylvester Nworu 《Pharmaceutical biology》2014,52(11):1478-1486
Context: Alstonia boonei De Wild (Apocyanaceae) is used in ethnomedicine for the management of malaria, ulcer, rhematic pain, toothache, and inflammatory disorders.Objective: To investigate the anti-inflammatory potential of β-amyrin and α-amyrin acetate isolated from the stem bark of Alstonia boonei using animal models.Materials and methods: Chromatographic purification of the crude methanol extract led to the isolation and structure elucidation of β-amyrin and α-amyrin acetate. Their anti-inflammatory activities were evaluated in rodents using egg albumen-induced paw edema and xylene-induced ear edema models. The gastric ulcerogenic, in vivo leucocyte migration, and RBC membrane stabilization tests were also investigated.Results: α-Amyrin acetate at 100?mg/kg showed significant (p?0.05) inhibition of egg albumen-induced paw edema with % inhibition of 40 at the 5th hour. Oral administration up to 100?mg/kg did not produce significant (p?>?0.01) irritation of the gastric mucosa while significant (p?0.01) ulceration was recorded for indomethacin at 40?mg/kg compared with the negative control. At 100?μg/mL, both β-amyrin and α-amyrin acetate inhibited heat-induced hemolysis to as much 47.2 and 61.5%, respectively, while diclofenac sodium (100?μg/mL) evoked only 40.5% inhibition. Both compounds at 100?µg/ear produced significant (p?0.01) inhibition of ear edema in mice by 39.4 and 55.5%, respectively. Also at 100?mg/kg (p.o.) α-amyrin acetate evoked 60.3% reduction in total leucocyte count and significant (p?0.05) suppression (47.9%) of neutrophil infiltration.Discussion and conclusion: This study generally provided evidence of profound anti-inflammatory activity of β-amyrin and α-amyrin acetate isolated from the Alstonia boonei stem bark. 相似文献
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本文用高效液相色谱法,以YWG-5μ硅胶柱、己烷—氯仿—异丙醇(68:27:5)为流动相,对醋酸泼尼松中的甾类杂质进行了分离、鉴定,并用制备柱对其中三个主要甾类杂质进行了制备,经红外吸收光谱、质谱、核磁共振氢谱测定,推定其结构为16-溴-17,21-二羟基(17α)孕甾-1,4-二烯-3,11,20-三酮-21-醋酸酯;另外两个主要甾类杂质与对照品的红外吸收图谱比较分别确证为;11-去氧醋酸泼尼松及醋酸可的松。以苯甲酸雌二醇为内标,对醋酸泼尼松中的11-去氧醋酸泼尼松及醋酸可的松进行了定量分析,并做了回收率试验,同时考察了内标与11-去氧醋酸泼尼松及醋酸可的松的线性关系。 相似文献
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The anti-inflammatory activity of α-amyrin acetate and β-amyrin acetate was found similar to hydrocortisone on granulation tissue formation induced by “cotton wool” pellet implantation in albino rats. Quantitatively, β-amyrin acetate showed more potent anti-inflammatory activity in comparison to α-amyrin acetate. 相似文献
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Two new oleanane-type triterpenes, (23Z)-feruloylhederagenin (1) and (23E)-feruloylhederagenin (2), together with two known oleanane-type triterpenes, β-amyrin acetate and β-amyrin palmitate, have been isolated from the whole plant of Ludwigia octovalvis. The structures of 1 and 2 were characterised on the basis of spectral evidence. 相似文献