Effects of sex hormones on plasma lipid peroxidationin vitro

The effects of sex steroid hormones on the level of plasma lipid peroxidation are studiedin vitro. Estradiol shows pronounced antioxidative activity; progesterone and testosterone slightly suppress lipid peroxidation only when used in high concentrations. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 7, pp. 73–76, July, 1997     

Effects of hormones on phospholipase A2 activity in rat skin

We studied the effects of hydrocortisone, progesterone, estradiol, and testosterone on phospholipase A₂ activity in plasma and lysosomal membranes of rat dermis and epidermis. The dermal enzyme was more sensitive to estradiol, while epidermal to testosterone. The effects of progesterone and hydrocortisone were mediated by lipocortin-like protein, while estradiol and testosterone directly by modulated phospholipase A₂ activity Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 1, pp. 70–72, January, 2000     

Effect of glucocorticoids and gestagens on glutathione redox-system in rat skin involved in dermatitis

In the model of experimental dermatitis the effect of hydrocortisone and two gestagens (endogenous progesterone and synthetic mecygestone) on the level of glutathione redox-system components (reduced glutathione, glutathione reductase, and glutathione peroxidase) in rat dermis and epidermis is characterized by different degree of activation of this system.     

Effect of pH and glutathione on lipid peroxidation in tocopherol-enriched liposomes

Tocopherol-enriched liver microsomes are more resistant to lipid peroxidation at an alkaline pH of 8.5 in comparison with microsomes incubated at pH 7.5. An alkaline pH provides conditions for two-electron oxidation of tocopherol, which causes the lipid molecule to revert to the initial state (O₂/H exchange). A possible mechanism of inhibition of lipid peroxidation within the physiological range of pH with participation of a glutathione-dependent enzyme is discussed. Translated fromByullenten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N ^o 9, pp. 268–270, September, 1995 Presented by E. I. Chazov, Member of the Russian Academy of Medical Sciences     

Effects of diuretics on the intensity of lipid peroxidation and antioxidant protection of blood plasma

An increase in the content of primary and final lipid peroxidation (LPO) products and a decrease in the fat- and water-soluble antioxidants in blood plasma are revealed in a study of hypohydration induced by administration of 40 mg furosemide alone or in combination with 1 tablet of triampure. Intensification of free radical processes in states simulating weightlessness may be related to the loss of fluid due to transformation of water-electrolyte metabolism. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N ^o 5, pp. 478–479, May, 1994 Presented by V. N. Smirnov, Member of the Russian Academy of Medical Sciences     

Multiresistance and lipid peroxidation system of thermoresistantShigella sonnei strains

The content of lipid peroxidation products increases in lipids isolated fromShigella sonnei after heating. Thermoresistant strains are characterized by higher activity of superoxide dismutase and catalase and by stable activity of glutathione reductase and glutathione transferase compared with thermolabile strains. Thermoresistant strains are also resistant to some antibiotics and hydrogen peroxide. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 7, pp. 69–71, July, 1996     

Antenatal effects of ethanol and limontar on lipid peroxidation and the antioxidant defense system in the brain and liver of rat progeny

In contrast to short-term exposure, prolonged exposure to ethanol in the anternatal period is found to inhibit lipid peroxidation in the brain and liver of rats. Activation of the system of antioxidant defense in the brain and liver is observed after both short-and long-term exposure to ethanol. After short-term ethanol exposure, limontar normalizes lipid peroxidation. Translated fromByulleten' Eksperimental'noii Biologii i Meditsiny, Vol. 117, N ^o 1, pp. 41–44, January, 1994 Presented by M. Ya. Studenikin, Member of the Russian Academy of Medical Sciences     

Correlation between the parameters of free-radical lipid peroxidation and antioxidant system in children living in the north

A comparative study of the parameters of free-radical lipid peroxidation and antioxidant system was performed in children living in the North for various time periods. Intense lipid peroxidation was shown to be the key factor in the pathogeneses of several diseases caused by disturbances in the cellular membrane. Decreased resistance of red blood cells to peroxidative hemolysis is a phenomenon characterizing the adaptation-violating processes. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 9, pp. 342–344, September, 1998     

Antioxidant defense and lipid peroxidation in rat tissue after hypobaric hypoxia

Posthypoxic period is characterized by increased formation of lipid peroxidation products. Changes in the antioxidant enzyme systems include decreased catalase and glutathione reductase activities and elevated content of reduced glutathione. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 11, pp. 519–521, November, 1998     

Effect of the tranquilizer mebicar on lipid metabolism and lipid peroxidation on the model of hypokinesia in rats

Daily 18-hour hypokinesia induces atherogenic shifts in the blood lipid spectrum and activates lipid peroxidation in rats. Mebicar is shown to have a correcting effect on lipid metabolism and on the intensity of lipid peroxidation. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 5, pp. 535–537, May, 1996     

In vitro effect of bilirubin on antioxidant activity and lipid peroxidation in the plasma and erythrocytes of cord blood

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 116, N ^o 7, pp. 50–52, July, 1993     

Lipid peroxidation and antioxidant system in children living in the Northern Transbaikal region

Exposure to extreme environmental factors of the North creates prerequisites for hyperactivation of free-radical oxidation reactions which may limit the adaptive potential of cells and organism. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 11, pp. 581–583, November, 1998     

Parameters of lipid peroxidation in erythrocytes of children being treated for acquired severe aplastic anemia

It is shown that a peroxidase-catalase mechanism of antioxidant defense predominates in the erythrocytes of children with acquired aplastic anemia, and that the high level of lipid peroxidation (LPO) processes in such children dictates the need for continued antioxidant therapy during all phases of the disease. The antioxidant effect of glucocorticoids appears to be quite sufficient for eliminating the more severe effects of LPO. Translated fromByulleten' Eksperimental'noii Biologii i Meditsiny, Vol. 117, N ^o 1, pp. 36–38, January, 1994 Presented by M. Ya. Studenikin, Member of the Russian Academy of Medical Sciences     

Time course of lipid peroxidation during adaptation of men to novel ecological conditions

Changes in the intensity of lipid peroxidation and serum activities of superoxide dismutase and catalase were similar after 18-month adaptation to new ecological conditions of soldiers serving in two different regions. All values increased and reached the maximum by the 6th month, after which they stabilized; catalase activity decreased after 6 months. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 12, pp. 678–682, December, 1997     

Effects of ubiquinone-10 on energy metabolism and lipid peroxidation in rats with myocardial ischemia

Preventive and therapeutic intraventricular administration of ubiquinone-10 to male rats with epinephrine-induced myocarditis increased the rate of oxidative phosphorylation, elevated the content of ATP, and inhibited lipid peroxidation in ischemic myocardium. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 7, pp. 35–38, July, 2000     

Effects of ubiquinone-10 on energy metabolism and lipid peroxidation in rats with myocardial ischemia

Preventive and therapeutic intraventricular administration of ubiquinone-10 to male rats with epinephrine-induced myocarditis increased the rate of oxidative phosphorylation, elevated the content of ATP, and inhibited lipid peroxidation in ischemic myocardium. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 7, pp. 35–38, July, 2000     

Chemiluminescence study of the contents of the products of Cu2+-induced lipid peroxidation in different fractions of human blood lipoproteins

It is demonstrated that the content of the primary products of lipid peroxidation reaches the maximum after about 1-h incubation with Cu²⁺ and then declines. At a Cu²⁺ concentration of about 10–15 μM, the content of lipid peroxidation products is maximal; it does not rise with a further increase in the Cu²⁺ concentration. Comparison of the kinetics of lipid peroxidation in different lipoprotein fractions shows that low density lipoproteins are much more strongly oxidized than high density lipoproteins. A strong positive correlation between the amplitude of the chemiluminescence burst and the diene conjugate content is established in 79 independent measurements. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 2, pp. 144–148, February, 1995     

Effect of ozone on lipid peroxidation in rat hearts isolated against the background of clinical death

Clinical death of outbred albino rats ensues after rapid blood loss due to a cut in the coronary coronary artery. Five minutes later, the isolated heart is perfused with ozonized Krebs-Henseleit solution. The activity of the antioxidant system in the heart is increased compared with that during routine oxygenation. The intensity of lipid peroxidation assessed by the intensity of chemiluminescence and the amount of lipid peroxidation products is significantly decreased during ozonization. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, № 2, pp. 161–163, February, 1996 Presented by B. A. Korolev, Member of the Russian Academy of Medical sciences